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ONTOLOGY REPORT - ANNOTATIONS


Term:signal transduction downstream of smoothened
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Accession:GO:0007227 term browser browse the term
Definition:The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.


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signal transduction downstream of smoothened term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IFT122 intraflagellar transport 122 JBrowse link 3 129,440,036 129,520,507 RGD:2290271
positive regulation of hh target transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SHH sonic hedgehog signaling molecule JBrowse link 7 155,799,980 155,812,463 RGD:2290271
G SMO smoothened, frizzled class receptor JBrowse link 7 129,188,633 129,213,548 RGD:2290271
G STK36 serine/threonine kinase 36 JBrowse link 2 218,672,049 218,702,717 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18019
    cellular process 16998
      signal transduction 6313
        intracellular signal transduction 2850
          signal transduction downstream of smoothened 4
            positive regulation of hh target transcription factor activity 3
Path 2
Term Annotations click to browse term
  biological_process 18019
    biological regulation 12659
      regulation of biological process 11961
        regulation of cellular process 11416
          signal transduction 6313
            cell surface receptor signaling pathway 3214
              smoothened signaling pathway 147
                signal transduction downstream of smoothened 4
                  positive regulation of hh target transcription factor activity 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.