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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of hh target transcription factor activity
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Accession:GO:0007228 term browser browse the term
Definition:Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited.
Synonyms:exact_synonym: activation of hh target transcription factor;   positive regulation of hedgehog target transcription factor


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positive regulation of hh target transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:1600115
RGD:1624291
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:1624291
RGD:1600115
G Stk36 serine/threonine kinase 36 JBrowse link 9 81,880,175 81,908,014 RGD:1624291
RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    positive regulation of biological process 6506
      positive regulation of DNA-binding transcription factor activity 270
        positive regulation of hh target transcription factor activity 3
Path 2
Term Annotations click to browse term
  biological_process 19576
    metabolic process 11899
      cellular metabolic process 10737
        cellular aromatic compound metabolic process 5503
          nucleobase-containing compound metabolic process 5276
            nucleic acid metabolic process 4782
              RNA metabolic process 4290
                RNA biosynthetic process 3330
                  nucleic acid-templated transcription 3318
                    transcription, DNA-templated 3269
                      regulation of transcription, DNA-templated 3156
                        regulation of DNA-binding transcription factor activity 425
                          positive regulation of DNA-binding transcription factor activity 270
                            positive regulation of hh target transcription factor activity 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.