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ONTOLOGY REPORT - ANNOTATIONS


Term:cholesterol metabolic process
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Accession:GO:0008203 term browser browse the term
Definition:The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.
Synonyms:exact_synonym: cholesterol metabolism
 never_in_taxon: NCBITaxon:4895 ! Schizosaccharomyces;   NCBITaxon:4930 ! Saccharomyces


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cholesterol metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07060293.1 RGD:1600115
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:1624291
G Abcg1 ATP binding cassette subfamily G member 1 JBrowse link 20 9,743,269 9,842,735 RGD:1624291
G Angptl3 angiopoietin-like 3 JBrowse link 5 117,698,590 117,706,729 RGD:1624291
G Aplp2 amyloid beta precursor like protein 2 JBrowse link 8 32,298,526 32,328,821 RGD:1624291
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
G Apoa2 apolipoprotein A2 JBrowse link 13 89,596,872 89,598,805 RGD:1624291
RGD:13792537
G Apoa4 apolipoprotein A4 JBrowse link 8 50,536,983 50,539,371 RGD:1624291
RGD:1600115
G Apob apolipoprotein B JBrowse link 6 33,176,826 33,216,381 RGD:1624291
G Apoc1 apolipoprotein C1 JBrowse link 1 80,606,638 80,609,921 RGD:1624291
G Apoc3 apolipoprotein C3 JBrowse link 8 50,529,318 50,531,498 RGD:1624291
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1600115
RGD:1624291
G Apof apolipoprotein F JBrowse link 7 2,689,501 2,690,938 RGD:1624291
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G Cat catalase JBrowse link 3 93,379,872 93,412,058 RGD:1624291
G Cebpa CCAAT/enhancer binding protein alpha JBrowse link 1 91,363,492 91,366,164 RGD:1624291
RGD:1600115
G Ch25h cholesterol 25-hydroxylase JBrowse link 1 252,807,062 252,811,409 RGD:1624291
RGD:13792537
G Cln6 CLN6, transmembrane ER protein JBrowse link 8 67,733,215 67,748,170 RGD:1624291
G Cln8 CLN8, transmembrane ER and ERGIC protein JBrowse link 16 79,828,321 79,838,212 RGD:1624291
RGD:1600115
G Cubn cubilin JBrowse link 17 80,584,921 80,807,181 RGD:1600115
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:1600115
RGD:13792537
RGD:1624291
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:13792537
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:13792537
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:1600115
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 JBrowse link 9 81,968,285 81,998,213 RGD:1299597
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 JBrowse link 2 102,701,903 102,871,257 RGD:1298868
G Dhcr24 24-dehydrocholesterol reductase JBrowse link 5 126,164,708 126,188,926 RGD:1624291
G Erlin2 ER lipid raft associated 2 JBrowse link 16 69,179,005 69,195,452 RGD:1600115
G Fdx1 ferredoxin 1 JBrowse link 8 56,373,729 56,393,199 RGD:1600115
RGD:1624291
G Fdxr ferredoxin reductase JBrowse link 10 103,817,724 103,826,413 RGD:1600115
G Fech ferrochelatase JBrowse link 18 59,941,992 59,975,192 RGD:1624291
G Fgl1 fibrinogen-like 1 JBrowse link 16 54,153,086 54,188,120 RGD:1624291
G Gba glucosylceramidase beta JBrowse link 2 188,511,781 188,522,602 RGD:1624291
G Gba2 glucosylceramidase beta 2 JBrowse link 5 59,068,081 59,079,719 RGD:1600115
RGD:1624291
G Hdlbp high density lipoprotein binding protein JBrowse link 9 100,554,574 100,624,707 RGD:1600115
G Hnf1a HNF1 homeobox A JBrowse link 12 47,407,811 47,433,342 RGD:1624291
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 JBrowse link 18 44,810,462 44,897,677 RGD:632889
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:1624291
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:1624291
G Insig2 insulin induced gene 2 JBrowse link 13 37,264,818 37,292,718 RGD:1624291
G Lcat lecithin cholesterol acyltransferase JBrowse link 19 37,913,333 37,916,799 RGD:1581789
RGD:1624291
RGD:1600115
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:1624291
RGD:1600115
G Ldlrap1 low density lipoprotein receptor adaptor protein 1 JBrowse link 5 152,964,294 152,987,286 RGD:1600115
G Lep leptin JBrowse link 4 56,337,695 56,351,818 RGD:1624291
G Lepr leptin receptor JBrowse link 5 120,503,475 120,682,281 RGD:1624291
G Lima1 LIM domain and actin binding 1 JBrowse link 7 141,428,113 141,528,447 RGD:1600115
G Lipc lipase C, hepatic type JBrowse link 8 77,272,582 77,398,485 RGD:1624291
RGD:1600115
G Lipe lipase E, hormone sensitive type JBrowse link 1 82,248,031 82,266,727 RGD:1600115
G Lrp1 LDL receptor related protein 1 JBrowse link 7 70,846,313 70,927,028 RGD:1624291
G Lrp5 LDL receptor related protein 5 JBrowse link 1 218,816,833 218,920,147 RGD:1624291
G Mbtps1 membrane-bound transcription factor peptidase, site 1 JBrowse link 19 52,146,507 52,206,310 RGD:1600115
G Nsdhl NAD(P) dependent steroid dehydrogenase-like JBrowse link X 152,933,118 152,964,399 RGD:1624291
RGD:13792537
G Pcsk9 proprotein convertase subtilisin/kexin type 9 JBrowse link 5 126,031,368 126,053,726 RGD:1624291
G Pctp phosphatidylcholine transfer protein JBrowse link 10 77,491,445 77,537,268 RGD:1624291
G Pip4p1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 JBrowse link 15 27,852,152 27,855,999 RGD:1624291
RGD:1600115
G Pmp22 peripheral myelin protein 22 JBrowse link 10 49,538,588 49,568,583 RGD:1624291
G Pon1 paraoxonase 1 JBrowse link 4 30,249,749 30,276,297 RGD:1624291
G Scap SREBF chaperone JBrowse link 8 118,551,869 118,628,650 RGD:1624291
G Smpd1 sphingomyelin phosphodiesterase 1 JBrowse link 1 170,383,682 170,387,525 RGD:1624291
G Soat1 sterol O-acyltransferase 1 JBrowse link 13 74,035,258 74,077,759 RGD:730254
RGD:13792537
RGD:1624291
RGD:1600115
G Soat2 sterol O-acyltransferase 2 JBrowse link 7 143,754,892 143,767,989 RGD:625687
RGD:13792537
RGD:1600115
RGD:1624291
G Sqle squalene epoxidase JBrowse link 7 99,609,929 99,624,803 RGD:1625701
RGD:13792537
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:1643359
G Srebf1_v2 sterol regulatory element binding factor 1, variant 2 RGD:1643359
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:1600115
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:1600115
G Sult2b1 sulfotransferase family 2B member 1 JBrowse link 1 101,712,254 101,774,683 RGD:1624291
RGD:1600115
G Tnfsf4 TNF superfamily member 4 JBrowse link 13 79,269,973 79,293,775 RGD:1624291
G Vldlr very low density lipoprotein receptor JBrowse link 1 245,236,819 245,273,688 RGD:1600115
cholesterol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acat2 acetyl-CoA acetyltransferase 2 JBrowse link 1 47,972,399 47,992,654 RGD:2326086
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
RGD:13792537
G Apoa4 apolipoprotein A4 JBrowse link 8 50,536,983 50,539,371 RGD:13792537
G Apoa5 apolipoprotein A5 JBrowse link 8 50,559,079 50,561,720 RGD:13792537
G Ces1d carboxylesterase 1D JBrowse link 19 15,195,514 15,239,827 RGD:1624291
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:1624291
RGD:1600115
G Cyb5r3 cytochrome b5 reductase 3 JBrowse link 7 124,024,003 124,041,564 RGD:1600115
G Dhcr24 24-dehydrocholesterol reductase JBrowse link 5 126,164,708 126,188,926 RGD:1624291
RGD:1600115
G Dhcr7 7-dehydrocholesterol reductase JBrowse link 1 217,018,916 217,034,890 RGD:625561
RGD:13792537
RGD:1624291
RGD:1600115
RGD:2316918
RGD:2316916
RGD:632010
G Ebp EBP, cholestenol delta-isomerase JBrowse link X 15,049,394 15,055,782 RGD:628445
RGD:13792537
RGD:1624291
RGD:1600115
G Fdft1 farnesyl diphosphate farnesyl transferase 1 JBrowse link 15 46,339,248 46,367,302 RGD:728402
RGD:13792537
RGD:1626611
G Fdps farnesyl diphosphate synthase JBrowse link 2 188,403,595 188,413,219 RGD:728501
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:1624291
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:1300058
RGD:1624291
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 JBrowse link 2 52,427,351 52,445,082 RGD:1600115
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 JBrowse link 2 200,452,623 200,480,785 RGD:1600115
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 JBrowse link 13 88,288,116 88,308,019 RGD:1624291
RGD:13792537
RGD:1600115
G Idi1 isopentenyl-diphosphate delta isomerase 1 JBrowse link 17 57,976,266 57,984,036 RGD:729078
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:1624291
G Insig2 insulin induced gene 2 JBrowse link 13 37,264,818 37,292,718 RGD:1624291
G Lbr lamin B receptor JBrowse link 13 100,431,390 100,450,209 RGD:1600115
RGD:1624291
G Lss lanosterol synthase JBrowse link 20 12,844,522 12,870,474 RGD:1626611
RGD:13792537
RGD:1600115
RGD:1624291
RGD:2316919
G Mvd mevalonate diphosphate decarboxylase JBrowse link 19 55,258,910 55,268,933 RGD:729305
RGD:1600115
G Mvk mevalonate kinase JBrowse link 12 47,904,266 47,920,457 RGD:728935
RGD:1600115
RGD:13792537
RGD:1624291
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 JBrowse link 14 86,345,946 86,560,694 RGD:1624291
G Nsdhl NAD(P) dependent steroid dehydrogenase-like JBrowse link X 152,933,118 152,964,399 RGD:1600115
G Pmvk phosphomevalonate kinase JBrowse link 2 188,784,329 188,793,890 RGD:8553625
RGD:13792537
RGD:1624291
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:1600115
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:1600115
G Tm7sf2 transmembrane 7 superfamily member 2 JBrowse link 1 221,426,017 221,430,340 RGD:13825441
RGD:1624291
cholesterol biosynthetic process via 24,25-dihydrolanosterol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp51 cytochrome P450, family 51 JBrowse link 4 27,175,564 27,194,018 RGD:2316902
RGD:13792537
cholesterol biosynthetic process via lathosterol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sc5d sterol-C5-desaturase JBrowse link 8 46,525,406 46,537,014 RGD:2316911
RGD:13792537
cholesterol catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1d1 aldo-keto reductase family 1, member D1 JBrowse link 4 65,110,706 65,143,930 RGD:1600115
RGD:1624291
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
RGD:13792537
G Cel carboxyl ester lipase JBrowse link 3 7,134,021 7,141,522 RGD:1624291
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 JBrowse link 9 81,968,285 81,998,213 RGD:1600115
RGD:1624291
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 JBrowse link 9 19,804,079 19,880,346 RGD:1624291
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 JBrowse link 6 132,242,328 132,273,788 RGD:13792537
RGD:1624291
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 JBrowse link 5 19,358,734 19,368,431 RGD:70534
RGD:1600115
RGD:1624291
G Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 JBrowse link 1 199,248,084 199,251,745 RGD:1599972
G Mt3 metallothionein 3 JBrowse link 19 11,324,708 11,326,112 RGD:1624291
RGD:1600115
G Scarb1 scavenger receptor class B, member 1 JBrowse link 12 36,694,952 36,761,445 RGD:1624291
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
RGD:1600115
RGD:10059686
G Erlin1 ER lipid raft associated 1 JBrowse link 1 263,810,439 263,845,762 RGD:1624291
G Erlin2 ER lipid raft associated 2 JBrowse link 16 69,179,005 69,195,452 RGD:1624291
G Idi2 isopentenyl-diphosphate delta isomerase 2 JBrowse link 17 63,107,152 63,107,469 RGD:1624291
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:1624291
RGD:1600115
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcg1 ATP binding cassette subfamily G member 1 JBrowse link 20 9,743,269 9,842,735 RGD:1624291
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 JBrowse link 5 19,358,734 19,368,431 RGD:13792517
G Fdps farnesyl diphosphate synthase JBrowse link 2 188,403,595 188,413,219 RGD:2316295
G Fgf1 fibroblast growth factor 1 JBrowse link 18 32,273,830 32,359,831 RGD:1624291
RGD:1600115
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:2316785
G Scp2 sterol carrier protein 2 JBrowse link 5 127,647,934 127,735,703 RGD:9850260
G Sec14l2 SEC14-like lipid binding 2 JBrowse link 14 84,335,594 84,360,354 RGD:727312
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:1624291
regulation of cholesterol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca2 ATP binding cassette subfamily A member 2 JBrowse link 3 2,648,787 2,668,770 RGD:1624291
G Apob apolipoprotein B JBrowse link 6 33,176,826 33,216,381 RGD:1624291
G Cyp51 cytochrome P450, family 51 JBrowse link 4 27,175,564 27,194,018 RGD:1298863
G Dhcr7 7-dehydrocholesterol reductase JBrowse link 1 217,018,916 217,034,890 RGD:632010
G Mvk mevalonate kinase JBrowse link 12 47,904,266 47,920,457 RGD:728935
G Pex2 peroxisomal biogenesis factor 2 JBrowse link 2 98,251,756 98,269,185 RGD:1624291
G Scap SREBF chaperone JBrowse link 8 118,551,869 118,628,650 RGD:1624291
regulation of cholesterol metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acadl acyl-CoA dehydrogenase, long chain JBrowse link 9 73,833,368 73,871,857 RGD:1624291
G Acadvl acyl-CoA dehydrogenase, very long chain JBrowse link 10 56,619,321 56,624,468 RGD:1624291
RGD:1600115
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
G Arv1 ARV1 homolog, fatty acid homeostasis modulator JBrowse link 19 57,484,720 57,496,539 RGD:1624291
G Dgat2 diacylglycerol O-acyltransferase 2 JBrowse link 1 164,113,459 164,143,818 RGD:10400884
G Dgkq diacylglycerol kinase, theta JBrowse link 14 2,069,409 2,083,370 RGD:1624291
G Ephx2 epoxide hydrolase 2 JBrowse link 15 42,757,241 42,794,211 RGD:1600115
RGD:1624291
G Gnb3 G protein subunit beta 3 JBrowse link 4 157,352,558 157,359,237 RGD:1624291
G Ldlr low density lipoprotein receptor JBrowse link 8 22,750,425 22,773,305 RGD:1600115
RGD:1624291
G Lmf1 lipase maturation factor 1 JBrowse link 10 14,945,185 15,031,855 RGD:1624291
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:2316785
G Serpina12 serpin family A member 12 JBrowse link 6 127,696,501 127,711,238 RGD:1624291
RGD:1600115
G Thrb thyroid hormone receptor beta JBrowse link 15 8,890,578 9,239,815 RGD:2315101
G Ttc39b tetratricopeptide repeat domain 39B JBrowse link 5 101,304,982 101,405,689 RGD:1600115
RGD:13792537
RGD:1624291
G Ttc39d tetratricopeptide repeat domain 39D JBrowse link 6 2,886,764 2,895,118 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19332
    metabolic process 11554
      small molecule metabolic process 1777
        alcohol metabolic process 352
          secondary alcohol metabolic process 140
            cholesterol metabolic process 124
              cholesterol biosynthetic process + 48
              cholesterol catabolic process 10
              cholesterol ester hydrolysis involved in cholesterol transport 0
              negative regulation of cholesterol metabolic process + 5
              peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine 0
              positive regulation of cholesterol metabolic process + 8
              regulation of cholesterol metabolic process + 33
Path 2
Term Annotations click to browse term
  biological_process 19332
    metabolic process 11554
      primary metabolic process 10411
        lipid metabolic process 1300
          steroid metabolic process 306
            sterol metabolic process 135
              cholesterol metabolic process 124
                cholesterol biosynthetic process + 48
                cholesterol catabolic process 10
                cholesterol ester hydrolysis involved in cholesterol transport 0
                negative regulation of cholesterol metabolic process + 5
                peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine 0
                positive regulation of cholesterol metabolic process + 8
                regulation of cholesterol metabolic process + 33
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.