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ONTOLOGY REPORT - ANNOTATIONS


Term:G protein-coupled acetylcholine receptor signaling pathway
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Accession:GO:0007213 term browser browse the term
Definition:Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: acetylcholine receptor signalling, muscarinic pathway;   muscarinic acetylcholine receptor signaling pathway


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G protein-coupled acetylcholine receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agrn agrin IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 IDA PMID:11276227 UniProt PMID:11276227 RGD:8554712 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 IDA
ISO
(PMID:12196552) RGD PMID:12196552, PMID:12534975 RGD:724727 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 IDA
ISO
(PMID:24256733)
MGI:MGI:2155543 (MGI:MGI:1331246|PMID:9990086)
RGD PMID:9990086, PMID:24256733, PMID:12534975 MGI:MGI:1331246, RGD:724727 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 IDA
IMP
PMID:1527051 RGD
UniProt
PMID:12185001, PMID:1527051, PMID:15141107 RGD:724728, RGD:10047264, RGD:2303392 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Gnai2 G protein subunit alpha i2 ISO MGI:MGI:2152603 (MGI:MGI:1934424|PMID:11299198) RGD PMID:11299198 MGI:MGI:1934424 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Plcb1 phospholipase C beta 1 ISO
IEA
(MGI:MGI:1097045|PMID:9305844)
GO_REF:0000107
RGD
Ensembl
PMID:9305844 GO_REF:0000107, MGI:MGI:1097045 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Rgs10 regulator of G-protein signaling 10 ISO
ISS
(PMID:11443111)
GO_REF:0000024
RGD
UniProt
PMID:11443111 GO_REF:0000024 NCBI chr 1:199,782,076...199,823,440
Ensembl chr 1:199,782,078...199,823,386
JBrowse link
G Rgs8 regulator of G-protein signaling 8 IDA PMID:9394004 UniProt PMID:9394004 RGD:69963 NCBI chr13:71,086,654...71,141,820
Ensembl chr13:71,086,745...71,141,075
JBrowse link
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrm1 cholinergic receptor, muscarinic 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:63,990,599...64,463,222
Ensembl chr17:63,990,599...63,994,169
JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 ISO
IBA
IEA
(MGI:MGI:61071|PMID:7916637)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:7916637, PMID:21873635 GO_REF:0000107, MGI:MGI:61071, RGD:13792537 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:103,966,451...104,018,815
Ensembl chr 3:103,966,451...104,018,861
JBrowse link
G Hrh3 histamine receptor H3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:175,474,310...175,479,395
Ensembl chr 3:175,473,078...175,479,395
JBrowse link
G Hrh4 histamine receptor H4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:4,365,429...4,382,599
Ensembl chr18:4,365,429...4,382,599
JBrowse link
G Oprm1 opioid receptor, mu 1 IDA PMID:8051154 GO_Central PMID:8051154 RGD:8656009 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20017
    signaling 7588
      signal transduction 7015
        G protein-coupled receptor signaling pathway 2506
          G protein-coupled acetylcholine receptor signaling pathway 14
            G protein-coupled acetylcholine receptor signaling pathway involved in heart process + 0
            G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission 0
            adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway + 8
            phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway 0
Path 2
Term Annotations click to browse term
  biological_process 20017
    response to stimulus 10569
      response to chemical 6330
        cellular response to chemical stimulus 3517
          cellular response to nitrogen compound 916
            cellular response to acetylcholine 33
              acetylcholine receptor signaling pathway 31
                G protein-coupled acetylcholine receptor signaling pathway 14
                  G protein-coupled acetylcholine receptor signaling pathway involved in heart process + 0
                  G protein-coupled acetylcholine receptor signaling pathway involved in positive regulation of acetylcholine secretion, neurotransmission 0
                  adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway + 8
                  phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.