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ONTOLOGY REPORT - ANNOTATIONS


Term:procollagen-lysine 5-dioxygenase activity
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Accession:GO:0008475 term browser browse the term
Definition:Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2.
Synonyms:broad_synonym: lysine hydroxylase activity;   lysine,2-oxoglutarate 5-dioxygenase activity;   lysine-2-oxoglutarate dioxygenase activity;   lysyl hydroxylase activity
 related_synonym: collagen lysine hydroxylase activity;   lysylprotocollagen dioxygenase activity;   procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating);   procollagen-lysine,2-oxoglutarate 5-dioxygenase activity;   protocollagen lysine dioxygenase activity;   protocollagen lysine hydroxylase activity;   protocollagen lysyl hydroxylase activity
 xref: EC:1.14.11.4;   MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN;   RHEA:16569;   reactome:R-HSA-1981104 "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines"


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procollagen-lysine 5-dioxygenase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plod1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 IMP
IBA
IEA
IDA
ISO
PMID:21873635
GO_REF:0000003
(PMID:10934207), (PMID:8621606), (PMID:9724729)
UniProt
RGD
PMID:8621606, PMID:9724729, PMID:10934207, PMID:11714250, PMID:21873635, PMID:11714250 GO_REF:0000003, RGD:1599090, RGD:13792537, RGD:1599090 NCBI chr 5:164,720,629...164,747,071
Ensembl chr 5:164,720,587...164,747,083
JBrowse link
G Plod2 procollagen lysine, 2-oxoglutarate 5-dioxygenase 2 ISO
IBA
IEA
(PMID:10934207)
PMID:21873635
GO_REF:0000003
RGD
UniProt
PMID:10934207, PMID:21873635 GO_REF:0000003, RGD:13792537 NCBI chr 8:99,977,334...100,059,736
Ensembl chr 8:99,977,334...100,059,736
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 ISS
ISO
IBA
GO_REF:0000024
(PMID:10934207), (PMID:18298658), (PMID:9582318), (PMID:9724729)
(MGI:3618677|PMID:16467571), (MGI:6202004|PMID:16447251)
PMID:21873635
UniProt
RGD
PMID:9582318, PMID:9724729, PMID:10934207, PMID:16447251, PMID:16467571, PMID:18298658, PMID:21873635 GO_REF:0000024, MGI:3618677, MGI:6202004, RGD:13792537 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20471
    catalytic activity 6068
      catalytic activity, acting on a protein 2384
        peptidyl-lysine 5-dioxygenase activity 4
          procollagen-lysine 5-dioxygenase activity 3
Path 2
Term Annotations click to browse term
  molecular_function 20471
    catalytic activity 6068
      oxidoreductase activity 877
        oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 223
          2-oxoglutarate-dependent dioxygenase activity 50
            peptidyl-lysine 5-dioxygenase activity 4
              procollagen-lysine 5-dioxygenase activity 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.