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ONTOLOGY REPORT - ANNOTATIONS


Term:mitotic spindle assembly checkpoint
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Accession:GO:0007094 term browser browse the term
Definition:A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
Synonyms:exact_synonym: mitotic cell cycle spindle assembly checkpoint;   mitotic checkpoint
 narrow_synonym: Dma1-dependent checkpoint;   Mad2-dependent checkpoint;   SAC-independent checkpoint
 alt_id: GO:0044810


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mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APC APC regulator of WNT signaling pathway IEA Ensembl GO_REF:0000107 NCBI chr 3:252,052...380,506
Ensembl chr 3:253,081...322,993
JBrowse link
G ATM ATM serine/threonine kinase IEA Ensembl GO_REF:0000107 NCBI chr 5:24,180,129...24,297,207
Ensembl chr 5:24,182,135...24,297,207
JBrowse link
G AURKB aurora kinase B IEA InterPro GO_REF:0000002 NCBI chr 5:33,014,098...33,028,951
Ensembl chr 5:33,014,102...33,033,948
JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 ISS UniProtKB GO_REF:0000024 NCBI chr 9:2,930,308...2,959,307 JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr17:35,208,989...35,252,296
Ensembl chr17:35,208,991...35,252,975
JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr30:7,361,982...7,410,162
Ensembl chr30:7,322,912...7,438,052
JBrowse link
G BUB3 BUB3 mitotic checkpoint protein IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr28:32,693,104...32,703,293
Ensembl chr28:32,679,421...32,703,023
JBrowse link
G CENPE centromere protein E ISO (MGI:MGI:2673075|PMID:12925705) UniProtKB PMID:12925705 MGI:MGI:2673075 NCBI chr32:24,447,373...24,530,407
Ensembl chr32:24,447,358...24,530,382
JBrowse link
G DOCK2 dedicator of cytokinesis 2 IEA InterPro GO_REF:0000002 NCBI chr 4:41,779,950...42,177,957
Ensembl chr 4:41,780,436...42,235,177
JBrowse link
G IK IK cytokine IEA Ensembl GO_REF:0000107 NCBI chr 2:35,805,631...35,818,205
Ensembl chr 2:35,805,689...35,818,050
JBrowse link
G KHDC3L KH domain containing 3 like, subcortical maternal complex member ISO (MGI:MGI:3844372|PMID:19376971) MGI PMID:19376971 MGI:MGI:3844372 NCBI chr12:35,434,123...35,435,679
Ensembl chr12:35,434,123...35,468,943
JBrowse link
G KLHL22 kelch like family member 22 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr26:30,248,253...30,281,989
Ensembl chr26:30,248,240...30,281,843
JBrowse link
G LOC100687713 BUB3-interacting and GLEBS motif-containing protein ZNF207 ISO (PMID:24462186), (PMID:24462187) UniProtKB PMID:24462186, PMID:24462187 NCBI chr11:1,027,387...1,029,505 JBrowse link
G MAD1L1 mitotic arrest deficient 1 like 1 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 6:14,889,126...15,236,194
Ensembl chr 6:14,882,875...15,236,192
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:55,653,677...55,661,017 JBrowse link
G PLK1 polo like kinase 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:22,165,338...22,176,847
Ensembl chr 6:22,165,338...22,176,441
JBrowse link
G PSMG2 proteasome assembly chaperone 2 IEA Ensembl GO_REF:0000107 NCBI chr 7:78,092,877...78,112,831
Ensembl chr 7:78,092,876...78,112,702
JBrowse link
G SPDL1 spindle apparatus coiled-coil protein 1 IEA InterPro GO_REF:0000002 NCBI chr 4:42,214,997...42,235,282
Ensembl chr 4:41,780,436...42,235,177
JBrowse link
G TEX14 testis expressed 14, intercellular bridge forming factor IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:33,174,813...33,289,202
Ensembl chr 9:33,174,814...33,262,870
JBrowse link
G TPR translocated promoter region, nuclear basket protein IEA Ensembl GO_REF:0000107 NCBI chr 7:19,376,951...19,442,368
Ensembl chr 7:19,376,975...19,442,303
JBrowse link
G TRIP13 thyroid hormone receptor interactor 13 IEA Ensembl GO_REF:0000107 NCBI chr34:11,522,940...11,539,885
Ensembl chr34:11,522,940...11,539,885
JBrowse link
G TTK TTK protein kinase IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr12:40,915,733...40,959,423
Ensembl chr12:40,915,439...40,957,279
JBrowse link
G ZNF207 zinc finger protein 207 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 Ensembl chr 9:40,588,735...40,612,626 JBrowse link
G ZW10 zw10 kinetochore protein IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:19,496,531...19,527,205
Ensembl chr 5:19,496,611...19,527,200
JBrowse link
deactivation of mitotic spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDT1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) CAFA PMID:22581055 NCBI chr 5:64,566,035...64,570,361
Ensembl chr 5:64,566,043...64,570,748
JBrowse link
positive regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DYNC1LI1 dynein cytoplasmic 1 light intermediate chain 1 IEA Ensembl GO_REF:0000107 NCBI chr23:12,235,539...12,283,851
Ensembl chr23:12,235,104...12,277,031
JBrowse link
G GEN1 GEN1 Holliday junction 5' flap endonuclease IEA Ensembl GO_REF:0000107 NCBI chr17:13,201,540...13,233,028
Ensembl chr17:13,201,777...13,232,120
JBrowse link
G MAD2L1 mitotic arrest deficient 2 like 1 ISO (MGI:MGI:4839685|PMID:20870947)
(PMID:20870947)
UniProtKB PMID:20870947 MGI:MGI:4839685 NCBI chr18:55,653,677...55,661,017 JBrowse link
G NDC80 NDC80 kinetochore complex component IEA Ensembl GO_REF:0000107 NCBI chr 7:69,268,218...69,317,126
Ensembl chr 7:69,268,242...69,317,072
JBrowse link
G PCID2 PCI domain containing 2 IEA Ensembl GO_REF:0000107 NCBI chr22:60,602,440...60,623,811
Ensembl chr22:60,602,888...60,623,719
JBrowse link
G TPR translocated promoter region, nuclear basket protein IEA Ensembl GO_REF:0000107 NCBI chr 7:19,376,951...19,442,368
Ensembl chr 7:19,376,975...19,442,303
JBrowse link
G XRCC3 X-ray repair cross complementing 3 IEA Ensembl GO_REF:0000107 NCBI chr 8:71,441,732...71,452,922
Ensembl chr 8:71,442,429...71,449,408
JBrowse link
regulation of mitotic cell cycle spindle assembly checkpoint term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANAPC15 anaphase promoting complex subunit 15 IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr21:25,971,680...25,975,556
Ensembl chr21:25,972,458...25,975,558
JBrowse link
G CCNB1 cyclin B1 ISO (PMID:18195732) BHF-UCL PMID:18195732 NCBI chr 2:54,256,957...54,264,749 JBrowse link
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr11:73,548,003...73,693,044
Ensembl chr11:73,548,038...73,690,199
JBrowse link
G LCMT1 leucine carboxyl methyltransferase 1 IEA Ensembl GO_REF:0000107 NCBI chr 6:21,026,125...21,066,884
Ensembl chr 6:21,026,186...21,066,876
JBrowse link
G USP44 ubiquitin specific peptidase 44 IEA Ensembl GO_REF:0000107 NCBI chr15:35,401,486...35,454,351
Ensembl chr15:35,402,207...35,414,261
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16187
    cellular process 15463
      cell cycle checkpoint 159
        spindle checkpoint 35
          spindle assembly checkpoint 35
            mitotic spindle assembly checkpoint 35
              deactivation of mitotic spindle assembly checkpoint 1
              detection of stimulus involved in mitotic spindle assembly checkpoint 0
              mitotic spindle assembly checkpoint signaling + 0
              positive regulation of mitotic cell cycle spindle assembly checkpoint + 7
              regulation of mitotic cell cycle spindle assembly checkpoint + 13
Path 2
Term Annotations click to browse term
  biological_process 16187
    cellular process 15463
      cellular component organization or biogenesis 6050
        cellular component organization 5882
          organelle organization 3730
            organelle fission 487
              nuclear division 432
                mitotic nuclear division 280
                  mitotic sister chromatid segregation 160
                    mitotic sister chromatid separation 60
                      regulation of mitotic sister chromatid separation 57
                        metaphase/anaphase transition of mitotic cell cycle 56
                          regulation of mitotic metaphase/anaphase transition 53
                            negative regulation of mitotic metaphase/anaphase transition 37
                              mitotic spindle assembly checkpoint 35
                                deactivation of mitotic spindle assembly checkpoint 1
                                detection of stimulus involved in mitotic spindle assembly checkpoint 0
                                mitotic spindle assembly checkpoint signaling + 0
                                positive regulation of mitotic cell cycle spindle assembly checkpoint + 7
                                regulation of mitotic cell cycle spindle assembly checkpoint + 13
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.