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ONTOLOGY REPORT - ANNOTATIONS


Term:lysosome organization
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Accession:GO:0007040 term browser browse the term
Definition:A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases.
Synonyms:exact_synonym: lysosome organisation
 related_synonym: lysosome organization and biogenesis


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lysosome organization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07008608.1 RGD:13792537
G AABR07019209.2 RGD:13792537
G AABR07026291.1 RGD:1600115
G AABR07028902.1 RGD:1600115
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:1624291
G Acp2 acid phosphatase 2, lysosomal JBrowse link 3 80,020,346 80,030,365 RGD:1600115
RGD:1624291
G Aktip AKT interacting protein JBrowse link 19 17,290,048 17,300,054 RGD:1624291
RGD:1600115
G Ap3b1 adaptor related protein complex 3 subunit beta 1 JBrowse link 2 24,022,815 24,227,522 RGD:1624291
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:1624291
G Chmp5 charged multivesicular body protein 5 JBrowse link 5 57,267,312 57,284,455 RGD:1624291
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:1624291
RGD:13792537
G Cln5 CLN5, intracellular trafficking protein JBrowse link 15 93,634,815 93,644,146 RGD:1624291
G Cln6 CLN6, transmembrane ER protein JBrowse link 8 67,733,215 67,748,170 RGD:1624291
RGD:13792537
G Cln8 CLN8, transmembrane ER and ERGIC protein JBrowse link 16 79,828,321 79,838,212 RGD:1624291
G Clvs1 clavesin 1 JBrowse link 5 22,380,318 22,580,391 RGD:1600115
RGD:13792537
RGD:8553526
G Clvs2 clavesin 2 JBrowse link 1 25,173,089 25,217,625 RGD:8553526
RGD:13792537
G Fam160a2 family with sequence similarity 160, member A2 JBrowse link 1 170,216,505 170,238,898 RGD:1624291
RGD:1600115
G Gaa glucosidase, alpha, acid JBrowse link 10 108,395,873 108,412,999 RGD:1624291
RGD:1600115
G Gba glucosylceramidase beta JBrowse link 2 188,511,781 188,522,602 RGD:1624291
G Gnptab N-acetylglucosamine-1-phosphate transferase subunits alpha and beta JBrowse link 7 28,956,363 29,023,232 RGD:1624291
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:1600115
RGD:1624291
G Hexa hexosaminidase subunit alpha JBrowse link 8 64,325,435 64,350,775 RGD:1624291
G Hexb hexosaminidase subunit beta JBrowse link 2 27,983,925 28,003,260 RGD:1624291
RGD:1600115
G Hook1 hook microtubule-tethering protein 1 JBrowse link 5 114,940,053 115,000,691 RGD:1624291
G Hook2 hook microtubule-tethering protein 2 JBrowse link 19 26,106,713 26,119,353 RGD:1624291
G Hook3 hook microtubule-tethering protein 3 JBrowse link 16 70,710,347 70,818,789 RGD:1624291
G Hps1 HPS1, biogenesis of lysosomal organelles complex 3 subunit 1 JBrowse link 1 261,989,178 262,015,282 RGD:1624291
G Hps4 HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 JBrowse link 12 50,285,239 50,315,893 RGD:1624291
G Idua alpha-L-iduronidase JBrowse link 14 2,041,828 2,056,762 RGD:1624291
G Lamtor1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 JBrowse link 1 166,991,474 166,997,045 RGD:1624291
RGD:1600115
G LOC100361543 RhoA activator C11orf59-like JBrowse link X 37,261,428 37,262,470 RGD:1600115
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
G Lyst lysosomal trafficking regulator JBrowse link 17 90,323,055 90,522,091 RGD:1624291
G Mbtps1 membrane-bound transcription factor peptidase, site 1 JBrowse link 19 52,146,507 52,206,310 RGD:1624291
RGD:1600115
G Mfsd8 major facilitator superfamily domain containing 8 JBrowse link 2 127,706,618 127,784,129 RGD:1624291
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:1624291
RGD:1600115
G Myo7a myosin VIIA JBrowse link 1 163,001,313 163,071,545 RGD:1624291
RGD:1600115
G Naglu N-acetyl-alpha-glucosaminidase JBrowse link 10 88,979,363 88,986,879 RGD:1624291
G Ppt1 palmitoyl-protein thioesterase 1 JBrowse link 5 140,538,260 140,558,163 RGD:1624291
G Snapin SNAP-associated protein JBrowse link 2 189,878,159 189,880,743 RGD:1624291
RGD:13792537
G Spg11 SPG11 vesicle trafficking associated, spatacsin JBrowse link 3 113,999,600 114,064,438 RGD:1624291
G Tfeb transcription factor EB JBrowse link 9 15,208,141 15,264,101 RGD:1624291
G Tmem106b transmembrane protein 106B JBrowse link 4 39,517,679 39,534,491 RGD:1624291
RGD:13792537
G Tpcn2 two pore segment channel 2 JBrowse link 1 218,419,182 218,448,902 RGD:1624291
G Tpp1 tripeptidyl peptidase 1 JBrowse link 1 170,588,036 170,594,159 RGD:1624291
RGD:1600115
G Vps18 VPS18 core subunit of CORVET and HOPS complexes JBrowse link 3 111,097,352 111,108,206 RGD:1624291
RGD:13792537
G Vps35 VPS35 retromer complex component JBrowse link 19 27,464,937 27,500,636 RGD:1624291
G Washc5 WASH complex subunit 5 JBrowse link 7 99,625,379 99,677,237 RGD:1624291
G Zkscan3 zinc finger with KRAB and SCAN domains 3 JBrowse link 17 45,247,724 45,263,422 RGD:1624291
lysosomal lumen acidification term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp6ap2 ATPase H+ transporting accessory protein 2 JBrowse link X 11,137,889 11,164,854 RGD:1624291
RGD:1600115
G Ccdc115 coiled-coil domain containing 115 JBrowse link 9 37,774,876 37,778,839 RGD:1624291
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:1624291
RGD:13792537
RGD:1600115
G Cln5 CLN5, intracellular trafficking protein JBrowse link 15 93,634,815 93,644,146 RGD:1624291
G Cln6 CLN6, transmembrane ER protein JBrowse link 8 67,733,215 67,748,170 RGD:1624291
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:1600115
RGD:1624291
G Ppt1 palmitoyl-protein thioesterase 1 JBrowse link 5 140,538,260 140,558,163 RGD:1624291
RGD:8553248
G Snapin SNAP-associated protein JBrowse link 2 189,878,159 189,880,743 RGD:1624291
G Tmem199 transmembrane protein 199 JBrowse link 10 65,775,721 65,780,293 RGD:1624291
RGD:1600115
lysosomal lumen pH elevation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:1624291
RGD:1600115
lysosomal membrane organization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arf1 ADP-ribosylation factor 1 JBrowse link 10 45,562,700 45,579,214 RGD:9684948
negative regulation of lysosome organization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:11561937
phagolysosome assembly term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Coro1a coronin 1A JBrowse link 1 198,123,883 198,128,890 RGD:1624291
G Myo7a myosin VIIA JBrowse link 1 163,001,313 163,071,545 RGD:1624291
G P2rx7 purinergic receptor P2X 7 JBrowse link 12 39,353,613 39,396,042 RGD:1624291
G Srpx sushi-repeat-containing protein, X-linked JBrowse link X 14,146,618 14,220,756 RGD:1624291
phagolysosome assembly involved in apoptotic cell clearance term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rab14 RAB14, member RAS oncogene family JBrowse link 3 14,373,270 14,395,357 RGD:13792537
phagosome-lysosome docking term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:1624291
phagosome-lysosome fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07037545.1 RGD:13792537
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin JBrowse link 1 197,986,384 197,999,726 RGD:1624291
G Pla2g5 phospholipase A2, group V JBrowse link 5 157,247,601 157,268,968 RGD:1600115
RGD:1624291
G Rab20 RAB20, member RAS oncogene family JBrowse link 16 83,358,116 83,382,326 RGD:1624291
G Rab34 RAB34, member RAS oncogene family JBrowse link 10 65,448,111 65,452,178 RGD:1624291
RGD:13792537
RGD:1600115
G Rab39a RAB39A, member RAS oncogene family JBrowse link 8 58,275,984 58,292,995 RGD:1624291
G Rab7a RAB7A, member RAS oncogene family JBrowse link 4 119,910,461 119,963,065 RGD:1624291
RGD:13792537
RGD:1600115
G Rab7b Rab7b, member RAS oncogene family JBrowse link 13 48,456,143 48,483,714 RGD:13792537
G Syt7 synaptotagmin 7 JBrowse link 1 226,435,816 226,498,008 RGD:1624291
RGD:1600115
G Tmem175 transmembrane protein 175 JBrowse link 14 2,083,745 2,100,006 RGD:1624291
RGD:1600115
phagosome-lysosome fusion involved in apoptotic cell clearance term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Spg11 SPG11 vesicle trafficking associated, spatacsin JBrowse link 3 113,999,600 114,064,438 RGD:1624291
positive regulation of lysosomal membrane permeability term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:10059368
G Mt3 metallothionein 3 JBrowse link 19 11,324,708 11,326,112 RGD:1624291
RGD:1600115
positive regulation of lysosome organization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:1600115
RGD:1624291
regulation of lysosomal lumen pH term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC681325 hypothetical protein LOC681325 JBrowse link X 80,359,555 80,363,168 RGD:13792537
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1624291
G RGD1565785 similar to chromosome X open reading frame 21 JBrowse link X 54,390,733 54,409,466 RGD:1624291
RGD:13792537
G Tmem165 transmembrane protein 165 JBrowse link 14 34,503,037 34,528,262 RGD:1624291
RGD:1600115
G Tmem175 transmembrane protein 175 JBrowse link 14 2,083,745 2,100,006 RGD:1624291
RGD:1600115
G Vps33a VPS33A core subunit of CORVET and HOPS complexes JBrowse link 12 38,459,816 38,482,903 RGD:1624291
RGD:1600115
regulation of lysosomal membrane permeability term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Laptm4b lysosomal protein transmembrane 4 beta JBrowse link 7 72,924,911 72,968,099 RGD:1624291
RGD:1600115
regulation of lysosome organization term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Laptm4b lysosomal protein transmembrane 4 beta JBrowse link 7 72,924,911 72,968,099 RGD:1624291
RGD:1600115
G Trex1 three prime repair exonuclease 1 JBrowse link 8 117,796,127 117,797,427 RGD:1624291

Term paths to the root
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Term Annotations click to browse term
  biological_process 19858
    cellular process 18618
      cellular component organization or biogenesis 6706
        cellular component organization 6456
          organelle organization 4029
            vacuole organization 194
              lytic vacuole organization 74
                lysosome organization 74
                  lysosomal membrane organization + 4
                  negative regulation of lysosome organization 1
                  phagolysosome assembly + 16
                  positive regulation of lysosome organization 1
                  regulation of lysosomal lumen pH + 15
                  regulation of lysosome organization + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.