ONTOLOGY REPORT - ANNOTATIONS


Term:acrosome reaction
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Accession:GO:0007340 term browser browse the term
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
Comment:If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss.
Synonyms:xref: Wikipedia:Acrosome_reaction


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acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd2 abhydrolase domain containing 2 JBrowse link 7 79,273,266 79,361,601 RGD:2290270
G Acr acrosin prepropeptide JBrowse link 15 89,567,560 89,578,853 RGD:2290270
G Adcy3 adenylate cyclase 3 JBrowse link 12 4,132,996 4,213,525 RGD:2290270
G Glra1 glycine receptor, alpha 1 subunit JBrowse link 11 55,514,239 55,608,198 RGD:2290270
G Glrb glycine receptor, beta subunit JBrowse link 3 80,843,598 80,913,660 RGD:2290270
G Gnpda1 glucosamine-6-phosphate deaminase 1 JBrowse link 18 38,327,537 38,338,993 RGD:2290270
G Pcsk4 proprotein convertase subtilisin/kexin type 4 JBrowse link 10 80,321,283 80,329,909 RGD:2290270
G Plcd4 phospholipase C, delta 4 JBrowse link 1 74,541,791 74,565,977 RGD:2290270
G Prnd prion like protein doppel JBrowse link 2 131,950,861 131,956,131 RGD:2290270
G Spesp1 sperm equatorial segment protein 1 JBrowse link 9 62,270,729 62,282,179 RGD:2290270
G Stx2 syntaxin 2 JBrowse link 5 128,984,557 129,008,600 RGD:2290270
G Syt6 synaptotagmin VI JBrowse link 3 103,575,242 103,645,567 RGD:2290270
G Syt8 synaptotagmin VIII JBrowse link 7 142,434,461 142,440,399 RGD:2290270
G Tnp2 transition protein 2 JBrowse link 16 10,787,935 10,788,655 RGD:2290270
G Trim36 tripartite motif-containing 36 JBrowse link 18 46,165,300 46,212,607 RGD:2290270
G Trpc2 transient receptor potential cation channel, subfamily C, member 2 JBrowse link 7 102,083,116 102,096,864 RGD:2290270
acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eqtn equatorin, sperm acrosome associated JBrowse link 4 94,875,698 94,929,952 RGD:2290270
G Rab3a RAB3A, member RAS oncogene family JBrowse link 8 70,754,679 70,758,686 RGD:2290270
G Rims1 regulating synaptic membrane exocytosis 1 JBrowse link 1 22,288,422 22,805,724 RGD:2290270
G Syt6 synaptotagmin VI JBrowse link 3 103,575,242 103,645,567 RGD:2290270
G Unc13b unc-13 homolog B JBrowse link 4 43,058,929 43,264,873 RGD:2290270
acrosome matrix dispersal term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acr acrosin prepropeptide JBrowse link 15 89,567,560 89,578,853 RGD:2290270
negative regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Spink13 serine peptidase inhibitor, Kazal type 13 JBrowse link 18 62,605,898 62,741,387 RGD:2290270
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hyal3 hyaluronoglucosaminidase 3 JBrowse link 9 107,581,296 107,587,359 RGD:2290270
G Zp3 zona pellucida glycoprotein 3 JBrowse link 5 135,980,105 135,988,624 RGD:2290270
positive regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1h calcium channel, voltage-dependent, T type, alpha 1H subunit JBrowse link 17 25,374,285 25,433,783 RGD:2290270
G Ccdc87 coiled-coil domain containing 87 JBrowse link 19 4,839,366 4,842,528 RGD:2290270
G Fam170b family with sequence similarity 170, member B JBrowse link 14 32,833,962 32,836,789 RGD:2290270
G Glra1 glycine receptor, alpha 1 subunit JBrowse link 11 55,514,239 55,608,198 RGD:2290270
G Iqcf1 IQ motif containing F1 JBrowse link 9 106,499,967 106,502,250 RGD:2290270
G Iqcf3 IQ motif containing F3 JBrowse link 9 106,504,665 106,561,631 RGD:2290270
G Plb1 phospholipase B1 JBrowse link 5 32,232,691 32,364,356 RGD:2290270
G Plcb1 phospholipase C, beta 1 JBrowse link 2 134,786,164 135,475,258 RGD:2290270
G Prss37 protease, serine 37 JBrowse link 6 40,514,820 40,519,546 RGD:2290270
G Zp3 zona pellucida glycoprotein 3 JBrowse link 5 135,980,105 135,988,624 RGD:2290270
regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B4galt1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 JBrowse link 4 40,804,582 40,855,712 RGD:2290270
G Crisp4 cysteine-rich secretory protein 4 JBrowse link 1 18,114,884 18,145,966 RGD:2290270
G Pkdrej polycystin (PKD) family receptor for egg jelly JBrowse link 15 85,814,676 85,821,733 RGD:2290270
G Spink1 serine peptidase inhibitor, Kazal type 1 JBrowse link 18 43,728,069 43,737,237 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22957
    reproductive process 1491
      acrosome reaction 35
        acrosomal vesicle exocytosis + 7
        acrosome matrix dispersal 1
        membrane fusion involved in acrosome reaction 0
        negative regulation of acrosome reaction 1
        positive regulation of acrosome reaction + 11
        positive regulation of actin filament depolymerization involved in acrosome reaction 0
        positive regulation of actin filament polymerization involved in acrosome reaction 0
        protein localization involved in acrosome reaction 0
        regulation of acrosome reaction + 16
Path 2
Term Annotations click to browse term
  biological_process 22957
    reproduction 1492
      reproductive process 1491
        multi-organism reproductive process 1019
          sexual reproduction 874
            fertilization 182
              single fertilization 138
                acrosome reaction 35
                  acrosomal vesicle exocytosis + 7
                  acrosome matrix dispersal 1
                  membrane fusion involved in acrosome reaction 0
                  negative regulation of acrosome reaction 1
                  positive regulation of acrosome reaction + 11
                  positive regulation of actin filament depolymerization involved in acrosome reaction 0
                  positive regulation of actin filament polymerization involved in acrosome reaction 0
                  protein localization involved in acrosome reaction 0
                  regulation of acrosome reaction + 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.