ONTOLOGY REPORT - ANNOTATIONS


Term:acrosome reaction
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Accession:GO:0007340 term browser browse the term
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
Comment:If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss.
Synonyms:xref: Wikipedia:Acrosome_reaction


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acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABHD2 abhydrolase domain containing 2 JBrowse link 15 89,088,150 89,202,360 RGD:2290271
G ACR acrosin JBrowse link 22 50,738,224 50,745,299 RGD:2290271
G ADCY3 adenylate cyclase 3 JBrowse link 2 24,819,169 24,920,017 RGD:2290271
G AKAP3 A-kinase anchoring protein 3 JBrowse link 12 4,615,508 4,649,047 RGD:2290271
G GLRA1 glycine receptor alpha 1 JBrowse link 5 151,822,513 151,924,836 RGD:2290271
G GLRB glycine receptor beta JBrowse link 4 157,076,125 157,172,090 RGD:2290271
G PCSK4 proprotein convertase subtilisin/kexin type 4 JBrowse link 19 1,481,428 1,490,874 RGD:2290271
G PKDREJ polycystin family receptor for egg jelly JBrowse link 22 46,255,663 46,263,322 RGD:2290271
G PLCD4 phospholipase C delta 4 JBrowse link 2 218,606,871 218,637,186 RGD:2290271
G PRND prion like protein doppel JBrowse link 20 4,721,854 4,728,462 RGD:2290271
G ROPN1B rhophilin associated tail protein 1B JBrowse link 3 125,969,144 125,983,454 RGD:2290271
G SPESP1 sperm equatorial segment protein 1 JBrowse link 15 68,930,500 68,946,811 RGD:2290271
G STX2 syntaxin 2 JBrowse link 12 130,789,600 130,839,274 RGD:2290271
G SYT6 synaptotagmin 6 JBrowse link 1 114,089,292 114,153,919 RGD:2290271
G SYT8 synaptotagmin 8 JBrowse link 11 1,827,484 1,837,521 RGD:2290271
G TNP2 transition protein 2 JBrowse link 16 11,267,857 11,269,303 RGD:2290271
G TRIM36 tripartite motif containing 36 JBrowse link 5 115,124,762 115,180,546 RGD:2290271
acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G EQTN equatorin JBrowse link 9 27,284,654 27,297,139 RGD:2290271
G RAB3A RAB3A, member RAS oncogene family JBrowse link 19 18,196,784 18,204,064 RGD:2290271
G RIMS1 regulating synaptic membrane exocytosis 1 JBrowse link 6 71,886,703 72,403,143 RGD:2290271
G SYT6 synaptotagmin 6 JBrowse link 1 114,089,292 114,153,919 RGD:2290271
G UNC13B unc-13 homolog B JBrowse link 9 35,161,969 35,405,338 RGD:2290271
G ZP4 zona pellucida glycoprotein 4 JBrowse link 1 237,882,377 237,890,922 RGD:2290271
acrosome matrix dispersal term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ACR acrosin JBrowse link 22 50,738,224 50,745,299 RGD:2290271
negative regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) JBrowse link 5 148,268,860 148,286,210 RGD:2290271
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G HYAL3 hyaluronidase 3 JBrowse link 3 50,292,828 50,299,468 RGD:2290271
G ZP3 zona pellucida glycoprotein 3 JBrowse link 7 76,397,524 76,442,071 RGD:2290271
positive regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CACNA1H calcium voltage-gated channel subunit alpha1 H JBrowse link 16 1,153,241 1,221,772 RGD:2290271
G CCDC87 coiled-coil domain containing 87 JBrowse link 11 66,590,169 66,593,083 RGD:2290271
G FAM170B family with sequence similarity 170 member B JBrowse link 10 49,131,154 49,134,020 RGD:2290271
G GLRA1 glycine receptor alpha 1 JBrowse link 5 151,822,513 151,924,836 RGD:2290271
G IQCF1 IQ motif containing F1 JBrowse link 3 51,894,876 51,903,370 RGD:2290271
G PLB1 phospholipase B1 JBrowse link 2 28,488,578 28,644,135 RGD:2290271
G PLCB1 phospholipase C beta 1 JBrowse link 20 8,132,265 8,884,900 RGD:2290271
G POMZP3 POM121 and ZP3 fusion JBrowse link 7 76,609,986 76,627,303 RGD:2290271
G PRSS37 serine protease 37 JBrowse link 7 141,836,278 141,849,725 RGD:2290271
G ZP3 zona pellucida glycoprotein 3 JBrowse link 7 76,397,524 76,442,071 RGD:2290271
G ZP4 zona pellucida glycoprotein 4 JBrowse link 1 237,882,377 237,890,922 RGD:2290271
regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B4GALT1 beta-1,4-galactosyltransferase 1 JBrowse link 9 33,110,641 33,167,358 RGD:2290271
G CRISP1 cysteine rich secretory protein 1 JBrowse link 6 49,833,939 49,877,096 RGD:2290271
G SERPINA10 serpin family A member 10 JBrowse link 14 94,280,460 94,293,353 RGD:2290271
G SPINK1 serine peptidase inhibitor, Kazal type 1 JBrowse link 5 147,824,580 147,839,231 RGD:2290271
G ZP2 zona pellucida glycoprotein 2 JBrowse link 16 21,197,450 21,214,510 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17597
    reproductive process 1490
      acrosome reaction 38
        acrosomal vesicle exocytosis + 8
        acrosome matrix dispersal 1
        membrane fusion involved in acrosome reaction 0
        negative regulation of acrosome reaction 1
        positive regulation of acrosome reaction + 12
        positive regulation of actin filament depolymerization involved in acrosome reaction 0
        positive regulation of actin filament polymerization involved in acrosome reaction 0
        protein localization involved in acrosome reaction 0
        regulation of acrosome reaction + 18
Path 2
Term Annotations click to browse term
  biological_process 17597
    reproduction 1493
      reproductive process 1490
        multi-organism reproductive process 1033
          sexual reproduction 857
            fertilization 185
              single fertilization 151
                acrosome reaction 38
                  acrosomal vesicle exocytosis + 8
                  acrosome matrix dispersal 1
                  membrane fusion involved in acrosome reaction 0
                  negative regulation of acrosome reaction 1
                  positive regulation of acrosome reaction + 12
                  positive regulation of actin filament depolymerization involved in acrosome reaction 0
                  positive regulation of actin filament polymerization involved in acrosome reaction 0
                  protein localization involved in acrosome reaction 0
                  regulation of acrosome reaction + 18
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.