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ONTOLOGY REPORT - ANNOTATIONS


Term:mitotic cell cycle checkpoint
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Accession:GO:0007093 term browser browse the term
Definition:A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.
Synonyms:related_synonym: mitotic checkpoint
 alt_id: GO:0031575;   GO:0071780


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deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) RGD PMID:22581055 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp2 caspase 2 ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO (PMID:15149599) RGD PMID:15149599 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain ISO
IBA
(PMID:21726810)
PMID:21873635
RGD PMID:21726810, PMID:21873635 RGD:13792537 NCBI chr 7:36,395,665...36,408,588
Ensembl chr 7:36,395,665...36,408,588
JBrowse link
G Mdm2 MDM2 proto-oncogene ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Muc1 mucin 1, cell surface associated ISO (PMID:15710329) RGD PMID:15710329 NCBI chr 2:188,543,137...188,547,874
Ensembl chr 2:188,543,137...188,547,874
JBrowse link
G Pidd1 p53-induced death domain protein 1 ISO (PMID:21726810) RGD PMID:21726810 NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881
JBrowse link
G Pml PML nuclear body scaffold ISO (MGI:MGI:3580934|PMID:15626733) RGD PMID:15626733 MGI:MGI:3580934 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma ISO (PMID:17245430) RGD PMID:17245430 NCBI chr 6:134,804,128...134,941,912
Ensembl chr 6:134,804,141...134,939,358
JBrowse link
G Rbm38 RNA binding motif protein 38 ISO (PMID:17050675) RGD PMID:17050675 NCBI chr 3:171,037,891...171,050,500
Ensembl chr 3:171,037,957...171,050,475
JBrowse link
G Rpl26 ribosomal protein L26 ISO (PMID:16213212)
(MGI:MGI:5882892|PMID:16213212)
RGD PMID:16213212 MGI:MGI:5882892 NCBI chr10:55,492,417...55,495,547
Ensembl chr10:55,492,404...55,496,012
JBrowse link
G Sox4 SRY-box transcription factor 4 ISO (PMID:19234109) RGD PMID:19234109 NCBI chr17:37,615,022...37,619,728 JBrowse link
G Tp53 tumor protein p53 ISO MGI:MGI:108027 (MGI:MGI:3589512|PMID:16107883)
(PMID:16213212)
RGD PMID:16107883, PMID:16213212 MGI:MGI:3589512 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
intra-S DNA damage checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf2 activating transcription factor 2 ISO
ISS
(PMID:15916964)
GO_REF:0000024
RGD
UniProt
PMID:15916964 GO_REF:0000024 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Eme1 essential meiotic structure-specific endonuclease 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:82,366,820...82,375,510
Ensembl chr10:82,367,084...82,374,171
JBrowse link
G Eme2 essential meiotic structure-specific endonuclease subunit 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:14,253,552...14,257,017
Ensembl chr10:14,254,252...14,256,930
JBrowse link
G Fancd2 FA complementation group D2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:145,489,869...145,551,479
Ensembl chr 4:145,489,869...145,551,479
JBrowse link
G Hus1 HUS1 checkpoint clamp component IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:89,194,086...89,208,825
Ensembl chr14:89,194,092...89,208,825
JBrowse link
G LOC103690165 checkpoint protein HUS1B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:34,691,084...34,694,690
Ensembl chr17:34,693,597...34,694,690
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
MGI:MGI:3027036 (MGI:MGI:2683367|PMID:14690604), (MGI:MGI:3805397|PMID:18614044)
Ensembl
RGD
PMID:14690604, PMID:18614044, PMID:21873635 GO_REF:0000107, MGI:MGI:2683367, MGI:MGI:3805397, RGD:13792537 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
JBrowse link
G Msh2 mutS homolog 2 ISO
IEA
MGI:MGI:103557 (MGI:MGI:3512823|PMID:15533840)
GO_REF:0000107
RGD
Ensembl
PMID:15533840 GO_REF:0000107, MGI:MGI:3512823 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:220,862,474...220,867,973
Ensembl chr 1:220,862,386...220,867,815
JBrowse link
G Nek11 NIMA-related kinase 11 ISO
IBA
(PMID:15161910)
PMID:21873635
RGD PMID:15161910, PMID:21873635 RGD:13792537 NCBI chr 8:113,703,406...113,937,097
Ensembl chr 8:113,787,128...113,937,097
JBrowse link
G Rad9a RAD9 checkpoint clamp component A ISO
IBA
UniProtKB:P26306 (MGI:MGI:1289930|PMID:9766521)
PMID:21873635
RGD PMID:9766521, PMID:21873635 MGI:MGI:1289930, RGD:13792537 NCBI chr 1:219,443,347...219,450,574
Ensembl chr 1:219,444,092...219,450,451
JBrowse link
G Rad9b RAD9 checkpoint clamp component B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:39,699,076...39,731,218
Ensembl chr12:39,699,181...39,729,516
JBrowse link
G Tipin timeless interacting protein ISO
ISS
(PMID:17102137)
GO_REF:0000024
RGD
UniProt
PMID:17102137 GO_REF:0000024 NCBI chr 8:69,753,363...69,768,640
Ensembl chr 8:69,753,373...69,768,305
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor ISO MGI:MGI:101816 (MGI:MGI:3512823|PMID:15533840) RGD PMID:15533840 MGI:MGI:3512823 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
JBrowse link
mitotic cytokinesis checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkb aurora kinase B ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Chmp4c charged multivesicular body protein 4C IEA
ISO
ISS
GO_REF:0000107
(PMID:22422861), (PMID:24814515)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:22422861, PMID:24814515 GO_REF:0000024, GO_REF:0000107 NCBI chr 2:93,574,554...93,641,497
Ensembl chr 2:93,574,559...93,641,497
JBrowse link
G Vps4a vacuolar protein sorting 4 homolog A ISO
ISS
(PMID:24814515)
GO_REF:0000024
RGD
UniProt
PMID:24814515 GO_REF:0000024 NCBI chr19:39,230,050...39,243,298
Ensembl chr19:39,229,754...39,243,496
JBrowse link
G Zfyve19 zinc finger FYVE-type containing 19 ISO
IBA
(PMID:24814515)
PMID:21873635
RGD PMID:24814515, PMID:21873635 RGD:13792537 NCBI chr 3:111,013,856...111,021,841
Ensembl chr 3:111,013,856...111,021,841
JBrowse link
mitotic DNA damage checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chek2 checkpoint kinase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Stk33 serine/threonine kinase 33 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:173,872,744...174,051,768
Ensembl chr 1:173,872,736...174,047,572
JBrowse link
G Zfp830 zinc finger protein 830 ISO
IBA
MGI:MGI:3583779 (MGI:MGI:5428139|PMID:23213458)
PMID:21873635
RGD PMID:23213458, PMID:21873635 MGI:MGI:5428139, RGD:13792537 NCBI chr10:70,118,250...70,119,714
Ensembl chr10:70,118,250...70,119,716
JBrowse link
mitotic DNA integrity checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Setmar SET domain and mariner transposase fusion gene ISO (PMID:18790802) RGD PMID:18790802 NCBI chr 4:140,092,346...140,104,495
Ensembl chr 4:140,092,352...140,105,316
JBrowse link
G Top2a DNA topoisomerase II alpha IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
mitotic DNA replication checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07049960.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 5:146,294,030...146,296,221 JBrowse link
G Cdc6 cell division cycle 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Clspn claspin ISO
IBA
(PMID:16885022)
PMID:21873635
RGD PMID:16885022, PMID:21873635 RGD:13792537 NCBI chr 5:144,577,670...144,617,507
Ensembl chr 5:144,581,427...144,616,335
JBrowse link
G Hus1 HUS1 checkpoint clamp component IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:89,194,086...89,208,825
Ensembl chr14:89,194,092...89,208,825
JBrowse link
G LOC103690165 checkpoint protein HUS1B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:34,691,084...34,694,690
Ensembl chr17:34,693,597...34,694,690
JBrowse link
G Nae1 NEDD8 activating enzyme E1 subunit 1 IEA
ISO
GO_REF:0000107
(PMID:10722740)
Ensembl
RGD
PMID:10722740 GO_REF:0000107 NCBI chr19:653,510...680,378
Ensembl chr19:653,510...680,378
JBrowse link
G Orc1 origin recognition complex, subunit 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:128,186,651...128,212,901
Ensembl chr 5:128,190,708...128,210,445
JBrowse link
G Rad17 RAD17 checkpoint clamp loader component IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:30,634,353...30,664,618
Ensembl chr 2:30,634,354...30,664,163
JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:141,391,738...141,433,615
Ensembl chr 1:141,391,262...141,433,109
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:111,790,655...111,835,224
Ensembl chr 8:111,790,678...111,827,151
JBrowse link
G Zfp830 zinc finger protein 830 ISO
IBA
ISS
(MGI:MGI:4950701|PMID:21191184)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:21191184, PMID:21873635 GO_REF:0000024, MGI:MGI:4950701, RGD:13792537 NCBI chr10:70,118,250...70,119,714
Ensembl chr10:70,118,250...70,119,716
JBrowse link
mitotic G1 DNA damage checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnd1 cyclin D1 ISO
ISS
(PMID:19412162)
GO_REF:0000024
RGD
UniProt
PMID:19412162 GO_REF:0000024 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Dgkz diacylglycerol kinase zeta ISO UniProtKB:P06400 (PMID:16286473) RGD PMID:16286473 NCBI chr 3:80,844,002...80,886,487
Ensembl chr 3:80,844,005...80,875,817
JBrowse link
G Fbxo31 F-box protein 31 IEA
ISS
ISO
GO_REF:0000002
GO_REF:0000024
(PMID:19412162)
InterPro
UniProt
RGD
PMID:19412162 GO_REF:0000002, GO_REF:0000024 NCBI chr19:53,487,610...53,625,673
Ensembl chr19:53,487,613...53,625,673
JBrowse link
G Gigyf2 GRB10 interacting GYF protein 2 ISO MGI:MGI:4126459 (MGI:MGI:4366664|PMID:19744960) RGD PMID:19744960 MGI:MGI:4366664 NCBI chr 9:94,425,191...94,550,431
Ensembl chr 9:94,425,252...94,550,431
JBrowse link
G Rfwd3 ring finger and WD repeat domain 3 ISO (PMID:20173098) RGD PMID:20173098 NCBI chr19:42,960,597...42,971,894
Ensembl chr19:42,964,586...42,972,101
JBrowse link
G Rpa2 replication protein A2 ISO (PMID:21731742) RGD PMID:21731742 NCBI chr 5:150,957,041...150,967,597
Ensembl chr 5:150,957,001...150,968,269
JBrowse link
G Rps27l ribosomal protein S27-like ISO (PMID:18056458) RGD PMID:18056458 NCBI chr 8:72,741,155...72,746,090
Ensembl chr 8:72,741,155...72,746,090
JBrowse link
G Tp53 tumor protein p53 ISO (PMID:7958916)
(MGI:MGI:3589512|PMID:16107883)
RGD PMID:7958916, PMID:16107883 MGI:MGI:3589512 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
mitotic G1/S transition checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plk3 polo-like kinase 3 ISO
IBA
ISS
(MGI:MGI:5142362|PMID:21376736)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:21376736, PMID:21873635 GO_REF:0000024, MGI:MGI:5142362, RGD:13792537 NCBI chr 5:135,997,725...136,002,900
Ensembl chr 5:135,997,725...136,002,900
JBrowse link
G Plk5 polo-like kinase 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:12,212,910...12,234,253
Ensembl chr 7:12,212,911...12,221,330
JBrowse link
mitotic G2 DNA damage checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07049960.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 5:146,294,030...146,296,221 JBrowse link
G Blm BLM RecQ like helicase ISO (PMID:11309417) RGD PMID:11309417 NCBI chr 1:142,246,773...142,332,616
Ensembl chr 1:142,246,790...142,332,588
JBrowse link
G Brsk1 BR serine/threonine kinase 1 ISO (PMID:15150265) RGD PMID:15150265 NCBI chr 1:72,701,281...72,727,061
Ensembl chr 1:72,701,610...72,727,112
JBrowse link
G Brsk2 BR serine/threonine kinase 2 ISS PMID:15150265 UniProt PMID:15150265 RGD:8554801 NCBI chr 1:214,918,757...214,940,883
Ensembl chr 1:214,927,172...214,947,624
JBrowse link
G Ccng1 cyclin G1 IMP RGD PMID:9464250 RGD:2316029 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Cdk1 cyclin-dependent kinase 1 ISO
IBA
(MGI:MGI:2679752|PMID:12937170)
PMID:21873635
RGD PMID:12937170, PMID:21873635 MGI:MGI:2679752, RGD:13792537 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:15790566)
Ensembl
UniProt
RGD
PMID:15790566 GO_REF:0000024, GO_REF:0000107 NCBI chr10:84,780,644...84,789,800
Ensembl chr10:84,780,608...84,789,832
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A ISO (PMID:23213251) RGD PMID:23213251 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Clspn claspin ISO
IBA
(PMID:18662541)
PMID:21873635
RGD PMID:18662541, PMID:21873635 RGD:13792537 NCBI chr 5:144,577,670...144,617,507
Ensembl chr 5:144,581,427...144,616,335
JBrowse link
G Donson DNA replication fork stabilization factor DONSON ISO (PMID:28191891) RGD PMID:28191891 NCBI chr11:31,834,608...31,847,751
Ensembl chr11:31,837,839...31,847,490
JBrowse link
G Foxn3 forkhead box N3 ISO UniProtKB:P38111 (PMID:9154802) RGD PMID:9154802 NCBI chr 6:123,183,720...123,577,719
Ensembl chr 6:123,187,726...123,577,695
JBrowse link
G Foxo4 forkhead box O4 ISO (MGI:MGI:2183145|PMID:12048180) RGD PMID:12048180 MGI:MGI:2183145 NCBI chr  X:71,155,284...71,162,158
Ensembl chr  X:71,155,601...71,162,158
JBrowse link
G Hmga2 high mobility group AT-hook 2 ISO
ISS
(PMID:16061642)
GO_REF:0000024
RGD
UniProt
PMID:16061642 GO_REF:0000024 NCBI chr 7:65,159,944...65,275,408
Ensembl chr 7:65,159,944...65,275,408
JBrowse link
G Ier3 immediate early response 3 ISO MGI:MGI:3773690 (MGI:MGI:5432078|PMID:20467439) RGD PMID:20467439 MGI:MGI:5432078 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G LOC100302465 hypothetical LOC100302465 ISO (MGI:MGI:4455105|PMID:20154723) RGD PMID:20154723 MGI:MGI:4455105 NCBI chr 1:206,324,763...206,417,143
Ensembl chr 1:206,324,765...206,417,143
JBrowse link
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase ISO MGI:MGI:2684310 (MGI:MGI:2682526|PMID:14614141) RGD PMID:14614141 MGI:MGI:2682526 NCBI chr 4:147,744,673...147,756,462
Ensembl chr 4:147,746,186...147,756,294
JBrowse link
G Mre11 MRE11 homolog, double strand break repair nuclease ISO
IBA
IEA
MGI:MGI:3027036 (MGI:MGI:2683367|PMID:14690604)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:14690604, PMID:21873635 GO_REF:0000107, MGI:MGI:2683367, RGD:13792537 NCBI chr 8:13,304,355...13,350,329
Ensembl chr 8:13,305,152...13,352,489
JBrowse link
G Mrnip MRN complex interacting protein ISO (PMID:27568553) RGD PMID:27568553 NCBI chr10:35,680,687...35,704,685
Ensembl chr10:35,680,658...35,704,776
JBrowse link
G Nbn nibrin ISO
IBA
ISS
IEA
MGI:MGI:2183796 (MGI:MGI:3805397|PMID:18614044)
PMID:21873635
GO_REF:0000024
(PMID:11438675)
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:11438675, PMID:18614044, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3805397, RGD:13792537 NCBI chr 5:29,622,347...29,656,877
Ensembl chr 5:29,622,281...29,656,864
JBrowse link
G Nop53 NOP53 ribosome biogenesis factor ISO (PMID:21741933) RGD PMID:21741933 NCBI chr 1:77,836,522...77,843,991
Ensembl chr 1:77,836,196...77,844,189
JBrowse link
G Syf2 SYF2 pre-mRNA-splicing factor ISO MGI:MGI:3904866 (MGI:MGI:5435138|PMID:22448250) RGD PMID:22448250 MGI:MGI:5435138 NCBI chr 5:153,269,638...153,277,562
Ensembl chr 5:153,269,526...153,277,563
JBrowse link
G Taok1 TAO kinase 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:17396146)
Ensembl
UniProt
RGD
PMID:17396146 GO_REF:0000024, GO_REF:0000107 NCBI chr10:62,542,870...62,630,341
Ensembl chr10:62,566,732...62,630,155
JBrowse link
G Taok2 TAO kinase 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:17396146)
Ensembl
UniProt
RGD
PMID:17396146 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:198,301,789...198,354,601
Ensembl chr 1:198,301,938...198,320,075
JBrowse link
G Taok3 TAO kinase 3 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:17396146)
Ensembl
UniProt
RGD
PMID:17396146 GO_REF:0000024, GO_REF:0000107 NCBI chr12:45,037,951...45,116,593
Ensembl chr12:45,037,883...45,182,974
JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:141,391,738...141,433,615
Ensembl chr 1:141,391,262...141,433,109
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:111,790,655...111,835,224
Ensembl chr 8:111,790,678...111,827,151
JBrowse link
G Trim39 tripartite motif-containing 39 ISS
ISO
GO_REF:0000024
(PMID:23213251)
UniProt
RGD
PMID:23213251 GO_REF:0000024 NCBI chr20:2,500,691...2,514,546
Ensembl chr20:2,500,689...2,514,546
JBrowse link
mitotic G2/M transition checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca1 BRCA1, DNA repair associated ISO
IEA
(MGI:MGI:3052267|PMID:15254237)
GO_REF:0000107
RGD
Ensembl
PMID:15254237 GO_REF:0000107, MGI:MGI:3052267 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 ISO
ISS
(PMID:19223857)
GO_REF:0000024
RGD
UniProt
PMID:19223857 GO_REF:0000024 NCBI chr10:84,780,644...84,789,800
Ensembl chr10:84,780,608...84,789,832
JBrowse link
mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO
IEA
(PMID:17227893)
GO_REF:0000107
RGD
Ensembl
PMID:17227893 GO_REF:0000107 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Atm ATM serine/threonine kinase ISO (PMID:11943150) RGD PMID:11943150 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Aurkb aurora kinase B IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 ISS
ISO
GO_REF:0000024
(PMID:12805209)
UniProt
RGD
PMID:12805209 GO_REF:0000024 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:120,373,604...120,404,910
Ensembl chr 3:120,373,604...120,404,910
JBrowse link
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:110,367,949...110,420,471
Ensembl chr 3:110,367,939...110,420,458
JBrowse link
G Bub3 BUB3 mitotic checkpoint protein IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:203,526,853...203,537,459
Ensembl chr 1:203,524,426...203,557,337
JBrowse link
G Cenpe centromere protein E ISO (MGI:MGI:2673075|PMID:12925705) RGD PMID:12925705 MGI:MGI:2673075 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
G Ik IK cytokine ISO
ISS
(PMID:22351768)
GO_REF:0000024
RGD
UniProt
PMID:22351768 GO_REF:0000024 NCBI chr18:29,587,901...29,602,705
Ensembl chr18:29,587,901...29,608,338
JBrowse link
G Khdc3 KH domain containing 3, subcortical maternal complex member ISO MGI:MGI:3844604 (MGI:MGI:3844372|PMID:19376971) RGD PMID:19376971 MGI:MGI:3844372 NCBI chr 8:79,781,941...79,783,845
Ensembl chr 8:79,781,983...79,783,592
JBrowse link
G Klhl22 kelch-like family member 22 ISO
IBA
ISS
(PMID:23455478)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:23455478, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr11:87,646,489...87,718,808
Ensembl chr11:87,677,966...87,718,826
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 ISO
IBA
(PMID:18981471)
PMID:21873635
RGD PMID:18981471, PMID:21873635 RGD:13792537 NCBI chr12:16,410,083...16,721,232
Ensembl chr12:16,410,083...16,719,824
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 ISO
IBA
MGI:MGI:2178781 (MGI:MGI:1930685|PMID:11201745)
PMID:21873635
(PMID:18981471)
RGD PMID:11201745, PMID:18981471, PMID:21873635 MGI:MGI:1930685, RGD:13792537 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Plk1 polo-like kinase 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:23455478)
Ensembl
UniProt
RGD
PMID:23455478 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:192,115,990...192,125,969
Ensembl chr 1:192,115,966...192,125,989
JBrowse link
G Psmg2 proteasome assembly chaperone 2 ISO (MGI:MGI:2388532|PMID:12147697) RGD PMID:12147697 MGI:MGI:2388532 NCBI chr18:63,394,991...63,420,491
Ensembl chr18:63,394,900...63,409,600
JBrowse link
G Spdl1 spindle apparatus coiled-coil protein 1 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:19,628,070...19,652,914
Ensembl chr10:19,628,258...19,652,898
JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(MGI:MGI:5318128|PMID:22405274)
Ensembl
UniProt
RGD
PMID:22405274, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5318128, RGD:13792537 NCBI chr10:74,724,070...74,849,172
Ensembl chr10:74,724,549...74,849,194
JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISS
ISO
GO_REF:0000024
(PMID:20133940)
UniProt
RGD
PMID:20133940 GO_REF:0000024 NCBI chr13:67,611,685...67,672,833
Ensembl chr13:67,611,708...67,672,827
JBrowse link
G Trip13 thyroid hormone receptor interactor 13 ISO
ISS
(PMID:28553959)
GO_REF:0000024
RGD
UniProt
PMID:28553959 GO_REF:0000024 NCBI chr 1:31,967,980...32,012,923
Ensembl chr 1:31,967,978...32,012,919
JBrowse link
G Ttk Ttk protein kinase ISO
IBA
MGI:MGI:5056148 (MGI:MGI:5608719|PMID:25197064)
PMID:21873635
RGD PMID:25197064, PMID:21873635 MGI:MGI:5608719, RGD:13792537 NCBI chr 8:91,368,065...91,405,995
Ensembl chr 8:91,368,111...91,405,993
JBrowse link
G Zfp207 zinc finger protein 207 ISO
IBA
(PMID:24462186), (PMID:24462187)
PMID:21873635
RGD PMID:24462186, PMID:24462187, PMID:21873635 RGD:13792537 NCBI chr10:67,762,970...67,784,854
Ensembl chr10:67,762,995...67,774,787
JBrowse link
G Zw10 zw10 kinetochore protein IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:53,365,881...53,390,742
Ensembl chr 8:53,365,857...53,390,930
JBrowse link
negative regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 IEA
ISO
GO_REF:0000107
UniProtKB:Q15554 (PMID:23426265)
Ensembl
RGD
PMID:23426265 GO_REF:0000107 NCBI chr20:3,329,677...3,344,286
Ensembl chr20:3,329,677...3,344,286
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:19229290)
Ensembl
UniProt
RGD
PMID:19229290 GO_REF:0000024, GO_REF:0000107 NCBI chr 8:122,743,274...122,776,801
Ensembl chr 8:122,743,189...122,776,806
JBrowse link
G Gen1 GEN1 Holliday junction 5' flap endonuclease ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:36,910,064...36,940,868
Ensembl chr 6:36,910,675...36,940,868
JBrowse link
G Mad2l1 mitotic arrest deficient 2 like 1 ISO (PMID:20870947)
(MGI:MGI:4839685|PMID:20870947)
RGD PMID:20870947 MGI:MGI:4839685 NCBI chr 4:97,530,993...97,543,179
Ensembl chr 4:97,531,083...97,537,086
JBrowse link
G Ndc80 NDC80 kinetochore complex component ISO (PMID:25743205) RGD PMID:25743205 NCBI chr 9:119,837,857...119,871,435
Ensembl chr 9:119,839,016...119,871,382
JBrowse link
G Pcid2 PCI domain containing 2 ISO (PMID:20870947)
(MGI:MGI:4839685|PMID:20870947)
RGD PMID:20870947 MGI:MGI:4839685 NCBI chr16:81,757,582...81,783,047
Ensembl chr16:81,756,971...81,783,047
JBrowse link
G Tpr translocated promoter region, nuclear basket protein ISS
ISO
GO_REF:0000024
(PMID:18981471), (PMID:19273613)
UniProt
RGD
PMID:18981471, PMID:19273613 GO_REF:0000024 NCBI chr13:67,611,685...67,672,833
Ensembl chr13:67,611,708...67,672,827
JBrowse link
G Xrcc3 X-ray repair cross complementing 3 ISO (PMID:23108668) RGD PMID:23108668 NCBI chr 6:136,366,917...136,380,751
Ensembl chr 6:136,371,555...136,379,348
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anapc15 anaphase promoting complex subunit 15 ISO
IBA
ISS
(PMID:21926987)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:21926987, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:166,981,738...166,985,363
Ensembl chr 1:166,983,175...166,985,054
JBrowse link
G Ccnb1 cyclin B1 ISO (PMID:18195732) RGD PMID:18195732 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 ISS
ISO
IEA
GO_REF:0000024
(PMID:19282672)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:19282672 GO_REF:0000024, GO_REF:0000107 NCBI chr 5:86,387,238...86,554,108
Ensembl chr 5:86,387,078...86,554,102
JBrowse link
G Dusp1 dual specificity phosphatase 1 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 ISO
IEA
(PMID:17724024)
GO_REF:0000107
RGD
Ensembl
PMID:17724024 GO_REF:0000107 NCBI chr 1:193,335,629...193,391,620
Ensembl chr 1:193,335,645...193,391,638
JBrowse link
G Usp44 ubiquitin specific peptidase 44 ISO (MGI:MGI:5448515|PMID:21853124) RGD PMID:21853124 MGI:MGI:5448515 NCBI chr 7:34,714,293...34,759,352
Ensembl chr 7:34,744,483...34,759,206
JBrowse link
regulation of signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rint1 RAD50 interactor 1 ISO
IBA
(PMID:11096100)
PMID:21873635
RGD PMID:11096100, PMID:21873635 RGD:13792537 NCBI chr 4:7,851,602...7,885,446
Ensembl chr 4:7,852,224...7,885,301
JBrowse link
signal transduction involved in intra-S DNA damage checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chek2 checkpoint kinase 2 ISO (PMID:11298456) RGD PMID:11298456 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
signal transduction involved in mitotic G1 DNA damage checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prkdc protein kinase, DNA-activated, catalytic subunit ISO (PMID:21731742) RGD PMID:21731742 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase ISO (PMID:15149599) RGD PMID:15149599 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      cell cycle checkpoint 166
        mitotic cell cycle checkpoint 110
          detection of stimulus involved in mitotic cell cycle checkpoint + 0
          mitotic DNA integrity checkpoint + 71
          mitotic G1/S transition checkpoint + 22
          mitotic G2/M transition checkpoint + 37
          mitotic cell size control checkpoint + 0
          mitotic cytokinesis checkpoint + 4
          mitotic spindle checkpoint + 34
          morphogenesis checkpoint + 0
          signal transduction involved in mitotic cell cycle checkpoint + 16
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        negative regulation of biological process 5696
          negative regulation of cellular process 5144
            negative regulation of cell cycle 444
              cell cycle checkpoint 166
                mitotic cell cycle checkpoint 110
                  detection of stimulus involved in mitotic cell cycle checkpoint + 0
                  mitotic DNA integrity checkpoint + 71
                  mitotic G1/S transition checkpoint + 22
                  mitotic G2/M transition checkpoint + 37
                  mitotic cell size control checkpoint + 0
                  mitotic cytokinesis checkpoint + 4
                  mitotic spindle checkpoint + 34
                  morphogenesis checkpoint + 0
                  signal transduction involved in mitotic cell cycle checkpoint + 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.