Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:acrosome reaction
go back to main search page
Accession:GO:0007340 term browser browse the term
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
Comment:If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss.
Synonyms:xref: Wikipedia:Acrosome_reaction


show annotations for term's descendants           Sort by:
 
acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase ISO (MGI:MGI:5770160|PMID:26989199) RGD PMID:26989199 MGI:MGI:5770160 NCBI chr 1:140,998,240...141,087,405
Ensembl chr 1:140,998,240...141,087,405
JBrowse link
G Acr acrosin TAS
IBA
ISS
ISO
PMID:12398221
PMID:21873635
GO_REF:0000024
(PMID:2550339)
UniProt
RGD
PMID:2550339, PMID:12398221, PMID:21873635 GO_REF:0000024, RGD:8553887, RGD:13792537 NCBI chr 7:130,541,320...130,548,356
Ensembl chr 7:130,542,202...130,548,356
JBrowse link
G Adcy3 adenylate cyclase 3 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:3576427|PMID:15705663)
Ensembl
UniProt
RGD
PMID:15705663 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3576427 NCBI chr 6:28,570,941...28,648,848
Ensembl chr 6:28,571,351...28,650,148
JBrowse link
G Glra1 glycine receptor, alpha 1 ISO MGI:MGI:1856362 (MGI:MGI:3621686|PMID:11076688) RGD PMID:11076688 MGI:MGI:3621686 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Glrb glycine receptor, beta ISO MGI:MGI:1856363 (MGI:MGI:3621686|PMID:11076688) RGD PMID:11076688 MGI:MGI:3621686 NCBI chr 2:179,768,040...179,842,612
Ensembl chr 2:179,769,009...179,842,547
JBrowse link
G Iftap intraflagellar transport associated protein ISO
IBA
MGI:MGI:4362302 (MGI:MGI:6268817|PMID:30521625)
PMID:21873635
RGD PMID:30521625, PMID:21873635 MGI:MGI:6268817, RGD:13792537 NCBI chr 3:91,086,186...91,195,981
Ensembl chr 3:91,086,186...91,195,981
JBrowse link
G Pcsk4 proprotein convertase subtilisin/kexin type 4 ISO
ISS
IEA
MGI:MGI:2665512 (MGI:MGI:3619873|PMID:16371590)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:16371590 GO_REF:0000024, GO_REF:0000107, MGI:MGI:3619873 NCBI chr 7:12,247,498...12,255,721
Ensembl chr 7:12,247,498...12,255,719
JBrowse link
G Plcd4 phospholipase C, delta 4 ISO
IEA
MGI:MGI:2155167 (MGI:MGI:1934056|PMID:11340203)
GO_REF:0000107
RGD
Ensembl
PMID:11340203 GO_REF:0000107, MGI:MGI:1934056 NCBI chr 9:81,816,395...81,844,364
Ensembl chr 9:81,816,872...81,844,364
JBrowse link
G Prnd prion like protein doppel ISO (MGI:MGI:3045928|PMID:15161660) RGD PMID:15161660 MGI:MGI:3045928 NCBI chr 3:124,543,227...124,548,548
Ensembl chr 3:124,545,364...124,545,900
JBrowse link
G Spesp1 sperm equatorial segment protein 1 ISO
IBA
MGI:MGI:4838302 (MGI:MGI:4452161|PMID:20375058)
PMID:21873635
RGD PMID:20375058, PMID:21873635 MGI:MGI:4452161, RGD:13792537 NCBI chr 8:67,217,801...67,233,172
Ensembl chr 8:67,217,802...67,232,298
JBrowse link
G Stx2 syntaxin 2 IEA
ISO
GO_REF:0000002
(MGI:MGI:3584221|PMID:15774481)
InterPro
RGD
PMID:15774481 GO_REF:0000002, MGI:MGI:3584221 NCBI chr12:31,324,203...31,360,249
Ensembl chr12:31,335,372...31,360,254
JBrowse link
G Syt6 synaptotagmin 6 ISO
IEA
(MGI:MGI:3584221|PMID:15774481)
GO_REF:0000002
RGD
InterPro
PMID:15774481 GO_REF:0000002, MGI:MGI:3584221 NCBI chr 2:206,064,181...206,119,034
Ensembl chr 2:206,064,179...206,127,907
JBrowse link
G Syt8 synaptotagmin 8 ISO
IEA
(MGI:MGI:3584221|PMID:15774481)
GO_REF:0000107
RGD
Ensembl
PMID:15774481 GO_REF:0000107, MGI:MGI:3584221 NCBI chr 1:215,605,408...215,607,602
Ensembl chr 1:215,605,404...215,607,696
JBrowse link
G Tnp2 transition protein 2 ISO
IBA
IEA
MGI:MGI:2180779 (MGI:MGI:2180725|PMID:11385107)
PMID:21873635
GO_REF:0000107
RGD
Ensembl
PMID:11385107, PMID:21873635 GO_REF:0000107, MGI:MGI:2180725, RGD:13792537 NCBI chr10:4,953,898...4,954,626
Ensembl chr10:4,953,879...4,954,624
JBrowse link
G Trim36 tripartite motif-containing 36 ISO (MGI:MGI:2680779|PMID:12917430) RGD PMID:12917430 MGI:MGI:2680779 NCBI chr18:40,081,028...40,134,673
Ensembl chr18:40,082,442...40,134,504
JBrowse link
G Trpc2 transient receptor potential cation channel subfamily C member 2 ISO (MGI:MGI:3045541|PMID:11331878) RGD PMID:11331878 MGI:MGI:3045541 NCBI chr 1:167,180,103...167,192,456
Ensembl chr 1:167,169,442...167,192,801
JBrowse link
acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eqtn equatorin ISO
IBA
(MGI:MGI:5293452|PMID:19285662)
PMID:21873635
RGD PMID:19285662, PMID:21873635 MGI:MGI:5293452, RGD:13792537 NCBI chr 5:113,852,191...113,881,142
Ensembl chr 5:113,871,230...113,880,911
JBrowse link
G Rab3a RAB3A, member RAS oncogene family ISO (PMID:22248876) RGD PMID:22248876 NCBI chr16:20,435,098...20,439,206
Ensembl chr16:20,435,101...20,439,206
JBrowse link
G Rims1 regulating synaptic membrane exocytosis 1 IEA
ISO
GO_REF:0000107
(PMID:22248876)
Ensembl
RGD
PMID:22248876 GO_REF:0000107 NCBI chr 9:28,440,408...28,973,246
Ensembl chr 9:28,442,229...28,973,246
JBrowse link
G Syt6 synaptotagmin 6 ISO (PMID:11437455) RGD PMID:11437455 NCBI chr 2:206,064,181...206,119,034
Ensembl chr 2:206,064,179...206,127,907
JBrowse link
G Unc13b unc-13 homolog B IEA
ISO
GO_REF:0000107
(PMID:22248876)
Ensembl
RGD
PMID:22248876 GO_REF:0000107 NCBI chr 5:58,505,449...58,714,396
Ensembl chr 5:58,505,500...58,715,576
JBrowse link
G Zp4 zona pellucida glycoprotein 4 IEA
ISO
GO_REF:0000107
(PMID:19004505)
Ensembl
RGD
PMID:19004505 GO_REF:0000107 NCBI chr17:65,497,359...65,503,912
Ensembl chr17:65,497,359...65,503,912
JBrowse link
acrosome matrix dispersal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acr acrosin IMP RGD PMID:28859281 RGD:13464336 NCBI chr 7:130,541,320...130,548,356
Ensembl chr 7:130,542,202...130,548,356
JBrowse link
negative regulation of acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spink13 serine peptidase inhibitor Kazal type 13 IMP PMID:23430248 UniProt PMID:23430248 RGD:8553255 NCBI chr18:57,935,271...58,081,096
Ensembl chr18:57,935,271...58,081,096
JBrowse link
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hyal3 hyaluronidase 3 IEA
ISO
ISS
GO_REF:0000107
(MGI:MGI:4834982|PMID:20586096)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:20586096 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4834982 NCBI chr 8:116,336,512...116,342,147
Ensembl chr 8:116,336,512...116,342,146
JBrowse link
G Zp3 zona pellucida glycoprotein 3 ISS
ISO
GO_REF:0000024
(PMID:19004505), (PMID:19246320)
UniProt
RGD
PMID:19004505, PMID:19246320 GO_REF:0000024 NCBI chr12:23,735,225...23,752,734
Ensembl chr12:23,735,223...23,742,190
JBrowse link
positive regulation of acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1h calcium voltage-gated channel subunit alpha1 H ISO
IEA
(PMID:20394732)
GO_REF:0000107
RGD
Ensembl
PMID:20394732 GO_REF:0000107 NCBI chr10:14,730,932...14,789,201
Ensembl chr10:14,730,941...14,788,617
JBrowse link
G Ccdc87 coiled-coil domain containing 87 ISO (MGI:MGI:6201938|PMID:29733332) RGD PMID:29733332 MGI:MGI:6201938 NCBI chr 1:220,096,478...220,099,174
Ensembl chr 1:220,096,422...220,099,611
JBrowse link
G Fam170b family with sequence similarity 170, member B ISO
IBA
(MGI:MGI:5705205|PMID:26179146)
PMID:21873635
RGD PMID:26179146, PMID:21873635 MGI:MGI:5705205, RGD:13792537 NCBI chr16:9,074,044...9,076,885
Ensembl chr16:9,074,033...9,076,865
JBrowse link
G Glra1 glycine receptor, alpha 1 ISO (PMID:11751269) RGD PMID:11751269 NCBI chr10:40,851,955...40,954,364
Ensembl chr10:40,855,559...40,953,651
JBrowse link
G Iqcf1 IQ motif containing F1 ISO
IBA
(MGI:MGI:5708001|PMID:25380116)
PMID:21873635
RGD PMID:25380116, PMID:21873635 MGI:MGI:5708001, RGD:13792537 NCBI chr 8:115,191,919...115,195,599
Ensembl chr 8:115,193,146...115,195,668
JBrowse link
G Pla2g10 phospholipase A2, group X ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:MGI:4459353|PMID:20424324)
UniProt
Ensembl
RGD
PMID:20424324 GO_REF:0000024, GO_REF:0000107, MGI:MGI:4459353 NCBI chr10:1,509,732...1,520,970
Ensembl chr10:1,509,732...1,520,970
JBrowse link
G Plb1 phospholipase B1 ISO (MGI:MGI:5528927|PMID:23943622) RGD PMID:23943622 MGI:MGI:5528927 NCBI chr 6:25,375,699...25,507,108
Ensembl chr 6:25,397,537...25,507,073
JBrowse link
G Plcb1 phospholipase C beta 1 ISO (MGI:MGI:2136696|PMID:11464583) RGD PMID:11464583 MGI:MGI:2136696 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Prss37 serine protease 37 ISO
IBA
(PMID:27649891)
PMID:21873635
RGD PMID:27649891, PMID:21873635 RGD:13792537 NCBI chr 4:68,337,498...68,349,286
Ensembl chr 4:68,337,480...68,349,273
JBrowse link
G Rln1 relaxin 1 ISO (PMID:16926527) RGD PMID:16926527 NCBI chr 1:247,483,298...247,486,331
Ensembl chr 1:247,483,302...247,486,202
JBrowse link
G Zp3 zona pellucida glycoprotein 3 ISO
IEA
IBA
ISS
(MGI:MGI:4942264|PMID:10793136)
GO_REF:0000104
PMID:21873635
(PMID:11751269), (PMID:18667750), (PMID:20394732)
GO_REF:0000024
RGD
UniProt
PMID:10793136, PMID:11751269, PMID:18667750, PMID:20394732, PMID:21873635 GO_REF:0000024, GO_REF:0000104, MGI:MGI:4942264, RGD:13792537 NCBI chr12:23,735,225...23,752,734
Ensembl chr12:23,735,223...23,742,190
JBrowse link
G Zp4 zona pellucida glycoprotein 4 IEA
ISO
GO_REF:0000107
(PMID:18667750), (PMID:20394732)
Ensembl
RGD
PMID:18667750, PMID:20394732 GO_REF:0000107 NCBI chr17:65,497,359...65,503,912
Ensembl chr17:65,497,359...65,503,912
JBrowse link
regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Stxbp1 syntaxin binding protein 1 ISO (PMID:23091057) RGD PMID:23091057 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
regulation of acrosome reaction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B4galt1 beta-1,4-galactosyltransferase 1 ISO
IEA
MGI:MGI:2178779 (MGI:MGI:1098917|PMID:9374408)
GO_REF:0000107
RGD
Ensembl
PMID:9374408 GO_REF:0000107, MGI:MGI:1098917 NCBI chr 5:57,121,768...57,168,610
Ensembl chr 5:57,121,769...57,168,610
JBrowse link
G Crisp1 cysteine-rich secretory protein 1 ISO MGI:MGI:4950060 (MGI:MGI:4949775|PMID:21482758) RGD PMID:21482758 MGI:MGI:4949775 NCBI chr 9:24,356,577...24,383,679
Ensembl chr 9:24,356,579...24,383,679
JBrowse link
G Pkdrej polycystin family receptor for egg jelly ISO MGI:MGI:3799312 (MGI:MGI:3798326|PMID:18562295) RGD PMID:18562295 MGI:MGI:3798326 NCBI chr 7:126,695,498...126,701,872
Ensembl chr 7:126,695,498...126,701,872
JBrowse link
G Serpina10 serpin family A member 10 NOT ISO (PMID:11751269) RGD PMID:11751269 NCBI chr 6:127,500,014...127,508,470
Ensembl chr 6:127,500,016...127,508,452
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 ISO (MGI:MGI:5428115|PMID:22228629) RGD PMID:22228629 MGI:MGI:5428115 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link
G Zp2 zona pellucida glycoprotein 2 NOT ISO (PMID:11751269), (PMID:20394732) RGD PMID:11751269, PMID:20394732 NCBI chr 1:189,899,906...189,911,650
Ensembl chr 1:189,899,892...189,911,650
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    reproductive process 1797
      acrosome reaction 40
        acrosomal vesicle exocytosis + 9
        acrosome matrix dispersal 1
        membrane fusion involved in acrosome reaction 0
        negative regulation of acrosome reaction 1
        positive regulation of acrosome reaction 12
        positive regulation of actin filament depolymerization involved in acrosome reaction 0
        positive regulation of actin filament polymerization involved in acrosome reaction 0
        protein localization involved in acrosome reaction 0
        regulation of acrosome reaction + 19
Path 2
Term Annotations click to browse term
  biological_process 20027
    reproduction 1800
      reproductive process 1797
        multi-organism reproductive process 1248
          sexual reproduction 992
            fertilization 195
              single fertilization 150
                acrosome reaction 40
                  acrosomal vesicle exocytosis + 9
                  acrosome matrix dispersal 1
                  membrane fusion involved in acrosome reaction 0
                  negative regulation of acrosome reaction 1
                  positive regulation of acrosome reaction 12
                  positive regulation of actin filament depolymerization involved in acrosome reaction 0
                  positive regulation of actin filament polymerization involved in acrosome reaction 0
                  protein localization involved in acrosome reaction 0
                  regulation of acrosome reaction + 19
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.