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ONTOLOGY REPORT - ANNOTATIONS


Term:protein kinase C-activating G protein-coupled receptor signaling pathway
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Accession:GO:0007205 term browser browse the term
Definition:The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
Synonyms:related_synonym: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway;   activation of protein kinase C activity by G-protein coupled receptor protein signalling pathway


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protein kinase C-activating G protein-coupled receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor IDA in PC12 cells, PKCs epsilon and zeta activated after short-term activation of Adora2a RGD PMID:12590138 RGD:1625697 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Bdkrb1 bradykinin receptor B1 IDA RGD PMID:15319421 RGD:1625754 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Cck cholecystokinin IDA RGD PMID:12496267 RGD:1626097 NCBI chr 8:130,120,525...130,127,515
Ensembl chr 8:130,120,523...130,127,392
JBrowse link
G Cish cytokine inducible SH2-containing protein IEA
ISO
GO_REF:0000107
(MGI:2652984|PMID:12618484)
Ensembl
RGD
PMID:12618484 GO_REF:0000107, MGI:2652984 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723
JBrowse link
G Crhr2 corticotropin releasing hormone receptor 2 IMP RGD PMID:19439178 RGD:5130951 NCBI chr 4:85,286,371...85,329,374
Ensembl chr 4:85,286,372...85,329,362
JBrowse link
G Dgka diacylglycerol kinase, alpha IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:3,143,826...3,170,764
Ensembl chr 7:3,143,827...3,170,146
JBrowse link
G Dgkb diacylglycerol kinase, beta IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 6:57,516,351...58,277,385
Ensembl chr 6:57,516,713...58,277,279
JBrowse link
G Dgkd diacylglycerol kinase, delta IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 9:94,980,328...95,071,531
Ensembl chr 9:94,980,409...95,069,714
JBrowse link
G Dgke diacylglycerol kinase epsilon IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:76,375,981...76,408,224
Ensembl chr10:76,386,471...76,407,989
JBrowse link
G Dgkg diacylglycerol kinase, gamma TAS RGD PMID:7809169 RGD:1298876 NCBI chr11:81,971,585...82,165,111
Ensembl chr11:81,972,219...82,163,165
JBrowse link
G Dgkh diacylglycerol kinase, eta ISO (PMID:12810723) RGD PMID:12810723 NCBI chr15:60,791,574...60,967,236
Ensembl chr15:60,803,098...60,959,769
JBrowse link
G Dgki diacylglycerol kinase, iota IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:64,365,115...64,831,473
Ensembl chr 4:64,374,342...64,831,473
JBrowse link
G Dgkk diacylglycerol kinase kappa IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:16,441,318...16,526,046
Ensembl chr  X:16,442,899...16,537,888
JBrowse link
G Dgkq diacylglycerol kinase, theta IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:2,069,409...2,083,370
Ensembl chr14:2,069,409...2,083,370
JBrowse link
G Dgkz diacylglycerol kinase zeta IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 3:80,844,002...80,886,487
Ensembl chr 3:80,844,005...80,875,817
JBrowse link
G Edn1 endothelin 1 ISO (MGI:70451|PMID:2542249) RGD PMID:2542249 MGI:70451 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn2 endothelin 2 IMP RGD PMID:1533364 RGD:1581817 NCBI chr 5:139,098,472...139,106,396
Ensembl chr 5:139,100,898...139,105,792
JBrowse link
G Ednra endothelin receptor type A IMP RGD PMID:12628492 RGD:728499 NCBI chr19:33,928,356...33,991,703
Ensembl chr19:33,928,356...33,991,703
JBrowse link
G F2r coagulation factor II (thrombin) receptor IMP RGD PMID:12644441 RGD:1582293 NCBI chr 2:26,118,760...26,135,340
Ensembl chr 2:26,118,760...26,135,340
JBrowse link
G Grm5 glutamate metabotropic receptor 5 IDA
TAS
PMID:12514208
PMID:15758184
UniProt PMID:12514208, PMID:15758184 RGD:728711, RGD:8554618 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Hcrt hypocretin neuropeptide precursor IMP RGD PMID:16247802 RGD:1600968 NCBI chr10:88,669,216...88,670,430
Ensembl chr10:88,669,214...88,670,430
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO (MGI:4821070|PMID:17325130) RGD PMID:17325130 MGI:4821070 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Htr2b 5-hydroxytryptamine receptor 2B IEA
ISO
ISS
GO_REF:0000107
(MGI:4821070|PMID:17325130)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:17325130 GO_REF:0000024, GO_REF:0000107, MGI:4821070 NCBI chr 9:93,112,781...93,130,135
Ensembl chr 9:93,112,805...93,125,014
JBrowse link
G Il2 interleukin 2 IMP RGD PMID:7859920 RGD:1600108 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Lrp1 LDL receptor related protein 1 IMP RGD PMID:17314289 RGD:1625020 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Ms4a2 membrane spanning 4-domains A2 IDA RGD PMID:11388899 RGD:1599963 NCBI chr 1:227,957,363...227,965,312
Ensembl chr 1:227,957,302...227,965,386
JBrowse link
G Pick1 protein interacting with PRKCA 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:10623590)
Ensembl
UniProt
RGD
PMID:10623590 GO_REF:0000024, GO_REF:0000107 NCBI chr 7:120,465,472...120,484,824
Ensembl chr 7:120,465,130...120,484,840
JBrowse link
G Rack1 receptor for activated C kinase 1 TAS PMID:8302854 UniProt PMID:8302854 RGD:68785 NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198
Ensembl chr12:34,149,717...34,155,198
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    signaling 7579
      signal transduction 7010
        G protein-coupled receptor signaling pathway 2509
          protein kinase C-activating G protein-coupled receptor signaling pathway 28
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of cellular process 12556
          signal transduction 7010
            G protein-coupled receptor signaling pathway 2509
              protein kinase C-activating G protein-coupled receptor signaling pathway 28
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.