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ONTOLOGY REPORT - ANNOTATIONS


Term:mitotic sister chromatid cohesion
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Accession:GO:0007064 term browser browse the term
Definition:The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission.


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mitotic sister chromatid cohesion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc20 cell division cycle 20 ISO MGI:MGI:1353578 (MGI:MGI:3710433|PMID:17325031) RGD PMID:17325031 MGI:MGI:3710433 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdca5 cell division cycle associated 5 ISO
IBA
UniProtKB:Q96FF9 (MGI:MGI:4936811|PMID:21111234)
PMID:21873635
UniProtKB:Q29RF7 (PMID:17349791), (PMID:21111234)
RGD PMID:17349791, PMID:21111234, PMID:21873635 MGI:MGI:4936811, RGD:13792537 NCBI chr 1:221,448,661...221,462,235
Ensembl chr 1:221,448,661...221,462,233
JBrowse link
G Chtf8 chromosome transmission fidelity factor 8 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr19:39,077,580...39,087,880
Ensembl chr19:39,077,580...39,087,880
JBrowse link
G Haspin histone H3 associated protein kinase ISO (PMID:20705812) RGD PMID:20705812 NCBI chr10:59,695,403...59,698,398
Ensembl chr10:59,695,913...59,698,168
JBrowse link
G LOC102553099 N-alpha-acetyltransferase 50-like IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:61,466,807...61,470,184
Ensembl chr11:61,466,962...61,470,348
JBrowse link
G Naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:61,508,162...61,530,830
Ensembl chr11:61,462,994...61,530,837
JBrowse link
G Nipbl NIPBL, cohesin loading factor ISO
IBA
(PMID:16100726)
PMID:21873635
RGD PMID:16100726, PMID:21873635 RGD:13792537 NCBI chr 2:57,508,830...57,676,197
Ensembl chr 2:57,509,428...57,600,820
JBrowse link
G Pds5a PDS5 cohesin associated factor A ISO
IBA
UniProtKB:Q96FF9 (PMID:21111234)
PMID:21873635
RGD PMID:21111234, PMID:21873635 RGD:13792537 NCBI chr14:44,185,445...44,282,308
Ensembl chr14:44,185,446...44,280,079
JBrowse link
G Pds5b PDS5 cohesin associated factor B IEA
IBA
ISS
ISO
GO_REF:0000107
GO_REF:0000002
PMID:21873635
GO_REF:0000024
(PMID:15855230)
Ensembl
InterPro
UniProt
RGD
PMID:15855230, PMID:21873635 GO_REF:0000002, GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr12:659,995...794,042
Ensembl chr12:660,011...794,042
JBrowse link
G Pogz pogo transposable element derived with ZNF domain ISO (PMID:20562864) RGD PMID:20562864 NCBI chr 2:195,995,322...196,041,500
Ensembl chr 2:195,996,521...196,041,497
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin ISO MGI:MGI:1859866 (MGI:MGI:3710433|PMID:17325031) RGD PMID:17325031 MGI:MGI:3710433 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Rad21 RAD21 cohesin complex component IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:91,511,755...91,538,673
Ensembl chr 7:91,511,756...91,538,673
JBrowse link
G Rad21l1 RAD21 cohesin complex component like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:147,163,335...147,191,008
Ensembl chr 3:147,163,838...147,188,929
JBrowse link
G Rec8 REC8 meiotic recombination protein IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:34,296,922...34,304,387
Ensembl chr15:34,296,922...34,304,552
JBrowse link
G Smc1a structural maintenance of chromosomes 1A IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:21,710,976...21,755,708
Ensembl chr  X:21,711,019...21,755,525
JBrowse link
G Smc1b structural maintenance of chromosomes 1B IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:125,966,480...126,028,287
Ensembl chr 7:125,966,480...126,028,279
JBrowse link
establishment of mitotic sister chromatid cohesion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit ISO (PMID:27422821) RGD PMID:27422821 NCBI chr11:61,508,162...61,530,830
Ensembl chr11:61,462,994...61,530,837
JBrowse link
G Nipbl NIPBL, cohesin loading factor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:57,508,830...57,676,197
Ensembl chr 2:57,509,428...57,600,820
JBrowse link
maintenance of mitotic sister chromatid cohesion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dscc1 DNA replication and sister chromatid cohesion 1 ISO
IBA
(PMID:16682347), (PMID:19907496)
PMID:21873635
RGD PMID:16682347, PMID:19907496, PMID:21873635 RGD:13792537 NCBI chr 7:94,759,076...94,774,787
Ensembl chr 7:94,758,800...94,774,569
JBrowse link
G Mau2 MAU2 sister chromatid cohesion factor ISO
IBA
(PMID:16682347), (PMID:16802858)
PMID:21873635
RGD PMID:16682347, PMID:16802858, PMID:21873635 RGD:13792537 NCBI chr16:21,132,115...21,163,257
Ensembl chr16:21,132,147...21,163,257
JBrowse link
G Nipbl NIPBL, cohesin loading factor ISO (PMID:16682347) RGD PMID:16682347 NCBI chr 2:57,508,830...57,676,197
Ensembl chr 2:57,509,428...57,600,820
JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO
IEA
(PMID:20551165)
GO_REF:0000107
RGD
Ensembl
PMID:20551165 GO_REF:0000107 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
mitotic sister chromatid cohesion, centromeric term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bod1 biorientation of chromosomes in cell division 1 ISO (PMID:24157919) RGD PMID:24157919 NCBI chr10:16,259,728...16,266,069
Ensembl chr10:16,259,728...16,266,061
JBrowse link
G Naa50 N(alpha)-acetyltransferase 50, NatE catalytic subunit ISO (PMID:17502424) RGD PMID:17502424 NCBI chr11:61,508,162...61,530,830
Ensembl chr11:61,462,994...61,530,837
JBrowse link
G Sgo1 shugoshin 1 ISO (PMID:24157919) RGD PMID:24157919 NCBI chr 9:4,420,158...4,435,939
Ensembl chr 9:4,421,069...4,436,601
JBrowse link
negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit ISO (PMID:27422821) RGD PMID:27422821 NCBI chr  X:156,863,655...156,868,950
Ensembl chr  X:156,863,754...156,868,950
JBrowse link
negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atrx ATRX, chromatin remodeler ISO
IEA
(PMID:26373281)
GO_REF:0000107
RGD
Ensembl
PMID:26373281 GO_REF:0000107 NCBI chr  X:76,820,110...76,979,155
Ensembl chr  X:76,692,970...76,708,878
Ensembl chr  X:76,692,970...76,708,878
JBrowse link
G Tnks tankyrase ISO (PMID:26373281) RGD PMID:26373281 NCBI chr16:60,925,093...61,067,192
Ensembl chr16:60,925,093...61,067,192
JBrowse link
positive regulation of maintenance of mitotic sister chromatid cohesion term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Macroh2a1 macroH2A.1 histone ISO (PMID:26373281) RGD PMID:26373281 NCBI chr17:9,282,109...9,344,698
Ensembl chr17:9,282,675...9,344,678
JBrowse link
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase ISO
ISS
(PMID:19502785)
GO_REF:0000024
RGD
UniProt
PMID:19502785 GO_REF:0000024 NCBI chr 7:99,677,295...99,900,765
Ensembl chr 7:99,677,290...99,900,764
JBrowse link
G Slf1 SMC5-SMC6 complex localization factor 1 ISO (PMID:25931565) RGD PMID:25931565 NCBI chr 2:4,095,126...4,195,819
Ensembl chr 2:4,095,129...4,195,810
JBrowse link
G Slf2 SMC5-SMC6 complex localization factor 2 ISO (PMID:25931565) RGD PMID:25931565 NCBI chr 1:264,670,836...264,733,465
Ensembl chr 1:264,670,841...264,733,306
JBrowse link
G Smc5 structural maintenance of chromosomes 5 ISO (PMID:19502785) RGD PMID:19502785 NCBI chr 1:240,977,898...241,046,273
Ensembl chr 1:240,977,898...241,046,256
JBrowse link
positive regulation of mitotic cohesin loading term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nipbl NIPBL, cohesin loading factor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:57,508,830...57,676,197
Ensembl chr 2:57,509,428...57,600,820
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cell cycle process 1210
        sister chromatid cohesion 57
          mitotic sister chromatid cohesion 29
            establishment of mitotic sister chromatid cohesion + 2
            maintenance of mitotic sister chromatid cohesion + 12
            mitotic sister chromatid cohesion, arms + 0
            mitotic sister chromatid cohesion, centromeric + 4
            mitotic sister chromatid cohesion, telomeric + 2
Path 2
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cellular component organization or biogenesis 6789
        cellular component organization 6534
          organelle organization 4101
            organelle fission 500
              nuclear division 445
                mitotic nuclear division 283
                  mitotic sister chromatid segregation 158
                    mitotic sister chromatid cohesion 29
                      establishment of mitotic sister chromatid cohesion + 2
                      maintenance of mitotic sister chromatid cohesion + 12
                      mitotic sister chromatid cohesion, arms + 0
                      mitotic sister chromatid cohesion, centromeric + 4
                      mitotic sister chromatid cohesion, telomeric + 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.