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ONTOLOGY REPORT - ANNOTATIONS


Term:mesodermal cell fate specification
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Accession:GO:0007501 term browser browse the term
Definition:The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
Comment:Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'.
Synonyms:exact_synonym: mesoderm cell fate specification


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mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eya1 EYA transcriptional coactivator and phosphatase 1 ISO (MGI:3768605|PMID:17785448) RGD PMID:17785448 MGI:3768605 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142
JBrowse link
G Hoxa11 homeobox A11 ISO (MGI:3768605|PMID:17785448) RGD PMID:17785448 MGI:3768605 NCBI chr 4:82,296,888...82,301,419
Ensembl chr 4:82,298,152...82,300,503
Ensembl chr 4:82,298,152...82,300,503
JBrowse link
G Pax2 paired box 2 ISS
ISO
GO_REF:0000024
(MGI:3768605|PMID:17785448)
UniProt
RGD
PMID:17785448 GO_REF:0000024, MGI:3768605 NCBI chr 1:264,493,579...264,585,073
Ensembl chr 1:264,504,591...264,583,329
JBrowse link
G Six2 SIX homeobox 2 ISO (MGI:3768605|PMID:17785448) RGD PMID:17785448 MGI:3768605 NCBI chr 6:8,952,572...8,955,893
Ensembl chr 6:8,952,572...8,956,276
JBrowse link
axial mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nodal nodal growth differentiation factor ISO (MGI:2677178|PMID:14511481) RGD PMID:14511481 MGI:2677178 NCBI chr20:31,035,729...31,044,096
Ensembl chr20:31,035,729...31,044,096
JBrowse link
BMP signaling pathway involved in mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Etv2 ETS variant transcription factor 2 ISO (MGI:4415813|PMID:18462699) RGD PMID:18462699 MGI:4415813 NCBI chr 1:89,091,239...89,094,570
Ensembl chr 1:89,091,239...89,094,530
JBrowse link
negative regulation of mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 ISO (PMID:20559569) RGD PMID:20559569 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Mesp1 mesoderm posterior bHLH transcription factor 1 ISO (MGI:4441249|PMID:18593560) RGD PMID:18593560 MGI:4441249 NCBI chr 1:141,532,390...141,533,908
Ensembl chr 1:141,532,390...141,533,908
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 ISO MGI:98956 (MGI:3711603|PMID:17462603) RGD PMID:17462603 MGI:3711603 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
positive regulation of mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt3a Wnt family member 3A ISO (PMID:20559569) RGD PMID:20559569 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
regulation of lateral mesodermal cell fate specification term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmpr1a bone morphogenetic protein receptor type 1A ISO MGI:95522 (MGI:3702797|PMID:16943278) RGD PMID:16943278 MGI:3702797 NCBI chr16:10,758,278...10,852,170
Ensembl chr16:10,758,527...10,802,512
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 IEA
ISO
GO_REF:0000107
MGI:1338938 (MGI:3702797|PMID:16943278)
Ensembl
RGD
PMID:16943278 GO_REF:0000107, MGI:3702797 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      cellular developmental process 4457
        cell fate specification 100
          mesodermal cell fate specification 12
            BMP signaling pathway involved in mesodermal cell fate specification 1
            axial mesodermal cell fate specification + 1
            intermediate mesodermal cell fate specification + 0
            lateral mesodermal cell fate specification + 2
            negative regulation of mesodermal cell fate specification + 3
            paraxial mesodermal cell fate specification + 0
            positive regulation of mesodermal cell fate specification + 1
            regulation of mesodermal cell fate specification + 6
            transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification + 0
Path 2
Term Annotations click to browse term
  biological_process 20020
    developmental process 6826
      anatomical structure development 6268
        multicellular organism development 5743
          embryo development 1307
            embryonic morphogenesis 690
              gastrulation 208
                formation of primary germ layer 128
                  mesoderm formation 75
                    mesodermal cell differentiation 31
                      mesodermal cell fate commitment 17
                        mesodermal cell fate specification 12
                          BMP signaling pathway involved in mesodermal cell fate specification 1
                          axial mesodermal cell fate specification + 1
                          intermediate mesodermal cell fate specification + 0
                          lateral mesodermal cell fate specification + 2
                          negative regulation of mesodermal cell fate specification + 3
                          paraxial mesodermal cell fate specification + 0
                          positive regulation of mesodermal cell fate specification + 1
                          regulation of mesodermal cell fate specification + 6
                          transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.