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ONTOLOGY REPORT - ANNOTATIONS


Term:palmitoyl-(protein) hydrolase activity
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Accession:GO:0008474 term browser browse the term
Definition:Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
Synonyms:exact_synonym: palmitoyl-protein thioesterase activity;   palmitoyl-protein thiolesterase activity
 broad_synonym: palmitoyl-[protein] hydrolase
 xref: EC:3.1.2.22;   MetaCyc:3.1.2.22-RXN;   RHEA:19233;   Reactome:R-HSA-9647994 "RAS proteins are depalmitoylated";   reactome:R-HSA-203613 "depalmitoylation of eNOS";   reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins";   reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43"


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palmitoyl-(protein) hydrolase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07006474.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 1:236,529,931...236,530,485 JBrowse link
G Abhd10 abhydrolase domain containing 10, depalmitoylase ISO
ISS
(PMID:31740833)
GO_REF:0000024
RGD
UniProt
PMID:31740833 GO_REF:0000024 NCBI chr11:60,053,719...60,068,142
Ensembl chr11:60,054,408...60,066,739
JBrowse link
G Abhd12 abhydrolase domain containing 12, lysophospholipase ISO
IBA
(MGI:MGI:6094388|PMID:27307232)
PMID:21873635
RGD PMID:27307232, PMID:21873635 MGI:MGI:6094388, RGD:13792537 NCBI chr 3:146,630,298...146,690,375
Ensembl chr 3:146,630,299...146,690,375
JBrowse link
G Abhd12b abhydrolase domain containing 12B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:92,568,975...92,596,327
Ensembl chr 6:92,568,975...92,596,327
JBrowse link
G Abhd13 abhydrolase domain containing 13 ISO
IBA
(MGI:MGI:6094388|PMID:27307232)
PMID:21873635
RGD PMID:27307232, PMID:21873635 MGI:MGI:6094388, RGD:13792537 NCBI chr16:85,315,275...85,330,108
Ensembl chr16:85,315,275...85,330,092
JBrowse link
G Abhd16a abhydrolase domain containing 16A, phospholipase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:5,080,070...5,094,935
Ensembl chr20:5,080,070...5,094,935
JBrowse link
G Abhd16b abhydrolase domain containing 16B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:176,985,900...176,987,797
Ensembl chr 3:176,985,900...176,987,796
JBrowse link
G Abhd17a abhydrolase domain containing 17A, depalmitoylase IDA
IBA
ISO
PMID:27307232
PMID:21873635
(PMID:26701913)
RGD PMID:26701913, PMID:27307232, PMID:21873635 RGD:13441201, RGD:13792537 NCBI chr 7:11,992,543...12,000,978
Ensembl chr 7:11,992,543...11,998,973
JBrowse link
G Abhd17b abhydrolase domain containing 17B, depalmitoylase ISO
IBA
(PMID:26701913)
PMID:21873635
(MGI:MGI:6094388|PMID:27307232), (MGI:MGI:6103577|PMID:28521134)
RGD PMID:26701913, PMID:27307232, PMID:28521134, PMID:21873635 MGI:MGI:6094388, MGI:MGI:6103577, RGD:13792537 NCBI chr 1:239,266,140...239,301,133
Ensembl chr 1:239,266,921...239,301,176
JBrowse link
G Abhd17c abhydrolase domain containing 17C, depalmitoylase ISO
IBA
(PMID:26701913)
PMID:21873635
(MGI:MGI:6094388|PMID:27307232)
RGD PMID:26701913, PMID:27307232, PMID:21873635 MGI:MGI:6094388, RGD:13792537 NCBI chr 1:146,248,505...146,289,465
Ensembl chr 1:146,248,503...146,289,465
JBrowse link
G LOC103691298 acyl-protein thioesterase 1 pseudogene IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:236,529,758...236,530,758 JBrowse link
G LOC103693563 mycophenolic acid acyl-glucuronide esterase, mitochondrial ISS
ISO
GO_REF:0000024
(PMID:31740833)
UniProt
RGD
PMID:31740833 GO_REF:0000024 NCBI chr11:57,485,649...57,500,476
Ensembl chr11:57,486,365...57,498,894
JBrowse link
G Lypla1 lysophospholipase 1 ISO
IBA
ISS
(MGI:MGI:6094388|PMID:27307232)
(PMID:19439193), (PMID:20418879)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:19439193, PMID:20418879, PMID:27307232, PMID:21873635 GO_REF:0000024, MGI:MGI:6094388, RGD:13792537 NCBI chr 5:14,559,333...14,588,447
Ensembl chr 5:14,559,334...14,588,422
JBrowse link
G Lypla2 lysophospholipase 2 ISO
IBA
ISS
(PMID:28826475)
PMID:21873635
GO_REF:0000024
(MGI:MGI:6094388|PMID:27307232)
RGD
UniProt
PMID:27307232, PMID:28826475, PMID:21873635 GO_REF:0000024, MGI:MGI:6094388, RGD:13792537 NCBI chr 5:154,315,033...154,319,629
Ensembl chr 5:154,315,033...154,319,629
JBrowse link
G Lyplal1 lysophospholipase-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:104,049,263...104,080,680
Ensembl chr13:104,049,386...104,080,631
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
MGI:MGI:2176390 (MGI:MGI:2154013|PMID:11717424), (MGI:MGI:3608104|PMID:16242638), (MGI:MGI:3655641|PMID:12483688)
(PMID:10658183), (PMID:10737604), (PMID:7637805)
PMID:8895569
UniProt
RGD
PMID:7637805, PMID:10658183, PMID:10737604, PMID:11717424, PMID:12483688, PMID:16242638, PMID:21873635, PMID:8895569 GO_REF:0000024, MGI:MGI:2154013, MGI:MGI:3608104, MGI:MGI:3655641, RGD:13792537, RGD:8553248 NCBI chr 5:140,538,260...140,558,163
Ensembl chr 5:140,538,260...140,558,162
JBrowse link
G Ppt2 palmitoyl-protein thioesterase 2 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr20:4,381,455...4,401,638
Ensembl chr20:4,381,455...4,401,610
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20467
    catalytic activity 6067
      catalytic activity, acting on a protein 2312
        palmitoyl-(protein) hydrolase activity 17
Path 2
Term Annotations click to browse term
  molecular_function 20467
    catalytic activity 6067
      hydrolase activity 2637
        hydrolase activity, acting on ester bonds 804
          thiolester hydrolase activity 54
            palmitoyl-(protein) hydrolase activity 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.