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ONTOLOGY REPORT - ANNOTATIONS


Term:nitric oxide mediated signal transduction
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Accession:GO:0007263 term browser browse the term
Definition:Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms.
Synonyms:exact_synonym: NO mediated signal transduction;   nitric oxide signaling


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nitric oxide mediated signal transduction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07060833.1 IEA GO_REF:0000107 Ensembl GO_REF:0000107 Ensembl chr 4:96,562,725...96,564,611 JBrowse link
G Apoe apolipoprotein E ISO
IEA
(PMID:8995232)
GO_REF:0000107
RGD
Ensembl
PMID:8995232 GO_REF:0000107 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Cd36 CD36 molecule ISO (PMID:17416590) RGD PMID:17416590 NCBI chr 4:14,150,309...14,191,498
Ensembl chr 4:14,001,761...14,249,749
JBrowse link
G Mafa MAF bZIP transcription factor A ISO (PMID:17941991) RGD PMID:17941991 NCBI chr 7:116,779,368...116,781,815
Ensembl chr 7:116,780,681...116,781,766
JBrowse link
G Mt1 metallothionein 1 ISO MGI:MGI:2668454 (MGI:MGI:2177111|PMID:11792622) RGD PMID:11792622 MGI:MGI:2177111 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A ISO MGI:MGI:2668455 (MGI:MGI:2177111|PMID:11792622) RGD PMID:11792622 MGI:MGI:2177111 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Ndnf neuron-derived neurotrophic factor ISO (PMID:24706764) RGD PMID:24706764 NCBI chr 4:96,528,830...96,565,780 JBrowse link
G Neurod1 neuronal differentiation 1 ISO (PMID:17941991) RGD PMID:17941991 NCBI chr 3:66,414,314...66,417,617
Ensembl chr 3:66,414,308...66,417,741
JBrowse link
G Nos1 nitric oxide synthase 1 IMP
IBA
PMID:19278978
PMID:21873635
BHF-UCL
GO_Central
PMID:19278978, PMID:21873635 RGD:10047220, RGD:13792537 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Npy2r neuropeptide Y receptor Y2 IMP nitric oxide stimulation of GnRH release RGD PMID:11711887 RGD:1642593 NCBI chr 2:181,528,949...181,538,145
Ensembl chr 2:181,530,832...181,531,978
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 ISO (PMID:17941991) RGD PMID:17941991 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Rasd1 ras related dexamethasone induced 1 IDA RGD PMID:11086993 RGD:633891 NCBI chr10:46,330,361...46,339,326
Ensembl chr10:46,330,368...46,332,172
JBrowse link
negative regulation of nitric oxide mediated signal transduction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b4 ATPase plasma membrane Ca2+ transporting 4 ISO (PMID:19278978) RGD PMID:19278978 NCBI chr13:50,091,644...50,153,808
Ensembl chr13:50,091,430...50,153,823
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 ISO (MGI:MGI:5428115|PMID:22228629) RGD PMID:22228629 MGI:MGI:5428115 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Thbs1 thrombospondin 1 ISO (PMID:16150726), (PMID:17416590) RGD PMID:16150726, PMID:17416590 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
nitric oxide-cGMP-mediated signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
JBrowse link
G Kcnc2 potassium voltage-gated channel subfamily C member 2 IDA PMID:11281123 UniProt PMID:11281123 RGD:10047322 NCBI chr 7:54,978,453...55,159,362
Ensembl chr 7:54,980,120...55,159,351
JBrowse link
positive regulation of nitric oxide mediated signal transduction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Egfr epidermal growth factor receptor ISO (PMID:12828935) RGD PMID:12828935 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 ISO
IEA
MGI:MGI:3640802 (MGI:MGI:3640061|PMID:16614755)
GO_REF:0000107
RGD
Ensembl
PMID:16614755 GO_REF:0000107, MGI:MGI:3640061 NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
JBrowse link
G Gucy1a2 guanylate cyclase 1 soluble subunit alpha 2 ISO MGI:MGI:3640794 (MGI:MGI:3640061|PMID:16614755) RGD PMID:16614755 MGI:MGI:3640061 NCBI chr 8:408,001...899,851
Ensembl chr 8:408,001...899,974
JBrowse link
G Ins2 insulin 2 ISO (PMID:14615391), (PMID:15792832) RGD PMID:14615391, PMID:15792832 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
regulation of nitric oxide mediated signal transduction term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbs cystathionine beta synthase ISO MGI:MGI:1857139 (MGI:MGI:1888627|PMID:10953023) RGD PMID:10953023 MGI:MGI:1888627 NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
JBrowse link
G Pde2a phosphodiesterase 2A ISO MGI:MGI:2651499 (MGI:MGI:3603989|PMID:16150726) RGD PMID:16150726 MGI:MGI:3603989 NCBI chr 1:166,534,643...166,626,158
Ensembl chr 1:166,534,643...166,626,158
JBrowse link
G Pde5a phosphodiesterase 5A ISO
IEA
MGI:MGI:2446107 (MGI:MGI:3603989|PMID:16150726)
GO_REF:0000107
RGD
Ensembl
PMID:16150726 GO_REF:0000107, MGI:MGI:3603989 NCBI chr 2:226,899,604...227,044,916
Ensembl chr 2:226,900,619...227,041,576
JBrowse link
G Rln1 relaxin 1 IDA
ISO
PMID:19073841
MGI:MGI:2668458 (MGI:MGI:3840054|PMID:19073841)
RGD PMID:19073841, PMID:19073841 MGI:MGI:3840054, RGD:8553970 NCBI chr 1:247,483,298...247,486,331
Ensembl chr 1:247,483,302...247,486,202
JBrowse link
G Vegfa vascular endothelial growth factor A ISO (PMID:16150726) RGD PMID:16150726 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    signaling 7580
      signal transduction 7011
        intracellular signal transduction 2594
          second-messenger-mediated signaling 467
            nitric oxide mediated signal transduction 28
              negative regulation of nitric oxide mediated signal transduction 3
              nitric oxide-cGMP-mediated signaling pathway 2
              positive regulation of nitric oxide mediated signal transduction 4
              regulation of nitric oxide mediated signal transduction + 12
Path 2
Term Annotations click to browse term
  biological_process 20028
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          signal transduction 7011
            intracellular signal transduction 2594
              second-messenger-mediated signaling 467
                nitric oxide mediated signal transduction 28
                  negative regulation of nitric oxide mediated signal transduction 3
                  nitric oxide-cGMP-mediated signaling pathway 2
                  positive regulation of nitric oxide mediated signal transduction 4
                  regulation of nitric oxide mediated signal transduction + 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.