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ONTOLOGY REPORT - ANNOTATIONS


Term:G protein-coupled acetylcholine receptor signaling pathway
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Accession:GO:0007213 term browser browse the term
Definition:Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: acetylcholine receptor signalling, muscarinic pathway;   muscarinic acetylcholine receptor signaling pathway
 xref: MIPS_funcat:30.05.02.24.02


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G protein-coupled acetylcholine receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agrn agrin JBrowse link 5 173,589,910 173,622,813 RGD:1600115
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 JBrowse link 10 67,862,054 67,863,255 RGD:8554712
G Chrm1 cholinergic receptor, muscarinic 1 JBrowse link 1 224,869,087 224,885,101 RGD:724727
RGD:1624291
G Chrm2 cholinergic receptor, muscarinic 2 JBrowse link 4 64,089,028 64,091,090 RGD:724727
RGD:1624291
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:724728
RGD:10047264
RGD:2303392
G Gnai2 G protein subunit alpha i2 JBrowse link 8 116,370,730 116,391,337 RGD:1624291
RGD:1600115
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:1624291
RGD:1600115
G Rgs10 regulator of G-protein signaling 10 JBrowse link 1 199,782,076 199,823,440 RGD:1624291
RGD:1600115
G Rgs8 regulator of G-protein signaling 8 JBrowse link 13 71,086,654 71,141,820 RGD:69963
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chrm1 cholinergic receptor, muscarinic 1 JBrowse link 1 224,869,087 224,885,101 RGD:13792537
G Chrm2 cholinergic receptor, muscarinic 2 JBrowse link 4 64,089,028 64,091,090 RGD:13792537
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:13792537
G Chrm4 cholinergic receptor, muscarinic 4 JBrowse link 3 80,833,272 80,841,165 RGD:1624291
RGD:13792537
RGD:1600115
G Chrm5 cholinergic receptor, muscarinic 5 JBrowse link 3 103,966,451 104,018,815 RGD:13792537
G Hrh3 histamine receptor H3 JBrowse link 3 175,474,310 175,479,395 RGD:13792537
G Hrh4 histamine receptor H4 JBrowse link 18 4,365,429 4,382,599 RGD:13792537
G Oprm1 opioid receptor, mu 1 JBrowse link 1 43,454,803 43,704,948 RGD:8656009

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18166
    cellular process 16266
      signal transduction 6597
        G protein-coupled receptor signaling pathway 2395
          G protein-coupled acetylcholine receptor signaling pathway 14
            G protein-coupled acetylcholine receptor signaling pathway involved in heart process + 0
            G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission 0
            adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway + 8
            phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 18166
    response to stimulus 9928
      response to chemical 6195
        cellular response to chemical stimulus 3387
          cellular response to nitrogen compound 901
            cellular response to ammonium ion 152
              signal transduction involved in cellular response to ammonium ion 108
                acetylcholine receptor signaling pathway 32
                  G protein-coupled acetylcholine receptor signaling pathway 14
                    G protein-coupled acetylcholine receptor signaling pathway involved in heart process + 0
                    G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission 0
                    adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway + 8
                    phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.