ONTOLOGY REPORT - ANNOTATIONS


Term:acrosome reaction
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Accession:GO:0007340 term browser browse the term
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
Comment:If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss.
Synonyms:xref: Wikipedia:Acrosome_reaction


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acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd2 abhydrolase domain containing 2 JBrowse link 1 140,998,240 141,087,405 RGD:1624291
RGD:1600115
G Acr acrosin JBrowse link 7 130,541,320 130,548,356 RGD:8553887
RGD:13792537
RGD:1600115
RGD:1624291
G Adcy3 adenylate cyclase 3 JBrowse link 6 28,570,941 28,648,848 RGD:1600115
RGD:1624291
G Glra1 glycine receptor, alpha 1 JBrowse link 10 40,851,955 40,954,364 RGD:1624291
RGD:1600115
G Glrb glycine receptor, beta JBrowse link 2 179,768,040 179,842,612 RGD:1624291
RGD:1600115
G Pcsk4 proprotein convertase subtilisin/kexin type 4 JBrowse link 7 12,247,498 12,255,721 RGD:1624291
RGD:1600115
G Plcd4 phospholipase C, delta 4 JBrowse link 9 81,816,395 81,844,364 RGD:1624291
RGD:1600115
G Prnd prion like protein doppel JBrowse link 3 124,543,227 124,548,548 RGD:1624291
G Spesp1 sperm equatorial segment protein 1 JBrowse link 8 67,217,801 67,233,172 RGD:1624291
RGD:13792537
G Stx2 syntaxin 2 JBrowse link 12 31,324,203 31,360,249 RGD:1600115
RGD:1624291
G Syt6 synaptotagmin 6 JBrowse link 2 206,064,181 206,119,034 RGD:1624291
RGD:1600115
G Syt8 synaptotagmin 8 JBrowse link 1 215,605,408 215,607,602 RGD:1624291
RGD:1600115
G Tnp2 transition protein 2 JBrowse link 10 4,953,898 4,954,626 RGD:1624291
RGD:13792537
RGD:1600115
G Trim36 tripartite motif-containing 36 JBrowse link 18 40,081,028 40,134,673 RGD:1624291
RGD:1600115
acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eqtn equatorin JBrowse link 5 113,852,191 113,881,142 RGD:1624291
RGD:13792537
G Rab3a RAB3A, member RAS oncogene family JBrowse link 16 20,435,098 20,439,206 RGD:1600115
RGD:1624291
G Rims1 regulating synaptic membrane exocytosis 1 JBrowse link 9 28,440,408 28,973,246 RGD:1600115
RGD:1624291
G Syt6 synaptotagmin 6 JBrowse link 2 206,064,181 206,119,034 RGD:1624291
RGD:1600115
G Unc13b unc-13 homolog B JBrowse link 5 58,505,449 58,714,396 RGD:1600115
RGD:1624291
G Zp4 zona pellucida glycoprotein 4 JBrowse link 17 65,497,359 65,503,912 RGD:1600115
RGD:1624291
acrosome matrix dispersal term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acr acrosin JBrowse link 7 130,541,320 130,548,356 RGD:13464336
negative regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Spink13 serine peptidase inhibitor, Kazal type 13 (putative) JBrowse link 18 57,935,271 58,081,096 RGD:8553255
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hyal3 hyaluronidase 3 JBrowse link 8 116,336,512 116,342,147 RGD:1600115
RGD:1624291
G Zp3 zona pellucida glycoprotein 3 JBrowse link 12 23,735,225 23,752,734 RGD:1600115
RGD:1624291
positive regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link 10 14,730,932 14,789,201 RGD:1624291
RGD:1600115
G Ccdc87 coiled-coil domain containing 87 JBrowse link 1 220,096,478 220,099,174 RGD:1600115
RGD:1624291
G Fam170b family with sequence similarity 170, member B JBrowse link 16 9,074,044 9,076,885 RGD:1624291
RGD:13792537
G Glra1 glycine receptor, alpha 1 JBrowse link 10 40,851,955 40,954,364 RGD:1624291
RGD:1600115
G Iqcf1 IQ motif containing F1 JBrowse link 8 115,191,919 115,195,599 RGD:1624291
RGD:13792537
G Plb1 phospholipase B1 JBrowse link 6 25,375,699 25,507,108 RGD:1624291
G Plcb1 phospholipase C beta 1 JBrowse link 3 127,721,244 128,419,565 RGD:1624291
RGD:1600115
G Prss37 serine protease 37 JBrowse link 4 68,337,498 68,349,286 RGD:1624291
RGD:13792537
G Rln1 relaxin 1 JBrowse link 1 247,483,298 247,486,331 RGD:1624291
G Zp3 zona pellucida glycoprotein 3 JBrowse link 12 23,735,225 23,752,734 RGD:1600115
RGD:13792537
RGD:1624291
G Zp4 zona pellucida glycoprotein 4 JBrowse link 17 65,497,359 65,503,912 RGD:1600115
RGD:1624291
regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:1600115
RGD:1624291
regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B4galt1 beta-1,4-galactosyltransferase 1 JBrowse link 5 57,121,768 57,168,610 RGD:1624291
RGD:1600115
G Crisp1 cysteine-rich secretory protein 1 JBrowse link 9 24,356,577 24,383,679 RGD:1624291
G Pkdrej polycystin family receptor for egg jelly JBrowse link 7 126,695,498 126,701,872 RGD:1624291
G Serpina10 serpin family A member 10 JBrowse link 6 127,500,014 127,508,470 RGD:1624291
G Spink1 serine peptidase inhibitor, Kazal type 1 JBrowse link 18 38,221,919 38,242,092 RGD:1624291
G Zp2 zona pellucida glycoprotein 2 JBrowse link 1 189,899,906 189,911,650 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17896
    reproductive process 1662
      acrosome reaction 37
        acrosomal vesicle exocytosis + 9
        acrosome matrix dispersal 1
        membrane fusion involved in acrosome reaction 0
        negative regulation of acrosome reaction 1
        positive regulation of acrosome reaction + 12
        positive regulation of actin filament depolymerization involved in acrosome reaction 0
        positive regulation of actin filament polymerization involved in acrosome reaction 0
        protein localization involved in acrosome reaction 0
        regulation of acrosome reaction + 20
Path 2
Term Annotations click to browse term
  biological_process 17896
    reproduction 1665
      reproductive process 1662
        multi-organism reproductive process 1151
          sexual reproduction 903
            fertilization 178
              single fertilization 134
                acrosome reaction 37
                  acrosomal vesicle exocytosis + 9
                  acrosome matrix dispersal 1
                  membrane fusion involved in acrosome reaction 0
                  negative regulation of acrosome reaction 1
                  positive regulation of acrosome reaction + 12
                  positive regulation of actin filament depolymerization involved in acrosome reaction 0
                  positive regulation of actin filament polymerization involved in acrosome reaction 0
                  protein localization involved in acrosome reaction 0
                  regulation of acrosome reaction + 20
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.