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ONTOLOGY REPORT - ANNOTATIONS


Term:COP9 signalosome
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Accession:GO:0008180 term browser browse the term
Definition:A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome.
Synonyms:exact_synonym: CSN
 narrow_synonym: COP9 complex
 broad_synonym: signalosome


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COP9 signalosome term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amot angiomotin JBrowse link X 116,751,231 116,810,238 RGD:1624291
G Amotl1 angiomotin-like 1 JBrowse link 8 13,037,265 13,157,701 RGD:1624291
RGD:1600115
G Atp5f1a ATP synthase F1 subunit alpha JBrowse link 18 74,156,553 74,164,490 RGD:1624291
G Basp1 brain abundant, membrane attached signal protein 1 JBrowse link 2 77,586,424 77,632,626 RGD:1624291
RGD:1600115
G Cops2 COP9 signalosome subunit 2 JBrowse link 3 118,109,394 118,137,125 RGD:1624291
RGD:13792537
G Cops3 COP9 signalosome subunit 3 JBrowse link 10 46,182,680 46,206,083 RGD:1624291
RGD:13792537
G Cops4 COP9 signalosome subunit 4 JBrowse link 14 10,718,863 10,749,134 RGD:1624291
RGD:13792537
G Cops5 COP9 signalosome subunit 5 JBrowse link 5 8,876,090 8,894,345 RGD:1624291
RGD:13792537
G Cops6 COP9 signalosome subunit 6 JBrowse link 12 19,303,387 19,306,226 RGD:1624291
RGD:13792537
G Cops7a COP9 signalosome subunit 7A JBrowse link 4 157,479,549 157,486,944 RGD:1624291
RGD:13792537
G Cops7b COP9 signalosome subunit 7B JBrowse link 9 93,607,199 93,633,064 RGD:1624291
RGD:13792537
G Cops8 COP9 signalosome subunit 8 JBrowse link 9 97,772,224 97,782,055 RGD:1624291
RGD:13792537
G Cops9 COP9 signalosome subunit 9 JBrowse link 9 99,813,332 99,818,262 RGD:1624291
RGD:13792537
G Dcaf1 DDB1 and CUL4 associated factor 1 JBrowse link 8 115,538,365 115,615,282 RGD:1624291
G Dock7 dedicator of cytokinesis 7 JBrowse link 5 117,595,194 117,780,844 RGD:1624291
G Dynll1 dynein light chain LC8-type 1 JBrowse link 12 47,074,200 47,076,573 RGD:1624291
G Epb41l2 erythrocyte membrane protein band 4.1-like 2 JBrowse link 1 20,881,820 21,067,713 RGD:1624291
G Flot1 flotillin 1 JBrowse link 20 3,427,890 3,438,418 RGD:1624291
G Gps1 G protein pathway suppressor 1 JBrowse link 10 109,966,875 109,971,912 RGD:1624291
RGD:13792537
RGD:1600115
G Grb2 growth factor receptor bound protein 2 JBrowse link 10 104,193,953 104,263,071 RGD:1624291
RGD:1600115
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:1624291
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:1624291
RGD:13792537
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1624291
RGD:13792537
G Hspa1l heat shock protein family A (Hsp70) member 1 like JBrowse link 20 4,879,998 4,965,191 RGD:1624291
RGD:13792537
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:1624291
G Lat linker for activation of T cells JBrowse link 1 197,765,644 197,770,669 RGD:1624291
RGD:1600115
G LOC108348108 heat shock 70 kDa protein 1A JBrowse link 20 2,699,707 2,701,856 RGD:13792537
G Myh9 myosin, heavy chain 9 JBrowse link 7 118,740,005 118,792,507 RGD:1624291
G Nckipsd NCK interacting protein with SH3 domain JBrowse link 8 117,601,035 117,612,302 RGD:1624291
G Plcg1 phospholipase C, gamma 1 JBrowse link 3 156,727,642 156,758,307 RGD:1600115
RGD:1624291
G Stoml2 stomatin like 2 JBrowse link 5 58,472,561 58,476,158 RGD:1624291
G Themis thymocyte selection associated JBrowse link 1 17,152,973 17,378,225 RGD:1624291
G Tmod1 tropomodulin 1 JBrowse link 5 61,635,244 61,712,052 RGD:1600115
RGD:1624291
G Wdr6 WD repeat domain 6 JBrowse link 8 117,358,345 117,364,761 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19843
    protein-containing complex 5779
      COP9 signalosome 34
Path 2
Term Annotations click to browse term
  cellular_component 19843
    cellular anatomical entity 19457
      organelle 12557
        membrane-bounded organelle 10879
          intracellular membrane-bounded organelle 9976
            nucleus 6783
              COP9 signalosome 34
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.