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ONTOLOGY REPORT - ANNOTATIONS


Term:palmitoyl-(protein) hydrolase activity
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Accession:GO:0008474 term browser browse the term
Definition:Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
Synonyms:exact_synonym: palmitoyl-protein thioesterase activity;   palmitoyl-protein thiolesterase activity
 broad_synonym: palmitoyl-[protein] hydrolase
 xref: EC:3.1.2.22;   MetaCyc:3.1.2.22-RXN;   RHEA:19233;   Reactome:R-HSA-9647994 "RAS proteins are depalmitoylated";   reactome:R-HSA-203613 "depalmitoylation of eNOS";   reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins";   reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43"


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palmitoyl-(protein) hydrolase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd10 abhydrolase domain containing 10 ISO
IDA
(MGI:6467702|PMID:31740833) MGI
UniProt
PMID:31740833 GO_REF:0000096, MGI:4834177, MGI:6467702 NCBI chr16:45,729,725...45,742,955
Ensembl chr16:45,729,725...45,742,955
JBrowse link
G Abhd12 abhydrolase domain containing 12 IBA
IDA
(MGI:6201960|PMID:21873635)
(MGI:6094388|PMID:27307232)
GO_Central
UniProt
PMID:21873635, PMID:27307232 MGI:6094388, MGI:6201960 NCBI chr 2:150,832,493...150,904,779
Ensembl chr 2:150,832,493...150,904,741
JBrowse link
G Abhd12b abhydrolase domain containing 12B IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr12:70,154,124...70,190,096
Ensembl chr12:70,154,142...70,183,887
JBrowse link
G Abhd13 abhydrolase domain containing 13 IBA
IDA
(MGI:6201960|PMID:21873635)
(MGI:6094388|PMID:27307232)
GO_Central
UniProt
PMID:21873635, PMID:27307232 MGI:6094388, MGI:6201960 NCBI chr 8:9,977,717...9,992,155
Ensembl chr 8:9,977,707...9,992,155
JBrowse link
G Abhd16a abhydrolase domain containing 16A IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr17:35,089,234...35,102,987
Ensembl chr17:35,089,263...35,102,987
JBrowse link
G Abhd16b abhydrolase domain containing 16B IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 2:181,493,206...181,494,980
Ensembl chr 2:181,493,206...181,494,980
JBrowse link
G Abhd17a abhydrolase domain containing 17A ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:4417868, MGI:4834177, MGI:6201960 NCBI chr10:80,583,649...80,590,341
Ensembl chr10:80,583,654...80,590,341
JBrowse link
G Abhd17b abhydrolase domain containing 17B ISO
IBA
IMP
(MGI:6201960|PMID:21873635)
(MGI:6094388|PMID:27307232), (MGI:6103577|PMID:28521134)
MGI
GO_Central
UniProt
PMID:21873635, PMID:27307232, PMID:28521134 GO_REF:0000096, MGI:4834177, MGI:6094388, MGI:6103577, MGI:6201960 NCBI chr19:21,653,267...21,685,638
Ensembl chr19:21,653,185...21,685,637
JBrowse link
G Abhd17c abhydrolase domain containing 17C IDA
ISO
IBA
(MGI:6094388|PMID:27307232)
(MGI:6201960|PMID:21873635)
UniProt
MGI
GO_Central
PMID:21873635, PMID:27307232 GO_REF:0000096, MGI:4834177, MGI:6094388, MGI:6201960 NCBI chr 7:84,109,356...84,151,893
Ensembl chr 7:84,109,356...84,151,893
JBrowse link
G Lypla1 lysophospholipase 1 IDA
IBA
ISO
(MGI:6094388|PMID:27307232)
(MGI:6201960|PMID:21873635)
UniProt
GO_Central
MGI
PMID:21873635, PMID:27307232 GO_REF:0000096, MGI:4834177, MGI:6094388, MGI:6201960 NCBI chr 1:4,807,823...4,846,735
Ensembl chr 1:4,807,788...4,848,410
JBrowse link
G Lypla2 lysophospholipase 2 IDA
ISO
IBA
(MGI:6094388|PMID:27307232)
(MGI:6201960|PMID:21873635)
UniProt
MGI
GO_Central
PMID:21873635, PMID:27307232 GO_REF:0000096, MGI:4834177, MGI:6094388, MGI:6201960 NCBI chr 4:135,968,224...135,972,612
Ensembl chr 4:135,968,224...135,972,626
JBrowse link
G Lyplal1 lysophospholipase-like 1 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 1:186,087,732...186,117,310
Ensembl chr 1:186,087,731...186,117,310
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 ISO
IBA
IMP
IDA
(MGI:6201960|PMID:21873635)
(MGI:2154013|PMID:11717424), (MGI:3608104|PMID:16242638)
(MGI:3655641|PMID:12483688)
MGI
GO_Central
PMID:11717424, PMID:12483688, PMID:16242638, PMID:21873635 GO_REF:0000096, MGI:2154013, MGI:3608104, MGI:3655641, MGI:4834177, MGI:6201960 NCBI chr 4:122,836,077...122,859,175
Ensembl chr 4:122,836,242...122,859,175
JBrowse link
G Ppt2 palmitoyl-protein thioesterase 2 IEA UniProt GO_REF:0000002, MGI:2152098 NCBI chr17:34,616,662...34,638,022
Ensembl chr17:34,616,662...34,628,510
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 23090
    catalytic activity 5756
      catalytic activity, acting on a protein 2291
        palmitoyl-(protein) hydrolase activity 14
Path 2
Term Annotations click to browse term
  molecular_function 23090
    catalytic activity 5756
      hydrolase activity 2497
        hydrolase activity, acting on ester bonds 770
          thiolester hydrolase activity 51
            palmitoyl-(protein) hydrolase activity 14
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.