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ONTOLOGY REPORT - ANNOTATIONS


Term:gamma-butyrobetaine dioxygenase activity
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Accession:GO:0008336 term browser browse the term
Definition:Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate.
Synonyms:exact_synonym: g-butyrobetaine dioxygenase activity;   gamma-butyrobetaine,2-oxoglutarate dioxygenase activity
 related_synonym: 4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating);   alpha-butyrobetaine hydroxylase activity;   butyrobetaine hydroxylase activity;   gamma-BBH activity;   gamma-butyrobetaine hydroxylase activity
 xref: EC:1.14.11.1;   KEGG_REACTION:R02397;   MetaCyc:1.14.11.1-RXN;   RHEA:24028;   Reactome:R-HSA-71261 "BBOX1:AscH-:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA"


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gamma-butyrobetaine dioxygenase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbox1 gamma-butyrobetaine hydroxylase 1 TAS
IMP
ISS
ISO
IBA
IEA
PMID:10526231
PMID:9753662
(PMID:20599753), (PMID:9753662)
PMID:21873635
GO_REF:0000003
RGD
UniProt
PMID:9753662, PMID:20599753, PMID:10526231, PMID:10526231, PMID:9753662, PMID:21873635 GO_REF:0000003, RGD:632240, RGD:632240, RGD:8554503, RGD:13792537 NCBI chr 3:101,425,684...101,474,848
Ensembl chr 3:101,427,055...101,474,890
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  molecular_function 20457
    catalytic activity 6065
      oxidoreductase activity 877
        dioxygenase activity 91
          2-oxoglutarate-dependent dioxygenase activity 50
            gamma-butyrobetaine dioxygenase activity 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.