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ONTOLOGY REPORT - ANNOTATIONS


Term:Rho protein signal transduction
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Accession:GO:0007266 term browser browse the term
Definition:A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state.
Synonyms:exact_synonym: Rho mediated signal transduction


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Rho protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrg1 adhesion G protein-coupled receptor G1 JBrowse link 19 10,423,534 10,460,674 RGD:1600115
RGD:1624291
G Adrb1 adrenoceptor beta 1 JBrowse link 1 277,537,585 277,538,985 RGD:5129131
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:1624291
G Arhgdia Rho GDP dissociation inhibitor alpha JBrowse link 10 109,754,012 109,757,506 RGD:1624291
RGD:13792537
G Arhgdib Rho GDP dissociation inhibitor beta JBrowse link 4 170,913,920 170,932,789 RGD:13792537
G Arhgef11 Rho guanine nucleotide exchange factor 11 JBrowse link 2 186,979,850 187,102,523 RGD:1600115
RGD:1624291
G Arhgef12 Rho guanine nucleotide exchange factor 12 JBrowse link 8 47,259,377 47,393,042 RGD:1600115
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:1624291
G Cdc42ep1 CDC42 effector protein 1 JBrowse link 7 120,063,256 120,071,154 RGD:1624291
RGD:13792537
G Cdc42ep2 CDC42 effector protein 2 JBrowse link 1 221,272,349 221,281,252 RGD:13792537
G Cdc42ep3 CDC42 effector protein 3 JBrowse link 6 1,922,500 1,942,972 RGD:13792537
G Cdc42ep4 CDC42 effector protein 4 JBrowse link 10 102,244,680 102,269,272 RGD:1624291
RGD:13792537
G Cdc42ep5 CDC42 effector protein 5 JBrowse link 1 73,717,207 73,719,600 RGD:1624291
RGD:13792537
G Cdh13 cadherin 13 JBrowse link 19 50,848,793 51,971,618 RGD:1624291
G Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 JBrowse link 7 126,774,010 126,914,085 RGD:1624291
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 1 263,848,829 263,884,354 RGD:2298665
G Cnksr1 connector enhancer of kinase suppressor of Ras 1 JBrowse link 5 152,447,348 152,458,005 RGD:1624291
G Col1a2 collagen type I alpha 2 chain JBrowse link 4 31,534,225 31,569,152 RGD:1624291
G Ctnnal1 catenin alpha-like 1 JBrowse link 5 73,561,249 73,621,070 RGD:1624291
G Ednra endothelin receptor type A JBrowse link 19 33,928,356 33,991,703 RGD:4892323
G Eps8 epidermal growth factor receptor pathway substrate 8 JBrowse link 4 171,475,155 171,645,620 RGD:13792537
G Eps8l1 EPS8-like 1 JBrowse link 1 72,926,106 72,942,433 RGD:1624291
RGD:13792537
G Eps8l2 EPS8-like 2 JBrowse link 1 214,327,992 214,353,466 RGD:1624291
RGD:13792537
G Eps8l3 EPS8 like 3 JBrowse link 2 210,668,249 210,681,930 RGD:13792537
G Gna12 G protein subunit alpha 12 JBrowse link 12 15,890,202 15,971,212 RGD:1624291
RGD:13792537
G Gna13 G protein subunit alpha 13 JBrowse link 10 97,647,196 97,680,030 RGD:1624291
RGD:13792537
G Hacd3 3-hydroxyacyl-CoA dehydratase 3 JBrowse link 8 70,471,572 70,509,874 RGD:1624291
G Kalrn kalirin, RhoGEF kinase JBrowse link 11 69,484,293 70,025,682 RGD:1624291
G LOC103692165 rhotekin JBrowse link 4 113,967,384 113,984,636 RGD:1600115
G LOC691418 hypothetical protein LOC691418 JBrowse link 3 110,980,265 110,983,932 RGD:13792537
G Mcf2l MCF.2 cell line derived transforming sequence-like JBrowse link 16 81,839,686 81,986,007 RGD:1624291
G Myo9b myosin IXb JBrowse link 16 19,669,373 19,754,065 RGD:633447
RGD:1600115
RGD:1624291
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:1600115
RGD:13792537
RGD:1624291
G Nradd neurotrophin receptor associated death domain JBrowse link 8 118,890,402 118,893,712 RGD:13792537
G Pdpn podoplanin JBrowse link 5 161,947,137 161,981,441 RGD:1624291
RGD:13792537
RGD:1600115
G Pecam1 platelet and endothelial cell adhesion molecule 1 JBrowse link 10 94,850,971 94,913,202 RGD:1624291
G Phactr4 phosphatase and actin regulator 4 JBrowse link 5 150,533,895 150,609,423 RGD:1624291
G Pth parathyroid hormone JBrowse link 1 178,215,829 178,218,761 RGD:1601516
G Rhoa ras homolog family member A JBrowse link 8 117,082,440 117,116,244 RGD:5688281
RGD:1624291
RGD:1600115
G Rhog ras homolog family member G JBrowse link 1 167,336,147 167,347,720 RGD:1624291
G Rhoj ras homolog family member J JBrowse link 6 98,284,361 98,367,122 RGD:1624291
G Ripor1 RHO family interacting cell polarization regulator 1 JBrowse link 19 37,555,940 37,584,842 RGD:1600115
RGD:1624291
G Rock1 Rho-associated coiled-coil containing protein kinase 1 JBrowse link 18 1,273,490 1,390,790 RGD:8554725
RGD:1600115
RGD:13792537
RGD:1624291
G Rock2 Rho-associated coiled-coil containing protein kinase 2 JBrowse link 6 42,180,864 42,289,910 RGD:8554725
RGD:1600115
RGD:13792537
G Rtkn rhotekin JBrowse link 4 114,833,453 114,850,705 RGD:1624291
RGD:1600115
G Srgap1 SLIT-ROBO Rho GTPase activating protein 1 JBrowse link 7 63,968,915 64,251,449 RGD:1624291
G Synj2bp synaptojanin 2 binding protein JBrowse link 6 105,224,166 105,261,549 RGD:1624291
G Tax1bp3 Tax1 binding protein 3 JBrowse link 10 59,743,356 59,748,063 RGD:1624291
RGD:13792537
RGD:1600115
G Vangl2 VANGL planar cell polarity protein 2 JBrowse link 13 90,379,203 90,405,627 RGD:1624291
G Was WASP actin nucleation promoting factor JBrowse link X 15,155,246 15,164,099 RGD:1624291
Cdc42 protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:5688281
RGD:13792537
G Ntn1 netrin 1 JBrowse link 10 54,761,925 54,982,072 RGD:10054078
G Rhoj ras homolog family member J JBrowse link 6 98,284,361 98,367,122 RGD:13792537
G Rhou ras homolog family member U RGD:13792537
G Rhov ras homolog family member V JBrowse link 3 111,078,642 111,087,347 RGD:13792537
G Shtn1 shootin 1 JBrowse link 1 280,129,228 280,233,873 RGD:10054078
G Was WASP actin nucleation promoting factor JBrowse link X 15,155,246 15,164,099 RGD:1624291
negative regulation of Rho protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl2 ABL proto-oncogene 2, non-receptor tyrosine kinase JBrowse link 13 74,154,533 74,333,244 RGD:1624291
G Adra1a adrenoceptor alpha 1A JBrowse link 15 43,296,997 43,398,314 RGD:8554725
G Adra1b adrenoceptor alpha 1B JBrowse link 10 29,392,762 29,450,644 RGD:8554725
G Arap3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 JBrowse link 18 31,112,083 31,138,142 RGD:1624291
G Arhgap35 Rho GTPase activating protein 35 JBrowse link 1 78,456,409 78,573,374 RGD:1600115
RGD:1624291
G Arhgap42 Rho GTPase activating protein 42 JBrowse link 8 7,210,999 7,446,215 RGD:1624291
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:1624291
G Ccdc125 coiled-coil domain containing 125 JBrowse link 2 30,685,845 30,726,617 RGD:1624291
RGD:13792537
G Cul3 cullin 3 JBrowse link 9 86,044,485 86,129,066 RGD:1600115
RGD:1624291
G Dlc1 DLC1 Rho GTPase activating protein JBrowse link 16 58,776,489 59,247,752 RGD:1600115
RGD:1624291
G Flcn folliculin JBrowse link 10 46,153,185 46,172,331 RGD:1624291
RGD:1600115
G Heg1 heart development protein with EGF-like domains 1 JBrowse link 11 70,234,248 70,322,966 RGD:1624291
G Itga3 integrin subunit alpha 3 JBrowse link 10 82,855,841 82,887,755 RGD:1624291
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:1624291
RGD:1600115
G Kank1 KN motif and ankyrin repeat domains 1 JBrowse link 1 243,201,073 243,398,531 RGD:1624291
G Kctd10 potassium channel tetramerization domain containing 10 JBrowse link 12 47,992,079 48,010,531 RGD:13792537
G Kctd13 potassium channel tetramerization domain containing 13 JBrowse link 1 198,360,627 198,378,935 RGD:1624291
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:1600115
RGD:1624291
G Myoc myocilin JBrowse link 13 80,517,531 80,527,928 RGD:1600115
RGD:1624291
G Rasip1 Ras interacting protein 1 JBrowse link 1 101,609,209 101,621,648 RGD:1624291
G Ripor1 RHO family interacting cell polarization regulator 1 JBrowse link 19 37,555,940 37,584,842 RGD:1624291
G Ripor2 RHO family interacting cell polarization regulator 2 JBrowse link 17 42,324,594 42,549,907 RGD:1624291
RGD:1600115
G Scai suppressor of cancer cell invasion JBrowse link 3 23,357,586 23,474,218 RGD:1624291
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:1624291
G Tnfaip1 TNF alpha induced protein 1 JBrowse link 10 65,791,002 65,805,693 RGD:1624291
RGD:13792537
RGD:1600115
positive regulation of Rho protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abra actin-binding Rho activating protein JBrowse link 7 80,792,615 80,796,683 RGD:1624291
RGD:13792537
RGD:1600115
G Adgrg1 adhesion G protein-coupled receptor G1 JBrowse link 19 10,423,534 10,460,674 RGD:1600115
RGD:1624291
G Akap13 A-kinase anchoring protein 13 JBrowse link 1 137,089,558 137,315,272 RGD:1600115
RGD:1624291
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
G Arhgef3 Rho guanine nucleotide exchange factor 3 JBrowse link 16 2,743,714 3,026,768 RGD:13792537
G Arrb1 arrestin, beta 1 JBrowse link 1 164,502,099 164,573,947 RGD:1624291
G Col3a1 collagen type III alpha 1 chain JBrowse link 9 52,023,295 52,059,221 RGD:1624291
RGD:1600115
G F11r F11 receptor JBrowse link 13 89,826,272 89,850,151 RGD:1624291
G F2r coagulation factor II (thrombin) receptor JBrowse link 2 26,118,760 26,135,340 RGD:1624291
RGD:1600115
RGD:13792537
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
RGD:13792537
RGD:1600115
G F2rl2 coagulation factor II (thrombin) receptor-like 2 JBrowse link 2 26,240,385 26,245,533 RGD:13792537
G F2rl3 F2R like thrombin or trypsin receptor 3 JBrowse link 16 18,817,797 18,819,790 RGD:13792537
G Gpr17 G protein-coupled receptor 17 JBrowse link 18 24,733,306 24,739,194 RGD:13792537
G Gpr174 G protein-coupled receptor 174 JBrowse link X 78,358,347 78,399,944 RGD:13792537
G Gpr18 G protein-coupled receptor 18 JBrowse link 15 108,323,157 108,326,907 RGD:13792537
G Gpr35 G protein-coupled receptor 35 JBrowse link 9 100,129,428 100,141,269 RGD:13792537
G Gpr4 G protein-coupled receptor 4 JBrowse link 1 80,125,639 80,136,786 RGD:13792537
RGD:1624291
G Gpr55 G protein-coupled receptor 55 JBrowse link 9 92,961,431 93,011,157 RGD:1624291
RGD:13792537
G Gpr65 G-protein coupled receptor 65 JBrowse link 6 122,248,528 122,256,115 RGD:13792537
G LOC100359656 rCG38062-like JBrowse link X 77,786,566 77,810,066 RGD:13792537
G Lpar1 lysophosphatidic acid receptor 1 JBrowse link 5 75,557,038 75,678,067 RGD:1600115
RGD:1624291
G Lpar2 lysophosphatidic acid receptor 2 JBrowse link 16 21,343,313 21,348,913 RGD:1624291
G Lpar4 lysophosphatidic acid receptor 4 JBrowse link X 78,042,859 78,056,347 RGD:13792537
G Lpar6 lysophosphatidic acid receptor 6 JBrowse link 15 55,126,953 55,128,762 RGD:13792537
G Mcf2l MCF.2 cell line derived transforming sequence-like JBrowse link 16 81,839,686 81,986,007 RGD:729022
RGD:1624291
G Net1 neuroepithelial cell transforming 1 JBrowse link 17 69,991,786 70,020,977 RGD:13792537
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:5508741
G P2ry10 P2Y receptor family member 10 JBrowse link X 78,158,729 78,210,413 RGD:13792537
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:10449505
G Prag1 PEAK1 related kinase activating pseudokinase 1 JBrowse link 16 59,666,794 59,730,681 RGD:11555369
G RGD1560455 similar to RIKEN cDNA A630033H20 gene JBrowse link X 78,258,495 78,284,180 RGD:13792537
G Robo1 roundabout guidance receptor 1 JBrowse link 11 9,079,291 10,146,302 RGD:1600115
RGD:1624291
G Rtn4r reticulon 4 receptor JBrowse link 11 86,992,665 87,017,091 RGD:1624291
RGD:1600115
G Synpo2l synaptopodin 2-like JBrowse link 15 4,064,706 4,074,151 RGD:1624291
regulation of Cdc42 protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:1624291
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:1624291
RGD:1600115
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
RGD:1600115
G Nrp1 neuropilin 1 JBrowse link 19 61,332,351 61,486,166 RGD:1624291
G Rit2 Ras-like without CAAX 2 JBrowse link 18 23,700,012 24,057,917 RGD:1624291
regulation of Rho protein signal transduction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07007642.1 RGD:1600115
G Akap13 A-kinase anchoring protein 13 JBrowse link 1 137,089,558 137,315,272 RGD:13792537
G Arhgap20 Rho GTPase activating protein 20 JBrowse link 8 56,179,581 56,264,343 RGD:1304008
G Arhgap4 Rho GTPase activating protein 4 JBrowse link X 156,873,094 156,888,762 RGD:632235
G Arhgdia Rho GDP dissociation inhibitor alpha JBrowse link 10 109,754,012 109,757,506 RGD:1624291
G Arhgdib Rho GDP dissociation inhibitor beta JBrowse link 4 170,913,920 170,932,789 RGD:1624291
G Arhgef10 Rho guanine nucleotide exchange factor 10 JBrowse link 16 79,725,629 79,817,065 RGD:1600115
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 JBrowse link 2 187,964,100 188,022,847 RGD:1624291
RGD:13792537
G Arhgef25 Rho guanine nucleotide exchange factor 25 JBrowse link 7 70,469,304 70,476,633 RGD:1600115
G Arhgef28 Rho guanine nucleotide exchange factor 28 JBrowse link 2 25,738,514 26,011,429 RGD:13792537
G Bcr BCR activator of RhoGEF and GTPase JBrowse link 20 14,421,250 14,546,406 RGD:1624291
G Cavin4 caveolae associated protein 4 JBrowse link 5 64,413,005 64,420,849 RGD:1600115
G Cdc42se1 CDC42 small effector 1 JBrowse link 2 196,402,837 196,410,664 RGD:1600115
G Cdc42se2 CDC42 small effector 2 JBrowse link 10 40,054,393 40,122,915 RGD:1600115
G Cdh2 cadherin 2 JBrowse link 18 8,146,971 8,366,037 RGD:1582675
G Dlc1 DLC1 Rho GTPase activating protein JBrowse link 16 58,776,489 59,247,752 RGD:1600115
RGD:13792537
G Eps8 epidermal growth factor receptor pathway substrate 8 JBrowse link 4 171,475,155 171,645,620 RGD:13792537
G Eps8l1 EPS8-like 1 JBrowse link 1 72,926,106 72,942,433 RGD:1624291
RGD:13792537
G Eps8l2 EPS8-like 2 JBrowse link 1 214,327,992 214,353,466 RGD:1624291
RGD:13792537
G Eps8l3 EPS8 like 3 JBrowse link 2 210,668,249 210,681,930 RGD:13792537
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:1624291
G Kalrn kalirin, RhoGEF kinase JBrowse link 11 69,484,293 70,025,682 RGD:1600115
G Kank1 KN motif and ankyrin repeat domains 1 JBrowse link 1 243,201,073 243,398,531 RGD:1624291
G Kank2 KN motif and ankyrin repeat domains 2 JBrowse link 8 22,792,000 22,821,459 RGD:1600115
RGD:1624291
G LOC100362023 CDC42 small effector 2-like JBrowse link 1 94,988,080 94,988,860 RGD:1600115
G Myo9b myosin IXb JBrowse link 16 19,669,373 19,754,065 RGD:1600115
RGD:1624291
G Ophn1 oligophrenin 1 JBrowse link X 68,185,865 68,579,518 RGD:1624291
G Pdcd10 programmed cell death 10 JBrowse link 2 173,966,701 174,012,730 RGD:1624291
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 JBrowse link 8 97,277,250 97,405,095 RGD:1600115
G Rasgrf2 RAS protein-specific guanine nucleotide-releasing factor 2 JBrowse link 2 21,460,041 21,698,937 RGD:1600115
G Stard13 StAR-related lipid transfer domain containing 13 JBrowse link 12 1,023,494 1,418,919 RGD:13792537
G Stard8 StAR-related lipid transfer domain containing 8 JBrowse link X 68,713,157 68,785,046 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    signaling 7553
      signal transduction 6968
        intracellular signal transduction 2597
          small GTPase mediated signal transduction 436
            Ras protein signal transduction 333
              Rho protein signal transduction 136
                Cdc42 protein signal transduction + 14
                negative regulation of Rho protein signal transduction 25
                positive regulation of Rho protein signal transduction 34
                regulation of Rho protein signal transduction + 94
Path 2
Term Annotations click to browse term
  biological_process 19858
    biological regulation 13636
      regulation of biological process 12959
        regulation of cellular process 12442
          signal transduction 6968
            intracellular signal transduction 2597
              small GTPase mediated signal transduction 436
                Ras protein signal transduction 333
                  Rho protein signal transduction 136
                    Cdc42 protein signal transduction + 14
                    negative regulation of Rho protein signal transduction 25
                    positive regulation of Rho protein signal transduction 34
                    regulation of Rho protein signal transduction + 94
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.