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ONTOLOGY REPORT - ANNOTATIONS


Term:palmitoyl-(protein) hydrolase activity
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Accession:GO:0008474 term browser browse the term
Definition:Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
Synonyms:exact_synonym: palmitoyl-protein thioesterase activity;   palmitoyl-protein thiolesterase activity
 broad_synonym: palmitoyl-[protein] hydrolase
 xref: EC:3.1.2.22;   MetaCyc:3.1.2.22-RXN;   RHEA:19233;   Reactome:R-HSA-9647994 "RAS proteins are depalmitoylated";   reactome:R-HSA-203613 "depalmitoylation of eNOS";   reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins";   reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43"


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palmitoyl-(protein) hydrolase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD10 abhydrolase domain containing 10, depalmitoylase ISO (PMID:31740833)
(MGI:6467702|PMID:31740833)
UniProt PMID:31740833 MGI:6467702 NCBI chr13:147,760,742...147,778,072
Ensembl chr13:147,759,762...147,775,940
JBrowse link
G ABHD12 abhydrolase domain containing 12, lysophospholipase IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr17:30,997,477...31,056,307
Ensembl chr17:30,997,480...31,056,312
JBrowse link
G ABHD12B abhydrolase domain containing 12B IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:180,635,479...180,662,432
Ensembl chr 1:180,635,727...180,661,065
JBrowse link
G ABHD13 abhydrolase domain containing 13 IEA Ensembl GO_REF:0000107 NCBI chr11:75,547,748...75,569,843
Ensembl chr11:75,547,747...75,570,263
JBrowse link
G ABHD16A abhydrolase domain containing 16A, phospholipase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:23,800,932...23,814,920
Ensembl chr 7:23,800,935...23,814,948
JBrowse link
G ABHD16B abhydrolase domain containing 16B IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:62,729,995...62,732,060
Ensembl chr17:62,730,062...62,731,474
JBrowse link
G ABHD17A abhydrolase domain containing 17A, depalmitoylase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:76,658,073...76,666,561
Ensembl chr 2:76,658,068...76,666,562
JBrowse link
G ABHD17B abhydrolase domain containing 17B, depalmitoylase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:225,149,922...225,193,329
Ensembl chr 1:225,150,664...225,193,334
JBrowse link
G ABHD17C abhydrolase domain containing 17C, depalmitoylase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:49,540,698...49,599,323
Ensembl chr 7:49,540,602...49,599,321
JBrowse link
G LYPLA1 lysophospholipase 1 IEA
IBA
(PMID:21873635) Ensembl
GO_Central
PMID:21873635 GO_REF:0000107 NCBI chr 4:77,083,624...77,102,407
Ensembl chr 4:77,083,585...77,102,408
JBrowse link
G LYPLA2 lysophospholipase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:81,601,492...81,605,914
Ensembl chr 6:81,601,437...81,730,657
JBrowse link
G LYPLAL1 lysophospholipase like 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:8,946,463...9,061,033
Ensembl chr10:8,946,487...9,062,412
JBrowse link
G PPT1 palmitoyl-protein thioesterase 1 IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000003 NCBI chr 6:95,840,906...95,860,858
Ensembl chr 6:95,840,905...95,860,837
JBrowse link
G PPT2 palmitoyl-protein thioesterase 2 IEA InterPro GO_REF:0000002 NCBI chr 7:24,188,335...24,200,707
Ensembl chr 7:24,188,030...24,200,704
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 17444
    catalytic activity 5460
      catalytic activity, acting on a protein 2196
        palmitoyl-(protein) hydrolase activity 14
Path 2
Term Annotations click to browse term
  molecular_function 17444
    catalytic activity 5460
      hydrolase activity 2355
        hydrolase activity, acting on ester bonds 735
          thiolester hydrolase activity 46
            palmitoyl-(protein) hydrolase activity 14
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.