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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, cholinergic
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Accession:GO:0007271 term browser browse the term
Definition:The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.


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synaptic transmission, cholinergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora2a adenosine A2a receptor JBrowse link 20 14,265,251 14,282,873 RGD:1625662
G Chrm3 cholinergic receptor, muscarinic 3 JBrowse link 17 63,990,599 64,463,222 RGD:1624291
RGD:1600115
G Chrna1 cholinergic receptor nicotinic alpha 1 subunit JBrowse link 3 60,445,657 60,460,724 RGD:13792537
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit JBrowse link 1 167,206,722 167,212,199 RGD:632442
RGD:1624291
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit JBrowse link 8 59,594,007 59,607,122 RGD:1624291
RGD:13792537
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit JBrowse link 3 176,533,182 176,547,965 RGD:1358635
RGD:13792537
RGD:1624291
RGD:1600115
G Chrna5 cholinergic receptor nicotinic alpha 5 subunit JBrowse link 8 59,561,817 59,590,172 RGD:13792537
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit JBrowse link 16 68,860,018 68,866,718 RGD:13792537
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit JBrowse link 1 123,897,341 124,039,263 RGD:1600975
RGD:13792537
RGD:1600115
RGD:1624291
G Chrnb1 cholinergic receptor nicotinic beta 1 subunit JBrowse link 10 56,390,671 56,403,255 RGD:1624291
RGD:13792537
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit JBrowse link 2 189,088,570 189,096,785 RGD:1358637
RGD:13792537
G Chrnb3 cholinergic receptor nicotinic beta 3 subunit JBrowse link 16 68,876,442 68,913,628 RGD:13792537
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit JBrowse link 8 59,610,489 59,629,073 RGD:13792537
G Chrnd cholinergic receptor nicotinic delta subunit JBrowse link 9 94,286,550 94,294,968 RGD:13792537
G Chrne cholinergic receptor nicotinic epsilon subunit JBrowse link 10 57,238,960 57,246,750 RGD:13792537
G Chrng cholinergic receptor nicotinic gamma subunit JBrowse link 9 94,302,218 94,308,591 RGD:13792537
G Lynx1 Ly6/neurotoxin 1 JBrowse link 7 115,982,877 115,988,121 RGD:1624291
RGD:1600115
G Lypd1 Ly6/Plaur domain containing 1 JBrowse link 13 42,219,884 42,263,024 RGD:1624291
RGD:1600115
G Rapsn receptor-associated protein of the synapse JBrowse link 3 79,859,815 79,869,486 RGD:1624291
RGD:1600115
G Ric3 RIC3 acetylcholine receptor chaperone JBrowse link 1 173,629,218 173,682,226 RGD:2317082
RGD:13792537
G Slc5a7 solute carrier family 5 member 7 JBrowse link 9 5,294,377 5,330,822 RGD:1600115
RGD:13792537
RGD:1624291
acetylcholine catabolic process in synaptic cleft term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ache acetylcholinesterase JBrowse link 12 22,472,358 22,477,052 RGD:12050110
negative regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Htr6 5-hydroxytryptamine receptor 6 JBrowse link 5 157,501,202 157,518,870 RGD:2317005
positive regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora2a adenosine A2a receptor JBrowse link 20 14,265,251 14,282,873 RGD:1625693
G Htr2c 5-hydroxytryptamine receptor 2C JBrowse link X 118,084,520 118,318,040 RGD:1625007
G Tacr2 tachykinin receptor 2 JBrowse link 20 31,892,515 31,905,153 RGD:5147477
positive regulation of synaptic transmission, cholinergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:2311499
G Lama2 laminin subunit alpha 2 JBrowse link 1 18,491,264 19,143,486 RGD:1624291
RGD:1600115
G Musk muscle associated receptor tyrosine kinase JBrowse link 5 75,392,790 75,498,694 RGD:2317092
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:5508750
G Tac1 tachykinin, precursor 1 JBrowse link 4 33,638,853 33,646,819 RGD:2304335
G Tacr1 tachykinin receptor 1 JBrowse link 4 113,247,236 113,416,139 RGD:2304335
G Uts2 urotensin 2 JBrowse link 5 168,078,748 168,084,133 RGD:2306844
regulation of acetylcholine secretion, neurotransmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:1600115
RGD:1624291
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit JBrowse link 8 59,594,007 59,607,122 RGD:1624291
regulation of synaptic transmission, cholinergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17883
    signaling 7034
      cell-cell signaling 1595
        synaptic signaling 866
          trans-synaptic signaling 857
            anterograde trans-synaptic signaling 848
              chemical synaptic transmission 848
                synaptic transmission, cholinergic 34
                  acetylcholine catabolic process in synaptic cleft 1
                  acetylcholine secretion, neurotransmission + 6
                  negative regulation of synaptic transmission, cholinergic + 1
                  positive regulation of synaptic transmission, cholinergic + 10
                  regulation of synaptic transmission, cholinergic + 14
Path 2
Term Annotations click to browse term
  biological_process 17883
    cellular process 16025
      cell communication 7127
        cell-cell signaling 1595
          synaptic signaling 866
            trans-synaptic signaling 857
              anterograde trans-synaptic signaling 848
                chemical synaptic transmission 848
                  synaptic transmission, cholinergic 34
                    acetylcholine catabolic process in synaptic cleft 1
                    acetylcholine secretion, neurotransmission + 6
                    negative regulation of synaptic transmission, cholinergic + 1
                    positive regulation of synaptic transmission, cholinergic + 10
                    regulation of synaptic transmission, cholinergic + 14
paths to the root