Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:cell aging
go back to main search page
Accession:GO:0007569 term browser browse the term
Definition:An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).
Synonyms:exact_synonym: cell ageing


show annotations for term's descendants       view all columns           Sort by:
 
cell aging term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:1624291
RGD:1600115
G Bglap bone gamma-carboxyglutamate protein JBrowse link 2 187,741,770 187,748,445 RGD:2316145
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:1624291
RGD:1600115
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:2301352
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 JBrowse link 1 12,823,363 12,825,806 RGD:5147849
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 10 11,059,701 11,085,186 RGD:1624291
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:1624291
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 JBrowse link X 21,696,796 21,699,241 RGD:2302236
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:1624291
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:4145420
G Ilk integrin-linked kinase JBrowse link 1 170,578,941 170,585,192 RGD:2301768
G Met MET proto-oncogene, receptor tyrosine kinase JBrowse link 4 44,747,467 44,854,628 RGD:2317463
G Mif macrophage migration inhibitory factor JBrowse link 20 13,715,219 13,732,980 RGD:1624291
G Mir125a microRNA 125a JBrowse link 1 59,704,827 59,704,911 RGD:1624291
G Mir125b1 microRNA 125b-1 JBrowse link 8 45,798,260 45,798,346 RGD:1624291
G Mir125b2 microRNA 125b-2 JBrowse link 11 16,097,346 16,097,433 RGD:1624291
G Mir128-1 microRNA 128-1 JBrowse link 13 44,916,534 44,916,615 RGD:1624291
G Mir128-2 microRNA 128-2 JBrowse link 8 120,378,945 120,379,028 RGD:1624291
G Mir130a microRNA 130a JBrowse link 3 72,141,037 72,141,124 RGD:1624291
G Mir132 microRNA 132 JBrowse link 10 62,014,995 62,015,095 RGD:1624291
G Mir134 microRNA 134 JBrowse link 6 133,884,547 133,884,619 RGD:1624291
G Mir140 microRNA 140 JBrowse link 19 39,608,951 39,609,049 RGD:1624291
G Mir15b microRNA 15b JBrowse link 2 165,605,923 165,606,020 RGD:1624291
G Mir16 microRNA 16 JBrowse link 2 165,606,072 165,606,166 RGD:1624291
G Mir183 microRNA 183 JBrowse link 4 57,463,569 57,463,678 RGD:1624291
G Mir188 microRNA 188 JBrowse link X 16,110,270 16,110,349 RGD:1624291
G Mir191 microRNA 191 JBrowse link 8 117,354,364 117,354,454 RGD:1624291
G Mir193b microRNA 193b JBrowse link 14 30,331,049 30,331,131 RGD:1624291
G Mir199a2 microRNA 199a-2 JBrowse link 13 80,125,487 80,125,596 RGD:1624291
G Mir19b1 microRNA 19b-1 JBrowse link 15 100,180,464 100,180,550 RGD:1624291
G Mir19b2 microRNA 19b-2 JBrowse link X 140,117,379 140,117,474 RGD:1624291
G Mir20a microRNA 20a JBrowse link 15 100,180,334 100,180,418 RGD:1624291
G Mir211 microRNA 211 JBrowse link 1 125,042,119 125,042,224 RGD:1624291
G Mir22 microRNA 22 JBrowse link 10 62,299,592 62,299,686 RGD:1624291
G Mir23a microRNA 23a JBrowse link 19 25,318,582 25,318,656 RGD:1624291
G Mir23b microRNA 23b JBrowse link 17 823,222 823,318 RGD:1624291
G Mir24-2 microRNA 24-2 JBrowse link 19 25,318,863 25,318,970 RGD:1624291
G Mir25 microRNA 25 JBrowse link 12 19,307,340 19,307,423 RGD:1624291
G Mir27a microRNA 27a JBrowse link 19 25,318,736 25,318,822 RGD:1624291
G Mir296 microRNA 296 JBrowse link 3 172,357,490 172,357,567 RGD:1624291
G Mir30a microRNA 30a JBrowse link 9 29,542,635 29,542,705 RGD:1624291
G Mir31 microRNA 31 JBrowse link 5 107,206,515 107,206,620 RGD:1624291
G Mir342 microRNA 342 JBrowse link 6 132,561,169 132,561,267 RGD:1624291
G Mir34a microRNA 34a JBrowse link 5 167,092,491 167,092,592 RGD:1624291
G Mir34b microRNA 34b JBrowse link 8 55,492,542 55,492,625 RGD:1624291
G Mir34c microRNA 34c JBrowse link 8 55,492,024 55,492,100 RGD:1624291
G Mir370 microRNA 370 JBrowse link 6 133,739,916 133,739,994 RGD:1624291
G Mir671 microRNA 671 JBrowse link 4 7,108,747 7,108,827 RGD:1624291
G Mir877 microRNA 877 JBrowse link 20 3,318,872 3,318,956 RGD:1624291
G Mir99a microRNA 99a JBrowse link 11 16,052,153 16,052,233 RGD:1624291
G Mirlet7b microRNA let-7b JBrowse link 7 126,590,627 126,590,711 RGD:1624291
G Mirlet7d microRNA let-7d JBrowse link 17 16,419,980 16,420,077 RGD:1624291
G Mirlet7f1 microRNA let-7f-1 JBrowse link 17 16,418,217 16,418,313 RGD:1624291
G Mirlet7f2 microRNA let-7f-2 JBrowse link X 21,583,272 21,583,354 RGD:1624291
G Mirlet7g microRNA let-7g JBrowse link 8 114,874,457 114,874,544 RGD:1624291
G Mirlet7i microRNA let-7i JBrowse link 7 66,802,731 66,802,815 RGD:1624291
G Mnt MAX network transcriptional repressor JBrowse link 10 61,683,776 61,700,504 RGD:1624291
G Morc3 MORC family CW-type zinc finger 3 JBrowse link 11 34,051,928 34,094,697 RGD:1624291
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:10003167
G Nox4 NADPH oxidase 4 JBrowse link 1 150,796,359 150,976,186 RGD:1624291
RGD:1600115
G Npm1 nucleophosmin 1 JBrowse link 10 18,080,949 18,091,062 RGD:1624291
RGD:1600115
G Nup62 nucleoporin 62 JBrowse link 1 100,811,140 100,827,119 RGD:1624291
G Pdcd4 programmed cell death 4 JBrowse link 1 274,616,625 274,648,204 RGD:1624291
RGD:1600115
G Pml PML nuclear body scaffold JBrowse link 8 63,002,515 63,034,310 RGD:1624291
G Pot1b protection of telomeres 1B JBrowse link 9 7,845,697 7,902,270 RGD:1600115
G Prelp proline and arginine rich end leucine rich repeat protein JBrowse link 13 50,749,526 50,773,934 RGD:1624291
G Rwdd1 RWD domain containing 1 JBrowse link 20 27,534,361 27,552,225 RGD:1624291
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:10047125
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:1624291
RGD:1600115
G Tbx2 T-box transcription factor 2 JBrowse link 10 73,278,932 73,290,764 RGD:1624291
G Tbx3 T-box transcription factor 3 JBrowse link 12 42,479,518 42,494,588 RGD:1624291
RGD:1600115
G Top2b DNA topoisomerase II beta JBrowse link 15 10,262,972 10,319,741 RGD:13432149
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
RGD:1600115
G Tp63 tumor protein p63 JBrowse link 11 78,234,853 78,456,559 RGD:1624291
G Wrn WRN RecQ like helicase JBrowse link 16 62,483,773 62,619,018 RGD:1624291
G Zmiz1 zinc finger, MIZ-type containing 1 JBrowse link 16 1,749,191 1,954,633 RGD:1624291
cellular senescence term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:1624291
G Cav1 caveolin 1 JBrowse link 4 44,597,123 44,630,206 RGD:9588563
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1624291
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Cdkn2b cyclin-dependent kinase inhibitor 2B JBrowse link 5 107,834,353 107,857,428 RGD:1600115
RGD:1624291
G Ecrg4 ECRG4 augurin precursor JBrowse link 9 50,526,811 50,548,056 RGD:1624291
RGD:13792537
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:8693719
G Hras HRas proto-oncogene, GTPase JBrowse link 1 214,178,404 214,181,841 RGD:1624291
RGD:13792537
RGD:11060281
G Id2 inhibitor of DNA binding 2 JBrowse link 6 44,360,077 44,361,908 RGD:1624291
RGD:1600115
G Igf1r insulin-like growth factor 1 receptor JBrowse link 1 128,924,921 129,213,816 RGD:10045872
G Kat6a lysine acetyltransferase 6A JBrowse link 16 73,942,669 74,020,750 RGD:1624291
RGD:1600115
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:12791030
G Map2k1 mitogen activated protein kinase kinase 1 JBrowse link 8 69,134,218 69,722,573 RGD:1624291
RGD:1600115
G Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase JBrowse link 7 99,677,295 99,900,765 RGD:1624291
RGD:1600115
G Opa1 OPA1, mitochondrial dynamin like GTPase JBrowse link 11 74,717,600 74,793,902 RGD:1624291
RGD:1600115
G Pml PML nuclear body scaffold JBrowse link 8 63,002,515 63,034,310 RGD:1624291
G Prkcd protein kinase C, delta JBrowse link 16 6,655,131 6,675,746 RGD:1624291
RGD:1600115
G Prmt6 protein arginine methyltransferase 6 JBrowse link 2 213,173,403 213,180,721 RGD:1624291
G Smc5 structural maintenance of chromosomes 5 JBrowse link 1 240,977,898 241,046,273 RGD:1624291
G Smc6 structural maintenance of chromosomes 6 JBrowse link 6 36,941,233 36,995,920 RGD:1624291
G Srf serum response factor JBrowse link 9 16,737,637 16,747,226 RGD:1624291
G Tbx2 T-box transcription factor 2 JBrowse link 10 73,278,932 73,290,764 RGD:1624291
G Tbx3 T-box transcription factor 3 JBrowse link 12 42,479,518 42,494,588 RGD:1624291
RGD:1600115
chronological cell aging term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:1624291
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:1624291
RGD:1600115
negative regulation of cell aging term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Foxm1 forkhead box M1 JBrowse link 4 161,685,236 161,697,633 RGD:1600115
RGD:1624291
G Fzr1 fizzy and cell division cycle 20 related 1 JBrowse link 7 11,201,690 11,213,614 RGD:1624291
G Marchf5 membrane associated ring-CH-type finger 5 JBrowse link 1 255,842,642 255,864,131 RGD:1624291
G Mif macrophage migration inhibitory factor JBrowse link 20 13,715,219 13,732,980 RGD:1624291
G Pten phosphatase and tensin homolog JBrowse link 1 251,421,814 251,487,634 RGD:1624291
G Wnt1 Wnt family member 1 JBrowse link 7 140,464,999 140,469,046 RGD:1624291
negative regulation of cellular senescence term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Akt3 AKT serine/threonine kinase 3 JBrowse link 13 95,076,308 95,348,913 RGD:1624291
G Bcl2l12 BCL2 like 12 JBrowse link 1 100,984,550 100,993,269 RGD:1624291
G Bcl6 BCL6, transcription repressor JBrowse link 11 80,255,790 80,279,075 RGD:1624291
G Cdk6 cyclin-dependent kinase 6 JBrowse link 4 27,781,728 27,969,653 RGD:1624291
G Fbxo5 F-box protein 5 JBrowse link 1 42,461,277 42,467,646 RGD:1624291
G Hmga2 high mobility group AT-hook 2 JBrowse link 7 65,159,944 65,275,408 RGD:1624291
G LOC100912427 nuclease-sensitive element-binding protein 1-like JBrowse link 1 186,635,408 186,641,503 RGD:1624291
G Map3k3 mitogen activated protein kinase kinase kinase 3 JBrowse link 10 94,280,703 94,349,372 RGD:1624291
G Nampt nicotinamide phosphoribosyltransferase JBrowse link 6 52,122,085 52,156,473 RGD:13781884
G Plk2 polo-like kinase 2 JBrowse link 2 41,911,143 41,916,901 RGD:1624291
G Prkdc protein kinase, DNA-activated, catalytic subunit JBrowse link 11 89,293,547 89,510,948 RGD:8696027
G Rbl1 RB transcriptional corepressor like 1 JBrowse link 3 153,263,692 153,321,351 RGD:1624291
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
G Slc30a10 solute carrier family 30, member 10 JBrowse link 13 103,396,295 103,406,759 RGD:1624291
G Terf2 telomeric repeat binding factor 2 JBrowse link 19 39,271,992 39,301,506 RGD:1624291
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:1624291
G Tp63 tumor protein p63 JBrowse link 11 78,234,853 78,456,559 RGD:1624291
G Twist1 twist family bHLH transcription factor 1 JBrowse link 6 53,401,241 53,403,235 RGD:1624291
G Ybx1 Y box binding protein 1 JBrowse link 5 138,319,754 138,336,721 RGD:1600115
G Zkscan3 zinc finger with KRAB and SCAN domains 3 JBrowse link 17 45,247,724 45,263,422 RGD:1624291
nucleolar fragmentation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Zfp354a zinc finger protein 354A JBrowse link 10 36,586,495 36,600,172 RGD:1303369
oncogene-induced cell senescence term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Hmga1 high mobility group AT-hook 1 JBrowse link 20 7,132,501 7,140,155 RGD:1624291
RGD:1600115
G Hmga2 high mobility group AT-hook 2 JBrowse link 7 65,159,944 65,275,408 RGD:1624291
RGD:1600115
oxidative stress-induced premature senescence term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arntl aryl hydrocarbon receptor nuclear translocator-like JBrowse link 1 178,039,002 178,137,469 RGD:1600115
RGD:1624291
G Pla2r1 phospholipase A2 receptor 1 JBrowse link 3 46,488,963 46,621,873 RGD:1624291
RGD:1600115
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Wnt16 Wnt family member 16 JBrowse link 4 49,369,246 49,388,156 RGD:1624291
positive regulation of cell aging term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lmna lamin A/C JBrowse link 2 187,842,884 187,863,552 RGD:1600115
RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
positive regulation of cellular senescence term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arg2 arginase 2 JBrowse link 6 102,311,097 102,338,406 RGD:1600115
RGD:1624291
G B2m beta-2 microglobulin JBrowse link 3 114,087,287 114,093,311 RGD:1624291
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Cgas cyclic GMP-AMP synthase JBrowse link 8 85,789,515 85,804,008 RGD:1624291
G Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 JBrowse link 17 26,785,017 26,795,723 RGD:1624291
G Hmga1 high mobility group AT-hook 1 JBrowse link 20 7,132,501 7,140,155 RGD:1624291
RGD:1600115
G Hmga2 high mobility group AT-hook 2 JBrowse link 7 65,159,944 65,275,408 RGD:1624291
RGD:1600115
G Kras KRAS proto-oncogene, GTPase JBrowse link 4 179,482,562 179,515,483 RGD:11060281
G Pawr pro-apoptotic WT1 regulator JBrowse link 7 51,273,764 51,353,700 RGD:1624291
RGD:1600115
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115
G Stk11 serine/threonine kinase 11 JBrowse link 7 12,440,751 12,457,513 RGD:1624291
G Ypel3 yippee-like 3 JBrowse link 1 198,210,525 198,213,821 RGD:1624291
regulation of cellular senescence term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase JBrowse link 3 10,041,820 10,145,076 RGD:1624291
G Arntl aryl hydrocarbon receptor nuclear translocator-like JBrowse link 1 178,039,002 178,137,469 RGD:1600115
RGD:1624291
G Bmpr1a bone morphogenetic protein receptor type 1A JBrowse link 16 10,758,278 10,852,170 RGD:1624291
G Icmt isoprenylcysteine carboxyl methyltransferase JBrowse link 5 169,475,270 169,482,031 RGD:1624291
G Ing2 inhibitor of growth family, member 2 JBrowse link 16 47,714,756 47,725,836 RGD:1600115
G Nek4 NIMA-related kinase 4 JBrowse link 16 7,035,002 7,080,272 RGD:1624291
G Nuak1 NUAK family kinase 1 JBrowse link 7 25,039,336 25,111,118 RGD:1624291
G Pnpt1 polyribonucleotide nucleotidyltransferase 1 JBrowse link 14 113,530,470 113,561,645 RGD:1624291
G Rsl1d1 ribosomal L1 domain containing 1 JBrowse link 10 4,375,329 4,387,195 RGD:1624291
G Suv39h1 suppressor of variegation 3-9 homolog 1 JBrowse link X 146,532,002 146,533,538 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Vash1 vasohibin 1 JBrowse link 6 110,624,377 110,640,942 RGD:1624291
G Zfp277 zinc finger protein 277 JBrowse link 6 60,246,209 60,374,388 RGD:1624291
G Zmpste24 zinc metallopeptidase STE24 JBrowse link 5 139,982,404 140,015,541 RGD:1624291
regulation of replicative cell aging term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nek4 NIMA-related kinase 4 JBrowse link 16 7,035,002 7,080,272 RGD:1624291
replicative cell aging term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chek2 checkpoint kinase 2 JBrowse link 12 51,845,574 51,878,098 RGD:1624291
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:1624291
G Romo1 reactive oxygen species modulator 1 JBrowse link 3 151,688,213 151,689,813 RGD:1624291
G Tmem115 transmembrane protein 115 JBrowse link 8 116,289,590 116,294,454 RGD:2303064
G Tp63 tumor protein p63 JBrowse link 11 78,234,853 78,456,559 RGD:1600401
G Wrn WRN RecQ like helicase JBrowse link 16 62,483,773 62,619,018 RGD:1624291
replicative senescence term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:1624291
G Atr ATR serine/threonine kinase JBrowse link 8 103,673,578 103,770,886 RGD:1624291
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:1600115
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Ctc1 CST telomere replication complex component 1 JBrowse link 10 55,596,172 55,616,873 RGD:1624291
G Mme membrane metallo-endopeptidase JBrowse link 2 153,799,203 153,880,910 RGD:1624291
RGD:1600115
G Pla2r1 phospholipase A2 receptor 1 JBrowse link 3 46,488,963 46,621,873 RGD:1624291
RGD:1600115
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:1600115
RGD:1624291
G Tert telomerase reverse transcriptase JBrowse link 1 32,250,876 32,275,330 RGD:1624291
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
G Wnt16 Wnt family member 16 JBrowse link 4 49,369,246 49,388,156 RGD:1624291
stress-induced premature senescence term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mapk14 mitogen activated protein kinase 14 JBrowse link 20 5,933,290 5,995,137 RGD:1624291
RGD:1600115
G Mapkapk5 MAPK activated protein kinase 5 JBrowse link 12 40,510,378 40,529,332 RGD:1624291
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    developmental process 6697
      aging 536
        cell aging 155
          cellular senescence + 70
          chronological cell aging + 2
          negative regulation of cell aging + 27
          nucleolar fragmentation + 1
          positive regulation of cell aging + 14
          progressive alteration of chromatin involved in cell aging + 0
          regulation of cell aging + 51
          replicative cell aging + 7
          replicative senescence + 11
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.