ONTOLOGY REPORT - ANNOTATIONS


Term:mitotic cell cycle checkpoint
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Accession:GO:0007093 term browser browse the term
Definition:A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage.
Synonyms:related_synonym: mitotic checkpoint
 alt_id: GO:0031575;   GO:0071780


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mitotic cell cycle checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:1624291
RGD:1600115
G Cdkn2b cyclin-dependent kinase inhibitor 2B JBrowse link 5 107,834,353 107,857,428 RGD:1624291
RGD:1600115
G Chek1 checkpoint kinase 1 JBrowse link 8 39,181,162 39,201,588 RGD:1624291
G Chfr checkpoint with forkhead and ring finger domains JBrowse link 12 52,562,594 52,596,162 RGD:1600115
RGD:13792537
RGD:1624291
G Dclre1b DNA cross-link repair 1B JBrowse link 2 206,285,085 206,293,599 RGD:1600115
RGD:1624291
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:1624291
RGD:1600115
G Hus1 HUS1 checkpoint clamp component JBrowse link 14 89,194,086 89,208,825 RGD:1624291
G Ints3 integrator complex subunit 3 JBrowse link 2 189,766,927 189,818,327 RGD:1624291
RGD:1600115
G Kntc1 kinetochore associated 1 JBrowse link 12 38,200,463 38,274,162 RGD:1624291
RGD:1600115
G LOC100910107 ubiquitin carboxyl-terminal hydrolase DUB-1-like JBrowse link 1 169,720,247 169,721,788 RGD:1624291
G Mad2l1 mitotic arrest deficient 2 like 1 JBrowse link 4 97,530,993 97,543,179 RGD:1624291
G Mad2l1bp MAD2L1 binding protein JBrowse link 9 17,217,141 17,221,465 RGD:1624291
RGD:1600115
G Map3k20 mitogen-activated protein kinase kinase kinase 20 JBrowse link 3 58,965,025 59,120,507 RGD:1624291
G Nabp1 nucleic acid binding protein 1 JBrowse link 9 55,049,893 55,057,784 RGD:1624291
RGD:13792537
RGD:1600115
G Nabp2 nucleic acid binding protein 2 JBrowse link 7 2,820,006 2,825,627 RGD:1600115
RGD:13792537
RGD:1624291
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:1624291
RGD:1600115
G Plk2 polo-like kinase 2 JBrowse link 2 41,911,143 41,916,901 RGD:1624291
RGD:13792537
RGD:1600115
G Prcc proline rich mitotic checkpoint control factor JBrowse link 2 187,232,458 187,258,140 RGD:1624291
RGD:1600115
G Rad17 RAD17 checkpoint clamp loader component JBrowse link 2 30,634,353 30,664,618 RGD:1624291
G Rpl24 ribosomal protein L24 JBrowse link 11 47,116,885 47,122,093 RGD:1624291
RGD:1600115
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:1624291
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:1624291
RGD:1600115
G Trrap transformation/transcription domain-associated protein JBrowse link 12 11,537,950 11,627,563 RGD:1624291
G Wee1 WEE1 G2 checkpoint kinase JBrowse link 1 174,765,228 174,790,882 RGD:13792537
G Wee2 WEE1 homolog 2 JBrowse link 4 68,604,770 68,631,341 RGD:13792537
G Wnt9a Wnt family member 9A JBrowse link 10 45,659,045 45,686,103 RGD:1624291
RGD:1600115
G Zw10 zw10 kinetochore protein JBrowse link 8 53,365,881 53,390,742 RGD:1624291
RGD:1600115
G Zwilch zwilch kinetochore protein JBrowse link 8 69,089,449 69,121,420 RGD:1624291
RGD:1600115
G Zwint ZW10 interacting kinetochore protein JBrowse link 20 17,075,781 17,091,715 RGD:1624291
RGD:1600115
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdt1 chromatin licensing and DNA replication factor 1 JBrowse link 19 55,381,565 55,386,511 RGD:1624291
RGD:1600115
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp2 caspase 2 JBrowse link 4 71,652,358 71,670,228 RGD:1624291
RGD:1600115
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1624291
RGD:1600115
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain JBrowse link 7 36,395,665 36,408,588 RGD:1624291
RGD:13792537
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:1624291
RGD:1600115
G Muc1 mucin 1, cell surface associated JBrowse link 2 188,543,137 188,547,874 RGD:1624291
G Pidd1 p53-induced death domain protein 1 JBrowse link 1 214,418,751 214,423,959 RGD:1624291
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:1624291
RGD:1600115
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma JBrowse link 6 134,804,128 134,941,912 RGD:1624291
G Rbm38 RNA binding motif protein 38 JBrowse link 3 171,037,891 171,050,500 RGD:1624291
G Rpl26 ribosomal protein L26 JBrowse link 10 55,492,417 55,495,547 RGD:1624291
RGD:1600115
G Sox4 SRY box 4 JBrowse link 17 37,615,022 37,619,728 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
RGD:1600115
intra-S DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:1624291
RGD:1600115
G Eme1 essential meiotic structure-specific endonuclease 1 JBrowse link 10 82,366,820 82,375,510 RGD:13792537
G Eme2 essential meiotic structure-specific endonuclease subunit 2 JBrowse link 10 14,253,552 14,257,017 RGD:13792537
G Hus1 HUS1 checkpoint clamp component JBrowse link 14 89,194,086 89,208,825 RGD:13792537
G Mre11a MRE11 homolog A, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:1600115
RGD:13792537
RGD:1624291
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:1624291
RGD:1600115
G Mus81 MUS81 structure-specific endonuclease subunit JBrowse link 1 220,862,474 220,867,973 RGD:13792537
G Nek11 NIMA-related kinase 11 JBrowse link 8 113,703,406 113,937,097 RGD:1624291
RGD:13792537
G Rad9a RAD9 checkpoint clamp component A JBrowse link 1 219,443,347 219,450,574 RGD:1624291
RGD:13792537
G Rad9b RAD9 checkpoint clamp component B JBrowse link 12 39,699,076 39,731,218 RGD:13792537
G Tipin timeless interacting protein JBrowse link 8 69,753,363 69,768,640 RGD:1624291
RGD:1600115
G Xpc XPC complex subunit, DNA damage recognition and repair factor JBrowse link 4 123,134,457 123,161,985 RGD:1624291
RGD:1600115
mitotic cytokinesis checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aurkb aurora kinase B JBrowse link 10 55,625,860 55,632,399 RGD:1600115
G Chmp4c charged multivesicular body protein 4C JBrowse link 2 93,574,554 93,641,497 RGD:1600115
RGD:1624291
G Vps4a vacuolar protein sorting 4 homolog A JBrowse link 19 39,230,050 39,243,298 RGD:1624291
RGD:1600115
G Zfyve19 zinc finger FYVE-type containing 19 JBrowse link 3 111,013,856 111,021,841 RGD:1624291
RGD:13792537
mitotic DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:13792537
G Stk33 serine/threonine kinase 33 JBrowse link 1 173,872,744 174,051,768 RGD:13792537
G Zfp830 zinc finger protein 830 JBrowse link 10 70,118,250 70,119,714 RGD:1624291
RGD:13792537
mitotic DNA integrity checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Setmar SET domain and mariner transposase fusion gene JBrowse link 4 140,092,346 140,104,495 RGD:1624291
G Top2a DNA topoisomerase II alpha JBrowse link 10 86,901,467 86,930,947 RGD:13792537
mitotic DNA replication checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc6 cell division cycle 6 JBrowse link 10 86,819,477 86,833,301 RGD:13792537
G Clspn claspin JBrowse link 5 144,577,670 144,617,507 RGD:1624291
RGD:13792537
G Hus1 HUS1 checkpoint clamp component JBrowse link 14 89,194,086 89,208,825 RGD:13792537
G Nae1 NEDD8 activating enzyme E1 subunit 1 JBrowse link 19 653,510 680,378 RGD:1600115
RGD:1624291
G Orc1 origin recognition complex, subunit 1 JBrowse link 5 128,186,651 128,212,901 RGD:13792537
G Rad17 RAD17 checkpoint clamp loader component JBrowse link 2 30,634,353 30,664,618 RGD:13792537
G Ticrr TOPBP1-interacting checkpoint and replication regulator JBrowse link 1 141,391,738 141,433,615 RGD:1600115
G Topbp1 DNA topoisomerase II binding protein 1 JBrowse link 8 111,790,655 111,835,224 RGD:13792537
G Zfp830 zinc finger protein 830 JBrowse link 10 70,118,250 70,119,714 RGD:1624291
RGD:13792537
RGD:1600115
mitotic G1 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:1624291
RGD:1600115
G Dgkz diacylglycerol kinase zeta JBrowse link 3 80,844,002 80,886,487 RGD:1624291
G Fbxo31 F-box protein 31 JBrowse link 19 53,487,610 53,625,673 RGD:1600115
RGD:1624291
G Gigyf2 GRB10 interacting GYF protein 2 JBrowse link 9 94,425,191 94,550,431 RGD:1624291
G Rfwd3 ring finger and WD repeat domain 3 JBrowse link 19 42,960,597 42,971,894 RGD:1624291
G Rpa2 replication protein A2 JBrowse link 5 150,957,041 150,967,597 RGD:1624291
RGD:1600115
G Rps27l ribosomal protein S27-like JBrowse link 8 72,741,155 72,746,090 RGD:1624291
RGD:1600115
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
mitotic G1/S transition checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Plk3 polo-like kinase 3 JBrowse link 5 135,997,725 136,002,900 RGD:1624291
RGD:13792537
RGD:1600115
mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Blm BLM RecQ like helicase JBrowse link 1 142,246,773 142,332,616 RGD:1624291
RGD:1600115
G Brsk1 BR serine/threonine kinase 1 JBrowse link 1 72,701,281 72,727,061 RGD:1600115
RGD:1624291
G Brsk2 BR serine/threonine kinase 2 JBrowse link 1 214,918,757 214,940,883 RGD:8554801
G Ccng1 cyclin G1 JBrowse link 10 25,903,925 25,910,298 RGD:2316029
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:1624291
RGD:1600115
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link 10 84,780,644 84,789,800 RGD:1600115
RGD:1624291
G Clspn claspin JBrowse link 5 144,577,670 144,617,507 RGD:1624291
RGD:13792537
G Donson downstream neighbor of SON JBrowse link 11 31,834,608 31,847,751 RGD:1624291
RGD:1600115
G Foxn3 forkhead box N3 JBrowse link 6 123,183,720 123,577,719 RGD:1624291
RGD:1600115
G Foxo4 forkhead box O4 JBrowse link X 71,155,284 71,162,158 RGD:1624291
RGD:1600115
G Hmga2 high mobility group AT-hook 2 JBrowse link 7 65,159,944 65,275,408 RGD:1624291
RGD:1600115
G Ier3 immediate early response 3 JBrowse link 20 3,438,798 3,440,002 RGD:1624291
G LOC100302465 hypothetical LOC100302465 JBrowse link 1 206,324,763 206,417,143 RGD:1624291
G Mbd4 methyl-CpG binding domain 4 DNA glycosylase JBrowse link 4 147,744,673 147,756,462 RGD:1624291
G Mre11a MRE11 homolog A, double strand break repair nuclease JBrowse link 8 13,304,355 13,350,329 RGD:1624291
RGD:13792537
RGD:1600115
G Mrnip MRN complex interacting protein JBrowse link 10 35,680,687 35,704,685 RGD:1624291
RGD:1600115
G Nbn nibrin JBrowse link 5 29,622,347 29,656,877 RGD:1624291
RGD:13792537
RGD:1600115
G Nop53 NOP53 ribosome biogenesis factor JBrowse link 1 77,836,522 77,843,991 RGD:1624291
RGD:1600115
G Syf2 SYF2 pre-mRNA-splicing factor JBrowse link 5 153,269,638 153,277,562 RGD:1624291
RGD:1600115
G Taok1 TAO kinase 1 JBrowse link 10 62,542,870 62,630,341 RGD:1600115
RGD:1624291
G Taok2 TAO kinase 2 JBrowse link 1 198,301,789 198,354,601 RGD:1600115
RGD:1624291
G Taok3 TAO kinase 3 JBrowse link 12 45,037,951 45,116,593 RGD:1600115
RGD:1624291
mitotic G2/M transition checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:1624291
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link 10 84,780,644 84,789,800 RGD:1624291
RGD:1600115
mitotic spindle assembly checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apc APC regulator of WNT signaling pathway JBrowse link 18 27,011,710 27,106,323 RGD:1624291
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291
RGD:1600115
G Aurkb aurora kinase B JBrowse link 10 55,625,860 55,632,399 RGD:1600115
G Birc5 baculoviral IAP repeat-containing 5 JBrowse link 10 106,856,097 106,864,419 RGD:1600115
RGD:1624291
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase JBrowse link 3 120,373,604 120,404,910 RGD:13792537
G Bub1b BUB1 mitotic checkpoint serine/threonine kinase B JBrowse link 3 110,367,949 110,420,471 RGD:13792537
G Bub3 BUB3 mitotic checkpoint protein JBrowse link 1 203,526,853 203,537,459 RGD:13792537
G Cenpe centromere protein E JBrowse link 2 240,395,974 240,454,785 RGD:1624291
G Ik IK cytokine JBrowse link 18 29,587,901 29,602,705 RGD:1624291
RGD:1600115
G Khdc3 KH domain containing 3, subcortical maternal complex member JBrowse link 8 79,781,941 79,783,845 RGD:1624291
G Klhl22 kelch-like family member 22 JBrowse link 11 87,646,489 87,718,808 RGD:1600115
RGD:13792537
RGD:1624291
G Mad1l1 mitotic arrest deficient 1 like 1 JBrowse link 12 16,410,083 16,721,232 RGD:13792537
RGD:1624291
G Mad2l1 mitotic arrest deficient 2 like 1 JBrowse link 4 97,530,993 97,543,179 RGD:1624291
RGD:13792537
G Plk1 polo-like kinase 1 JBrowse link 1 192,115,990 192,125,969 RGD:1600115
RGD:1624291
G Psmg2 proteasome assembly chaperone 2 JBrowse link 18 63,394,991 63,420,491 RGD:1624291
RGD:1600115
G Spdl1 spindle apparatus coiled-coil protein 1 JBrowse link 10 19,628,070 19,652,914 RGD:1600115
G Terf1 telomeric repeat binding factor 1 JBrowse link 5 2,853,455 2,882,731 RGD:1624291
G Tex14 testis expressed 14, intercellular bridge forming factor JBrowse link 10 74,724,070 74,849,172 RGD:1600115
RGD:13792537
RGD:1624291
G Tpr translocated promoter region, nuclear basket protein JBrowse link 13 67,611,685 67,672,833 RGD:1600115
RGD:1624291
RGD:13792537
G Trip13 thyroid hormone receptor interactor 13 JBrowse link 1 31,967,980 32,012,923 RGD:1624291
RGD:1600115
G Ttk Ttk protein kinase JBrowse link 8 91,368,065 91,405,995 RGD:1624291
RGD:13792537
G Zfp207 zinc finger protein 207 JBrowse link 10 67,762,970 67,784,854 RGD:1624291
RGD:13792537
G Zw10 zw10 kinetochore protein JBrowse link 8 53,365,881 53,390,742 RGD:13792537
negative regulation of mitotic DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 JBrowse link 20 3,329,677 3,344,286 RGD:1600115
RGD:1624291
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dync1li1 dynein cytoplasmic 1 light intermediate chain 1 JBrowse link 8 122,743,274 122,776,801 RGD:1600115
RGD:1624291
G Gen1 GEN1 Holliday junction 5' flap endonuclease JBrowse link 6 36,910,064 36,940,868 RGD:1624291
RGD:1600115
G Mad2l1 mitotic arrest deficient 2 like 1 JBrowse link 4 97,530,993 97,543,179 RGD:1624291
RGD:1600115
G Ndc80 NDC80 kinetochore complex component JBrowse link 9 119,837,857 119,871,435 RGD:1624291
RGD:1600115
G Pcid2 PCI domain containing 2 JBrowse link 16 81,757,582 81,783,047 RGD:1624291
RGD:1600115
G Tpr translocated promoter region, nuclear basket protein JBrowse link 13 67,611,685 67,672,833 RGD:1600115
RGD:1624291
G Xrcc3 X-ray repair cross complementing 3 JBrowse link 6 136,366,917 136,380,751 RGD:1624291
RGD:1600115
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Anapc15 anaphase promoting complex subunit 15 JBrowse link 1 166,981,738 166,985,363 RGD:1624291
RGD:13792537
RGD:1600115
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:1624291
RGD:1600115
G Cdk5rap2 CDK5 regulatory subunit associated protein 2 JBrowse link 5 86,387,238 86,554,108 RGD:1600115
RGD:1624291
G Dusp1 dual specificity phosphatase 1 JBrowse link 10 16,970,642 16,973,425 RGD:1600115
G Lcmt1 leucine carboxyl methyltransferase 1 JBrowse link 1 193,335,629 193,391,620 RGD:1624291
RGD:1600115
G Usp44 ubiquitin specific peptidase 44 JBrowse link 7 34,714,293 34,759,352 RGD:1624291
regulation of signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rint1 RAD50 interactor 1 JBrowse link 4 7,851,602 7,885,446 RGD:1624291
RGD:13792537
signal transduction involved in intra-S DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:1624291
RGD:1600115
signal transduction involved in mitotic G1 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:1624291
RGD:1600115
signal transduction involved in mitotic G2 DNA damage checkpoint term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17941
    cellular process 16091
      cell cycle checkpoint 184
        mitotic cell cycle checkpoint 130
          detection of stimulus involved in mitotic cell cycle checkpoint + 0
          mitotic DNA integrity checkpoint + 67
          mitotic G1/S transition checkpoint + 21
          mitotic G2/M transition checkpoint + 33
          mitotic cell cycle checkpoint inhibiting CAR assembly 0
          mitotic cell size control checkpoint + 0
          mitotic cytokinesis checkpoint + 4
          mitotic spindle checkpoint + 35
          morphogenesis checkpoint + 0
          signal transduction involved in mitotic cell cycle checkpoint + 16
Path 2
Term Annotations click to browse term
  biological_process 17941
    biological regulation 12628
      regulation of biological process 11967
        negative regulation of biological process 5369
          negative regulation of cellular process 4791
            negative regulation of cell cycle 461
              cell cycle checkpoint 184
                mitotic cell cycle checkpoint 130
                  detection of stimulus involved in mitotic cell cycle checkpoint + 0
                  mitotic DNA integrity checkpoint + 67
                  mitotic G1/S transition checkpoint + 21
                  mitotic G2/M transition checkpoint + 33
                  mitotic cell cycle checkpoint inhibiting CAR assembly 0
                  mitotic cell size control checkpoint + 0
                  mitotic cytokinesis checkpoint + 4
                  mitotic spindle checkpoint + 35
                  morphogenesis checkpoint + 0
                  signal transduction involved in mitotic cell cycle checkpoint + 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.