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ONTOLOGY REPORT - ANNOTATIONS


Term:G protein-coupled glutamate receptor signaling pathway
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Accession:GO:0007216 term browser browse the term
Definition:A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: metabotropic glutamate receptor signaling pathway;   metabotropic glutamate receptor signalling pathway


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G protein-coupled glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07002241.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:69,496,522...69,521,420 JBrowse link
G AABR07061755.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 4:142,453,013...142,453,531 JBrowse link
G AC119691.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:149,439,312...149,441,437 JBrowse link
G Dagla diacylglycerol lipase, alpha IBA
ISO
PMID:21873635
(MGI:4880854|PMID:20159446)
RGD PMID:20159446, PMID:21873635 MGI:4880854, RGD:13792537 NCBI chr 1:226,297,013...226,353,712
Ensembl chr 1:226,297,016...226,353,611
JBrowse link
G Daglb diacylglycerol lipase, beta IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:13,113,073...13,157,748
Ensembl chr12:13,113,237...13,157,666
JBrowse link
G Gnai2 G protein subunit alpha i2 NOT IDA RGD PMID:11923410 RGD:625670 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307
JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 ISO (PMID:9144652) RGD PMID:9144652 NCBI chr 5:143,500,441...143,715,546
Ensembl chr 5:143,500,441...143,715,546
JBrowse link
G Grm1 glutamate metabotropic receptor 1 IMP
IBA
IEA
ISS
ISO
PMID:14614461
PMID:21873635
GO_REF:0000107
GO_REF:0000024
(PMID:24603153)
Ensembl
UniProt
RGD
PMID:24603153, PMID:14614461, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:1304458, RGD:13792537 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Grm2 glutamate metabotropic receptor 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:115,344,999...115,358,628
Ensembl chr 8:115,344,999...115,358,046
JBrowse link
G Grm3 glutamate metabotropic receptor 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:21,316,761...21,567,561
Ensembl chr 4:21,317,695...21,560,490
JBrowse link
G Grm4 glutamate metabotropic receptor 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:6,745,682...6,791,521
Ensembl chr20:6,745,682...6,791,519
JBrowse link
G Grm5 glutamate metabotropic receptor 5 IMP
IBA
ISS
ISO
IEA
PMID:1320017
PMID:21873635
GO_REF:0000024
(PMID:7908515)
PMID:21993209
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:7908515, PMID:1320017, PMID:21873635, PMID:21993209 GO_REF:0000024, GO_REF:0000107, RGD:8553991, RGD:13792537, RGD:12050103 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link
G Grm6 glutamate metabotropic receptor 6 ISO
IBA
ISS
(PMID:23452348)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:23452348, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:36,345,503...36,363,416
Ensembl chr10:36,345,939...36,360,665
JBrowse link
G Grm7 glutamate metabotropic receptor 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:142,452,616...143,368,460
Ensembl chr 4:142,780,987...143,367,578
JBrowse link
G Grm8 glutamate metabotropic receptor 8 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:54,474,344...55,409,526
Ensembl chr 4:54,474,136...55,407,922
JBrowse link
G Homer1 homer scaffold protein 1 IDA
IBA
PMID:21873635 RGD
GO_Central
PMID:9069287, PMID:21873635 RGD:633021, RGD:13792537 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678
JBrowse link
G Homer2 homer scaffold protein 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:143,443,300...143,535,579
Ensembl chr 1:143,443,300...143,535,583
JBrowse link
G Homer3 homer scaffold protein 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr16:20,880,447...20,890,968
Ensembl chr16:20,881,518...20,890,949
JBrowse link
G Trpm1 transient receptor potential cation channel, subfamily M, member 1 IEA
ISO
ISS
GO_REF:0000107
(PMID:23452348)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:23452348 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:124,983,391...125,101,759
Ensembl chr 1:124,983,452...125,099,573
JBrowse link
G Vom2r-ps45 vomeronasal 2 receptor, pseudogene 45 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:69,496,309...69,523,063 JBrowse link
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07002241.1 IEA GO_REF:0000108 GOC GO_REF:0000108 Ensembl chr 1:69,496,522...69,521,420 JBrowse link
G AABR07061755.1 IEA GO_REF:0000108 GOC GO_REF:0000108 Ensembl chr 4:142,453,013...142,453,531 JBrowse link
G AC119691.1 IEA GO_REF:0000108 GOC GO_REF:0000108 Ensembl chr 1:149,439,312...149,441,437 JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:143,500,441...143,715,546
Ensembl chr 5:143,500,441...143,715,546
JBrowse link
G Grm2 glutamate metabotropic receptor 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:115,344,999...115,358,628
Ensembl chr 8:115,344,999...115,358,046
JBrowse link
G Grm3 glutamate metabotropic receptor 3 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 4:21,316,761...21,567,561
Ensembl chr 4:21,317,695...21,560,490
JBrowse link
G Grm4 glutamate metabotropic receptor 4 ISO
ISS
(PMID:15102938)
GO_REF:0000024
RGD
UniProt
PMID:15102938 GO_REF:0000024 NCBI chr20:6,745,682...6,791,521
Ensembl chr20:6,745,682...6,791,519
JBrowse link
G Grm6 glutamate metabotropic receptor 6 IDA RGD PMID:8389366 RGD:69945 NCBI chr10:36,345,503...36,363,416
Ensembl chr10:36,345,939...36,360,665
JBrowse link
G Grm7 glutamate metabotropic receptor 7 IDA
IEA
ISO
GO_REF:0000107
(PMID:9473604)
Ensembl
RGD
PMID:9473604, PMID:11825890 GO_REF:0000107, RGD:728749 NCBI chr 4:142,452,616...143,368,460
Ensembl chr 4:142,780,987...143,367,578
JBrowse link
G Grm8 glutamate metabotropic receptor 8 TAS
IEA
ISS
ISO
PMID:16084932
GO_REF:0000107
GO_REF:0000024
(PMID:9473604)
Ensembl
UniProt
RGD
PMID:9473604, PMID:16084932 GO_REF:0000024, GO_REF:0000107, RGD:6484727 NCBI chr 4:54,474,344...55,409,526
Ensembl chr 4:54,474,136...55,407,922
JBrowse link
G Vom2r-ps45 vomeronasal 2 receptor, pseudogene 45 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:69,496,309...69,523,063 JBrowse link
phospholipase C-activating G protein-coupled glutamate receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grm1 glutamate metabotropic receptor 1 TAS PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Grm5 glutamate metabotropic receptor 5 TAS PMID:12514208 RGD
UniProt
PMID:12189203, PMID:12514208 RGD:625594, RGD:728711 NCBI chr 1:151,207,846...151,785,038
Ensembl chr 1:151,439,409...151,783,392
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    signaling 7579
      signal transduction 7010
        G protein-coupled receptor signaling pathway 2509
          G protein-coupled glutamate receptor signaling pathway 20
            adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway 11
            phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 2
Path 2
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of biological process 13071
        regulation of cellular process 12556
          signal transduction 7010
            cell surface receptor signaling pathway 2761
              glutamate receptor signaling pathway 61
                G protein-coupled glutamate receptor signaling pathway 20
                  adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway 11
                  phospholipase C-activating G protein-coupled glutamate receptor signaling pathway 2
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.