ONTOLOGY REPORT - ANNOTATIONS


Term:acrosome reaction
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Accession:GO:0007340 term browser browse the term
Definition:The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
Comment:If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss.
Synonyms:xref: Wikipedia:Acrosome_reaction


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acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abhd2 abhydrolase domain containing 2 JBrowse link NW_004936483 14,974,053 15,079,824 RGD:9068941
G Acr acrosin JBrowse link NW_004936629 104,301 111,377 RGD:9068941
G Adcy3 adenylate cyclase 3 JBrowse link NW_004936493 7,250,194 7,333,433 RGD:9068941
G Akap3 A-kinase anchoring protein 3 JBrowse link NW_004936606 4,771,158 4,794,666 RGD:9068941
G Glra1 glycine receptor alpha 1 JBrowse link NW_004936515 10,816,712 10,896,958 RGD:9068941
G Glrb glycine receptor beta JBrowse link NW_004936576 3,665,128 3,752,592 RGD:9068941
G Pcsk4 proprotein convertase subtilisin/kexin type 4 JBrowse link NW_004936588 793,615 800,038 RGD:9068941
G Pkdrej polycystin family receptor for egg jelly JBrowse link NW_004936629 3,641,786 3,651,827 RGD:9068941
G Plcd4 phospholipase C delta 4 JBrowse link NW_004936569 1,058,092 1,097,662 RGD:9068941
G Prnd prion like protein doppel JBrowse link NW_004936485 14,079,691 14,081,246 RGD:9068941
G Spesp1 sperm equatorial segment protein 1 JBrowse link NW_004936471 28,730,571 28,747,066 RGD:9068941
G Stx2 syntaxin 2 JBrowse link NW_004936660 1,616,774 1,652,585 RGD:9068941
G Syt6 synaptotagmin 6 JBrowse link NW_004936690 2,435,573 2,497,332 RGD:9068941
G Syt8 synaptotagmin 8 JBrowse link NW_004936816 732,948 737,371 RGD:9068941
G Trim36 tripartite motif containing 36 JBrowse link NW_004936742 317,095 352,509 RGD:9068941
acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eqtn equatorin JBrowse link NW_004936611 2,370,269 2,397,903 RGD:9068941
G LOC101974478 protein unc-13 homolog B JBrowse link NW_004936524 3,320,859 3,369,865 RGD:9068941
G Rab3a RAB3A, member RAS oncogene family JBrowse link NW_004936596 2,990,367 2,995,935 RGD:9068941
G Rims1 regulating synaptic membrane exocytosis 1 JBrowse link NW_004936618 3,678,400 4,047,994 RGD:9068941
G Syt6 synaptotagmin 6 JBrowse link NW_004936690 2,435,573 2,497,332 RGD:9068941
G Zp4 zona pellucida glycoprotein 4 JBrowse link NW_004936484 15,370,443 15,376,564 RGD:9068941
acrosome matrix dispersal term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acr acrosin JBrowse link NW_004936629 104,301 111,377 RGD:9068941
positive regulation of acrosomal vesicle exocytosis term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hyal3 hyaluronidase 3 JBrowse link NW_004936529 1,831,639 1,837,314 RGD:9068941
G Zp3 zona pellucida glycoprotein 3 JBrowse link NW_004936543 2,013,231 2,022,270 RGD:9068941
positive regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link NW_004936694 2,702,224 2,724,574 RGD:9068941
G Ccdc87 coiled-coil domain containing 87 JBrowse link NW_004936599 3,005,067 3,008,053 RGD:9068941
G Fam170b family with sequence similarity 170 member B JBrowse link NW_004936728 1,133,569 1,135,742 RGD:9068941
G Glra1 glycine receptor alpha 1 JBrowse link NW_004936515 10,816,712 10,896,958 RGD:9068941
G Plb1 phospholipase B1 JBrowse link NW_004936493 4,112,632 4,210,882 RGD:9068941
G Plcb1 phospholipase C beta 1 JBrowse link NW_004936485 10,548,966 11,254,139 RGD:9068941
G Prss37 serine protease 37 JBrowse link NW_004936592 5,676,944 5,681,651 RGD:9068941
G Zp3 zona pellucida glycoprotein 3 JBrowse link NW_004936543 2,013,231 2,022,270 RGD:9068941
G Zp4 zona pellucida glycoprotein 4 JBrowse link NW_004936484 15,370,443 15,376,564 RGD:9068941
regulation of acrosome reaction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G B4galt1 beta-1,4-galactosyltransferase 1 JBrowse link NW_004936524 1,659,791 1,713,971 RGD:9068941
G Crisp1 cysteine rich secretory protein 1 JBrowse link NW_004936476 10,729,598 10,753,000 RGD:9068941
G Serpina10 serpin family A member 10 JBrowse link NW_004936733 2,121,875 2,129,988 RGD:9068941
G Spink1 serine peptidase inhibitor, Kazal type 1 JBrowse link NW_004936504 6,975,044 6,981,304 RGD:9068941
G Zp2 zona pellucida glycoprotein 2 JBrowse link NW_004936501 6,394,838 6,407,512 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 14770
    reproductive process 1328
      acrosome reaction 33
        acrosomal vesicle exocytosis + 8
        acrosome matrix dispersal 1
        membrane fusion involved in acrosome reaction 0
        negative regulation of acrosome reaction 0
        positive regulation of acrosome reaction + 10
        positive regulation of actin filament depolymerization involved in acrosome reaction 0
        positive regulation of actin filament polymerization involved in acrosome reaction 0
        protein localization involved in acrosome reaction 0
        regulation of acrosome reaction + 15
Path 2
Term Annotations click to browse term
  biological_process 14770
    reproduction 1331
      reproductive process 1328
        multi-organism reproductive process 898
          sexual reproduction 741
            fertilization 162
              single fertilization 132
                acrosome reaction 33
                  acrosomal vesicle exocytosis + 8
                  acrosome matrix dispersal 1
                  membrane fusion involved in acrosome reaction 0
                  negative regulation of acrosome reaction 0
                  positive regulation of acrosome reaction + 10
                  positive regulation of actin filament depolymerization involved in acrosome reaction 0
                  positive regulation of actin filament polymerization involved in acrosome reaction 0
                  protein localization involved in acrosome reaction 0
                  regulation of acrosome reaction + 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.