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ONTOLOGY REPORT - ANNOTATIONS


Term:signal transduction downstream of smoothened
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Accession:GO:0007227 term browser browse the term
Definition:The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.


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signal transduction downstream of smoothened term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G IFT122 intraflagellar transport 122 JBrowse link 13 68,828,710 68,902,062 RGD:14298760
positive regulation of hh target transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SHH sonic hedgehog signaling molecule JBrowse link 18 2,546,202 2,555,484 RGD:14298760
G SMO smoothened, frizzled class receptor JBrowse link 18 19,450,730 19,478,796 RGD:14298760
G STK36 serine/threonine kinase 36 JBrowse link 15 120,719,635 120,747,832 RGD:14298760

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16408
    cellular process 15621
      signal transduction 5869
        intracellular signal transduction 2465
          signal transduction downstream of smoothened 4
            positive regulation of hh target transcription factor activity 3
Path 2
Term Annotations click to browse term
  biological_process 16408
    biological regulation 11878
      regulation of biological process 11309
        regulation of cellular process 10862
          signal transduction 5869
            cell surface receptor signaling pathway 2492
              smoothened signaling pathway 158
                signal transduction downstream of smoothened 4
                  positive regulation of hh target transcription factor activity 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.