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ONTOLOGY REPORT - ANNOTATIONS


Term:palmitoyl-(protein) hydrolase activity
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Accession:GO:0008474 term browser browse the term
Definition:Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein.
Synonyms:exact_synonym: palmitoyl-protein thioesterase activity;   palmitoyl-protein thiolesterase activity
 broad_synonym: palmitoyl-[protein] hydrolase
 xref: EC:3.1.2.22;   MetaCyc:3.1.2.22-RXN;   RHEA:19233;   Reactome:R-HSA-9647994 "RAS proteins are depalmitoylated";   reactome:R-HSA-203613 "depalmitoylation of eNOS";   reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins";   reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43"


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palmitoyl-(protein) hydrolase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd10 abhydrolase domain containing 10, depalmitoylase ISO (PMID:31740833)
(MGI:6467702|PMID:31740833)
UniProt PMID:31740833 MGI:6467702 NCBI chrNW_004936834:794,006...805,758 JBrowse link
G Abhd12 abhydrolase domain containing 12, lysophospholipase ISO (MGI:6094388|PMID:27307232) UniProt PMID:27307232 MGI:6094388 NCBI chrNW_004936620:451,216...531,353 JBrowse link
G Abhd13 abhydrolase domain containing 13 ISO (MGI:6094388|PMID:27307232) UniProt PMID:27307232 MGI:6094388 NCBI chrNW_004936472:3,845,934...3,858,465 JBrowse link
G Abhd17a abhydrolase domain containing 17A, depalmitoylase ISO PMID:27307232
(PMID:26701913)
UniProt
UniProtKB
PMID:26701913, PMID:27307232 RGD:13441201 NCBI chrNW_004936588:1,081,719...1,089,514 JBrowse link
G Abhd17b abhydrolase domain containing 17B, depalmitoylase ISO (PMID:26701913)
(MGI:6094388|PMID:27307232), (MGI:6103577|PMID:28521134)
UniProtKB
UniProt
PMID:26701913, PMID:27307232, PMID:28521134 MGI:6094388, MGI:6103577 NCBI chrNW_004936503:7,902,116...7,943,300 JBrowse link
G Abhd17c abhydrolase domain containing 17C, depalmitoylase ISO (PMID:26701913)
(MGI:6094388|PMID:27307232)
UniProtKB
UniProt
PMID:26701913, PMID:27307232 MGI:6094388 NCBI chrNW_004936483:19,908,853...19,964,627 JBrowse link
G Lypla1 lysophospholipase 1 ISO (PMID:19439193)
(MGI:6094388|PMID:27307232)
(PMID:20418879)
UniProt
UniProtKB
PMID:19439193, PMID:20418879, PMID:27307232 MGI:6094388 NCBI chrNW_004936496:937,918...971,315 JBrowse link
G Lypla2 lysophospholipase 2 ISO (PMID:28826475)
(MGI:6094388|PMID:27307232)
UniProtKB
UniProt
PMID:27307232, PMID:28826475 MGI:6094388 NCBI chrNW_004936474:8,945,247...8,949,756 JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 ISO (PMID:7637805)
(MGI:2154013|PMID:11717424), (MGI:3608104|PMID:16242638)
(MGI:3655641|PMID:12483688)
(PMID:10658183), (PMID:10737604)
UniProtKB
MGI
PMID:7637805, PMID:10658183, PMID:10737604, PMID:11717424, PMID:12483688, PMID:16242638 MGI:2154013, MGI:3608104, MGI:3655641 NCBI chrNW_004936474:21,881,692...21,906,564 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 14080
    catalytic activity 3557
      catalytic activity, acting on a protein 1498
        palmitoyl-(protein) hydrolase activity 9
Path 2
Term Annotations click to browse term
  molecular_function 14080
    catalytic activity 3557
      hydrolase activity 1373
        hydrolase activity, acting on ester bonds 520
          thiolester hydrolase activity 29
            palmitoyl-(protein) hydrolase activity 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.