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Term:IkappaB kinase complex
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Accession:GO:0008385 term browser browse the term
Definition:A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Synonyms:exact_synonym: IKK complex;   heterotrimeric IKK complex;   trimeric IKK complex

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IkappaB kinase complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Chuk component of inhibitor of nuclear factor kappa B kinase complex JBrowse link 1 263,848,829 263,884,354 RGD:2298661
G Erc1 ELKS/RAB6-interacting/CAST family member 1 JBrowse link 4 152,087,393 152,380,023 RGD:1624291
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:2298661
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma JBrowse link X 156,254,187 156,280,046 RGD:2298661
G Map3k7 mitogen activated protein kinase kinase kinase 7 JBrowse link 5 47,183,142 47,244,424 RGD:1624291
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:1624291
G Trim40 tripartite motif-containing 40 JBrowse link 20 2,169,674 2,178,477 RGD:1624291

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Path 1
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  cellular_component 20300
    cellular anatomical entity 19956
      cytosol 4144
        IkappaB kinase complex 7
Path 2
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  cellular_component 20300
    protein-containing complex 6095
      catalytic complex 1479
        transferase complex 823
          transferase complex, transferring phosphorus-containing groups 267
            protein kinase complex 106
              serine/threonine protein kinase complex 88
                IkappaB kinase complex 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.