Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:cohesin complex
go back to main search page
Accession:GO:0008278 term browser browse the term
Definition:A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3).
Synonyms:exact_synonym: SMC/kleisin ring complex
 narrow_synonym: 14S cohesin;   9S cohesin;   Smc1-Smc3 complex
 related_synonym: SMC complex;   cohesin core heterodimer
 alt_id: GO:0008279;   GO:0008280;   GO:0043222


show annotations for term's descendants       view all columns           Sort by:
 
cohesin complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rad21 RAD21 cohesin complex component JBrowse link 7 91,511,755 91,538,673 RGD:1624291
G Smc1a structural maintenance of chromosomes 1A JBrowse link X 21,710,976 21,755,708 RGD:1624291
G Smc3 structural maintenance of chromosomes 3 JBrowse link 1 274,310,120 274,352,856 RGD:1624291
G Stag1 stromal antigen 1 JBrowse link 8 108,958,099 109,342,738 RGD:1624291
RGD:13792537
G Stag2 stromal antigen 2 JBrowse link X 128,493,603 128,624,418 RGD:13792537
RGD:1624291
G Stag3 stromal antigen 3 JBrowse link 12 19,599,741 19,630,775 RGD:13792537
meiotic cohesin complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rad21 RAD21 cohesin complex component JBrowse link 7 91,511,755 91,538,673 RGD:13792537
G Rad21l1 RAD21 cohesin complex component like 1 JBrowse link 3 147,163,335 147,191,008 RGD:1624291
RGD:13792537
G Rec8 REC8 meiotic recombination protein JBrowse link 15 34,296,922 34,304,387 RGD:1624291
RGD:13792537
G Smc1a structural maintenance of chromosomes 1A JBrowse link X 21,710,976 21,755,708 RGD:1600115
RGD:1624291
G Smc1b structural maintenance of chromosomes 1B JBrowse link 7 125,966,480 126,028,287 RGD:1624291
G Smc3 structural maintenance of chromosomes 3 JBrowse link 1 274,310,120 274,352,856 RGD:1624291
RGD:1600115
G Stag3 stromal antigen 3 JBrowse link 12 19,599,741 19,630,775 RGD:1624291
mitotic cohesin complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddx11 DEAD/H-box helicase 11 JBrowse link 9 114,113,642 114,133,908 RGD:1624291
G Sgo2 shugoshin 2 JBrowse link 9 64,898,380 64,923,023 RGD:1624291
nuclear cohesin complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rad21 RAD21 cohesin complex component JBrowse link 7 91,511,755 91,538,673 RGD:13792537
G Rad21l1 RAD21 cohesin complex component like 1 JBrowse link 3 147,163,335 147,191,008 RGD:13792537
G Rec8 REC8 meiotic recombination protein JBrowse link 15 34,296,922 34,304,387 RGD:13792537
nuclear meiotic cohesin complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Rad21l1 RAD21 cohesin complex component like 1 JBrowse link 3 147,163,335 147,191,008 RGD:1624291
G Rec8 REC8 meiotic recombination protein JBrowse link 15 34,296,922 34,304,387 RGD:1624291
G Smc1b structural maintenance of chromosomes 1B JBrowse link 7 125,966,480 126,028,287 RGD:1624291
G Smc3 structural maintenance of chromosomes 3 JBrowse link 1 274,310,120 274,352,856 RGD:1600115
RGD:1624291
G Stag3 stromal antigen 3 JBrowse link 12 19,599,741 19,630,775 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 19843
    protein-containing complex 5779
      cohesin complex 11
        meiotic cohesin complex + 7
        mitotic cohesin complex + 2
        nuclear cohesin complex + 6
Path 2
Term Annotations click to browse term
  cellular_component 19843
    cellular anatomical entity 19457
      organelle 12557
        non-membrane-bounded organelle 4641
          intracellular non-membrane-bounded organelle 4622
            chromosome 1102
              condensed chromosome 193
                cohesin complex 11
                  meiotic cohesin complex + 7
                  mitotic cohesin complex + 2
                  nuclear cohesin complex + 6
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.