Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:small GTPase mediated signal transduction
go back to main search page
Accession:GO:0007264 term browser browse the term
Definition:Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.
Synonyms:xref: MIPS_funcat:30.01.05.05.01


show annotations for term's descendants       view all columns           Sort by:
 
small GTPase mediated signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07007642.1 RGD:1600115
G AABR07011057.1 RGD:1600115
G AABR07011057.2 RGD:13792537
G AABR07029272.1 RGD:1600115
G Arhgap1 Rho GTPase activating protein 1 JBrowse link 3 80,555,196 80,576,881 RGD:1624291
G Arhgap18 Rho GTPase activating protein 18 JBrowse link 1 19,227,115 19,463,139 RGD:1624291
G Arhgap30 Rho GTPase activating protein 30 JBrowse link 13 89,774,764 89,796,113 RGD:13792537
G Arhgap31 Rho GTPase activating protein 31 JBrowse link 11 64,600,968 64,714,114 RGD:1624291
RGD:13792537
G Arhgap32 Rho GTPase activating protein 32 JBrowse link 8 33,131,874 33,392,198 RGD:13792537
G Arhgap33 Rho GTPase activating protein 33 JBrowse link 1 88,977,460 88,990,780 RGD:13792537
G Arhgef18 Rho/Rac guanine nucleotide exchange factor 18 JBrowse link 12 1,889,252 1,998,128 RGD:1624291
G Arhgef7 Rho guanine nucleotide exchange factor 7 JBrowse link 16 83,006,732 83,117,065 RGD:633693
G Arl3 ADP ribosylation factor like GTPase 3 JBrowse link 1 266,287,015 266,333,099 RGD:1600115
RGD:1624291
G Bcar3 BCAR3 adaptor protein, NSP family member JBrowse link 2 226,563,050 226,679,449 RGD:1600115
G Bcr BCR activator of RhoGEF and GTPase JBrowse link 20 14,421,250 14,546,406 RGD:1624291
G Ccdc88a coiled coil domain containing 88A JBrowse link 14 113,771,093 113,936,376 RGD:1600115
RGD:1624291
G Ccdc88c coiled-coil domain containing 88C JBrowse link 6 124,905,811 125,028,011 RGD:1624291
RGD:1600115
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:1600115
G Chm CHM Rab escort protein JBrowse link X 84,666,900 84,821,775 RGD:1600115
G Dab1 DAB adaptor protein 1 JBrowse link 5 123,154,360 124,279,170 RGD:1624291
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 10 11,059,701 11,085,186 RGD:1624291
G Dock1 dedicator of cyto-kinesis 1 JBrowse link 1 206,900,617 207,414,852 RGD:1600115
G Dock11 dedicator of cytokinesis 11 JBrowse link X 122,507,169 122,690,463 RGD:1600115
G Dock3 dedicator of cyto-kinesis 3 JBrowse link 8 115,627,282 115,982,260 RGD:1600115
G Dock4 dedicator of cytokinesis 4 JBrowse link 6 60,374,839 60,782,648 RGD:1600115
G Dock5 dedicator of cytokinesis 5 JBrowse link 15 44,449,108 44,627,774 RGD:1600115
G Dock6 dedicator of cytokinesis 6 JBrowse link 8 22,822,412 22,874,670 RGD:1600115
G Dock7 dedicator of cytokinesis 7 JBrowse link 5 117,595,194 117,780,844 RGD:1600115
G Dock8 dedicator of cytokinesis 8 JBrowse link 1 242,934,685 243,153,472 RGD:1600115
G Dock9 dedicator of cytokinesis 9 JBrowse link 15 107,945,664 108,210,967 RGD:1600115
G Gdi2 GDP dissociation inhibitor 2 JBrowse link 17 70,299,177 70,325,864 RGD:1624291
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:628519
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:1624291
G Itsn1 intersectin 1 JBrowse link 11 31,943,119 32,069,249 RGD:1624291
G Kndc1 kinase non-catalytic C-lobe domain containing 1 JBrowse link 1 212,229,751 212,279,254 RGD:1600115
G Nucb1 nucleobindin 1 JBrowse link 1 101,480,160 101,511,029 RGD:14929204
G Nucb2 nucleobindin 2 JBrowse link 1 185,106,773 185,143,278 RGD:14929204
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:61685
G Plcd4 phospholipase C, delta 4 JBrowse link 9 81,816,395 81,844,364 RGD:1624291
G Rab4a RAB4A, member RAS oncogene family JBrowse link 19 56,585,598 56,613,078 RGD:1624291
G Rabif RAB interacting factor JBrowse link 13 51,317,476 51,330,536 RGD:1600115
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1600115
RGD:1624291
G Rac3 Rac family small GTPase 3 JBrowse link 10 109,903,920 109,906,596 RGD:1600115
G Ralbp1 ralA binding protein 1 JBrowse link 9 113,579,107 113,598,477 RGD:633902
RGD:13792537
RGD:1600115
RGD:1624291
G Ralgds ral guanine nucleotide dissociation stimulator JBrowse link 3 7,090,134 7,130,548 RGD:69953
RGD:1600115
G Ralgps1 Ral GEF with PH domain and SH3 binding motif 1 JBrowse link 3 12,182,722 12,415,081 RGD:1600115
G Ralgps2 Ral GEF with PH domain and SH3 binding motif 2 JBrowse link 13 74,446,001 74,520,640 RGD:1600115
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:1624291
G Rap1b RAP1B, member of RAS oncogene family JBrowse link 7 60,850,406 60,878,226 RGD:1624291
G Rapgef2 Rap guanine nucleotide exchange factor 2 JBrowse link 2 177,836,191 178,057,378 RGD:1600115
G Rapgef3 Rap guanine nucleotide exchange factor 3 JBrowse link 7 139,232,263 139,254,668 RGD:1600115
G Rapgef4 Rap guanine nucleotide exchange factor 4 JBrowse link 3 58,632,338 58,925,127 RGD:1600115
G Rapgef5 Rap guanine nucleotide exchange factor 5 JBrowse link 6 145,387,890 145,625,243 RGD:1600115
G Rapgef6 Rap guanine nucleotide exchange factor 6 JBrowse link 10 39,875,322 40,039,929 RGD:1600115
G Rapgefl1 Rap guanine nucleotide exchange factor like 1 JBrowse link 10 86,749,220 86,765,677 RGD:1600115
G Rasgef1a RasGEF domain family, member 1A JBrowse link 4 150,063,484 150,144,203 RGD:1600115
G Rasgef1b RasGEF domain family, member 1B JBrowse link 14 11,499,692 12,028,513 RGD:1600115
G Rasgef1c RasGEF domain family, member 1C JBrowse link 10 35,392,762 35,459,267 RGD:1600115
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 JBrowse link 8 97,277,250 97,405,095 RGD:1600115
G Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 JBrowse link 2 21,460,041 21,698,937 RGD:1600115
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:1600115
G Rasgrp2 RAS guanyl releasing protein 2 JBrowse link 1 221,771,238 221,788,765 RGD:1600115
G Rasgrp4 RAS guanyl releasing protein 4 JBrowse link 1 88,078,350 88,094,331 RGD:1600115
G RGD1563962 similar to Mss4 protein JBrowse link 2 165,805,230 165,816,725 RGD:1600115
G Rgl1 ral guanine nucleotide dissociation stimulator,-like 1 JBrowse link 13 69,909,122 70,174,590 RGD:1600115
G Rgl2 ral guanine nucleotide dissociation stimulator-like 2 JBrowse link 20 5,458,509 5,466,853 RGD:1600115
G Rgl3 ral guanine nucleotide dissociation stimulator-like 3 JBrowse link 8 22,980,727 23,000,881 RGD:1600115
G Rheb Ras homolog, mTORC1 binding JBrowse link 4 6,827,429 6,873,384 RGD:1625606
RGD:13792537
G Rhebl1 RHEB like 1 JBrowse link 7 140,552,704 140,556,980 RGD:13792537
G Rhov ras homolog family member V JBrowse link 3 111,078,642 111,087,347 RGD:1600115
G Rufy1 RUN and FYVE domain containing 1 JBrowse link 10 35,882,805 35,927,268 RGD:1624291
G Sh2d3c SH2 domain containing 3C JBrowse link 3 11,756,427 11,793,547 RGD:1600115
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:1624291
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:1624291
G Tiam1 TIAM Rac1 associated GEF 1 JBrowse link 11 29,931,083 30,061,173 RGD:1624291
RGD:13792537
G Tiam2 TIAM Rac1 associated GEF 2 JBrowse link 1 44,232,520 44,433,450 RGD:13792537
G Uso1 USO1 vesicle transport factor JBrowse link 14 17,371,451 17,436,948 RGD:1624291
G Vav1 vav guanine nucleotide exchange factor 1 JBrowse link 9 9,617,551 9,675,167 RGD:1600115
G Vav2 vav guanine nucleotide exchange factor 2 JBrowse link 3 5,811,504 5,976,311 RGD:1624291
G Vav3 vav guanine nucleotide exchange factor 3 JBrowse link 2 212,247,061 212,585,818 RGD:1624291
G Ywhaq tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta JBrowse link 6 43,463,294 43,493,816 RGD:1624291
ARF protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Myo9b myosin IXb JBrowse link 16 19,669,373 19,754,065 RGD:1624291
Cdc42 protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:5688281
RGD:13792537
G Ntn1 netrin 1 JBrowse link 10 54,761,925 54,982,072 RGD:10054078
G Rhou ras homolog family member U RGD:13792537
G Rhov ras homolog family member V JBrowse link 3 111,078,642 111,087,347 RGD:13792537
G Shtn1 shootin 1 JBrowse link 1 280,129,228 280,233,873 RGD:10054078
G Was WASP actin nucleation promoting factor JBrowse link X 15,155,246 15,164,099 RGD:1624291
negative regulation of ARF protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Git1 GIT ArfGAP 1 JBrowse link 10 62,656,000 62,664,467 RGD:11344921
negative regulation of Rac protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 JBrowse link 18 31,112,083 31,138,142 RGD:1624291
G Arhgap24 Rho GTPase activating protein 24 JBrowse link 14 8,383,211 8,600,526 RGD:1624291
G Arhgap44 Rho GTPase activating protein 44 JBrowse link 10 51,501,547 51,669,546 RGD:1600115
RGD:13792537
RGD:1624291
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:1624291
RGD:1600115
G Stmn3 stathmin 3 JBrowse link 3 176,808,016 176,816,108 RGD:1624291
RGD:8554560
RGD:1600115
negative regulation of Ras protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:632628
G Dgkz diacylglycerol kinase zeta JBrowse link 3 80,844,002 80,886,487 RGD:1624291
G Ephb2 Eph receptor B2 JBrowse link 5 155,024,478 155,143,539 RGD:1624291
G Fbp1 fructose-bisphosphatase 1 JBrowse link 17 396,175 417,480 RGD:1600115
RGD:1624291
G Lztr1 leucine-zipper-like transcription regulator 1 JBrowse link 11 87,381,638 87,397,849 RGD:1624291
G Mapkap1 MAPK associated protein 1 JBrowse link 3 13,484,952 13,701,772 RGD:1624291
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:1624291
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:1624291
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:1624291
G Ppp2cb protein phosphatase 2 catalytic subunit beta JBrowse link 16 62,273,276 62,294,767 RGD:729591
G Rabgef1 RAB guanine nucleotide exchange factor 1 JBrowse link 12 29,960,132 30,004,727 RGD:1624291
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:1624291
G Rasa1 RAS p21 protein activator 1 JBrowse link 2 13,617,021 13,696,531 RGD:1600115
G Rasa2 RAS p21 protein activator 2 JBrowse link 8 104,417,827 104,542,313 RGD:1600115
G Rasa3 RAS p21 protein activator 3 JBrowse link 16 81,320,090 81,434,239 RGD:1600115
G Rasa4 RAS p21 protein activator 4 JBrowse link 12 23,596,989 23,624,386 RGD:1600115
G Rasal1 RAS protein activator like 1 JBrowse link 12 41,416,218 41,449,445 RGD:1600115
G Rasal3 RAS protein activator like 3 JBrowse link 7 14,403,592 14,419,570 RGD:1624291
G Spry1 sprouty RTK signaling antagonist 1 JBrowse link 2 124,400,689 124,405,331 RGD:1624291
RGD:13792537
G Spry2 sprouty RTK signaling antagonist 2 JBrowse link 15 90,172,769 90,177,823 RGD:1624291
RGD:13792537
G Spry3 sprouty RTK signaling antagonist 3 JBrowse link 12 18,930,087 18,940,622 RGD:13792537
G Spry4 sprouty RTK signaling antagonist 4 JBrowse link 18 32,593,370 32,609,890 RGD:13792537
G Stambp Stam binding protein JBrowse link 4 115,249,343 115,277,340 RGD:1624291
G Syngap1 synaptic Ras GTPase activating protein 1 JBrowse link 20 5,535,434 5,564,657 RGD:7241548
RGD:1600115
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
G Timp2 TIMP metallopeptidase inhibitor 2 JBrowse link 10 107,338,465 107,386,072 RGD:1598578
G Tnk1 tyrosine kinase, non-receptor, 1 JBrowse link 10 56,458,650 56,475,183 RGD:1624291
G Trim67 tripartite motif-containing 67 JBrowse link 19 57,554,665 57,593,401 RGD:1624291
negative regulation of Rho protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:1624291
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:8554725
G Adra1b adrenoceptor alpha 1B JBrowse link 10 29,392,762 29,450,644 RGD:8554725
G Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 JBrowse link 18 31,112,083 31,138,142 RGD:1624291
G Arhgap35 Rho GTPase activating protein 35 JBrowse link 1 78,456,409 78,573,374 RGD:1600115
RGD:1624291
G Arhgap42 Rho GTPase activating protein 42 JBrowse link 8 7,210,999 7,446,215 RGD:1624291
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:1624291
G Ccdc125 coiled-coil domain containing 125 JBrowse link 2 30,685,845 30,726,617 RGD:1624291
RGD:13792537
G Cul3 cullin 3 JBrowse link 9 86,044,485 86,129,066 RGD:1600115
RGD:1624291
G Dlc1 DLC1 Rho GTPase activating protein JBrowse link 16 58,776,489 59,247,752 RGD:1600115
RGD:1624291
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:1624291
RGD:1600115
G Heg1 heart development protein with EGF-like domains 1 JBrowse link 11 70,234,248 70,322,966 RGD:1624291
G Itga3 integrin subunit alpha 3 JBrowse link 10 82,855,841 82,887,755 RGD:1624291
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1624291
RGD:1600115
G Kank1 KN motif and ankyrin repeat domains 1 JBrowse link 1 243,201,073 243,398,531 RGD:1624291
G Kctd10 potassium channel tetramerization domain containing 10 JBrowse link 12 47,992,079 48,010,531 RGD:13792537
G Kctd13 potassium channel tetramerization domain containing 13 JBrowse link 1 198,360,627 198,378,935 RGD:1624291
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:1600115
RGD:1624291
G Myoc myocilin JBrowse link 13 80,517,531 80,527,928 RGD:1600115
RGD:1624291
G Rasip1 Ras interacting protein 1 JBrowse link 1 101,609,209 101,621,648 RGD:1624291
G Ripor1 RHO family interacting cell polarization regulator 1 JBrowse link 19 37,555,940 37,584,842 RGD:1624291
G Ripor2 RHO family interacting cell polarization regulator 2 JBrowse link 17 42,324,594 42,549,907 RGD:1624291
RGD:1600115
G Scai suppressor of cancer cell invasion JBrowse link 3 23,357,586 23,474,218 RGD:1624291
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:1624291
G Tnfaip1 TNF alpha induced protein 1 JBrowse link 10 65,791,002 65,805,693 RGD:1624291
RGD:13792537
RGD:1600115
negative regulation of small GTPase mediated signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arhgap12 Rho GTPase activating protein 12 JBrowse link 17 54,280,815 54,394,716 RGD:1624291
G Arhgap25 Rho GTPase activating protein 25 JBrowse link 4 119,249,682 119,327,822 RGD:1624291
G Cd2ap CD2-associated protein JBrowse link 9 20,794,680 20,858,438 RGD:1624291
RGD:1600115
G Cgnl1 cingulin-like 1 JBrowse link 8 78,126,670 78,278,490 RGD:1624291
G Cyrib CYFIP related Rac1 interactor B JBrowse link 7 104,514,566 104,641,875 RGD:1624291
RGD:1600115
G Sh3bp1 SH3-domain binding protein 1 JBrowse link 7 120,125,747 120,138,148 RGD:1600115
RGD:1624291
G Slit2 slit guidance ligand 2 JBrowse link 14 66,831,848 67,171,491 RGD:1600115
RGD:1624291
positive regulation of ARF protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 JBrowse link 9 46,657,444 46,782,545 RGD:1624291
G Mapre2 microtubule-associated protein, RP/EB family, member 2 JBrowse link 18 14,814,149 15,780,290 RGD:1624291
positive regulation of Rac protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 JBrowse link 2 187,964,100 188,022,847 RGD:1624291
G Auts2 activator of transcription and developmental regulator AUTS2 JBrowse link 12 27,155,362 28,252,752 RGD:1624291
G Camk2d calcium/calmodulin-dependent protein kinase II delta JBrowse link 2 230,900,907 231,132,207 RGD:6907067
G Dynlt1 dynein light chain Tctex-type 1 JBrowse link 1 47,206,892 47,213,785 RGD:8553295
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:1624291
G Rtn4 reticulon 4 JBrowse link 14 114,126,931 114,174,459 RGD:1600115
RGD:1624291
positive regulation of Ras protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arpp19 cAMP-regulated phosphoprotein 19 JBrowse link 8 81,949,577 81,972,054 RGD:625586
G Csf1 colony stimulating factor 1 JBrowse link 2 210,522,370 210,550,546 RGD:1624291
G Dgki diacylglycerol kinase, iota JBrowse link 4 64,365,115 64,831,473 RGD:1624291
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:1624291
RGD:13792537
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:1582125
G Fgf10 fibroblast growth factor 10 JBrowse link 2 51,673,480 51,747,533 RGD:1624291
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:8553977
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:1624291
RGD:1600115
G Itpkb inositol-trisphosphate 3-kinase B JBrowse link 13 98,615,287 98,710,426 RGD:1624291
G Kitlg KIT ligand JBrowse link 7 42,269,784 42,351,054 RGD:1624291
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:8553977
G Mmd2 monocyte to macrophage differentiation-associated 2 JBrowse link 12 14,021,724 14,078,121 RGD:1624291
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:1624291
G Notch1 notch receptor 1 JBrowse link 3 3,905,562 3,951,015 RGD:1624291
G Notch2 notch receptor 2 JBrowse link 2 200,187,184 200,320,403 RGD:1600115
RGD:1624291
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:1624291
RGD:1600115
G Ntrk1 neurotrophic receptor tyrosine kinase 1 JBrowse link 2 187,143,568 187,160,373 RGD:1624291
RGD:1600115
G Rasgef1a RasGEF domain family, member 1A JBrowse link 4 150,063,484 150,144,203 RGD:1624291
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 JBrowse link 8 97,277,250 97,405,095 RGD:7241548
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:1624291
G Rasgrp4 RAS guanyl releasing protein 4 JBrowse link 1 88,078,350 88,094,331 RGD:1600115
RGD:1624291
G Shoc2 SHOC2 leucine-rich repeat scaffold protein JBrowse link 1 274,700,621 274,751,195 RGD:1600115
RGD:1624291
G Stk19 serine/threonine kinase 19 JBrowse link 20 4,317,440 4,517,128 RGD:1624291
positive regulation of Rho protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abra actin-binding Rho activating protein JBrowse link 7 80,792,615 80,796,683 RGD:1624291
RGD:13792537
RGD:1600115
G Adgrg1 adhesion G protein-coupled receptor G1 JBrowse link 19 10,423,534 10,460,674 RGD:1600115
RGD:1624291
G Akap13 A-kinase anchoring protein 13 JBrowse link 1 137,089,558 137,315,272 RGD:1600115
RGD:1624291
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
G Arhgef3 Rho guanine nucleotide exchange factor 3 JBrowse link 16 2,743,714 3,026,768 RGD:13792537
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:1624291
G Col3a1 collagen type III alpha 1 chain JBrowse link 9 52,023,295 52,059,221 RGD:1624291
RGD:1600115
G F11r F11 receptor JBrowse link 13 89,826,272 89,850,151 RGD:1624291
G F2r coagulation factor II (thrombin) receptor JBrowse link 2 26,118,760 26,135,340 RGD:1624291
RGD:1600115
RGD:13792537
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
RGD:13792537
RGD:1600115
G F2rl2 coagulation factor II (thrombin) receptor-like 2 JBrowse link 2 26,240,385 26,245,533 RGD:13792537
G F2rl3 F2R like thrombin or trypsin receptor 3 JBrowse link 16 18,817,797 18,819,790 RGD:13792537
G Gpr17 G protein-coupled receptor 17 JBrowse link 18 24,733,306 24,739,194 RGD:13792537
G Gpr174 G protein-coupled receptor 174 JBrowse link X 78,358,347 78,399,944 RGD:13792537
G Gpr18 G protein-coupled receptor 18 JBrowse link 15 108,323,157 108,326,907 RGD:13792537
G Gpr35 G protein-coupled receptor 35 JBrowse link 9 100,129,428 100,141,269 RGD:13792537
G Gpr4 G protein-coupled receptor 4 JBrowse link 1 80,125,639 80,136,786 RGD:13792537
G Gpr55 G protein-coupled receptor 55 JBrowse link 9 92,961,431 93,011,157 RGD:1624291
RGD:13792537
G Gpr65 G-protein coupled receptor 65 JBrowse link 6 122,248,528 122,256,115 RGD:13792537
G LOC100359656 rCG38062-like JBrowse link X 77,786,566 77,810,066 RGD:13792537
G Lpar1 lysophosphatidic acid receptor 1 JBrowse link 5 75,557,038 75,678,067 RGD:1600115
RGD:1624291
G Lpar2 lysophosphatidic acid receptor 2 JBrowse link 16 21,343,313 21,348,913 RGD:1624291
G Lpar4 lysophosphatidic acid receptor 4 JBrowse link X 78,042,859 78,056,347 RGD:13792537
G Lpar6 lysophosphatidic acid receptor 6 JBrowse link 15 55,126,953 55,128,762 RGD:13792537
G Mcf2l MCF.2 cell line derived transforming sequence-like JBrowse link 16 81,839,686 81,986,007 RGD:729022
RGD:1624291
G Net1 neuroepithelial cell transforming 1 JBrowse link 17 69,991,786 70,020,977 RGD:13792537
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:5508741
G P2ry10 P2Y receptor family member 10 JBrowse link X 78,158,729 78,210,413 RGD:13792537
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:10449505
G Prag1 PEAK1 related kinase activating pseudokinase 1 JBrowse link 16 59,666,794 59,730,681 RGD:11555369
G RGD1560455 similar to RIKEN cDNA A630033H20 gene JBrowse link X 78,258,495 78,284,180 RGD:13792537
G Robo1 roundabout guidance receptor 1 JBrowse link 11 9,079,291 10,146,302 RGD:1600115
RGD:1624291
G Rtn4r reticulon 4 receptor JBrowse link 11 86,992,665 87,017,091 RGD:1624291
RGD:1600115
G Synpo2l synaptopodin 2-like JBrowse link 15 4,064,706 4,074,151 RGD:1624291
positive regulation of small GTPase mediated signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adcyap1r1 ADCYAP receptor type I JBrowse link 4 85,662,809 85,711,696 RGD:2325271
G Bnip2 BCL2 interacting protein 2 JBrowse link 8 76,400,333 76,426,307 RGD:1624291
G Cdon cell adhesion associated, oncogene regulated JBrowse link 8 36,625,757 36,712,091 RGD:1624291
RGD:1600115
G Frmd7 FERM domain containing 7 JBrowse link X 138,095,707 138,149,702 RGD:1624291
G Reln reelin JBrowse link 4 9,347,533 9,774,257 RGD:1624291
RGD:1600115
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:5686649
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 JBrowse link 6 91,885,292 92,008,059 RGD:5686649
G Src SRC proto-oncogene, non-receptor tyrosine kinase JBrowse link 3 153,547,807 153,595,643 RGD:1624291
Rab protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07002683.1 RGD:13792537
G AABR07009572.1 RGD:13792537
G Aatk apoptosis-associated tyrosine kinase JBrowse link 10 109,184,338 109,224,455 RGD:1624291
G Dnajc27 DnaJ heat shock protein family (Hsp40) member C27 JBrowse link 6 28,515,054 28,544,756 RGD:13792537
G Gdi1 GDP dissociation inhibitor 1 JBrowse link X 156,400,734 156,407,396 RGD:1600115
G Ift22 intraflagellar transport 22 JBrowse link 12 22,804,384 22,811,036 RGD:13792537
G Ift27 intraflagellar transport 27 JBrowse link 7 119,393,384 119,409,710 RGD:13792537
G Rab10 RAB10, member RAS oncogene family JBrowse link 6 27,668,387 27,721,120 RGD:13792537
G Rab11a RAB11a, member RAS oncogene family JBrowse link 8 70,192,975 70,215,719 RGD:13792537
G Rab11b RAB11B, member RAS oncogene family JBrowse link 7 18,598,991 18,612,132 RGD:13792537
G Rab12 RAB12, member RAS oncogene family JBrowse link 9 114,683,985 114,709,613 RGD:13792537
G Rab13 RAB13, member RAS oncogene family JBrowse link 2 189,581,209 189,586,358 RGD:13792537
G Rab14 RAB14, member RAS oncogene family JBrowse link 3 14,373,270 14,395,357 RGD:13792537
G Rab15 RAB15, member RAS oncogene family JBrowse link 6 99,845,952 99,870,320 RGD:13792537
G Rab17 RAB17, member RAS oncogene family JBrowse link 9 98,118,907 98,131,883 RGD:13792537
G Rab18 RAB18, member RAS oncogene family JBrowse link 17 59,844,781 59,876,170 RGD:13792537
G Rab19 RAB19, member RAS oncogene family JBrowse link 4 67,166,412 67,176,141 RGD:13792537
G Rab1a RAB1A, member RAS oncogene family JBrowse link 14 104,475,082 104,500,176 RGD:2306441
RGD:13792537
G Rab1b RAB1B, member RAS oncogene family JBrowse link 1 220,483,529 220,491,469 RGD:13792537
G Rab20 RAB20, member RAS oncogene family JBrowse link 16 83,358,116 83,382,326 RGD:13792537
G Rab21 RAB21, member RAS oncogene family JBrowse link 7 58,261,985 58,286,770 RGD:13792537
G Rab22a RAB22A, member RAS oncogene family JBrowse link 3 171,743,884 171,790,558 RGD:13792537
G Rab23 RAB23, member RAS oncogene family JBrowse link 9 38,469,784 38,496,185 RGD:13792537
G Rab25 RAB25, member RAS oncogene family JBrowse link 2 187,903,301 187,909,398 RGD:13792537
G Rab26 RAB26, member RAS oncogene family JBrowse link 10 13,894,271 13,898,578 RGD:13792537
G Rab27a RAB27A, member RAS oncogene family JBrowse link 8 79,722,334 79,776,228 RGD:13792537
G Rab27b RAB27B, member RAS oncogene family JBrowse link 18 68,486,006 68,644,595 RGD:13792537
G Rab28 RAB28, member RAS oncogene family JBrowse link 14 73,888,968 73,963,209 RGD:13792537
G Rab29 RAB29, member RAS oncogene family JBrowse link 13 48,644,575 48,650,229 RGD:13792537
G Rab2a RAB2A, member RAS oncogene family JBrowse link 5 21,632,654 21,696,721 RGD:2306441
RGD:13792537
G Rab2b RAB2B, member RAS oncogene family JBrowse link 15 28,675,504 28,696,192 RGD:13792537
G Rab30 RAB30, member RAS oncogene family JBrowse link 1 157,573,344 157,667,973 RGD:13792537
G Rab31 RAB31, member RAS oncogene family JBrowse link 9 113,370,072 113,504,606 RGD:13792537
G Rab32 RAB32, member RAS oncogene family JBrowse link 1 4,638,663 4,653,220 RGD:13792537
G Rab33a RAB33A, member RAS oncogene family JBrowse link X 135,348,799 135,360,204 RGD:13792537
G Rab33b RAB33B, member RAS oncogene family JBrowse link 2 140,541,619 140,552,220 RGD:13792537
G Rab34 RAB34, member RAS oncogene family JBrowse link 10 65,448,111 65,452,178 RGD:13792537
G Rab35 RAB35, member RAS oncogene family JBrowse link 12 46,704,274 46,718,404 RGD:13792537
G Rab36 RAB36, member RAS oncogene family JBrowse link 20 14,557,485 14,573,939 RGD:13792537
G Rab37 RAB37, member RAS oncogene family JBrowse link 10 103,643,841 103,711,830 RGD:13792537
G Rab38 RAB38, member RAS oncogene family JBrowse link 1 152,072,716 152,153,449 RGD:13792537
G Rab39a RAB39A, member RAS oncogene family JBrowse link 8 58,275,984 58,292,995 RGD:13792537
G Rab3a RAB3A, member RAS oncogene family JBrowse link 16 20,435,098 20,439,206 RGD:2306441
RGD:13792537
G Rab3b RAB3B, member RAS oncogene family JBrowse link 5 128,501,789 128,568,170 RGD:13792537
G Rab3c RAB3C, member RAS oncogene family JBrowse link 2 41,570,955 41,786,681 RGD:13792537
G Rab3d RAB3D, member RAS oncogene family JBrowse link 8 22,920,238 22,929,368 RGD:13792537
G Rab40b Rab40b, member RAS oncogene family JBrowse link 10 110,557,798 110,585,424 RGD:13792537
G Rab40c Rab40c, member RAS oncogene family JBrowse link 10 15,247,913 15,283,111 RGD:13792537
G Rab42 RAB42, member RAS oncogene family JBrowse link 5 150,482,283 150,484,168 RGD:13792537
G Rab43 RAB43, member RAS oncogene family JBrowse link 4 119,695,012 119,714,490 RGD:13792537
G Rab44 RAB44, member RAS oncogene family JBrowse link 20 6,363,839 6,410,878 RGD:13792537
G Rab4a RAB4A, member RAS oncogene family JBrowse link 19 56,585,598 56,613,078 RGD:2306441
RGD:13792537
RGD:2306443
G Rab4b RAB4B, member RAS oncogene family JBrowse link 1 83,979,298 83,990,680 RGD:13792537
G Rab5a RAB5A, member RAS oncogene family JBrowse link 9 5,910 6,065 RGD:13792537
G Rab5al1 Rab5a, member RAS oncogene family-like 1 JBrowse link 14 72,889,022 72,891,156 RGD:13792537
G Rab5b RAB5B, member RAS oncogene family JBrowse link 7 3,104,530 3,123,384 RGD:13792537
G Rab5c RAB5C, member RAS oncogene family JBrowse link 10 88,621,924 88,645,364 RGD:13792537
G Rab6a RAB6A, member RAS oncogene family JBrowse link 1 165,624,973 165,664,201 RGD:2306441
RGD:13792537
G Rab6b RAB6B, member RAS oncogene family JBrowse link 8 111,600,375 111,668,817 RGD:13792537
G Rab7a RAB7A, member RAS oncogene family JBrowse link 4 119,910,461 119,963,065 RGD:13792537
G Rab7b Rab7b, member RAS oncogene family JBrowse link 13 48,456,143 48,483,714 RGD:13792537
G Rab8a RAB8A, member RAS oncogene family JBrowse link 16 19,355,047 19,376,776 RGD:13792537
G Rab8b RAB8B, member RAS oncogene family JBrowse link 8 72,641,680 72,714,646 RGD:13792537
G Rab9a RAB9A, member RAS oncogene family JBrowse link X 29,525,256 29,547,295 RGD:13792537
G Rab9b RAB9B, member RAS oncogene family JBrowse link X 107,531,404 107,542,510 RGD:13792537
G Rabl2 RAB, member of RAS oncogene family like 2 JBrowse link 7 130,556,056 130,564,764 RGD:13792537
G Rabl3 RAB, member of RAS oncogene family-like 3 JBrowse link 11 66,049,635 66,078,669 RGD:13792537
Rac protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abi2 abl-interactor 2 JBrowse link 9 67,234,612 67,284,504 RGD:1624291
G Aif1 allograft inflammatory factor 1 JBrowse link 20 5,161,350 5,167,176 RGD:1624291
RGD:1600115
G Als2 alsin Rho guanine nucleotide exchange factor ALS2 JBrowse link 9 65,961,361 66,034,396 RGD:1599082
G Brk1 BRICK1 subunit of SCAR/WAVE actin nucleating complex JBrowse link 4 145,559,206 145,574,438 RGD:1624291
G Cdh13 cadherin 13 JBrowse link 19 50,848,793 51,971,618 RGD:1624291
G Cyfip1 cytoplasmic FMR1 interacting protein 1 JBrowse link 1 114,258,773 114,347,138 RGD:1624291
G Dbnl drebrin-like JBrowse link 14 86,029,335 86,044,364 RGD:1624291
RGD:1600115
G Elmo1 engulfment and cell motility 1 JBrowse link 17 46,352,102 46,888,788 RGD:1624291
G Eps8 epidermal growth factor receptor pathway substrate 8 JBrowse link 4 171,475,155 171,645,620 RGD:1624291
RGD:1600115
G Farp2 FERM, ARH/RhoGEF and pleckstrin domain protein 2 JBrowse link 9 100,660,366 100,767,940 RGD:1624291
G Nckap1 NCK-associated protein 1 JBrowse link 3 67,725,180 67,804,680 RGD:1600115
RGD:1624291
G Nisch nischarin JBrowse link 16 7,254,372 7,290,670 RGD:1624291
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1299245
RGD:13792537
RGD:12050102
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:13792537
G Rhog ras homolog family member G JBrowse link 1 167,336,147 167,347,720 RGD:1624291
RGD:13792537
G Rhou ras homolog family member U JBrowse link 19 56,431,787 56,443,896 RGD:1624291
G Rhou ras homolog family member U RGD:1600115
G Tiam1 TIAM Rac1 associated GEF 1 JBrowse link 11 29,931,083 30,061,173 RGD:1624291
G Wasf1 WASP family member 1 JBrowse link 20 48,456,191 48,503,768 RGD:1624291
G Wasf2 WASP family member 2 JBrowse link 5 151,319,382 151,385,051 RGD:1624291
Ral protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ralgapa2 Ral GTPase activating protein catalytic subunit alpha 2 JBrowse link 3 140,451,850 140,728,305 RGD:1624291
G Ralgapb Ral GTPase activating protein non-catalytic subunit beta JBrowse link 3 154,910,291 154,983,021 RGD:1624291
Ran protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gpsm2 G-protein signaling modulator 2 JBrowse link 2 211,480,120 211,528,096 RGD:1624291
G Kpnb1 karyopherin subunit beta 1 JBrowse link 10 85,096,517 85,124,641 RGD:1600115
RGD:1624291
G Rcc1 regulator of chromosome condensation 1 JBrowse link 5 150,508,840 150,531,062 RGD:13792537
Rap protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Diras3 DIRAS family GTPase 3 JBrowse link 6 135,938,345 135,940,205 RGD:13792537
G Plk2 polo-like kinase 2 JBrowse link 2 41,911,143 41,916,901 RGD:7241548
G Rap1a RAP1A, member of RAS oncogene family JBrowse link 2 208,193,950 208,215,186 RGD:1624291
RGD:13792537
RGD:1600115
G Rap1b RAP1B, member of RAS oncogene family JBrowse link 7 60,850,406 60,878,226 RGD:1624291
RGD:13792537
RGD:1600115
G Rap2a RAP2A, member of RAS oncogene family JBrowse link 15 105,851,543 105,852,033 RGD:1624291
RGD:13792537
G Rap2b RAP2B, member of RAS oncogene family JBrowse link 2 151,685,251 151,685,802 RGD:1624291
RGD:13792537
RGD:1600115
G Rap2c RAP2C, member of RAS oncogene family JBrowse link X 138,224,039 138,237,157 RGD:1624291
RGD:13792537
G Rapgef1 Rap guanine nucleotide exchange factor 1 JBrowse link 3 8,189,594 8,307,077 RGD:1624291
G Rapgef2 Rap guanine nucleotide exchange factor 2 JBrowse link 2 177,836,191 178,057,378 RGD:1600115
RGD:1624291
G Rapgef3 Rap guanine nucleotide exchange factor 3 JBrowse link 7 139,232,263 139,254,668 RGD:1624291
RGD:1600115
G Sgsm3 small G protein signaling modulator 3 JBrowse link 7 122,203,498 122,232,993 RGD:1600115
RGD:1624291
Ras protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Brap BRCA1 associated protein JBrowse link 12 40,381,892 40,417,764 RGD:1624291
G Ccna2 cyclin A2 JBrowse link 2 123,274,727 123,282,266 RGD:1624291
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:1624291
RGD:1600115
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1624291
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 JBrowse link 5 152,447,348 152,458,005 RGD:1624291
G Dhcr24 24-dehydrocholesterol reductase JBrowse link 5 126,164,708 126,188,926 RGD:1600898
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:1600115
RGD:1624291
G Dok1 docking protein 1 JBrowse link 4 113,864,211 113,866,695 RGD:1624291
G Dok2 docking protein 2 JBrowse link 15 52,449,884 52,455,414 RGD:1624291
G Dok3 docking protein 3 JBrowse link 17 9,639,064 9,644,090 RGD:1624291
G Eras ES cell expressed Ras JBrowse link X 15,318,215 15,322,601 RGD:13792537
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:728541
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:1358732
RGD:13792537
RGD:1624291
G Iqgap3 IQ motif containing GTPase activating protein 3 JBrowse link 2 187,447,477 187,489,630 RGD:1624291
G Jun Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 5 114,011,184 114,014,277 RGD:1624291
RGD:1600115
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:1624291
RGD:13792537
G Ksr1 kinase suppressor of ras 1 JBrowse link 10 66,323,704 66,342,469 RGD:1624291
RGD:13792537
G Ksr2 kinase suppressor of ras 2 JBrowse link 12 44,531,376 44,911,835 RGD:13792537
G Lat linker for activation of T cells JBrowse link 1 197,765,644 197,770,669 RGD:1624291
G LOC108348138 GTPase ERas JBrowse link X 15,419,055 15,423,400 RGD:13792537
G Mapkapk5 MAPK activated protein kinase 5 JBrowse link 12 40,510,378 40,529,332 RGD:1624291
RGD:13792537
G Mras muscle RAS oncogene homolog JBrowse link 8 107,629,028 107,656,851 RGD:13792537
RGD:1600115
RGD:1624291
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:1600115
RGD:1624291
G Nras NRAS proto-oncogene, GTPase JBrowse link 2 205,553,119 205,563,716 RGD:1600115
RGD:13792537
RGD:1624291
G Ntn1 netrin 1 JBrowse link 10 54,761,925 54,982,072 RGD:10054078
G Plce1 phospholipase C, epsilon 1 JBrowse link 1 257,156,023 257,465,440 RGD:68714
RGD:1624291
RGD:1600115
G Plk2 polo-like kinase 2 JBrowse link 2 41,911,143 41,916,901 RGD:7241548
G Prkd1 protein kinase D1 JBrowse link 6 71,035,017 71,349,531 RGD:1624291
RGD:1600115
G Rala RAS like proto-oncogene A JBrowse link 17 49,676,073 49,729,133 RGD:13792537
G Ralb RAS like proto-oncogene B JBrowse link 13 35,494,716 35,531,503 RGD:1600115
RGD:13792537
G Rasgrp3 RAS guanyl releasing protein 3 JBrowse link 6 21,072,634 21,171,619 RGD:1624291
G Rasl12 RAS-like, family 12 JBrowse link 8 70,915,944 70,931,275 RGD:13792537
G Rassf1 Ras association domain family member 1 JBrowse link 8 116,307,149 116,318,289 RGD:1624291
G Rb1 RB transcriptional corepressor 1 JBrowse link 15 55,081,582 55,209,060 RGD:1624291
RGD:1600115
G Rerg RAS-like, estrogen-regulated, growth-inhibitor JBrowse link 4 171,069,161 171,176,678 RGD:13792537
G Rfxank regulatory factor X-associated ankyrin-containing protein JBrowse link 16 21,029,449 21,037,080 RGD:1624291
G Rit1 Ras-like without CAAX 1 JBrowse link 2 188,087,486 188,099,444 RGD:1624291
RGD:13792537
G Rit2 Ras-like without CAAX 2 JBrowse link 18 23,700,012 24,057,917 RGD:1624291
RGD:13792537
G Rras RAS related JBrowse link 1 101,012,822 101,016,720 RGD:13792537
G Rras2 RAS related 2 JBrowse link 1 178,940,515 179,010,257 RGD:1624291
RGD:13792537
G Rsu1 Ras suppressor protein 1 JBrowse link 17 80,388,477 80,577,338 RGD:1624291
G Sdcbp syndecan binding protein JBrowse link 5 19,471,664 19,498,499 RGD:1624291
G Setdb1 SET domain bifurcated histone lysine methyltransferase 1 JBrowse link 2 196,495,867 196,527,412 RGD:1624291
G Shtn1 shootin 1 JBrowse link 1 280,129,228 280,233,873 RGD:10054078
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 JBrowse link 6 3,105,443 3,182,977 RGD:1581104
G Syngap1 synaptic Ras GTPase activating protein 1 JBrowse link 20 5,535,434 5,564,657 RGD:1624291
RGD:1600115
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Trim28 tripartite motif-containing 28 JBrowse link 1 65,544,369 65,551,043 RGD:1624291
RGD:1600115
G Ulk1 unc-51 like autophagy activating kinase 1 JBrowse link 12 51,908,105 51,934,704 RGD:1624291
G Usp28 ubiquitin specific peptidase 28 JBrowse link 8 53,295,188 53,355,572 RGD:1600115
RGD:1624291
G Usp50 ubiquitin specific peptidase 50 JBrowse link 3 119,225,055 119,247,442 RGD:13792537
G Usp8 ubiquitin specific peptidase 8 JBrowse link 3 119,173,818 119,222,499 RGD:1624291
RGD:13792537
regulation of ARF protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arfgap1 ADP-ribosylation factor GTPase activating protein 1 JBrowse link 3 176,475,847 176,490,642 RGD:13792537
G Arfgef1 ADP ribosylation factor guanine nucleotide exchange factor 1 JBrowse link 5 8,666,046 8,760,458 RGD:1600115
G Arfgef2 ADP ribosylation factor guanine nucleotide exchange factor 2 JBrowse link 3 163,570,435 163,656,612 RGD:1600115
G Arfgef3 ARFGEF family member 3 JBrowse link 1 13,837,861 13,918,277 RGD:1600115
G Cyth1 cytohesin 1 JBrowse link 10 107,197,983 107,281,285 RGD:1600115
G Cyth2 cytohesin 2 JBrowse link 1 101,796,349 101,803,407 RGD:1600115
G Cyth3 cytohesin 3 JBrowse link 12 12,877,559 12,907,771 RGD:1600115
G Cyth4 cytohesin 4 JBrowse link 7 119,820,521 119,845,003 RGD:1600115
G Fbxo8 F-box protein 8 JBrowse link 16 37,131,566 37,177,033 RGD:1600115
G Gbf1 golgi brefeldin A resistant guanine nucleotide exchange factor 1 JBrowse link 1 265,904,616 266,033,107 RGD:1600115
G Iqsec1 IQ motif and Sec7 domain ArfGEF 1 JBrowse link 4 123,400,717 123,454,656 RGD:1600115
G Iqsec2 IQ motif and Sec7 domain ArfGEF 2 JBrowse link X 22,212,137 22,293,810 RGD:1600115
G Iqsec3 IQ motif and Sec7 domain ArfGEF 3 JBrowse link 4 153,948,052 154,044,493 RGD:1600115
G Psd pleckstrin and Sec7 domain containing JBrowse link 1 266,059,331 266,074,774 RGD:1600115
G Psd2 pleckstrin and Sec7 domain containing 2 JBrowse link 18 28,781,267 28,832,429 RGD:1600115
G Psd3 pleckstrin and Sec7 domain containing 3 JBrowse link 16 23,212,165 23,789,414 RGD:1600115
G Psd4 pleckstrin and Sec7 domain containing 4 JBrowse link 3 1,478,432 1,515,094 RGD:1600115
regulation of Cdc42 protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:1624291
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:1624291
RGD:1600115
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
RGD:1600115
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:1624291
G Rit2 Ras-like without CAAX 2 JBrowse link 18 23,700,012 24,057,917 RGD:1624291
regulation of microtubule nucleation by Ran protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rangrf RAN guanine nucleotide release factor JBrowse link 10 55,559,049 55,560,420 RGD:1624291
regulation of Rab protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dennd1a DENN domain containing 1A JBrowse link 3 22,061,120 22,501,502 RGD:1624291
G Dennd4b DENN domain containing 4B JBrowse link 2 189,626,922 189,642,732 RGD:1624291
G Madd MAP-kinase activating death domain JBrowse link 3 79,960,301 80,003,023 RGD:1624291
RGD:13792537
RGD:1600115
G Rab3gap1 RAB3 GTPase activating protein catalytic subunit 1 JBrowse link 13 44,578,208 44,649,876 RGD:1600115
G Sgsm3 small G protein signaling modulator 3 JBrowse link 7 122,203,498 122,232,993 RGD:1600115
RGD:1624291
regulation of Rac protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arf6 ADP-ribosylation factor 6 JBrowse link 6 91,697,109 91,698,257 RGD:1624291
G Arhgap17 Rho GTPase activating protein 17 JBrowse link 1 193,239,036 193,328,425 RGD:13792537
G Arhgap44 Rho GTPase activating protein 44 JBrowse link 10 51,501,547 51,669,546 RGD:13792537
G Cadm4 cell adhesion molecule 4 JBrowse link 1 81,365,200 81,369,841 RGD:1600115
RGD:1624291
G Crk CRK proto-oncogene, adaptor protein JBrowse link 10 63,829,731 63,855,999 RGD:1298803
G Dnm2 dynamin 2 JBrowse link 8 22,458,869 22,540,649 RGD:9685179
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase JBrowse link X 71,540,870 71,585,906 RGD:1600115
RGD:1624291
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 JBrowse link 8 97,277,250 97,405,095 RGD:1624291
RGD:8554560
RGD:1600115
G Sh3bp1 SH3-domain binding protein 1 JBrowse link 7 120,125,747 120,138,148 RGD:13792537
G Ssx2ip SSX family member 2 interacting protein JBrowse link 2 252,263,323 252,296,049 RGD:1624291
G Tiam1 TIAM Rac1 associated GEF 1 JBrowse link 11 29,931,083 30,061,173 RGD:12050147
regulation of Ral protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ralgps1 Ral GEF with PH domain and SH3 binding motif 1 JBrowse link 3 12,182,722 12,415,081 RGD:1624291
G Ralgps2 Ral GEF with PH domain and SH3 binding motif 2 JBrowse link 13 74,446,001 74,520,640 RGD:1600115
G Rgl2 ral guanine nucleotide dissociation stimulator-like 2 JBrowse link 20 5,458,509 5,466,853 RGD:1624291
regulation of Rap protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cbl Cbl proto-oncogene JBrowse link 8 48,481,256 48,564,775 RGD:1624291
G Kif14 kinesin family member 14 JBrowse link 13 53,350,073 53,421,992 RGD:1624291
G Timp2 TIMP metallopeptidase inhibitor 2 JBrowse link 10 107,338,465 107,386,072 RGD:1598578
regulation of Ras protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxm1 forkhead box M1 JBrowse link 4 161,685,236 161,697,633 RGD:1624291
RGD:1600115
G Icmt isoprenylcysteine carboxyl methyltransferase JBrowse link 5 169,475,270 169,482,031 RGD:1624291
G Plce1 phospholipase C, epsilon 1 JBrowse link 1 257,156,023 257,465,440 RGD:1600115
RGD:1624291
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 JBrowse link 8 97,277,250 97,405,095 RGD:1624291
RGD:8554560
G Sh2b2 SH2B adaptor protein 2 JBrowse link 12 23,471,477 23,501,043 RGD:68805
regulation of Rho protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07007642.1 RGD:1600115
G Arhgap20 Rho GTPase activating protein 20 JBrowse link 8 56,179,581 56,264,343 RGD:1304008
G Arhgap4 Rho GTPase activating protein 4 JBrowse link X 156,873,094 156,888,762 RGD:632235
G Arhgdia Rho GDP dissociation inhibitor alpha JBrowse link 10 109,754,012 109,757,506 RGD:1624291
G Arhgdib Rho GDP dissociation inhibitor beta JBrowse link 4 170,913,920 170,932,789 RGD:1624291
G Arhgef10 Rho guanine nucleotide exchange factor 10 JBrowse link 16 79,725,629 79,817,065 RGD:1600115
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 JBrowse link 2 187,964,100 188,022,847 RGD:1624291
G Arhgef25 Rho guanine nucleotide exchange factor 25 JBrowse link 7 70,469,304 70,476,633 RGD:1600115
G Bcr BCR activator of RhoGEF and GTPase JBrowse link 20 14,421,250 14,546,406 RGD:1624291
G Cavin4 caveolae associated protein 4 JBrowse link 5 64,413,005 64,420,849 RGD:1600115
G Cdc42se1 CDC42 small effector 1 JBrowse link 2 196,402,837 196,410,664 RGD:1600115
G Cdc42se2 CDC42 small effector 2 JBrowse link 10 40,054,393 40,122,915 RGD:1600115
G Cdh2 cadherin 2 JBrowse link 18 8,146,971 8,366,037 RGD:1582675
G Dlc1 DLC1 Rho GTPase activating protein JBrowse link 16 58,776,489 59,247,752 RGD:1600115
G Eps8 epidermal growth factor receptor pathway substrate 8 JBrowse link 4 171,475,155 171,645,620 RGD:13792537
G Eps8l1 EPS8-like 1 JBrowse link 1 72,926,106 72,942,433 RGD:1624291
RGD:13792537
G Eps8l2 EPS8-like 2 JBrowse link 1 214,327,992 214,353,466 RGD:1624291
RGD:13792537
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:1624291
G Kalrn kalirin, RhoGEF kinase JBrowse link 11 69,484,293 70,025,682 RGD:1600115
G Kank1 KN motif and ankyrin repeat domains 1 JBrowse link 1 243,201,073 243,398,531 RGD:1624291
G Kank2 KN motif and ankyrin repeat domains 2 JBrowse link 8 22,792,000 22,821,459 RGD:1600115
RGD:1624291
G LOC100362023 CDC42 small effector 2-like JBrowse link 1 94,988,080 94,988,860 RGD:1600115
G Myo9b myosin IXb JBrowse link 16 19,669,373 19,754,065 RGD:1600115
RGD:1624291
G Ophn1 oligophrenin 1 JBrowse link X 68,185,865 68,579,518 RGD:1624291
G Pdcd10 programmed cell death 10 JBrowse link 2 173,966,701 174,012,730 RGD:1624291
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 JBrowse link 8 97,277,250 97,405,095 RGD:1600115
G Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 JBrowse link 2 21,460,041 21,698,937 RGD:1600115
regulation of small GTPase mediated signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amot angiomotin JBrowse link X 116,751,231 116,810,238 RGD:1624291
G Arhgap18 Rho GTPase activating protein 18 JBrowse link 1 19,227,115 19,463,139 RGD:1624291
RGD:13792537
G Arhgap19 Rho GTPase activating protein 19 JBrowse link 1 261,015,083 261,051,515 RGD:13792537
G Arhgap26 Rho GTPase activating protein 26 JBrowse link 18 31,807,052 32,557,176 RGD:1600115
G Arhgap28 Rho GTPase activating protein 28 JBrowse link 9 116,057,229 116,222,440 RGD:13792537
G Arhgap40 Rho GTPase activating protein 40 JBrowse link 3 154,996,685 155,042,199 RGD:13792537
G Cdc42bpa CDC42 binding protein kinase alpha JBrowse link 13 98,231,326 98,447,762 RGD:632451
G Chn1 chimerin 1 JBrowse link 3 60,512,360 60,668,413 RGD:1600115
G Chn2 chimerin 2 JBrowse link 4 84,423,708 84,452,989 RGD:1600115
G Garnl3 GTPase activating Rap/RanGAP domain-like 3 JBrowse link 3 12,034,131 12,176,591 RGD:1600115
G Iqsec3 IQ motif and Sec7 domain ArfGEF 3 JBrowse link 4 153,948,052 154,044,493 RGD:8554231
G Ralgapa1 Ral GTPase activating protein catalytic subunit alpha 1 JBrowse link 6 76,386,971 76,661,530 RGD:1600115
G Ralgapa2 Ral GTPase activating protein catalytic subunit alpha 2 JBrowse link 3 140,451,850 140,728,305 RGD:1600115
G Ralgapb Ral GTPase activating protein non-catalytic subunit beta JBrowse link 3 154,910,291 154,983,021 RGD:1600115
G Rap1gap Rap1 GTPase-activating protein JBrowse link 5 156,008,868 156,074,350 RGD:1600115
G Rap1gap2 RAP1 GTPase activating protein 2 JBrowse link 10 61,177,936 61,395,856 RGD:1600115
G Sipa1 signal-induced proliferation-associated 1 JBrowse link 1 221,006,305 221,018,820 RGD:1600115
G Sipa1l1 signal-induced proliferation-associated 1 like 1 JBrowse link 6 106,052,212 106,163,249 RGD:1600115
G Sipa1l2 signal-induced proliferation-associated 1 like 2 JBrowse link 19 58,236,201 58,399,842 RGD:1600115
G Sipa1l3 signal-induced proliferation-associated 1 like 3 JBrowse link 1 87,260,832 87,467,846 RGD:1600115
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:1600115
G Tsc2_v1 TSC complex subunit 2, variant 1 RGD:1600115
G Tsc2_v2 TSC complex subunit 2, variant 2 RGD:1600115
Rho protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrg1 adhesion G protein-coupled receptor G1 JBrowse link 19 10,423,534 10,460,674 RGD:1600115
RGD:1624291
G Adrb1 adrenoceptor beta 1 JBrowse link 1 277,537,585 277,538,985 RGD:5129131
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1624291
G Arhgdia Rho GDP dissociation inhibitor alpha JBrowse link 10 109,754,012 109,757,506 RGD:1624291
RGD:13792537
G Arhgdib Rho GDP dissociation inhibitor beta JBrowse link 4 170,913,920 170,932,789 RGD:13792537
G Arhgef11 Rho guanine nucleotide exchange factor 11 JBrowse link 2 186,979,850 187,102,523 RGD:1600115
RGD:1624291
G Arhgef12 Rho guanine nucleotide exchange factor 12 JBrowse link 8 47,259,377 47,393,042 RGD:1600115
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:1624291
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:13792537
G Cdc42ep1 CDC42 effector protein 1 JBrowse link 7 120,063,256 120,071,154 RGD:1624291
RGD:13792537
G Cdc42ep2 CDC42 effector protein 2 JBrowse link 1 221,272,349 221,281,252 RGD:13792537
G Cdc42ep3 CDC42 effector protein 3 JBrowse link 6 1,922,500 1,942,972 RGD:13792537
G Cdc42ep4 CDC42 effector protein 4 JBrowse link 10 102,244,680 102,269,272 RGD:1624291
RGD:13792537
G Cdc42ep5 CDC42 effector protein 5 JBrowse link 1 73,717,207 73,719,600 RGD:1624291
RGD:13792537
G Cdh13 cadherin 13 JBrowse link 19 50,848,793 51,971,618 RGD:1624291
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 JBrowse link 7 126,774,010 126,914,085 RGD:1624291
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 1 263,848,829 263,884,354 RGD:2298665
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 JBrowse link 5 152,447,348 152,458,005 RGD:1624291
G Col1a2 collagen type I alpha 2 chain JBrowse link 4 31,534,225 31,569,152 RGD:1624291
G Ctnnal1 catenin alpha-like 1 JBrowse link 5 73,561,249 73,621,070 RGD:1624291
G Ednra endothelin receptor type A JBrowse link 19 33,928,356 33,991,703 RGD:4892323
G Eps8 epidermal growth factor receptor pathway substrate 8 JBrowse link 4 171,475,155 171,645,620 RGD:13792537
G Eps8l1 EPS8-like 1 JBrowse link 1 72,926,106 72,942,433 RGD:1624291
RGD:13792537
G Eps8l2 EPS8-like 2 JBrowse link 1 214,327,992 214,353,466 RGD:1624291
RGD:13792537
G Gna12 G protein subunit alpha 12 JBrowse link 12 15,890,202 15,971,212 RGD:1624291
RGD:13792537
G Gna13 G protein subunit alpha 13 JBrowse link 10 97,647,196 97,680,030 RGD:1624291
RGD:13792537
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 JBrowse link 8 70,471,572 70,509,874 RGD:1624291
G Kalrn kalirin, RhoGEF kinase JBrowse link 11 69,484,293 70,025,682 RGD:1624291
G LOC103692165 rhotekin JBrowse link 4 113,967,384 113,984,636 RGD:1600115
G LOC691418 hypothetical protein LOC691418 JBrowse link 3 110,980,265 110,983,932 RGD:13792537
G Mcf2l MCF.2 cell line derived transforming sequence-like JBrowse link 16 81,839,686 81,986,007 RGD:1624291
G Myo9b myosin IXb JBrowse link 16 19,669,373 19,754,065 RGD:633447
RGD:1600115
RGD:1624291
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:1600115
RGD:13792537
RGD:1624291
G Nradd neurotrophin receptor associated death domain JBrowse link 8 118,890,402 118,893,712 RGD:13792537
G Pdpn podoplanin JBrowse link 5 161,947,137 161,981,441 RGD:1624291
RGD:1600115
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link 10 94,850,971 94,913,202 RGD:1624291
G Phactr4 phosphatase and actin regulator 4 JBrowse link 5 150,533,895 150,609,423 RGD:1624291
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:1601516
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:13792537
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:13792537
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:5688281
RGD:13792537
RGD:1624291
RGD:1600115
G Rhob ras homolog family member B JBrowse link 6 33,689,127 33,691,301 RGD:13792537
G Rhobtb1 Rho-related BTB domain containing 1 JBrowse link 20 20,638,579 20,715,437 RGD:13792537
G Rhobtb2 Rho-related BTB domain containing 2 JBrowse link 15 51,465,148 51,485,562 RGD:13792537
G Rhobtb3 Rho-related BTB domain containing 3 JBrowse link 2 2,627,655 2,683,305 RGD:13792537
G Rhoc ras homolog family member C JBrowse link 2 207,271,692 207,278,010 RGD:13792537
G Rhod ras homolog family member D JBrowse link 1 219,668,352 219,682,287 RGD:13792537
G Rhof ras homolog family member F, filopodia associated JBrowse link 12 38,879,763 38,894,095 RGD:13792537
G Rhog ras homolog family member G JBrowse link 1 167,336,147 167,347,720 RGD:1624291
RGD:13792537
G Rhoh ras homolog family member H JBrowse link 14 43,961,756 43,992,587 RGD:13792537
G Rhoj ras homolog family member J JBrowse link 6 98,284,361 98,367,122 RGD:1624291
RGD:13792537
G Rhoq ras homolog family member Q JBrowse link 6 10,533,151 10,568,582 RGD:13792537
G Rhot1 ras homolog family member T1 JBrowse link 10 67,559,277 67,640,622 RGD:13792537
G Rhot2 ras homolog family member T2 JBrowse link 10 15,205,943 15,211,739 RGD:13792537
G Rhou ras homolog family member U RGD:13792537
G Rhov ras homolog family member V JBrowse link 3 111,078,642 111,087,347 RGD:13792537
G Ripor1 RHO family interacting cell polarization regulator 1 JBrowse link 19 37,555,940 37,584,842 RGD:1600115
RGD:1624291
G Rnd1 Rho family GTPase 1 JBrowse link 7 140,349,138 140,356,209 RGD:13792537
G Rnd2 Rho family GTPase 2 JBrowse link 10 89,376,530 89,380,101 RGD:13792537
G Rnd3 Rho family GTPase 3 JBrowse link 3 36,643,374 36,660,727 RGD:13792537
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:8554725
RGD:1600115
RGD:13792537
RGD:1624291
G Rock2 Rho-associated coiled-coil containing protein kinase 2 JBrowse link 6 42,180,864 42,289,910 RGD:8554725
RGD:1600115
RGD:13792537
G RSA-14-44 RSA-14-44 protein JBrowse link 4 96,831,880 96,833,252 RGD:13792537
G Rtkn rhotekin JBrowse link 4 114,833,453 114,850,705 RGD:1624291
RGD:1600115
G Srgap1 SLIT-ROBO Rho GTPase activating protein 1 JBrowse link 7 63,968,915 64,251,449 RGD:1624291
G Synj2bp synaptojanin 2 binding protein JBrowse link 6 105,224,166 105,261,549 RGD:1624291
G Tax1bp3 Tax1 binding protein 3 JBrowse link 10 59,743,356 59,748,063 RGD:1624291
RGD:13792537
RGD:1600115
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Was WASP actin nucleation promoting factor JBrowse link X 15,155,246 15,164,099 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19336
    signaling 7456
      signal transduction 6872
        intracellular signal transduction 2584
          small GTPase mediated signal transduction 479
            Ras protein signal transduction + 388
            negative regulation of small GTPase mediated signal transduction + 64
            positive regulation of floral organ abscission by small GTPase mediated signal transduction 0
            positive regulation of small GTPase mediated signal transduction + 73
            regulation of small GTPase mediated signal transduction + 227
            regulation of vesicle-mediated transport involved in floral organ abscission by small GTPase mediated signal transduction 0
Path 2
Term Annotations click to browse term
  biological_process 19336
    biological regulation 13340
      regulation of biological process 12655
        regulation of cellular process 11995
          signal transduction 6872
            intracellular signal transduction 2584
              small GTPase mediated signal transduction 479
                Ras protein signal transduction + 388
                negative regulation of small GTPase mediated signal transduction + 64
                positive regulation of floral organ abscission by small GTPase mediated signal transduction 0
                positive regulation of small GTPase mediated signal transduction + 73
                regulation of small GTPase mediated signal transduction + 227
                regulation of vesicle-mediated transport involved in floral organ abscission by small GTPase mediated signal transduction 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.