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ONTOLOGY REPORT - ANNOTATIONS


Term:signal transduction downstream of smoothened
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Accession:GO:0007227 term browser browse the term
Definition:The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.


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signal transduction downstream of smoothened term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ift122 intraflagellar transport 122 JBrowse link 4 147,756,574 147,826,983 RGD:1624291
positive regulation of hh target transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1600115
RGD:1624291
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:1624291
RGD:1600115
G Stk36 serine/threonine kinase 36 JBrowse link 9 81,880,175 81,908,014 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19678
    cellular process 18452
      signal transduction 6946
        intracellular signal transduction 2594
          signal transduction downstream of smoothened 4
            positive regulation of hh target transcription factor activity 3
Path 2
Term Annotations click to browse term
  biological_process 19678
    biological regulation 13599
      regulation of biological process 12921
        regulation of cellular process 12405
          signal transduction 6946
            cell surface receptor signaling pathway 2759
              smoothened signaling pathway 160
                signal transduction downstream of smoothened 4
                  positive regulation of hh target transcription factor activity 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.