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ONTOLOGY REPORT - ANNOTATIONS


Term:signal transduction
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Accession:GO:0007165 term browser browse the term
Definition:The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
Comment:Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
Synonyms:narrow_synonym: signaling cascade;   signalling cascade
 related_synonym: signaling pathway;   signalling pathway
 alt_id: GO:0023033
 xref: Wikipedia:Signal_transduction


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Path 1
Term Annotations click to browse term
  biological_process 16411
    signaling 6414
      signal transduction 5871
        ER-nucleus signaling pathway + 39
        G protein-coupled receptor signaling pathway + 1832
        SMAD protein signal transduction + 91
        apoptotic signaling pathway + 608
        bile acid signaling pathway + 19
        calmodulin dependent kinase signaling pathway + 9
        carbohydrate mediated signaling + 7
        cell surface receptor signaling pathway + 2493
        chloroplast-nucleus signaling pathway 0
        dopamine receptor signaling pathway + 38
        endoplasmic reticulum unfolded protein response + 70
        extracellular ATP signaling 0
        hormone-mediated signaling pathway + 173
        hydrogen peroxide mediated signaling pathway + 0
        hypoxia-inducible factor-1alpha signaling pathway + 7
        immune response-regulating signaling pathway + 204
        intracellular receptor signaling pathway + 230
        intracellular signal transduction + 2465
        ligand-gated ion channel signaling pathway + 0
        lipoprotein particle mediated signaling + 4
        mitochondria-nucleus signaling pathway 2
        necroptotic signaling pathway 8
        negative regulation of signal transduction + 1190
        neuronal signal transduction + 6
        osmosensory signaling pathway + 3
        pattern recognition receptor signaling pathway + 147
        peptidoglycan recognition protein signaling pathway + 0
        phototransduction + 26
        positive regulation of signal transduction + 1582
        postsynaptic signal transduction + 44
        presynaptic signal transduction + 3
        red or far-red light signaling pathway + 1
        regulation of blood pressure by chemoreceptor signaling pathway 0
        regulation of floral organ abscission by signal transduction + 0
        regulation of signal transduction + 2820
        salicylic acid mediated signaling pathway + 0
        serotonin receptor signaling pathway + 37
        signal transduction by conformational transition 0
        signal transduction by protein phosphorylation + 807
        signal transduction in absence of ligand + 77
        signal transduction involved in cellular response to ammonium ion 0
        signal transduction involved in filamentous growth 0
        signal transduction involved in morphogenesis checkpoint 0
        signal transduction involved in positive regulation of conjugation with cellular fusion + 0
        signal transduction involved in regulation of gene expression 23
        sphingolipid mediated signaling pathway + 14
Path 2
Term Annotations click to browse term
  biological_process 16411
    biological regulation 11882
      regulation of biological process 11314
        regulation of cellular process 10867
          signal transduction 5871
            ER-nucleus signaling pathway + 39
            G protein-coupled receptor signaling pathway + 1832
            SMAD protein signal transduction + 91
            apoptotic signaling pathway + 608
            bile acid signaling pathway + 19
            calmodulin dependent kinase signaling pathway + 9
            carbohydrate mediated signaling + 7
            cell surface receptor signaling pathway + 2493
            chloroplast-nucleus signaling pathway 0
            dopamine receptor signaling pathway + 38
            endoplasmic reticulum unfolded protein response + 70
            extracellular ATP signaling 0
            hormone-mediated signaling pathway + 173
            hydrogen peroxide mediated signaling pathway + 0
            hypoxia-inducible factor-1alpha signaling pathway + 7
            immune response-regulating signaling pathway + 204
            intracellular receptor signaling pathway + 230
            intracellular signal transduction + 2465
            ligand-gated ion channel signaling pathway + 0
            lipoprotein particle mediated signaling + 4
            mitochondria-nucleus signaling pathway 2
            necroptotic signaling pathway 8
            negative regulation of signal transduction + 1190
            neuronal signal transduction + 6
            osmosensory signaling pathway + 3
            pattern recognition receptor signaling pathway + 147
            peptidoglycan recognition protein signaling pathway + 0
            phototransduction + 26
            positive regulation of signal transduction + 1582
            postsynaptic signal transduction + 44
            presynaptic signal transduction + 3
            red or far-red light signaling pathway + 1
            regulation of blood pressure by chemoreceptor signaling pathway 0
            regulation of floral organ abscission by signal transduction + 0
            regulation of signal transduction + 2820
            salicylic acid mediated signaling pathway + 0
            serotonin receptor signaling pathway + 37
            signal transduction by conformational transition 0
            signal transduction by protein phosphorylation + 807
            signal transduction in absence of ligand + 77
            signal transduction involved in cellular response to ammonium ion 0
            signal transduction involved in filamentous growth 0
            signal transduction involved in morphogenesis checkpoint 0
            signal transduction involved in positive regulation of conjugation with cellular fusion + 0
            signal transduction involved in regulation of gene expression 23
            sphingolipid mediated signaling pathway + 14
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.