Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:metaphase/anaphase transition of mitotic cell cycle
go back to main search page
Accession:GO:0007091 term browser browse the term
Definition:The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
Synonyms:exact_synonym: metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;   mitotic metaphase/anaphase transition


show annotations for term's descendants           Sort by:
 
metaphase/anaphase transition of mitotic cell cycle term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc1 anaphase promoting complex subunit 1 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 2:128,610,083...128,687,406
Ensembl chr 2:128,610,104...128,687,391
JBrowse link
G Anapc7 anaphase promoting complex subunit 7 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 5:122,422,444...122,444,912
Ensembl chr 5:122,421,693...122,444,912
JBrowse link
G Apc APC, WNT signaling pathway regulator IGI
IMP
(MGI:3574170|PMID:15767571)
(MGI:3588595|PMID:16025118)
MGI PMID:15767571, PMID:16025118 MGI:3574170, MGI:3588595 NCBI chr18:34,220,297...34,322,190
Ensembl chr18:34,220,924...34,322,552
JBrowse link
G Bub1b BUB1B, mitotic checkpoint serine/threonine kinase IGI (MGI:3574170|PMID:15767571) MGI PMID:15767571 MGI:3574170 NCBI chr 2:118,598,202...118,641,592
Ensembl chr 2:118,598,211...118,641,591
JBrowse link
G Cdc16 CDC16 cell division cycle 16 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 8:13,757,649...13,781,951
Ensembl chr 8:13,757,676...13,781,938
JBrowse link
G Cdc23 CDC23 cell division cycle 23 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr18:34,628,348...34,651,749
Ensembl chr18:34,630,951...34,651,735
JBrowse link
G Cdc27 cell division cycle 27 ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000008, MGI:2154458, MGI:6201960 NCBI chr11:104,502,524...104,550,620
Ensembl chr11:104,502,745...104,550,620
JBrowse link
G Cit citron IMP (MGI:3606716|PMID:12764032) MGI PMID:12764032 MGI:3606716 NCBI chr 5:115,845,224...116,008,953
Ensembl chr 5:115,845,278...116,008,947
JBrowse link
G Tacc3 transforming, acidic coiled-coil containing protein 3 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 5:33,658,128...33,672,203
Ensembl chr 5:33,658,128...33,678,995
JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 8:122,568,015...122,573,130
Ensembl chr 8:122,568,015...122,573,554
JBrowse link
mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC, WNT signaling pathway regulator ISO MGI GO_REF:0000008, MGI:2154458 NCBI chr18:34,220,297...34,322,190
Ensembl chr18:34,220,924...34,322,552
JBrowse link
G Atm ataxia telangiectasia mutated ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 9:53,437,122...53,536,828
Ensembl chr 9:53,439,149...53,536,740
JBrowse link
G Aurkb aurora kinase B IEA UniProt GO_REF:0000002, MGI:2152098 NCBI chr11:69,045,624...69,051,664
Ensembl chr11:69,045,647...69,051,664
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr11:117,849,237...117,855,743
Ensembl chr11:117,849,251...117,855,743
JBrowse link
G Bub1 BUB1, mitotic checkpoint serine/threonine kinase IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 2:127,800,197...127,831,859
Ensembl chr 2:127,801,122...127,831,865
JBrowse link
G Bub1b BUB1B, mitotic checkpoint serine/threonine kinase IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 2:118,598,202...118,641,592
Ensembl chr 2:118,598,211...118,641,591
JBrowse link
G Bub3 BUB3 mitotic checkpoint protein IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 7:131,560,367...131,571,895
Ensembl chr 7:131,560,222...131,571,895
JBrowse link
G Cenpe centromere protein E IMP (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chr 3:135,212,563...135,273,540
Ensembl chr 3:135,212,537...135,273,611
JBrowse link
G Cep192 centrosomal protein 192 ISO (MGI:3773587|PMID:18207742) MGI PMID:18207742 MGI:3773587 NCBI chr18:67,800,054...67,885,170
Ensembl chr18:67,800,107...67,885,170
JBrowse link
G Ik IK cytokine ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr18:36,744,656...36,757,639
Ensembl chr18:36,744,656...36,757,639
JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member IMP (MGI:3844372|PMID:19376971) MGI PMID:19376971 MGI:3844372 NCBI chr 9:73,101,381...73,106,631
Ensembl chr 9:73,101,836...73,104,438
JBrowse link
G Klhl22 kelch-like 22 IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr16:17,759,621...17,793,382
Ensembl chr16:17,759,618...17,793,382
JBrowse link
G Mad1l1 MAD1 mitotic arrest deficient 1-like 1 ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr 5:140,008,689...140,321,608
Ensembl chr 5:140,008,689...140,321,552
JBrowse link
G Mad2l1 MAD2 mitotic arrest deficient-like 1 ISA
IMP
IBA
ISO
(MGI:1859722|PMID:10892650)
(MGI:1930685|PMID:11201745)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:10892650, PMID:11201745, PMID:21873635 GO_REF:0000096, MGI:1859722, MGI:1930685, MGI:4834177, MGI:6201960 NCBI chr 6:66,535,221...66,541,107
Ensembl chr 6:66,535,390...66,547,220
JBrowse link
G Mad2l1bp MAD2L1 binding protein ISO (MGI:2678840|PMID:14568551), (MGI:2678953|PMID:12456649) MGI PMID:12456649, PMID:14568551 MGI:2678840, MGI:2678953 NCBI chr17:46,147,385...46,153,551
Ensembl chr17:46,147,387...46,153,553
JBrowse link
G Plk1 polo like kinase 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 7:122,159,435...122,169,884
Ensembl chr 7:122,159,439...122,169,873
JBrowse link
G Psmg2 proteasome (prosome, macropain) assembly chaperone 2 IDA (MGI:2388532|PMID:12147697) MGI PMID:12147697 MGI:2388532 NCBI chr18:67,641,587...67,654,181
Ensembl chr18:67,641,599...67,654,162
JBrowse link
G Spdl1 spindle apparatus coiled-coil protein 1 IEA UniProt GO_REF:0000002, MGI:2152098 NCBI chr11:34,809,185...34,833,665
Ensembl chr11:34,809,190...34,833,641
JBrowse link
G Tex14 testis expressed gene 14 IBA
IMP
(MGI:6201960|PMID:21873635)
(MGI:5318128|PMID:22405274)
GO_Central
UniProt
PMID:21873635, PMID:22405274 MGI:5318128, MGI:6201960 NCBI chr11:87,405,013...87,555,823
Ensembl chr11:87,405,065...87,555,823
JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 1:150,392,802...150,449,935
Ensembl chr 1:150,392,838...150,449,935
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr13:73,912,450...73,937,795
Ensembl chr13:73,911,347...73,937,784
JBrowse link
G Ttk Ttk protein kinase IMP
IBA
(MGI:5608719|PMID:25197064)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:21873635, PMID:25197064 MGI:5608719, MGI:6201960 NCBI chr 9:83,834,651...83,872,390
Ensembl chr 9:83,834,689...83,872,389
JBrowse link
G Zfp207 zinc finger protein 207 IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr11:80,383,279...80,408,561
Ensembl chr11:80,383,279...80,405,733
JBrowse link
G Zw10 zw10 kinetochore protein IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 9:49,055,576...49,078,775
Ensembl chr 9:49,055,613...49,078,775
JBrowse link
negative regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo5 F-box protein 5 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr10:5,799,158...5,805,465
Ensembl chr10:5,799,160...5,805,600
JBrowse link
G Mad2l1 MAD2 mitotic arrest deficient-like 1 TAS (MGI:2388532|PMID:12147697) MGI PMID:12147697 MGI:2388532 NCBI chr 6:66,535,221...66,541,107
Ensembl chr 6:66,535,390...66,547,220
JBrowse link
G Rad21 RAD21 cohesin complex component IMP (MGI:1340883|PMID:10375619) CAFA PMID:10375619 MGI:1340883 NCBI chr15:51,962,604...51,993,538
Ensembl chr15:51,962,240...51,991,747
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 9:114,688,831...114,723,788
Ensembl chr 9:114,688,790...114,724,302
JBrowse link
G Gen1 GEN1, Holliday junction 5' flap endonuclease ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr12:11,238,928...11,266,029
Ensembl chr12:11,238,920...11,265,801
JBrowse link
G Mad2l1 MAD2 mitotic arrest deficient-like 1 IMP
ISO
(MGI:4839685|PMID:20870947) UniProt
MGI
PMID:20870947 GO_REF:0000096, MGI:4834177, MGI:4839685 NCBI chr 6:66,535,221...66,541,107
Ensembl chr 6:66,535,390...66,547,220
JBrowse link
G Ndc80 NDC80 kinetochore complex component ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr17:71,496,100...71,526,857
Ensembl chr17:71,496,100...71,526,857
JBrowse link
G Pcid2 PCI domain containing 2 IMP
ISO
(MGI:4839685|PMID:20870947) UniProt
MGI
PMID:20870947 GO_REF:0000096, MGI:4834177, MGI:4839685 NCBI chr 8:13,075,476...13,105,343
Ensembl chr 8:13,077,189...13,105,459
JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 1:150,392,802...150,449,935
Ensembl chr 1:150,392,838...150,449,935
JBrowse link
G Xrcc3 X-ray repair complementing defective repair in Chinese hamster cells 3 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr12:111,803,192...111,813,893
Ensembl chr12:111,803,192...111,813,873
JBrowse link
positive regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc11 anaphase promoting complex subunit 11 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr11:120,598,421...120,608,198
Ensembl chr11:120,598,421...120,608,198
JBrowse link
G Anapc4 anaphase promoting complex subunit 4 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 5:52,834,135...52,866,734
Ensembl chr 5:52,834,012...52,867,797
JBrowse link
G Anapc5 anaphase-promoting complex subunit 5 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 5:122,787,459...122,822,339
Ensembl chr 5:122,787,459...122,821,339
JBrowse link
G Anapc7 anaphase promoting complex subunit 7 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 5:122,422,444...122,444,912
Ensembl chr 5:122,421,693...122,444,912
JBrowse link
G Cdc16 CDC16 cell division cycle 16 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 8:13,757,649...13,781,951
Ensembl chr 8:13,757,676...13,781,938
JBrowse link
G Cdc23 CDC23 cell division cycle 23 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr18:34,628,348...34,651,749
Ensembl chr18:34,630,951...34,651,735
JBrowse link
G Cdc27 cell division cycle 27 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr11:104,502,524...104,550,620
Ensembl chr11:104,502,745...104,550,620
JBrowse link
G Cenpe centromere protein E IMP (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chr 3:135,212,563...135,273,540
Ensembl chr 3:135,212,537...135,273,611
JBrowse link
G Cul3 cullin 3 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 1:80,264,923...80,340,690
Ensembl chr 1:80,264,923...80,340,480
JBrowse link
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr15:59,374,198...59,601,689
Ensembl chr15:59,374,247...59,601,684
JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr14:73,192,858...73,325,951
Ensembl chr14:73,183,673...73,325,822
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex C subunit 15 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 7:101,881,300...101,901,849
Ensembl chr 7:101,863,715...101,901,849
JBrowse link
G Ccnb1 cyclin B1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr13:100,778,739...100,786,486
Ensembl chr13:100,778,650...100,786,570
JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr 4:70,216,855...70,410,435
Ensembl chr 4:70,216,856...70,410,443
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 ISO MGI GO_REF:0000008, MGI:2154458 NCBI chr 7:123,377,803...123,430,358
Ensembl chr 7:123,369,784...123,430,358
JBrowse link
G Usp44 ubiquitin specific peptidase 44 IDA (MGI:5448515|PMID:21853124) UniProt PMID:21853124 MGI:5448515 NCBI chr10:93,819,969...93,859,425
Ensembl chr10:93,831,555...93,858,088
JBrowse link
regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc4 anaphase promoting complex subunit 4 IEA UniProt GO_REF:0000002, MGI:2152098 NCBI chr 5:52,834,135...52,866,734
Ensembl chr 5:52,834,012...52,867,797
JBrowse link
G Cdc23 CDC23 cell division cycle 23 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr18:34,628,348...34,651,749
Ensembl chr18:34,630,951...34,651,735
JBrowse link
G Cdc26 cell division cycle 26 IEA UniProt GO_REF:0000002, MGI:2152098 NCBI chr 4:62,392,344...62,408,625
Ensembl chr 4:62,383,654...62,408,642
JBrowse link
G Cdc6 cell division cycle 6 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr11:98,907,709...98,923,942
Ensembl chr11:98,907,801...98,923,940
JBrowse link
G Cenpe centromere protein E ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 3:135,212,563...135,273,540
Ensembl chr 3:135,212,537...135,273,611
JBrowse link
G Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 1:53,806,872...54,195,034
Ensembl chr 1:53,806,876...54,195,168
JBrowse link
G Nek6 NIMA (never in mitosis gene a)-related expressed kinase 6 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 2:38,483,863...38,587,490
Ensembl chr 2:38,511,643...38,594,606
JBrowse link
G Plk1 polo like kinase 1 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 7:122,159,435...122,169,884
Ensembl chr 7:122,159,439...122,169,873
JBrowse link
G Riok2 RIO kinase 2 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr17:17,374,332...17,394,899
Ensembl chr17:17,374,309...17,394,899
JBrowse link
G Ube2c ubiquitin-conjugating enzyme E2C IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 2:164,769,929...164,772,902
Ensembl chr 2:164,769,898...164,778,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23387
    cellular process 17460
      cell cycle process 1181
        mitotic cell cycle process 685
          mitotic cell cycle phase transition 387
            metaphase/anaphase transition of mitotic cell cycle 56
              negative regulation of mitotic metaphase/anaphase transition + 37
              positive regulation of mitotic metaphase/anaphase transition + 12
              regulation of mitotic metaphase/anaphase transition + 53
Path 2
Term Annotations click to browse term
  biological_process 23387
    cellular process 17460
      cellular component organization or biogenesis 6413
        cellular component organization 6225
          organelle organization 3856
            organelle fission 493
              nuclear division 438
                mitotic nuclear division 277
                  mitotic sister chromatid segregation 155
                    mitotic sister chromatid separation 60
                      regulation of mitotic sister chromatid separation 57
                        metaphase/anaphase transition of mitotic cell cycle 56
                          negative regulation of mitotic metaphase/anaphase transition + 37
                          positive regulation of mitotic metaphase/anaphase transition + 12
                          regulation of mitotic metaphase/anaphase transition + 53
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.