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ONTOLOGY REPORT - ANNOTATIONS


Term:mitotic centrosome separation
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Accession:GO:0007100 term browser browse the term
Definition:Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.


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mitotic centrosome separation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurka aurora kinase A IEA
ISO
GO_REF:0000107
MGI:MGI:1932915|MGI:MGI:3836423 (MGI:MGI:3697244|PMID:17060449), (MGI:MGI:3835913|PMID:19075002)
Ensembl
RGD
PMID:17060449, PMID:19075002 GO_REF:0000107, MGI:MGI:3697244, MGI:MGI:3835913 NCBI chr 3:170,364,177...170,380,278
Ensembl chr 3:170,364,181...170,378,210
JBrowse link
G Kif11 kinesin family member 11 ISO (MGI:MGI:2671632|PMID:12840069) RGD PMID:12840069 MGI:MGI:2671632 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
JBrowse link
G Nde1 nudE neurodevelopment protein 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:860,513...904,624
Ensembl chr10:860,521...896,938
JBrowse link
G Ndel1 nudE neurodevelopment protein 1-like 1 ISO
IBA
MGI:MGI:894678 (MGI:MGI:3697244|PMID:17060449)
PMID:21873635
RGD PMID:17060449, PMID:21873635 MGI:MGI:3697244, RGD:13792537 NCBI chr10:55,398,919...55,456,654
Ensembl chr10:55,411,901...55,444,861
JBrowse link
G Nup62 nucleoporin 62 ISO (PMID:24107630) RGD PMID:24107630 NCBI chr 1:100,811,140...100,827,119
Ensembl chr 1:100,811,755...100,827,111
JBrowse link
positive regulation of mitotic centrosome separation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nsfl1c NSFL1 cofactor ISO UniProtKB:Q14CS0 (PMID:23649807) RGD PMID:23649807 NCBI chr 3:146,980,923...147,005,478
Ensembl chr 3:146,980,923...147,005,439
JBrowse link
G Ranbp1 RAN binding protein 1 ISO
IBA
(MGI:MGI:2671632|PMID:12840069)
PMID:21873635
RGD PMID:12840069, PMID:21873635 MGI:MGI:2671632, RGD:13792537 NCBI chr11:86,890,585...86,898,818
Ensembl chr11:86,890,585...86,898,818
JBrowse link
G Ubxn2b UBX domain protein 2B ISO UniProtKB:Q9UNZ2 (PMID:23649807) RGD PMID:23649807 NCBI chr 5:19,285,368...19,314,199
Ensembl chr 5:19,284,548...19,311,088
JBrowse link
regulation of mitotic centrosome separation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cep85 centrosomal protein 85 ISO (PMID:26220856) RGD PMID:26220856 NCBI chr 5:152,359,693...152,406,530
Ensembl chr 5:152,359,700...152,406,518
JBrowse link
G Chek1 checkpoint kinase 1 ISO
ISS
(PMID:15311285)
GO_REF:0000024
RGD
UniProt
PMID:15311285 GO_REF:0000024 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Kif11 kinesin family member 11 ISO (PMID:15843429) RGD PMID:15843429 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
JBrowse link
G Map9 microtubule-associated protein 9 ISO (PMID:16049101) RGD PMID:16049101 NCBI chr 2:181,331,426...181,367,245
Ensembl chr 2:181,331,464...181,367,244
JBrowse link
G Nek2 NIMA-related kinase 2 ISO (PMID:26220856) RGD PMID:26220856 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cell cycle process 1210
        centrosome separation 13
          mitotic centrosome separation 12
            negative regulation of mitotic centrosome separation 0
            positive regulation of mitotic centrosome separation 3
            regulation of mitotic centrosome separation + 8
Path 2
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cellular component organization or biogenesis 6789
        cellular component organization 6534
          organelle organization 4101
            cytoskeleton organization 1461
              microtubule cytoskeleton organization 647
                microtubule organizing center organization 150
                  centrosome cycle 138
                    centrosome separation 13
                      mitotic centrosome separation 12
                        negative regulation of mitotic centrosome separation 0
                        positive regulation of mitotic centrosome separation 3
                        regulation of mitotic centrosome separation + 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.