ONTOLOGY REPORT - ANNOTATIONS


Term:acrosome reaction
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Accession:GO:0007340 term browser browse the term
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
Comment:If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss.
Synonyms:xref: Wikipedia:Acrosome_reaction


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acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABHD2 abhydrolase domain containing 2 JBrowse link 3 52,151,500 52,255,024 RGD:13508589
RGD:9068941
G ACR acrosin JBrowse link 10 16,607,514 16,615,399 RGD:9068941
G ADCY3 adenylate cyclase 3 JBrowse link 17 19,153,732 19,231,943 RGD:9068941
G AKAP3 A-kinase anchoring protein 3 JBrowse link 27 40,217,313 40,255,934 RGD:9068941
G GLRA1 glycine receptor alpha 1 JBrowse link 4 57,443,094 57,541,494 RGD:13508589
RGD:9068941
G GLRB glycine receptor beta JBrowse link 15 54,429,131 54,519,844 RGD:13508589
RGD:9068941
G PCSK4 proprotein convertase subtilisin/kexin type 4 JBrowse link 20 57,370,035 57,376,207 RGD:9068941
G PKDREJ polycystin family receptor for egg jelly JBrowse link 10 19,914,217 19,921,766 RGD:9068941
G PLCD4 phospholipase C delta 4 JBrowse link 37 25,221,329 25,244,492 RGD:13508589
RGD:9068941
G PRND prion like protein doppel JBrowse link 24 16,822,807 16,828,473 RGD:9068941
G SPESP1 sperm equatorial segment protein 1 JBrowse link 30 32,900,322 32,904,206 RGD:9068941
G STX2 syntaxin 2 JBrowse link 26 1,459,110 1,494,801 RGD:9068941
G SYT6 synaptotagmin 6 JBrowse link 17 51,859,564 51,923,044 RGD:9068941
G SYT8 synaptotagmin 8 JBrowse link 18 46,069,380 46,075,477 RGD:9068941
G TNP2 transition protein 2 JBrowse link 6 31,498,361 31,498,740 RGD:9068941
G TRIM36 tripartite motif containing 36 JBrowse link 11 4,881,067 4,927,365 RGD:13508589
RGD:9068941
acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EQTN equatorin JBrowse link 11 45,417,579 45,431,255 RGD:9068941
G RAB3A RAB3A, member RAS oncogene family JBrowse link 20 44,796,740 44,802,224 RGD:9068941
G RIMS1 regulating synaptic membrane exocytosis 1 JBrowse link 12 34,473,974 34,661,893 RGD:9068941
G SYT6 synaptotagmin 6 JBrowse link 17 51,859,564 51,923,044 RGD:9068941
G UNC13B unc-13 homolog B JBrowse link 11 51,707,968 51,941,148 RGD:9068941
G ZP4 zona pellucida glycoprotein 4 JBrowse link 4 2,324,657 2,332,357 RGD:9068941
acrosome matrix dispersal term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACR acrosin JBrowse link 10 16,607,514 16,615,399 RGD:9068941
negative regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) JBrowse link 4 60,480,662 60,491,529 RGD:9068941
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HYAL3 hyaluronidase 3 JBrowse link 20 39,041,940 39,047,388 RGD:9068941
G ZP3 zona pellucida glycoprotein 3 JBrowse link 6 7,586,212 7,594,610 RGD:13508589
RGD:9068941
positive regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CACNA1H calcium voltage-gated channel subunit alpha1 H JBrowse link 6 39,510,129 39,533,129 RGD:9068941
G CCDC87 coiled-coil domain containing 87 JBrowse link 18 50,759,378 50,762,205 RGD:9068941
G FAM170B family with sequence similarity 170 member B JBrowse link 28 1,046,362 1,059,992 RGD:9068941
G GLRA1 glycine receptor alpha 1 JBrowse link 4 57,443,094 57,541,494 RGD:13508589
RGD:9068941
G IQCF1 IQ motif containing F1 JBrowse link 20 37,797,253 37,799,110 RGD:9068941
G PLB1 phospholipase B1 JBrowse link 17 22,420,679 22,558,318 RGD:9068941
G PLCB1 phospholipase C beta 1 JBrowse link 24 13,337,285 13,996,218 RGD:9068941
G PRSS37 serine protease 37 JBrowse link 16 7,379,344 7,385,160 RGD:9068941
G ZP3 zona pellucida glycoprotein 3 JBrowse link 6 7,586,212 7,594,610 RGD:13508589
RGD:9068941
G ZP4 zona pellucida glycoprotein 4 JBrowse link 4 2,324,657 2,332,357 RGD:9068941
regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G STXBP1 syntaxin binding protein 1 JBrowse link 9 55,690,939 55,768,008 RGD:9068941
regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B4GALT1 beta-1,4-galactosyltransferase 1 JBrowse link 11 50,223,880 50,276,745 RGD:13508589
RGD:9068941
G CRISP1 cysteine rich secretory protein 1 JBrowse link 12 17,659,446 17,696,557 RGD:9068941
G SPINK1 serine peptidase inhibitor, Kazal type 1 JBrowse link 2 42,112,015 42,120,738 RGD:9068941
G ZP2 zona pellucida glycoprotein 2 JBrowse link 6 24,230,202 24,242,441 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15735
    reproductive process 1387
      acrosome reaction 36
        acrosomal vesicle exocytosis + 9
        acrosome matrix dispersal 1
        membrane fusion involved in acrosome reaction 0
        negative regulation of acrosome reaction 1
        positive regulation of acrosome reaction + 11
        positive regulation of actin filament depolymerization involved in acrosome reaction 0
        positive regulation of actin filament polymerization involved in acrosome reaction 0
        protein localization involved in acrosome reaction 0
        regulation of acrosome reaction + 17
Path 2
Term Annotations click to browse term
  biological_process 15735
    reproduction 1390
      reproductive process 1387
        multi-organism reproductive process 956
          sexual reproduction 796
            fertilization 181
              single fertilization 145
                acrosome reaction 36
                  acrosomal vesicle exocytosis + 9
                  acrosome matrix dispersal 1
                  membrane fusion involved in acrosome reaction 0
                  negative regulation of acrosome reaction 1
                  positive regulation of acrosome reaction + 11
                  positive regulation of actin filament depolymerization involved in acrosome reaction 0
                  positive regulation of actin filament polymerization involved in acrosome reaction 0
                  protein localization involved in acrosome reaction 0
                  regulation of acrosome reaction + 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.