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ONTOLOGY REPORT - ANNOTATIONS


Term:metaphase/anaphase transition of mitotic cell cycle
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Accession:GO:0007091 term browser browse the term
Definition:The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
Synonyms:exact_synonym: metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process;   mitotic metaphase/anaphase transition


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metaphase/anaphase transition of mitotic cell cycle term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO (MGI:3588595|PMID:16025118)
(MGI:3574170|PMID:15767571)
MGI PMID:15767571, PMID:16025118 MGI:3574170, MGI:3588595 NCBI chrNW_004936531:6,899,580...7,019,016 JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B ISO (MGI:3574170|PMID:15767571) MGI PMID:15767571 MGI:3574170 NCBI chrNW_004936471:3,631,760...3,696,024 JBrowse link
G Cdc27 cell division cycle 27 ISO (PMID:7736578) MGI PMID:7736578 NCBI chrNW_004936541:2,700,997...2,762,180 JBrowse link
G Cit citron rho-interacting serine/threonine kinase ISO (MGI:3606716|PMID:12764032) MGI PMID:12764032 MGI:3606716 NCBI chrNW_004936668:991,043...1,146,578 JBrowse link
G Tacc3 transforming acidic coiled-coil containing protein 3 ISO (PMID:23532825) UniProtKB PMID:23532825 NCBI chrNW_004936477:21,648,958...21,665,855 JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) CAFA PMID:22581055 NCBI chrNW_004936641:916,695...925,411 JBrowse link
mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO (PMID:17227893) MGI PMID:17227893 NCBI chrNW_004936531:6,899,580...7,019,016 JBrowse link
G Atm ATM serine/threonine kinase ISO (PMID:11943150) UniProtKB PMID:11943150 NCBI chrNW_004936551:359,134...534,672 JBrowse link
G Birc5 baculoviral IAP repeat containing 5 ISO (PMID:12805209) UniProtKB PMID:12805209 NCBI chrNW_004936594:2,812,165...2,820,618 JBrowse link
G Cenpe centromere protein E ISO (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chrNW_004936520:188,601...265,904 JBrowse link
G Ik IK cytokine ISO (PMID:22351768) UniProtKB PMID:22351768 NCBI chrNW_004936531:9,589,035...9,601,266 JBrowse link
G Klhl22 kelch like family member 22 ISO (PMID:23455478) UniProtKB PMID:23455478 NCBI chrNW_004936619:2,854,915...2,899,386 JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 ISO (PMID:18981471) UniProt PMID:18981471 NCBI chrNW_004936754:1,842,588...1,957,116 JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 ISO (PMID:18981471)
(MGI:1930685|PMID:11201745)
UniProt
MGI
PMID:11201745, PMID:18981471 MGI:1930685 NCBI chrNW_004936662:92,421...98,531 JBrowse link
G Plk1 polo like kinase 1 ISO (PMID:23455478) UniProtKB PMID:23455478 NCBI chrNW_004936501:8,321,415...8,332,414 JBrowse link
G Psmg2 proteasome assembly chaperone 2 ISO (MGI:2388532|PMID:12147697) MGI PMID:12147697 MGI:2388532 NCBI chrNW_004936626:2,328,646...2,344,831 JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor ISO (MGI:5318128|PMID:22405274) UniProt PMID:22405274 MGI:5318128 NCBI chrNW_004936490:4,499,825...4,576,952 JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISO (PMID:20133940) UniProt PMID:20133940 NCBI chrNW_004936481:4,050,693...4,111,682 JBrowse link
G Trip13 thyroid hormone receptor interactor 13 ISO (PMID:28553959) UniProtKB PMID:28553959 NCBI chrNW_004936815:734,029...745,381 JBrowse link
G Ttk TTK protein kinase ISO (MGI:5608719|PMID:25197064) MGI PMID:25197064 MGI:5608719 NCBI chrNW_004936510:10,176,968...10,213,483 JBrowse link
G Znf207 zinc finger protein 207 ISO (PMID:24462186), (PMID:24462187) UniProtKB PMID:24462186, PMID:24462187 NCBI chrNW_004936538:2,514,772...2,541,198 JBrowse link
negative regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fbxo5 F-box protein 5 ISO (PMID:11988738), (PMID:16921029) UniProtKB PMID:11988738, PMID:16921029 NCBI chrNW_004936489:5,589,621...5,602,221 JBrowse link
G Rad21 RAD21 cohesin complex component ISO (MGI:1340883|PMID:10375619) CAFA PMID:10375619 MGI:1340883 NCBI chrNW_004936470:29,377,793...29,403,422 JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 ISO (PMID:19229290) UniProtKB PMID:19229290 NCBI chrNW_004936473:23,011,888...23,042,497 JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chrNW_004936493:13,157,114...13,182,797 JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)
UniProtKB
UniProt
PMID:20870947 MGI:4839685 NCBI chrNW_004936662:92,421...98,531 JBrowse link
G Ndc80 NDC80 kinetochore complex component ISO (PMID:25743205) UniProtKB PMID:25743205 NCBI chrNW_004936672:1,872,205...1,910,956 JBrowse link
G Pcid2 PCI domain containing 2 ISO (PMID:20870947)
(MGI:4839685|PMID:20870947)
UniProtKB
UniProt
PMID:20870947 MGI:4839685 NCBI chrNW_004936472:440,440...464,116 JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISO (PMID:18981471), (PMID:19273613) UniProt PMID:18981471, PMID:19273613 NCBI chrNW_004936481:4,050,693...4,111,682 JBrowse link
G Xrcc3 X-ray repair cross complementing 3 ISO (PMID:23108668) UniProtKB PMID:23108668 NCBI chrNW_004936621:1,462,441...1,474,937 JBrowse link
positive regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpe centromere protein E ISO (MGI:2673075|PMID:12925705) UniProt PMID:12925705 MGI:2673075 NCBI chrNW_004936520:188,601...265,904 JBrowse link
G Cul3 cullin 3 ISO (PMID:17543862) UniProtKB PMID:17543862 NCBI chrNW_004936569:6,067,230...6,131,467 JBrowse link
G Nsmce2 NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase ISO (PMID:19502785) UniProtKB PMID:19502785 NCBI chrNW_004936470:22,447,278...22,667,302 JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO (PMID:20551165) BHF-UCL PMID:20551165 NCBI chrNW_004936565:1,596,227...1,746,706 JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 ISO (PMID:21926987) UniProtKB PMID:21926987 NCBI chrNW_004936498:1,460,795...1,468,363 JBrowse link
G Ccnb1 cyclin B1 ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chrNW_004936480:400,287...407,677 JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 ISO (PMID:19282672) UniProtKB PMID:19282672 NCBI chrNW_004936487:8,900,375...9,081,547 JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 ISO (PMID:17724024) MGI PMID:17724024 NCBI chrNW_004936501:9,354,607...9,397,675 JBrowse link
G Usp44 ubiquitin specific peptidase 44 ISO (MGI:5448515|PMID:21853124) UniProt PMID:21853124 MGI:5448515 NCBI chrNW_004936507:11,663,069...11,692,174 JBrowse link
regulation of mitotic metaphase/anaphase transition term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdc23 cell division cycle 23 ISO (PMID:9790767) UniProtKB PMID:9790767 NCBI chrNW_004936531:7,371,818...7,392,999 JBrowse link
G Cdc6 cell division cycle 6 ISO (PMID:21041660) BHF-UCL PMID:21041660 NCBI chrNW_004936490:15,360,477...15,370,519 JBrowse link
G Cenpe centromere protein E ISO (PMID:2022189) UniProtKB PMID:2022189 NCBI chrNW_004936520:188,601...265,904 JBrowse link
G Hecw2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 ISO (PMID:24163370) UniProtKB PMID:24163370 NCBI chrNW_004936506:2,704,885...2,913,663 JBrowse link
G Nek6 NIMA related kinase 6 ISO (PMID:14563848) UniProtKB PMID:14563848 NCBI chrNW_004936487:12,606,312...12,632,982 JBrowse link
G Plk1 polo like kinase 1 ISO (PMID:23509069)
(PMID:21041660)
UniProt
BHF-UCL
PMID:21041660, PMID:23509069 NCBI chrNW_004936501:8,321,415...8,332,414 JBrowse link
G Riok2 RIO kinase 2 ISO (PMID:21880710) UniProtKB PMID:21880710 NCBI chrNW_004936523:6,293,735...6,313,840 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12002
    cellular process 11179
      cell cycle process 973
        mitotic cell cycle process 549
          mitotic cell cycle phase transition 307
            metaphase/anaphase transition of mitotic cell cycle 40
              negative regulation of mitotic metaphase/anaphase transition + 28
              positive regulation of mitotic metaphase/anaphase transition + 5
              regulation of mitotic metaphase/anaphase transition + 36
Path 2
Term Annotations click to browse term
  biological_process 12002
    cellular process 11179
      cellular component organization or biogenesis 4923
        cellular component organization 4845
          organelle organization 3004
            organelle fission 414
              nuclear division 369
                mitotic nuclear division 234
                  mitotic sister chromatid segregation 125
                    mitotic sister chromatid separation 43
                      regulation of mitotic sister chromatid separation 40
                        metaphase/anaphase transition of mitotic cell cycle 40
                          negative regulation of mitotic metaphase/anaphase transition + 28
                          positive regulation of mitotic metaphase/anaphase transition + 5
                          regulation of mitotic metaphase/anaphase transition + 36
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.