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ONTOLOGY REPORT - ANNOTATIONS


Term:signal transduction downstream of smoothened
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Accession:GO:0007227 term browser browse the term
Definition:The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.


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signal transduction downstream of smoothened term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ift122 intraflagellar transport 122 JBrowse link 6 115,853,379 115,926,699 RGD:2290270
positive regulation of hh target transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Shh sonic hedgehog JBrowse link 5 28,456,840 28,467,101 RGD:2290270
G Smo smoothened, frizzled class receptor JBrowse link 6 29,735,497 29,761,366 RGD:2290270
G Stk36 serine/threonine kinase 36 JBrowse link 1 74,601,391 74,636,894 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23164
    cellular process 17043
      signal transduction 6272
        intracellular signal transduction 2541
          signal transduction downstream of smoothened 4
            positive regulation of hh target transcription factor activity 3
Path 2
Term Annotations click to browse term
  biological_process 23164
    biological regulation 12764
      regulation of biological process 12157
        regulation of cellular process 11597
          signal transduction 6272
            cell surface receptor signaling pathway 2738
              smoothened signaling pathway 157
                signal transduction downstream of smoothened 4
                  positive regulation of hh target transcription factor activity 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.