ONTOLOGY REPORT - ANNOTATIONS


Term:acrosome reaction
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Accession:GO:0007340 term browser browse the term
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
Comment:If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss.
Synonyms:xref: Wikipedia:Acrosome_reaction


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acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd2 abhydrolase domain containing 2 JBrowse link NW_004955416 15,878,972 15,983,322 RGD:9068941
G Acr acrosin JBrowse link NW_004955413 33,721,984 33,728,088 RGD:9068941
G Adcy3 adenylate cyclase 3 JBrowse link NW_004955469 6,933,208 7,026,179 RGD:9068941
G Akap3 A-kinase anchoring protein 3 JBrowse link NW_004955413 2,411,618 2,432,658 RGD:9068941
G Glra1 glycine receptor alpha 1 JBrowse link NW_004955408 6,236,092 6,333,166 RGD:9068941
G Glrb glycine receptor beta JBrowse link NW_004955471 10,153,197 10,238,052 RGD:9068941
G Pcsk4 proprotein convertase subtilisin/kexin type 4 JBrowse link NW_004955495 6,424,426 6,460,252 RGD:9068941
G Pkdrej polycystin family receptor for egg jelly JBrowse link NW_004955413 30,377,627 30,384,749 RGD:9068941
G Plcd4 phospholipase C delta 4 JBrowse link NW_004955453 14,775,119 14,812,872 RGD:9068941
G Prnd prion like protein doppel JBrowse link NW_004955415 15,469,500 15,474,817 RGD:9068941
G Spesp1 sperm equatorial segment protein 1 JBrowse link NW_004955450 7,355,144 7,370,413 RGD:9068941
G Stx2 syntaxin 2 JBrowse link NW_004955482 1,249,972 1,273,250 RGD:9068941
G Syt6 synaptotagmin 6 JBrowse link NW_004955435 17,349,971 17,405,526 RGD:9068941
G Syt8 synaptotagmin 8 JBrowse link NW_004955422 13,642,933 13,648,351 RGD:9068941
G Tnp2 transition protein 2 JBrowse link NW_004955442 7,311,826 7,314,046 RGD:9068941
G Trim36 tripartite motif containing 36 JBrowse link NW_004955408 34,909,194 34,939,635 RGD:9068941
acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eqtn equatorin JBrowse link NW_004955472 7,554,243 7,563,620 RGD:9068941
G Rab3a RAB3A, member RAS oncogene family JBrowse link NW_004955524 3,220,108 3,224,376 RGD:9068941
G Rims1 regulating synaptic membrane exocytosis 1 JBrowse link NW_004955488 6,999,128 7,196,583 RGD:9068941
G Syt6 synaptotagmin 6 JBrowse link NW_004955435 17,349,971 17,405,526 RGD:9068941
G Zp4 zona pellucida glycoprotein 4 JBrowse link NW_004955492 2,599,579 2,606,837 RGD:9068941
acrosome matrix dispersal term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acr acrosin JBrowse link NW_004955413 33,721,984 33,728,088 RGD:9068941
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hyal3 hyaluronidase 3 JBrowse link NW_004955532 2,107,019 2,112,356 RGD:9068941
G Zp3 zona pellucida glycoprotein 3 JBrowse link NW_004955456 15,013,472 15,020,809 RGD:9068941
positive regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link NW_004955442 16,047,965 16,108,862 RGD:9068941
G Ccdc87 coiled-coil domain containing 87 JBrowse link NW_004955422 18,772,869 18,775,548 RGD:9068941
G Fam170b family with sequence similarity 170 member B JBrowse link NW_004955556 1,072,826 1,075,332 RGD:9068941
G Glra1 glycine receptor alpha 1 JBrowse link NW_004955408 6,236,092 6,333,166 RGD:9068941
G Plb1 phospholipase B1 JBrowse link NW_004955469 10,370,646 10,511,263 RGD:9068941
G Plcb1 phospholipase C beta 1 JBrowse link NW_004955415 18,210,608 18,915,099 RGD:9068941
G Prss37 serine protease 37 JBrowse link NW_004955494 1,742,104 1,747,310 RGD:9068941
G Zp3 zona pellucida glycoprotein 3 JBrowse link NW_004955456 15,013,472 15,020,809 RGD:9068941
G Zp4 zona pellucida glycoprotein 4 JBrowse link NW_004955492 2,599,579 2,606,837 RGD:9068941
regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Stxbp1 syntaxin binding protein 1 JBrowse link NW_004955419 963,829 1,000,759 RGD:9068941
regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B4galt1 beta-1,4-galactosyltransferase 1 JBrowse link NW_004955472 2,490,649 2,536,053 RGD:9068941
G Serpina10 serpin family A member 10 JBrowse link NW_004955438 16,335,201 16,345,093 RGD:9068941
G Spink1 serine peptidase inhibitor, Kazal type 1 JBrowse link NW_004955415 6,328,672 6,378,611 RGD:9068941
G Zp2 zona pellucida glycoprotein 2 JBrowse link NW_004955493 400,868 412,660 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14516
    reproductive process 1331
      acrosome reaction 33
        acrosomal vesicle exocytosis + 8
        acrosome matrix dispersal 1
        membrane fusion involved in acrosome reaction 0
        negative regulation of acrosome reaction 0
        positive regulation of acrosome reaction + 10
        positive regulation of actin filament depolymerization involved in acrosome reaction 0
        positive regulation of actin filament polymerization involved in acrosome reaction 0
        protein localization involved in acrosome reaction 0
        regulation of acrosome reaction + 15
Path 2
Term Annotations click to browse term
  biological_process 14516
    reproduction 1334
      reproductive process 1331
        multi-organism reproductive process 897
          sexual reproduction 739
            fertilization 155
              single fertilization 124
                acrosome reaction 33
                  acrosomal vesicle exocytosis + 8
                  acrosome matrix dispersal 1
                  membrane fusion involved in acrosome reaction 0
                  negative regulation of acrosome reaction 0
                  positive regulation of acrosome reaction + 10
                  positive regulation of actin filament depolymerization involved in acrosome reaction 0
                  positive regulation of actin filament polymerization involved in acrosome reaction 0
                  protein localization involved in acrosome reaction 0
                  regulation of acrosome reaction + 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.