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ONTOLOGY REPORT - ANNOTATIONS


Term:activation of JNKK activity
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Accession:GO:0007256 term browser browse the term
Definition:The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress.
Synonyms:exact_synonym: activation of JUN kinase kinase activity
 broad_synonym: positive regulation of JUNKK activity


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activation of JNKK activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link NW_004955556 745,175 812,215 RGD:9068941
G Map3k10 mitogen-activated protein kinase kinase kinase 10 JBrowse link NW_004955578 1,018,280 1,037,553 RGD:9068941
G Map3k11 mitogen-activated protein kinase kinase kinase 11 JBrowse link NW_004955422 19,651,371 19,666,468 RGD:9068941
G Map3k12 mitogen-activated protein kinase kinase kinase 12 JBrowse link NW_004955458 774,478 793,654 RGD:9068941
G Map3k13 mitogen-activated protein kinase kinase kinase 13 JBrowse link NW_004955420 22,064,384 22,190,662 RGD:9068941
G Map3k9 mitogen-activated protein kinase kinase kinase 9 JBrowse link NW_004955523 4,326,315 4,387,390 RGD:9068941
G Nrk Nik related kinase JBrowse link NW_004955548 2,675,645 2,797,548 RGD:9068941
G Ripk1 receptor interacting serine/threonine kinase 1 JBrowse link NW_004955465 10,127,907 10,167,895 RGD:9068941
G Tnik TRAF2 and NCK interacting kinase JBrowse link NW_004955420 1,166,340 1,542,712 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14546
    cellular process 13383
      signal transduction 5192
        signal transduction by protein phosphorylation 885
          MAPK cascade 866
            stress-activated MAPK cascade 271
              JNK cascade 206
                activation of JNKK activity 9
Path 2
Term Annotations click to browse term
  biological_process 14546
    metabolic process 9943
      organic substance metabolic process 9450
        macromolecule metabolic process 8134
          protein metabolic process 5251
            protein modification process 3828
              cellular protein modification process 3828
                protein phosphorylation 1860
                  signal transduction by protein phosphorylation 885
                    MAPK cascade 866
                      stress-activated MAPK cascade 271
                        regulation of stress-activated MAPK cascade 224
                          regulation of JNK cascade 178
                            positive regulation of JNK cascade 134
                              positive regulation of JUN kinase activity 70
                                activation of JNKK activity 9
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.