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ONTOLOGY REPORT - ANNOTATIONS


Term:palmitoyl-(protein) hydrolase activity
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Accession:GO:0008474 term browser browse the term
Definition:Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
Synonyms:exact_synonym: palmitoyl-protein thioesterase activity;   palmitoyl-protein thiolesterase activity
 broad_synonym: palmitoyl-[protein] hydrolase
 xref: EC:3.1.2.22;   MetaCyc:3.1.2.22-RXN;   RHEA:19233;   Reactome:R-HSA-9647994 "RAS proteins are depalmitoylated";   reactome:R-HSA-203613 "depalmitoylation of eNOS";   reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins";   reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43"


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palmitoyl-(protein) hydrolase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD10 abhydrolase domain containing 10, depalmitoylase IDA (PMID:31740833) UniProt PMID:31740833 NCBI chr 3:111,979,026...111,993,368
Ensembl chr 3:111,979,010...111,993,368
JBrowse link
G ABHD12 abhydrolase domain containing 12, lysophospholipase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:25,294,743...25,390,835
Ensembl chr20:25,294,742...25,390,835
JBrowse link
G ABHD12B abhydrolase domain containing 12B IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:50,872,053...50,904,970
Ensembl chr14:50,872,053...50,904,970
JBrowse link
G ABHD13 abhydrolase domain containing 13 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:108,218,392...108,235,440
Ensembl chr13:108,218,392...108,234,243
JBrowse link
G ABHD16A abhydrolase domain containing 16A, phospholipase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:31,686,955...31,703,324
Ensembl chr 6:31,686,955...31,703,356
JBrowse link
G ABHD16B abhydrolase domain containing 16B IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:63,861,498...63,862,988
Ensembl chr20:63,861,498...63,862,988
JBrowse link
G ABHD17A abhydrolase domain containing 17A, depalmitoylase IMP
IBA
(PMID:26701913)
(PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:26701913 NCBI chr19:1,876,810...1,885,519
Ensembl chr19:1,876,810...1,885,496
Ensembl chr19:1,876,810...1,885,496
JBrowse link
G ABHD17B abhydrolase domain containing 17B, depalmitoylase IMP
IBA
(PMID:26701913)
(PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:26701913 NCBI chr 9:71,862,452...71,911,536
Ensembl chr 9:71,862,452...71,911,193
Ensembl chr 9:71,862,452...71,911,193
JBrowse link
G ABHD17C abhydrolase domain containing 17C, depalmitoylase IMP
IBA
(PMID:26701913)
(PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:26701913 NCBI chr15:80,695,310...80,755,621
Ensembl chr15:80,679,684...80,755,621
JBrowse link
G LYPLA1 lysophospholipase 1 IMP
IBA
IDA
(PMID:20418879)
(PMID:21873635)
(PMID:19439193)
UniProtKB
GO_Central
UniProt
PMID:19439193, PMID:20418879, PMID:21873635 NCBI chr 8:54,046,367...54,101,997
Ensembl chr 8:54,046,367...54,102,017
JBrowse link
G LYPLA2 lysophospholipase 2 TAS
IBA
IDA
(PMID:21873635)
(PMID:28826475)
Reactome
GO_Central
UniProtKB
PMID:21873635, PMID:28826475 Reactome:R-HSA-8933328 NCBI chr 1:23,790,789...23,795,539
Ensembl chr 1:23,791,145...23,795,539
JBrowse link
G LYPLAL1 lysophospholipase like 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:219,173,850...219,445,121
Ensembl chr 1:219,173,869...219,212,865
JBrowse link
G PPT1 palmitoyl-protein thioesterase 1 IEA
IBA
IDA
ISS
TAS
IMP
(PMID:21873635)
(PMID:10658183), (PMID:10737604)
(PMID:7637805)
InterPro
GO_Central
UniProt
UniProtKB
Reactome
PMID:7637805, PMID:10658183, PMID:10737604, PMID:21873635 GO_REF:0000002, GO_REF:0000003, GO_REF:0000024, Reactome:R-HSA-5690517 NCBI chr 1:40,071,461...40,097,252
Ensembl chr 1:40,072,710...40,097,260
Ensembl chr 1:40,072,710...40,097,260
JBrowse link
G PPT2 palmitoyl-protein thioesterase 2 IEA InterPro GO_REF:0000002 NCBI chr 6:32,153,528...32,163,675
Ensembl chr 6:32,153,441...32,163,678
JBrowse link
G PPT2-EGFL8 PPT2-EGFL8 readthrough (NMD candidate) IEA InterPro GO_REF:0000002 NCBI chr 6:32,153,999...32,168,285
Ensembl chr 6:32,153,845...32,171,978
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 18823
    catalytic activity 5961
      catalytic activity, acting on a protein 2401
        palmitoyl-(protein) hydrolase activity 15
Path 2
Term Annotations click to browse term
  molecular_function 18823
    catalytic activity 5961
      hydrolase activity 2629
        hydrolase activity, acting on ester bonds 809
          thiolester hydrolase activity 47
            palmitoyl-(protein) hydrolase activity 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.