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ONTOLOGY REPORT - ANNOTATIONS


Term:I-kappaB kinase/NF-kappaB signaling
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Accession:GO:0007249 term browser browse the term
Definition:The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Synonyms:exact_synonym: I-kappaB kinase/NF-kappaB signal transduction;   NF-kappaB cascade;   canonical NF-kappaB signaling cascade
 related_synonym: I-kappaB kinase/NF-kappaB cascade;   activation of the inhibitor of kappa kinase;   p50-dependent NF-kappaB signaling
 xref: MIPS_funcat:30.01.05.01.04


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I-kappaB kinase/NF-kappaB signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
G Avpr2 arginine vasopressin receptor 2 JBrowse link X 156,889,006 156,892,707 RGD:1624291
G Azi2 5-azacytidine induced 2 JBrowse link 8 126,411,030 126,435,581 RGD:1624291
RGD:1600115
G Bcl10 BCL10, immune signaling adaptor JBrowse link 2 251,805,392 251,814,957 RGD:1624291
RGD:13792537
G Bcl3 BCL3, transcription coactivator JBrowse link 1 80,730,758 80,745,273 RGD:1624291
G Btk Bruton tyrosine kinase JBrowse link X 105,360,922 105,390,580 RGD:1624291
G Card11 caspase recruitment domain family, member 11 JBrowse link 12 15,700,600 15,844,512 RGD:1624291
G Card9 caspase recruitment domain family, member 9 JBrowse link 3 3,798,346 3,806,841 RGD:1299399
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 1 263,848,829 263,884,354 RGD:1624291
G Defb25 defensin beta 25 JBrowse link 3 148,103,643 148,104,483 RGD:1624291
G Faim Fas apoptotic inhibitory molecule JBrowse link 8 107,225,119 107,247,228 RGD:1357927
RGD:13792537
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 JBrowse link 8 70,471,572 70,509,874 RGD:1624291
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:1624291
G Irak1bp1 interleukin-1 receptor-associated kinase 1 binding protein 1 JBrowse link 8 90,343,307 90,360,085 RGD:1624291
RGD:13792537
G Irak2 interleukin-1 receptor-associated kinase 2 JBrowse link 4 145,594,575 145,651,066 RGD:1600115
G Irf1 interferon regulatory factor 1 JBrowse link 10 39,109,530 39,116,532 RGD:5128786
G LOC684466 similar to Fas apoptotic inhibitory molecule 1 (rFAIM) JBrowse link 8 107,480,451 107,495,215 RGD:13792537
G Map3k14 mitogen-activated protein kinase kinase kinase 14 JBrowse link 10 91,303,428 91,353,601 RGD:1624291
G Nfkb1 nuclear factor kappa B subunit 1 JBrowse link 2 240,773,520 240,890,053 RGD:13792537
G Nfkb2 nuclear factor kappa B subunit 2 JBrowse link 1 266,050,634 266,059,277 RGD:13792537
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:1624291
G Nfkbil1 NFKB inhibitor like 1 JBrowse link 20 4,823,590 4,839,202 RGD:1624291
RGD:13792537
RGD:1600115
G Nkiras1 NFKB inhibitor interacting Ras-like 1 JBrowse link 15 8,179,090 8,188,656 RGD:1600115
G Nkiras2 NFKB inhibitor interacting Ras-like 2 JBrowse link 10 88,536,564 88,540,739 RGD:1600115
G Nlrc3 NLR family, CARD domain containing 3 JBrowse link 10 11,809,531 11,844,184 RGD:1624291
RGD:1600115
G Rel REL proto-oncogene, NF-kB subunit JBrowse link 14 108,490,794 108,517,582 RGD:2300288
RGD:13792537
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:13792537
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link 1 80,517,081 80,545,019 RGD:13792537
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
G Ripk3 receptor-interacting serine-threonine kinase 3 JBrowse link 15 34,470,796 34,479,741 RGD:1624291
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:1600115
RGD:1624291
G Rock2 Rho-associated coiled-coil containing protein kinase 2 JBrowse link 6 42,180,864 42,289,910 RGD:1600115
RGD:1624291
G Snip1 Smad nuclear interacting protein 1 JBrowse link 15 19,275,273 19,282,753 RGD:1624291
G Tank TRAF family member-associated NFKB activator JBrowse link 3 47,439,007 47,515,706 RGD:1624291
RGD:13792537
G Tifa TRAF-interacting protein with forkhead-associated domain JBrowse link 2 232,104,394 232,137,425 RGD:1624291
RGD:13792537
RGD:1600115
G Tifab TIFA inhibitor JBrowse link 17 9,234,948 9,239,266 RGD:1600115
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
G Tlr7 toll-like receptor 7 JBrowse link X 28,486,836 28,513,004 RGD:13792537
G Tlr8 toll-like receptor 8 JBrowse link X 28,539,158 28,562,803 RGD:1624291
RGD:13792537
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1624291
RGD:13792537
G Tnip2 TNFAIP3 interacting protein 2 JBrowse link 14 81,487,934 81,505,889 RGD:1624291
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:1624291
I-kappaB phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 1 263,848,829 263,884,354 RGD:1600115
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1600115
RGD:1624291
G Elp1 elongator complex protein 1 JBrowse link 5 73,503,406 73,552,798 RGD:1626124
G Erc1 ELKS/RAB6-interacting/CAST family member 1 JBrowse link 4 152,087,393 152,380,023 RGD:1624291
RGD:1600115
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:1600115
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon JBrowse link 13 48,031,325 48,056,394 RGD:1600115
G LOC100910771 mitogen-activated protein kinase kinase kinase 7-like JBrowse link 9 114,022,058 114,077,887 RGD:1600115
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:1624291
RGD:1600115
G Tlr2 toll-like receptor 2 JBrowse link 2 182,840,171 182,846,061 RGD:1624291
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
G Tlr7 toll-like receptor 7 JBrowse link X 28,486,836 28,513,004 RGD:1624291
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1624291
modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tnip1 TNFAIP3 interacting protein 1 JBrowse link 10 40,255,776 40,303,092 RGD:1624291
RGD:13792537
negative regulation of I-kappaB kinase/NF-kappaB signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:1624291
RGD:1600115
G Ash1l ASH1 like histone lysine methyltransferase JBrowse link 2 188,252,592 188,389,251 RGD:1624291
G Cactin cactin, spliceosome C complex subunit JBrowse link 7 11,258,526 11,266,509 RGD:1600115
RGD:1624291
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:1624291
G Ccdc22 coiled-coil domain containing 22 JBrowse link X 15,742,978 15,754,925 RGD:1624291
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1600115
RGD:1624291
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 10 11,059,701 11,085,186 RGD:1624291
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:1600115
RGD:1624291
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:1624291
RGD:1600115
G Hdac1 histone deacetylase 1 JBrowse link 5 147,716,664 147,743,723 RGD:1624291
G Il1rl1 interleukin 1 receptor-like 1 JBrowse link 9 47,133,483 47,184,316 RGD:1624291
G Mapkbp1 mitogen activated protein kinase binding protein 1 JBrowse link 3 111,767,126 111,817,103 RGD:1624291
G Nfkbid NFKB inhibitor delta JBrowse link 1 88,883,816 88,892,543 RGD:1624291
G Nlrc3 NLR family, CARD domain containing 3 JBrowse link 10 11,809,531 11,844,184 RGD:1624291
RGD:13792537
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 1 64,506,750 64,543,908 RGD:1624291
RGD:13792537
G Nlrp1b NLR family, pyrin domain containing 1B JBrowse link 10 57,755,957 57,847,867 RGD:1624291
G Nlrp6 NLR family, pyrin domain containing 6 JBrowse link 1 213,676,954 213,683,114 RGD:1624291
G Nlrx1 NLR family member X1 JBrowse link 8 48,583,559 48,600,203 RGD:1624291
RGD:1600115
RGD:13792537
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 JBrowse link 10 86,683,875 86,690,815 RGD:1600115
RGD:1624291
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 JBrowse link 7 30,003,429 30,162,095 RGD:1600115
RGD:1624291
G Olfm4 olfactomedin 4 JBrowse link 15 62,384,263 62,429,450 RGD:1624291
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:1624291
RGD:1600115
G Otud7b OTU deubiquitinase 7B JBrowse link 2 198,231,353 198,302,220 RGD:1624291
RGD:13792537
RGD:1600115
G Per1 period circadian regulator 1 JBrowse link 10 55,681,761 55,696,557 RGD:8655527
G Ppm1a protein phosphatase, Mg2+/Mn2+ dependent, 1A JBrowse link 6 94,433,658 94,484,979 RGD:1624291
RGD:13792537
RGD:1600115
G Ppm1b protein phosphatase, Mg2+/Mn2+ dependent, 1B JBrowse link 6 8,219,385 8,280,127 RGD:1624291
RGD:13792537
RGD:1600115
G Ppm1n protein phosphatase, Mg2+/Mn2+ dependent 1N JBrowse link 1 80,190,293 80,193,002 RGD:13792537
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:1624291
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:1642824
G Rhoh ras homolog family member H JBrowse link 14 43,961,756 43,992,587 RGD:1624291
G Riok3 RIO kinase 3 JBrowse link 18 3,565,166 3,590,739 RGD:1624291
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:1624291
G Rora RAR-related orphan receptor A JBrowse link 8 75,515,886 75,616,477 RGD:1624291
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:1624291
G Tank TRAF family member-associated NFKB activator JBrowse link 3 47,439,007 47,515,706 RGD:1624291
G Tle1 TLE family member 1, transcriptional corepressor JBrowse link 5 88,546,607 88,630,277 RGD:1624291
G Tnfaip3 TNF alpha induced protein 3 JBrowse link 1 14,401,103 14,416,369 RGD:1624291
G Tnip1 TNFAIP3 interacting protein 1 JBrowse link 10 40,255,776 40,303,092 RGD:1624291
RGD:13792537
G Tnip3 TNFAIP3 interacting protein 3 JBrowse link 4 96,386,207 96,490,517 RGD:1624291
RGD:13792537
G Trim39 tripartite motif-containing 39 JBrowse link 20 2,500,691 2,514,546 RGD:1600115
RGD:1624291
G Trim59 tripartite motif-containing 59 JBrowse link 2 165,629,903 165,641,751 RGD:1624291
RGD:13792537
G Usp10 ubiquitin specific peptidase 10 JBrowse link 19 52,566,274 52,608,820 RGD:1624291
RGD:1600115
G Zc3h12a zinc finger CCCH type containing 12A JBrowse link 5 143,111,342 143,120,131 RGD:1624291
RGD:1600115
G Zmynd11 zinc finger, MYND-type containing 11 JBrowse link 17 63,825,616 63,914,740 RGD:1624291
negative regulation of I-kappaB phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sirpa signal-regulatory protein alpha JBrowse link 3 122,113,735 122,152,478 RGD:1624291
RGD:1600115
positive regulation of I-kappaB kinase/NF-kappaB signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:1624291
G Adipoq adiponectin, C1Q and collagen domain containing JBrowse link 11 81,330,845 81,344,488 RGD:1600115
RGD:1624291
G Ajuba ajuba LIM protein JBrowse link 15 33,208,210 33,218,456 RGD:1624291
G Akap13 A-kinase anchoring protein 13 JBrowse link 1 137,089,558 137,315,272 RGD:11059571
RGD:1600115
RGD:1624291
G Alpk1 alpha-kinase 1 JBrowse link 2 231,997,360 232,117,471 RGD:1624291
G Ankrd17 ankyrin repeat domain 17 JBrowse link 14 19,291,025 19,431,521 RGD:1624291
G Atp2c1 ATPase secretory pathway Ca2+ transporting 1 JBrowse link 8 113,953,959 114,039,965 RGD:1600115
G Bcl10 BCL10, immune signaling adaptor JBrowse link 2 251,805,392 251,814,957 RGD:1624291
RGD:1600115
G Birc2 baculoviral IAP repeat-containing 2 JBrowse link 8 6,014,014 6,036,668 RGD:1624291
G Brd4 bromodomain containing 4 JBrowse link 7 14,222,101 14,303,055 RGD:1624291
G Card11 caspase recruitment domain family, member 11 JBrowse link 12 15,700,600 15,844,512 RGD:1624291
G Card9 caspase recruitment domain family, member 9 JBrowse link 3 3,798,346 3,806,841 RGD:1624291
RGD:13792537
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:1600115
RGD:1624291
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:1624291
G Ccdc22 coiled-coil domain containing 22 JBrowse link X 15,742,978 15,754,925 RGD:1624291
G Ccl19 C-C motif chemokine ligand 19 JBrowse link 5 58,181,025 58,182,969 RGD:1624291
G Ccl21 C-C motif chemokine ligand 21 JBrowse link 5 58,197,678 58,198,782 RGD:1624291
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:1624291
G Cd4 Cd4 molecule JBrowse link 4 157,381,862 157,408,357 RGD:1624291
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:1624291
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:1624291
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:1624291
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 1 263,848,829 263,884,354 RGD:1624291
G Clec4n C-type lectin domain family 4, member n RGD:1600115
G Cth cystathionine gamma-lyase JBrowse link 2 264,266,959 264,293,040 RGD:1624291
RGD:1600115
G Ctnnb1 catenin beta 1 JBrowse link 8 129,601,511 129,628,378 RGD:1624291
RGD:1600115
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:13673777
G Ddx1 DEAD-box helicase 1 JBrowse link 6 38,422,892 38,453,762 RGD:1600115
RGD:1624291
G Ddx21 DExD-box helicase 21 JBrowse link 20 32,213,147 32,232,632 RGD:1600115
RGD:1624291
G Dhx36 DEAH-box helicase 36 JBrowse link 2 152,785,844 152,824,549 RGD:1600115
RGD:1624291
G Eda ectodysplasin-A JBrowse link X 69,730,123 70,222,693 RGD:1624291
G Eda2r ectodysplasin A2 receptor JBrowse link X 66,560,200 66,602,509 RGD:13792537
G Edar ectodysplasin-A receptor JBrowse link 20 28,179,132 28,263,092 RGD:13792537
G F2r coagulation factor II (thrombin) receptor JBrowse link 2 26,118,760 26,135,340 RGD:1624291
RGD:1600115
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
RGD:1600115
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:1624291
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:1624291
RGD:13792537
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:1624291
G Gprc5b G protein-coupled receptor, class C, group 5, member B JBrowse link 1 188,688,743 188,713,724 RGD:1624291
G Htr2b 5-hydroxytryptamine receptor 2B JBrowse link 9 93,112,781 93,130,135 RGD:1600115
RGD:1624291
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:1600115
RGD:1624291
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon JBrowse link 13 48,031,325 48,056,394 RGD:1624291
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:1624291
RGD:13792537
G Il1a interleukin 1 alpha JBrowse link 3 121,824,712 121,836,122 RGD:1358666
RGD:13792537
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1358666
RGD:13792537
RGD:1600115
RGD:1624291
G Il1f10 interleukin 1 family member 10 JBrowse link 3 1,408,560 1,416,601 RGD:13792537
G Il36a interleukin 36, alpha JBrowse link 3 1,330,790 1,335,811 RGD:13792537
G Il36b interleukin 36, beta JBrowse link 3 1,366,123 1,464,851 RGD:13792537
G Il36g interleukin 36, gamma JBrowse link 3 1,285,658 1,291,836 RGD:13792537
G Inava innate immunity activator JBrowse link 13 53,088,438 53,108,713 RGD:1624291
G Irak1 interleukin-1 receptor-associated kinase 1 JBrowse link X 156,716,469 156,726,367 RGD:1624291
RGD:13792537
G Irak4 interleukin-1 receptor-associated kinase 4 JBrowse link 7 135,803,723 135,831,006 RGD:1624291
RGD:13792537
G Irf3 interferon regulatory factor 3 JBrowse link 1 100,992,244 100,997,202 RGD:5128809
G Jmjd8 jumonji domain containing 8 JBrowse link 10 15,195,954 15,198,870 RGD:1600115
RGD:1624291
G Lamtor5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 JBrowse link 2 210,034,095 210,039,451 RGD:1624291
G Litaf lipopolysaccharide-induced TNF factor JBrowse link 10 4,753,546 4,763,272 RGD:1600115
G LOC100910771 mitogen-activated protein kinase kinase kinase 7-like JBrowse link 9 114,022,058 114,077,887 RGD:13792537
G LOC103694380 tumor necrosis factor-like JBrowse link 20 4,855,792 4,858,447 RGD:13673777
RGD:13792537
G Lpar1 lysophosphatidic acid receptor 1 JBrowse link 5 75,557,038 75,678,067 RGD:1624291
G Ltbr lymphotoxin beta receptor JBrowse link 4 157,822,838 157,829,291 RGD:1624291
RGD:13792537
G Ltf lactotransferrin JBrowse link 8 119,290,416 119,313,261 RGD:1624291
G Lurap1 leucine rich adaptor protein 1 JBrowse link 5 134,991,997 135,001,720 RGD:1624291
G Lurap1l leucine rich adaptor protein 1-like JBrowse link 5 98,468,039 98,515,126 RGD:1600115
G Map3k14 mitogen-activated protein kinase kinase kinase 14 JBrowse link 10 91,303,428 91,353,601 RGD:1624291
RGD:13792537
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:1624291
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:5508194
RGD:13792537
RGD:1624291
G Mid2 midline 2 JBrowse link X 112,019,897 112,121,980 RGD:1624291
G Mtdh metadherin JBrowse link 7 72,771,018 72,830,599 RGD:1624291
G Myd88 MYD88, innate immune signal transduction adaptor JBrowse link 8 128,022,512 128,027,462 RGD:1302746
RGD:1624291
G Nod1 nucleotide-binding oligomerization domain containing 1 JBrowse link 4 85,123,965 85,175,206 RGD:1624291
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:1624291
RGD:13792537
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:1624291
RGD:1600115
G Peli1 pellino E3 ubiquitin protein ligase 1 JBrowse link 14 106,008,086 106,062,566 RGD:1624291
G Pim2 Pim-2 proto-oncogene, serine/threonine kinase JBrowse link X 15,462,621 15,467,890 RGD:1624291
G Pink1 PTEN induced kinase 1 JBrowse link 5 156,677,146 156,689,258 RGD:1624291
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:1600115
RGD:1624291
G Prkce protein kinase C, epsilon JBrowse link 6 9,483,400 9,973,396 RGD:1624291
G Prkd1 protein kinase D1 JBrowse link 6 71,035,017 71,349,531 RGD:1624291
RGD:1600115
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:1600115
RGD:1624291
G Rbck1 RANBP2-type and C3HC4-type zinc finger containing 1 JBrowse link 3 147,793,014 147,809,941 RGD:1624291
RGD:13792537
RGD:1600115
G Rel REL proto-oncogene, NF-kB subunit JBrowse link 14 108,490,794 108,517,582 RGD:1624291
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:1624291
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:1624291
RGD:1600115
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link 17 31,537,580 31,569,904 RGD:1624291
G Ripk2 receptor-interacting serine-threonine kinase 2 JBrowse link 5 29,838,713 29,870,390 RGD:1624291
G Rnf31 ring finger protein 31 JBrowse link 15 34,270,037 34,282,385 RGD:1624291
G Ror1 receptor tyrosine kinase-like orphan receptor 1 JBrowse link 5 118,892,874 119,239,528 RGD:1624291
RGD:13792537
G S100a13 S100 calcium binding protein A13 JBrowse link 2 189,906,022 189,912,516 RGD:1624291
G S100a4 S100 calcium-binding protein A4 JBrowse link 2 189,997,278 189,999,587 RGD:1624291
G S100b S100 calcium binding protein B JBrowse link 20 13,130,633 13,142,856 RGD:1624291
G Sharpin SHANK-associated RH domain interactor JBrowse link 7 117,413,151 117,417,455 RGD:1624291
RGD:1600115
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 JBrowse link 1 1,999,574 2,017,574 RGD:1624291
RGD:13792537
G Tab3 TGF-beta activated kinase 1 (MAP3K7) binding protein 3 JBrowse link X 54,035,958 54,090,282 RGD:1624291
RGD:13792537
G Tbk1 TANK-binding kinase 1 JBrowse link 7 63,655,247 63,687,978 RGD:1624291
G Terf2ip TERF2 interacting protein JBrowse link 19 44,231,317 44,238,406 RGD:1624291
RGD:1600115
G Tfrc transferrin receptor JBrowse link 11 71,397,423 71,419,263 RGD:1624291
RGD:1600115
G Tgm2 transglutaminase 2 JBrowse link 3 154,597,165 154,627,257 RGD:1579987
G Ticam1 toll-like receptor adaptor molecule 1 JBrowse link 9 10,780,185 10,790,280 RGD:1624291
G Tifa TRAF-interacting protein with forkhead-associated domain JBrowse link 2 232,104,394 232,137,425 RGD:1600115
RGD:13792537
RGD:1624291
G Tirap TIR domain containing adaptor protein JBrowse link 8 36,382,029 36,399,625 RGD:1624291
G Tlr3 toll-like receptor 3 JBrowse link 16 50,016,466 50,031,011 RGD:1624291
G Tlr4 toll-like receptor 4 JBrowse link 5 82,587,424 82,601,056 RGD:1624291
RGD:1600115
G Tlr6 toll-like receptor 6 JBrowse link 14 45,024,351 45,041,188 RGD:1624291
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:1624291
G Tmem106a transmembrane protein 106A JBrowse link 10 89,484,269 89,493,288 RGD:1600115
RGD:1624291
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1580306
RGD:13792537
RGD:13673777
RGD:1624291
G Tnfrsf19 TNF receptor superfamily member 19 JBrowse link 15 41,249,820 41,316,203 RGD:1624291
RGD:13792537
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:1600115
RGD:1624291
G Tnfsf10 TNF superfamily member 10 JBrowse link 2 113,008,008 113,026,899 RGD:1624291
RGD:13792537
G Tnfsf11 TNF superfamily member 11 JBrowse link 15 60,482,527 60,512,704 RGD:1624291
G Tnip2 TNFAIP3 interacting protein 2 JBrowse link 14 81,487,934 81,505,889 RGD:1624291
RGD:13792537
G Tradd TNFRSF1A-associated via death domain JBrowse link 19 37,214,461 37,221,099 RGD:1624291
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:1624291
RGD:13792537
G Traf3ip2 Traf3 interacting protein 2 JBrowse link 20 44,679,861 44,722,874 RGD:1624291
RGD:13792537
G Traf5 TNF receptor-associated factor 5 JBrowse link 13 110,758,556 110,801,871 RGD:1624291
RGD:1600115
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:1624291
RGD:1600115
G Trim13 tripartite motif-containing 13 JBrowse link 15 41,897,191 41,936,545 RGD:1624291
G Trim25 tripartite motif-containing 25 JBrowse link 10 76,343,847 76,362,159 RGD:1624291
G Trim32 tripartite motif-containing 32 JBrowse link 5 81,431,554 81,449,023 RGD:1624291
G Trim38 tripartite motif containing 38 JBrowse link 17 43,600,006 43,607,879 RGD:1624291
G Trim5 tripartite motif-containing 5 JBrowse link 1 169,446,774 169,463,760 RGD:1624291
G Trim52 tripartite motif-containing 52 JBrowse link 15 90,364,517 90,388,295 RGD:1624291
G Trim62 tripartite motif-containing 62 JBrowse link 5 147,068,725 147,099,024 RGD:1624291
G Trim8 tripartite motif-containing 8 JBrowse link 1 266,255,797 266,270,694 RGD:1624291
G Ubd ubiquitin D JBrowse link 20 1,876,175 1,878,126 RGD:1600115
RGD:13792537
RGD:1624291
G Ube2i ubiquitin-conjugating enzyme E2I JBrowse link 10 14,618,615 14,639,274 RGD:1624291
G Ube2n ubiquitin-conjugating enzyme E2N JBrowse link 7 36,610,147 36,640,190 RGD:1624291
G Ube2v1 ubiquitin conjugating enzyme E2 V1 JBrowse link 3 164,343,833 164,366,684 RGD:1624291
G Unc5cl unc-5 family C-terminal like JBrowse link 9 14,494,080 14,510,302 RGD:1624291
RGD:13792537
G Zc3hav1 zinc finger CCCH-type containing, antiviral 1 JBrowse link 4 66,012,111 66,062,160 RGD:1624291
positive regulation of I-kappaB phosphorylation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
G Cx3cl1 C-X3-C motif chemokine ligand 1 JBrowse link 19 10,644,267 10,654,861 RGD:1600115
RGD:1624291
G Cx3cr1 C-X3-C motif chemokine receptor 1 JBrowse link 8 128,740,756 128,754,514 RGD:4892026
G Ddrgk1 DDRGK domain containing 1 JBrowse link 3 123,195,580 123,206,828 RGD:1624291
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:1624291
regulation of I-kappaB kinase/NF-kappaB signaling term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Angpt1 angiopoietin 1 JBrowse link 7 81,338,327 81,592,459 RGD:1624291
RGD:1600115
G Btrc beta-transducin repeat containing E3 ubiquitin protein ligase JBrowse link 1 265,100,094 265,270,263 RGD:1624291
G Capn3 calpain 3 JBrowse link 3 112,227,486 112,278,408 RGD:1600115
RGD:1624291
G Cpne1 copine 1 JBrowse link 3
3
151,617,733
152,150,143
151,625,448
152,192,936
RGD:1624291
RGD:13792537
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1624291
RGD:1600115
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
RGD:1600115
G Hspb1 heat shock protein family B (small) member 1 JBrowse link 12 23,839,390 23,841,051 RGD:1624291
RGD:1600115
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:13792537
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1624291
G Lime1 Lck interacting transmembrane adaptor 1 JBrowse link 3 176,881,881 176,888,230 RGD:1624291
RGD:13792537
G Nlrp12 NLR family, pyrin domain containing 12 JBrowse link 1 64,506,750 64,543,908 RGD:1624291
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:13792537
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1624291
G Pidd1 p53-induced death domain protein 1 JBrowse link 1 214,418,751 214,423,959 RGD:1624291
G Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 JBrowse link 1 260,527,344 260,679,132 RGD:1624291
G Rbm12 RNA binding motif protein 12 JBrowse link 3 151,616,038 151,658,427 RGD:13792537
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:1624291
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:1624291
RGD:1600115
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
G Traf1 TNF receptor-associated factor 1 JBrowse link 3 14,003,340 14,022,955 RGD:13792537
G Traf2 Tnf receptor-associated factor 2 JBrowse link 3 2,746,061 2,770,690 RGD:13792537
G Traf3 Tnf receptor-associated factor 3 JBrowse link 6 135,610,698 135,720,247 RGD:13792537
G Traf4 Tnf receptor associated factor 4 JBrowse link 10 65,418,688 65,424,802 RGD:13792537
G Traf6 TNF receptor associated factor 6 JBrowse link 3 91,252,829 91,271,607 RGD:13792537
G Wnt5a Wnt family member 5A JBrowse link 16 4,469,451 4,490,271 RGD:1600115
RGD:1624291
G Zfand6 zinc finger AN1-type containing 6 JBrowse link 1 146,745,850 146,823,762 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19336
    signaling 7456
      signal transduction 6872
        intracellular signal transduction 2584
          I-kappaB kinase/NF-kappaB signaling 220
            I-kappaB phosphorylation + 19
            negative regulation of I-kappaB kinase/NF-kappaB signaling + 47
            positive regulation of I-kappaB kinase/NF-kappaB signaling + 134
            regulation of I-kappaB kinase/NF-kappaB signaling + 192
Path 2
Term Annotations click to browse term
  biological_process 19336
    biological regulation 13340
      regulation of biological process 12655
        regulation of cellular process 11994
          signal transduction 6872
            intracellular signal transduction 2584
              I-kappaB kinase/NF-kappaB signaling 220
                I-kappaB phosphorylation + 19
                negative regulation of I-kappaB kinase/NF-kappaB signaling + 47
                positive regulation of I-kappaB kinase/NF-kappaB signaling + 134
                regulation of I-kappaB kinase/NF-kappaB signaling + 192
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.