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ONTOLOGY REPORT - ANNOTATIONS


Term:metaphase/anaphase transition of mitotic cell cycle
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Accession:GO:0007091 term browser browse the term
Definition:The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
Synonyms:exact_synonym: metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;   mitotic metaphase/anaphase transition


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metaphase/anaphase transition of mitotic cell cycle term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway ISO (MGI:3574170|PMID:15767571)
(MGI:3588595|PMID:16025118)
MGI PMID:15767571, PMID:16025118 MGI:3574170, MGI:3588595 NCBI chr 5:108,070,697...108,208,273
Ensembl chr 5:113,904,352...114,009,709
JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B ISO (MGI:3574170|PMID:15767571) MGI PMID:15767571 MGI:3574170 NCBI chr15:19,095,383...19,155,557
Ensembl chr15:37,350,826...37,410,648
JBrowse link
G CDC27 cell division cycle 27 ISO (PMID:7736578) MGI PMID:7736578 NCBI chr17:10,259,194...10,331,011
Ensembl chr17:10,473,646...10,545,549
JBrowse link
G CIT citron rho-interacting serine/threonine kinase ISO (MGI:3606716|PMID:12764032) MGI PMID:12764032 MGI:3606716 NCBI chr12:117,264,627...117,456,069
Ensembl chr12:120,641,747...120,832,511
JBrowse link
G TACC3 transforming acidic coiled-coil containing protein 3 ISO (PMID:23532825) UniProtKB PMID:23532825 NCBI chr 4:1,858,595...1,882,727
Ensembl chr 4:1,772,836...1,796,019
JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) CAFA PMID:22581055 NCBI chr16:69,516,728...69,522,419
Ensembl chr16:89,174,071...89,177,823
JBrowse link
mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway ISO (PMID:17227893) MGI PMID:17227893 NCBI chr 5:108,070,697...108,208,273
Ensembl chr 5:113,904,352...114,009,709
JBrowse link
G ATM ATM serine/threonine kinase ISO (PMID:11943150) UniProtKB PMID:11943150 NCBI chr11:103,109,979...103,256,405
Ensembl chr11:106,584,228...106,727,041
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 ISO (PMID:12805209) UniProtKB PMID:12805209 NCBI chr17:72,292,332...72,303,493
Ensembl chr17:77,842,724...77,854,159
JBrowse link
G CENPE centromere protein E ISO (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chr 4:95,562,005...95,654,397
Ensembl chr 4:106,185,283...106,277,229
JBrowse link
G IK IK cytokine ISO (PMID:22351768) UniProtKB PMID:22351768 NCBI chr 5:136,012,381...136,027,099
Ensembl chr 5:142,129,130...142,143,393
JBrowse link
G KHDC3L KH domain containing 3 like, subcortical maternal complex member ISO (MGI:3844372|PMID:19376971) MGI PMID:19376971 MGI:3844372 NCBI chr 6:71,089,817...71,190,700
Ensembl chr 6:74,478,303...74,479,826
JBrowse link
G KLHL22 kelch like family member 22 ISO (PMID:23455478) UniProtKB PMID:23455478 Ensembl chr22:19,122,875...19,174,842 JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 ISO (PMID:18981471) UniProt PMID:18981471 NCBI chr 7:2,070,299...2,502,471
Ensembl chr 7:2,187,104...2,601,328
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 ISO (PMID:18981471)
(MGI:1930685|PMID:11201745)
UniProt
MGI
PMID:11201745, PMID:18981471 MGI:1930685 NCBI chr 4:112,247,808...112,255,202
Ensembl chr 4:123,397,355...123,405,535
JBrowse link
G PLK1 polo like kinase 1 ISO (PMID:23455478) UniProtKB PMID:23455478 NCBI chr16:14,420,972...14,432,821
Ensembl chr16:23,928,773...23,940,779
JBrowse link
G PSMG2 proteasome assembly chaperone 2 ISO (MGI:2388532|PMID:12147697) MGI PMID:12147697 MGI:2388532 NCBI chr18:1,597,981...1,620,721
Ensembl chr18:16,713,534...16,735,531
JBrowse link
G TEX14 testis expressed 14, intercellular bridge forming factor ISO (MGI:5318128|PMID:22405274) UniProt PMID:22405274 MGI:5318128 NCBI chr17:52,627,335...52,768,926
Ensembl chr17:57,480,369...57,621,055
JBrowse link
G TPR translocated promoter region, nuclear basket protein ISO (PMID:20133940) UniProt PMID:20133940 NCBI chr 1:161,842,037...161,903,567
Ensembl chr 1:165,993,726...166,055,223
JBrowse link
G TTK TTK protein kinase ISO (MGI:5608719|PMID:25197064) MGI PMID:25197064 MGI:5608719 NCBI chr 6:77,887,382...77,925,737
Ensembl chr 6:81,158,143...81,196,478
JBrowse link
G ZNF207 zinc finger protein 207 ISO (PMID:24462186), (PMID:24462187) UniProtKB PMID:24462186, PMID:24462187 NCBI chr17:24,405,632...24,425,868
Ensembl chr17:24,690,903...24,714,628
JBrowse link
negative regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FBXO5 F-box protein 5 ISO (PMID:11988738), (PMID:16921029) UniProtKB PMID:11988738, PMID:16921029 NCBI chr 6:150,793,020...150,806,008
Ensembl chr 6:155,481,753...155,494,231
JBrowse link
G RAD21 RAD21 cohesin complex component ISO (MGI:1340883|PMID:10375619) CAFA PMID:10375619 MGI:1340883 NCBI chr 8:113,520,456...113,549,339
Ensembl chr 8:116,063,503...116,092,421
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 ISO (PMID:19229290) UniProtKB PMID:19229290 NCBI chr 3:32,450,693...32,495,400
Ensembl chr 3:32,758,407...32,804,117
JBrowse link
G GEN1 GEN1 Holliday junction 5' flap endonuclease ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chr2A:17,735,953...17,766,018
Ensembl chr2A:17,862,070...17,892,048
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)
UniProtKB
UniProt
PMID:20870947 MGI:4839685 NCBI chr 4:112,247,808...112,255,202
Ensembl chr 4:123,397,355...123,405,535
JBrowse link
G NDC80 NDC80 kinetochore complex component ISO (PMID:25743205) UniProtKB PMID:25743205 NCBI chr18:11,666,099...11,711,456
Ensembl chr18:13,972,637...14,018,261
JBrowse link
G PCID2 PCI domain containing 2 ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)
UniProtKB
UniProt
PMID:20870947 MGI:4839685 NCBI chr13:94,319,699...94,350,763
Ensembl chr13:113,388,251...113,419,251
JBrowse link
G TPR translocated promoter region, nuclear basket protein ISO (PMID:18981471), (PMID:19273613) UniProt PMID:18981471, PMID:19273613 NCBI chr 1:161,842,037...161,903,567
Ensembl chr 1:165,993,726...166,055,223
JBrowse link
G XRCC3 X-ray repair cross complementing 3 ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chr14:84,323,644...84,341,763
Ensembl chr14:104,131,903...104,149,037
JBrowse link
positive regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CENPE centromere protein E ISO (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chr 4:95,562,005...95,654,397
Ensembl chr 4:106,185,283...106,277,229
JBrowse link
G CUL3 cullin 3 ISO (PMID:17543862) UniProtKB PMID:17543862 NCBI chr2B:111,714,533...111,827,080
Ensembl chr2B:230,289,195...230,378,991
JBrowse link
G NSMCE2 NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase ISO (PMID:19502785) UniProtKB PMID:19502785 NCBI chr 8:121,777,986...122,052,094
Ensembl chr 8:124,529,268...124,803,114
JBrowse link
G RB1 RB transcriptional corepressor 1 ISO (PMID:20551165) BHF-UCL PMID:20551165 NCBI chr13:29,453,872...29,624,665
Ensembl chr13:48,155,795...48,324,575
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANAPC15 anaphase promoting complex subunit 15 ISO (PMID:21926987) UniProtKB PMID:21926987 NCBI chr11:67,186,653...67,193,102
Ensembl chr11:70,411,031...70,416,484
JBrowse link
G CCNB1 cyclin B1 ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chr 5:44,826,103...44,836,832
Ensembl chr 5:46,394,362...46,405,332
JBrowse link
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 ISO (PMID:19282672) UniProtKB PMID:19282672 NCBI chr 9:91,519,179...91,707,469
Ensembl chr 9:119,868,015...120,055,608
JBrowse link
G LCMT1 leucine carboxyl methyltransferase 1 ISO (PMID:17724024) MGI PMID:17724024 Ensembl chr16:25,351,814...25,418,285 JBrowse link
G USP44 ubiquitin specific peptidase 44 ISO (MGI:5448515|PMID:21853124) UniProt PMID:21853124 MGI:5448515 NCBI chr12:93,111,293...93,146,889
Ensembl chr12:96,503,794...96,536,094
JBrowse link
regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC23 cell division cycle 23 ISO (PMID:9790767) UniProtKB PMID:9790767 NCBI chr 5:133,566,022...133,591,528
Ensembl chr 5:139,699,421...139,724,991
JBrowse link
G CDC6 cell division cycle 6 ISO (PMID:21041660) BHF-UCL PMID:21041660 NCBI chr17:16,987,721...17,002,488
Ensembl chr17:17,211,681...17,225,972
JBrowse link
G CENPE centromere protein E ISO (PMID:2022189) UniProtKB PMID:2022189 NCBI chr 4:95,562,005...95,654,397
Ensembl chr 4:106,185,283...106,277,229
JBrowse link
G HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 ISO (PMID:24163370) UniProtKB PMID:24163370 NCBI chr2B:83,445,401...83,838,065
Ensembl chr2B:201,351,023...201,584,044
JBrowse link
G NEK6 NIMA related kinase 6 ISO (PMID:14563848) UniProtKB PMID:14563848 NCBI chr 9:95,379,090...95,474,348
Ensembl chr 9:123,903,240...123,994,658
JBrowse link
G PLK1 polo like kinase 1 ISO (PMID:23509069)
(PMID:21041660)
UniProt
BHF-UCL
PMID:21041660, PMID:23509069 NCBI chr16:14,420,972...14,432,821
Ensembl chr16:23,928,773...23,940,779
JBrowse link
G RIOK2 RIO kinase 2 ISO (PMID:21880710) UniProtKB PMID:21880710 NCBI chr 5:92,473,239...92,494,763
Ensembl chr 5:98,028,426...98,048,256
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12567
    cellular process 11672
      cell cycle process 1004
        mitotic cell cycle process 567
          mitotic cell cycle phase transition 323
            metaphase/anaphase transition of mitotic cell cycle 40
              negative regulation of mitotic metaphase/anaphase transition + 28
              positive regulation of mitotic metaphase/anaphase transition + 5
              regulation of mitotic metaphase/anaphase transition + 36
Path 2
Term Annotations click to browse term
  biological_process 12567
    cellular process 11672
      cellular component organization or biogenesis 5016
        cellular component organization 4936
          organelle organization 3054
            organelle fission 419
              nuclear division 374
                mitotic nuclear division 234
                  mitotic sister chromatid segregation 125
                    mitotic sister chromatid separation 43
                      regulation of mitotic sister chromatid separation 40
                        metaphase/anaphase transition of mitotic cell cycle 40
                          negative regulation of mitotic metaphase/anaphase transition + 28
                          positive regulation of mitotic metaphase/anaphase transition + 5
                          regulation of mitotic metaphase/anaphase transition + 36
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.