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ONTOLOGY REPORT - ANNOTATIONS


Term:signal transduction downstream of smoothened
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Accession:GO:0007227 term browser browse the term
Definition:The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway.


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signal transduction downstream of smoothened term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ift122 intraflagellar transport 122 JBrowse link NW_004936602 908,034 956,634 RGD:9068941
positive regulation of hh target transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Shh sonic hedgehog signaling molecule JBrowse link NW_004936527 10,033,095 10,042,713 RGD:9068941
G Smo smoothened, frizzled class receptor JBrowse link NW_004936579 5,893,064 5,917,021 RGD:9068941
G Stk36 serine/threonine kinase 36 JBrowse link NW_004936569 1,115,790 1,143,450 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11933
    cellular process 11116
      signal transduction 3676
        intracellular signal transduction 1973
          signal transduction downstream of smoothened 4
            positive regulation of hh target transcription factor activity 3
Path 2
Term Annotations click to browse term
  biological_process 11933
    biological regulation 8734
      regulation of biological process 8295
        regulation of cellular process 7876
          signal transduction 3676
            cell surface receptor signaling pathway 2031
              smoothened signaling pathway 152
                signal transduction downstream of smoothened 4
                  positive regulation of hh target transcription factor activity 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.