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ONTOLOGY REPORT - ANNOTATIONS


Term:positive regulation of hh target transcription factor activity
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Accession:GO:0007228 term browser browse the term
Definition:Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited.
Synonyms:exact_synonym: activation of hh target transcription factor;   positive regulation of hedgehog target transcription factor


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positive regulation of hh target transcription factor activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Shh sonic hedgehog JBrowse link 5 28,456,840 28,467,101 RGD:2290270
G Smo smoothened, frizzled class receptor JBrowse link 6 29,735,497 29,761,366 RGD:2290270
G Stk36 serine/threonine kinase 36 JBrowse link 1 74,601,391 74,636,894 RGD:2290270

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Path 1
Term Annotations click to browse term
  biological_process 23163
    positive regulation of biological process 6569
      positive regulation of DNA-binding transcription factor activity 272
        positive regulation of hh target transcription factor activity 3
Path 2
Term Annotations click to browse term
  biological_process 23163
    metabolic process 10979
      cellular metabolic process 9774
        cellular aromatic compound metabolic process 5140
          nucleobase-containing compound metabolic process 4911
            nucleic acid metabolic process 4474
              RNA metabolic process 3990
                RNA biosynthetic process 3082
                  nucleic acid-templated transcription 3071
                    transcription, DNA-templated 3057
                      regulation of transcription, DNA-templated 2963
                        regulation of DNA-binding transcription factor activity 431
                          positive regulation of DNA-binding transcription factor activity 272
                            positive regulation of hh target transcription factor activity 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.