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ONTOLOGY REPORT - ANNOTATIONS


Term:phospholipase C-activating G protein-coupled receptor signaling pathway
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Accession:GO:0007200 term browser browse the term
Definition:The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG).
Comment:This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) activity.
Synonyms:exact_synonym: G protein signaling, coupled to IP3 second messenger (phospholipase C activating);   G protein signalling, coupled to IP3 second messenger (phospholipase C activating);   G-protein coupled receptor signaling pathway coupled to IP3 second messenger;   PLC-activating GPCR signaling pathway
 related_synonym: activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger;   phospholipase C-activating dopamine receptor signaling pathway


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phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:1624291
RGD:13792537
G Adra1b adrenoceptor alpha 1B JBrowse link 10 29,392,762 29,450,644 RGD:13792537
G Adra1d adrenoceptor alpha 1D JBrowse link 3 124,129,558 124,145,566 RGD:13792537
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:70819
G Ano1 anoctamin 1 JBrowse link 1 217,754,349 217,902,540 RGD:1624291
G C3ar1 complement C3a receptor 1 JBrowse link 4 155,681,767 155,691,240 RGD:13792537
G C5ar1 complement C5a receptor 1 JBrowse link 1 78,186,777 78,195,132 RGD:13792537
G C5ar2 complement component 5a receptor 2 JBrowse link 1 78,165,155 78,183,426 RGD:13792537
G Casr calcium-sensing receptor JBrowse link 11 67,188,204 67,262,261 RGD:7207059
G Cckbr cholecystokinin B receptor JBrowse link 1 170,262,218 170,272,298 RGD:1624291
RGD:1600115
G Cmklr1 chemerin chemokine-like receptor 1 JBrowse link 12 48,743,556 48,796,582 RGD:13792537
G Crhr1 corticotropin releasing hormone receptor 1 JBrowse link 10 92,191,473 92,233,662 RGD:1626241
G Cx3cr1 C-X3-C motif chemokine receptor 1 JBrowse link 8 128,740,756 128,754,514 RGD:1600115
RGD:1624291
G Cxcr2 C-X-C motif chemokine receptor 2 JBrowse link 9 81,427,275 81,435,065 RGD:1624291
RGD:1600115
G Ednrb endothelin receptor type B JBrowse link 15 88,004,775 88,036,354 RGD:1581866
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:8553914
G F2r coagulation factor II (thrombin) receptor JBrowse link 2 26,118,760 26,135,340 RGD:1624291
RGD:1600115
G Fpr-rs3 formyl peptide receptor, related sequence 3 JBrowse link 1 59,902,308 59,903,339 RGD:13792537
G Fpr-rs4 formyl peptide receptor, related sequence 4 JBrowse link 1 86,073,435 86,074,406 RGD:13792537
G Fpr-rs6 formyl peptide receptor, related sequence 6 JBrowse link 1 86,262,503 86,263,534 RGD:13792537
G Fpr1 formyl peptide receptor 1 JBrowse link 1 59,759,025 59,767,258 RGD:1624291
RGD:13792537
G Fpr2 formyl peptide receptor 2 JBrowse link 1 59,800,558 59,809,507 RGD:1624291
RGD:13792537
G Fpr3 formyl peptide receptor 3 JBrowse link 1 116,152,526 116,161,873 RGD:13792537
G Fshr follicle stimulating hormone receptor JBrowse link 6 12,796,383 12,997,817 RGD:1624291
RGD:1600115
G Galr2 galanin receptor 2 JBrowse link 10 105,156,793 105,159,221 RGD:1624291
RGD:1600115
G Gna15 G protein subunit alpha 15 JBrowse link 7 11,054,249 11,075,152 RGD:728647
RGD:1624291
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:1598490
G Gnb1 G protein subunit beta 1 JBrowse link 5 172,914,025 172,981,403 RGD:1624291
RGD:1600115
G Gng13 G protein subunit gamma 13 JBrowse link 10 15,088,935 15,090,839 RGD:1624291
RGD:1600115
G Gpr139 G protein-coupled receptor 139 JBrowse link 1 188,854,371 188,895,223 RGD:1624291
RGD:1600115
G Gpr33 G protein-coupled receptor 33 JBrowse link 6 72,804,843 72,805,848 RGD:13792537
G Grpr gastrin releasing peptide receptor JBrowse link X 32,746,259 32,786,266 RGD:1624291
RGD:1600115
G Hcrt hypocretin neuropeptide precursor JBrowse link 10 88,669,216 88,670,430 RGD:1600968
G Hcrtr2 hypocretin receptor 2 JBrowse link 8 83,307,684 83,421,612 RGD:1624291
RGD:1600115
G Htr2a 5-hydroxytryptamine receptor 2A JBrowse link 15 56,666,152 56,732,469 RGD:13792537
G Htr2b 5-hydroxytryptamine receptor 2B JBrowse link 9 93,112,781 93,130,135 RGD:13792537
G Htr2c 5-hydroxytryptamine receptor 2C JBrowse link X 118,084,520 118,318,040 RGD:1624291
RGD:13792537
G Lhcgr luteinizing hormone/choriogonadotropin receptor JBrowse link 6 12,493,182 12,554,482 RGD:2292621
RGD:13792537
RGD:1600115
RGD:1624291
G LOC103690156 galanin receptor type 2 JBrowse link 10 105,234,244 105,241,704 RGD:1600115
G Mlnr motilin receptor JBrowse link 19 55,176,617 55,183,562 RGD:13792537
G Nmur1 neuromedin U receptor 1 JBrowse link 9 93,402,871 93,407,264 RGD:1624291
RGD:1600115
G Nmur2 neuromedin U receptor 2 JBrowse link 10 41,392,663 41,408,518 RGD:1624291
RGD:1600115
G Npr3 natriuretic peptide receptor 3 JBrowse link 2 61,883,946 61,950,291 RGD:1581459
G Ntsr2 neurotensin receptor 2 JBrowse link 6 41,917,065 41,923,780 RGD:1624291
RGD:1600115
G Oprd1 opioid receptor, delta 1 JBrowse link 5 150,288,126 150,323,063 RGD:8553369
G Oprk1 opioid receptor, kappa 1 JBrowse link 5 13,742,655 13,760,460 RGD:8553369
G Oprm1 opioid receptor, mu 1 JBrowse link 1 43,454,803 43,704,948 RGD:8553369
G P2ry1 purinergic receptor P2Y1 JBrowse link 2 151,314,818 151,320,312 RGD:1600115
RGD:1624291
G P2ry12 purinergic receptor P2Y12 JBrowse link 2 149,440,807 149,482,592 RGD:13673786
G P2ry2 purinergic receptor P2Y2 JBrowse link 1 166,031,228 166,045,423 RGD:1600115
G Plcb2 phospholipase C, beta 2 JBrowse link 3 110,497,760 110,517,563 RGD:729588
G Plce1 phospholipase C, epsilon 1 JBrowse link 1 257,156,023 257,465,440 RGD:1600115
RGD:1624291
G Ptger3 prostaglandin E receptor 3 JBrowse link 2 263,895,093 263,979,682 RGD:1624291
RGD:13792537
G Pth1r parathyroid hormone 1 receptor JBrowse link 8 118,984,531 119,012,803 RGD:1624291
RGD:8553376
RGD:7207455
G Tgm2 transglutaminase 2 JBrowse link 3 154,597,165 154,627,257 RGD:8553754
G Trhr thyrotropin releasing hormone receptor JBrowse link 7 83,113,641 83,153,520 RGD:13792537
G Vip vasoactive intestinal peptide JBrowse link 1 42,169,307 42,177,582 RGD:13792537
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bicd1 BICD cargo adaptor 1 JBrowse link 4 184,018,845 184,167,628 RGD:8693367
RGD:1624291
phospholipase C-activating adrenergic receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adra2a adrenoceptor alpha 2A JBrowse link 1 274,766,283 274,769,083 RGD:1624291
RGD:1600115
phospholipase C-activating angiotensin-activated signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Actn2 actinin alpha 2 JBrowse link 17 66,304,530 66,397,647 RGD:1624291
RGD:1600115
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1624291
RGD:1600115
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:1600115
phospholipase C-activating dopamine receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:1600115
RGD:1624291
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1624291
RGD:13792537
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:13792537
G Gna11 G protein subunit alpha 11 JBrowse link 7 11,033,400 11,047,284 RGD:1624291
RGD:13792537
RGD:1600115
G Gna14 G protein subunit alpha 14 JBrowse link 1 235,165,775 235,347,986 RGD:13792537
G Gna15 G protein subunit alpha 15 JBrowse link 7 11,054,249 11,075,152 RGD:13792537
G Gnaq G protein subunit alpha q JBrowse link 1 233,382,778 233,622,584 RGD:1624291
RGD:13792537
RGD:1600115
G LOC500460 similar to olfactory receptor Olr841 JBrowse link 5 64,614,755 64,615,714 RGD:13792537
G Olr1257 olfactory receptor 1257 JBrowse link 8 42,429,993 42,430,928 RGD:13792537
G Olr1320 olfactory receptor 1320 JBrowse link 8 43,628,182 43,629,120 RGD:13792537
G Olr533 olfactory receptor 533 JBrowse link 3 74,574,075 74,575,010 RGD:13792537
G Olr841 olfactory receptor 841 JBrowse link 5 64,621,407 64,622,359 RGD:13792537
G Slc9a3r1 SLC9A3 regulator 1 JBrowse link 10 103,713,045 103,730,145 RGD:1624291
RGD:1600115
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Grm1 glutamate metabotropic receptor 1 JBrowse link 1 4,753,141 5,165,859 RGD:728711
G Grm5 glutamate metabotropic receptor 5 JBrowse link 1 151,207,846 151,785,038 RGD:625594
RGD:728711
phospholipase C-activating serotonin receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htr2a 5-hydroxytryptamine receptor 2A JBrowse link 15 56,666,152 56,732,469 RGD:1624387
G Htr2c 5-hydroxytryptamine receptor 2C JBrowse link X 118,084,520 118,318,040 RGD:1598460
RGD:1624291
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1624291
G C3ar1 complement C3a receptor 1 JBrowse link 4 155,681,767 155,691,240 RGD:1600115
RGD:1624291
G Calca calcitonin-related polypeptide alpha JBrowse link 1 184,184,018 184,188,922 RGD:1624291
RGD:1600115
G Drd1 dopamine receptor D1 JBrowse link 17 11,099,736 11,104,352 RGD:1624291
RGD:1600115
G Drd2 dopamine receptor D2 JBrowse link 8 53,678,777 53,743,643 RGD:1624291
RGD:13792537
G Drd3 dopamine receptor D3 JBrowse link 11 61,819,102 61,883,223 RGD:13792537
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:1624291
RGD:1600115
G Ednra endothelin receptor type A JBrowse link 19 33,928,356 33,991,703 RGD:728499
G F2r coagulation factor II (thrombin) receptor JBrowse link 2 26,118,760 26,135,340 RGD:1582290
RGD:13792537
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:13792537
G F2rl2 coagulation factor II (thrombin) receptor-like 2 JBrowse link 2 26,240,385 26,245,533 RGD:13792537
G F2rl3 F2R like thrombin or trypsin receptor 3 JBrowse link 16 18,817,797 18,819,790 RGD:13792537
G Gna15 G protein subunit alpha 15 JBrowse link 7 11,054,249 11,075,152 RGD:1600115
RGD:1624291
G Gpr157 G protein-coupled receptor 157 JBrowse link 5 167,109,691 167,125,380 RGD:1624291
RGD:1600115
G Gpr17 G protein-coupled receptor 17 JBrowse link 18 24,733,306 24,739,194 RGD:13792537
G Gpr174 G protein-coupled receptor 174 JBrowse link X 78,358,347 78,399,944 RGD:13792537
G Gpr18 G protein-coupled receptor 18 JBrowse link 15 108,323,157 108,326,907 RGD:13792537
G Gpr35 G protein-coupled receptor 35 JBrowse link 9 100,129,428 100,141,269 RGD:13792537
G Gpr4 G protein-coupled receptor 4 JBrowse link 1 80,125,639 80,136,786 RGD:13792537
G Gpr55 G protein-coupled receptor 55 JBrowse link 9 92,961,431 93,011,157 RGD:13792537
G Gpr65 G-protein coupled receptor 65 JBrowse link 6 122,248,528 122,256,115 RGD:13792537
G Grm1 glutamate metabotropic receptor 1 JBrowse link 1 4,753,141 5,165,859 RGD:728711
RGD:1600115
RGD:1624291
G Grm5 glutamate metabotropic receptor 5 JBrowse link 1 151,207,846 151,785,038 RGD:8554618
G Htr2c 5-hydroxytryptamine receptor 2C JBrowse link X 118,084,520 118,318,040 RGD:1624291
RGD:1600115
G Kiss1 KiSS-1 metastasis-suppressor JBrowse link 13 50,529,506 50,537,603 RGD:1357971
RGD:1599289
G LOC100359656 rCG38062-like JBrowse link X 77,786,566 77,810,066 RGD:13792537
G LOC500460 similar to olfactory receptor Olr841 JBrowse link 5 64,614,755 64,615,714 RGD:13792537
G Lpar1 lysophosphatidic acid receptor 1 JBrowse link 5 75,557,038 75,678,067 RGD:1626474
RGD:1624291
G Lpar3 lysophosphatidic acid receptor 3 JBrowse link 2 252,090,634 252,159,221 RGD:1626474
G Lpar4 lysophosphatidic acid receptor 4 JBrowse link X 78,042,859 78,056,347 RGD:13792537
G Lpar6 lysophosphatidic acid receptor 6 JBrowse link 15 55,126,953 55,128,762 RGD:13792537
G Myh9 myosin, heavy chain 9 JBrowse link 7 118,740,005 118,792,507 RGD:6902910
G Olr1257 olfactory receptor 1257 JBrowse link 8 42,429,993 42,430,928 RGD:13792537
G Olr1320 olfactory receptor 1320 JBrowse link 8 43,628,182 43,629,120 RGD:13792537
G Olr533 olfactory receptor 533 JBrowse link 3 74,574,075 74,575,010 RGD:13792537
G Olr841 olfactory receptor 841 JBrowse link 5 64,621,407 64,622,359 RGD:13792537
G Oprl1 opioid related nociceptin receptor 1 JBrowse link 3 177,223,779 177,231,663 RGD:1624291
RGD:1600115
G P2ry1 purinergic receptor P2Y1 JBrowse link 2 151,314,818 151,320,312 RGD:8554370
G P2ry10 P2Y receptor family member 10 JBrowse link X 78,158,729 78,210,413 RGD:13792537
G Plcd1 phospholipase C, delta 1 JBrowse link 8 127,753,514 127,782,070 RGD:2300424
G RGD1560455 similar to RIKEN cDNA A630033H20 gene JBrowse link X 78,258,495 78,284,180 RGD:13792537
G Rxfp3 relaxin family peptide receptor 3 JBrowse link 2 61,006,337 61,007,767 RGD:1624291
RGD:1600115
G S1pr1 sphingosine-1-phosphate receptor 1 JBrowse link 2 218,654,406 218,658,761 RGD:1581785
G Tgm2 transglutaminase 2 JBrowse link 3 154,597,165 154,627,257 RGD:634393
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chga chromogranin A JBrowse link 6 126,434,226 126,445,569 RGD:6907050
G F2 coagulation factor II JBrowse link 3 80,529,468 80,542,993 RGD:1624291
RGD:1600115
G Gpr27 G protein-coupled receptor 27 JBrowse link 4 132,137,793 132,138,926 RGD:1624291
RGD:1600115
G Grp gastrin releasing peptide JBrowse link 18 61,563,458 61,576,818 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    signaling 7108
      signal transduction 6597
        G protein-coupled receptor signaling pathway 2395
          phospholipase C-activating G protein-coupled receptor signaling pathway 105
            negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
            phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway 0
            phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 2
            phospholipase C-activating adrenergic receptor signaling pathway 1
            phospholipase C-activating angiotensin-activated signaling pathway + 3
            phospholipase C-activating dopamine receptor signaling pathway + 13
            phospholipase C-activating rhodopsin mediated signaling pathway 0
            phospholipase C-activating serotonin receptor signaling pathway 2
            phospholipase C-activating tachykinin receptor signaling pathway 0
            positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 44
            positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway 4
            regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 5
Path 2
Term Annotations click to browse term
  biological_process 18166
    biological regulation 12793
      regulation of biological process 12128
        regulation of cellular process 11458
          signal transduction 6597
            G protein-coupled receptor signaling pathway 2395
              phospholipase C-activating G protein-coupled receptor signaling pathway 105
                negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 1
                phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway 0
                phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 2
                phospholipase C-activating adrenergic receptor signaling pathway 1
                phospholipase C-activating angiotensin-activated signaling pathway + 3
                phospholipase C-activating dopamine receptor signaling pathway + 13
                phospholipase C-activating rhodopsin mediated signaling pathway 0
                phospholipase C-activating serotonin receptor signaling pathway 2
                phospholipase C-activating tachykinin receptor signaling pathway 0
                positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 44
                positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway 4
                regulation of phospholipase C-activating G protein-coupled receptor signaling pathway + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.