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ONTOLOGY REPORT - ANNOTATIONS


Term:sodium:potassium:chloride symporter activity
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Accession:GO:0008511 term browser browse the term
Definition:Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in).
Synonyms:xref: Reactome:R-HSA-5623588 "Defective SLC12A1 does not cotransport Na+, K+, 2Cl- from extracellular region to cytosol";   reactome:R-HSA-426086 "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol"


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sodium:potassium:chloride symporter activity term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G SLC12A1 solute carrier family 12 member 1 JBrowse link 15 45,479,583 45,577,084 RGD:9068941
G SLC12A2 solute carrier family 12 member 2 JBrowse link 5 129,260,476 129,364,563 RGD:9068941
G SLC12A3 solute carrier family 12 member 3 JBrowse link 16 56,276,026 56,326,973 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 15806
    transporter activity 1159
      transmembrane transporter activity 1021
        inorganic molecular entity transmembrane transporter activity 796
          inorganic anion transmembrane transporter activity 137
            chloride transmembrane transporter activity 98
              cation:chloride symporter activity 16
                sodium:chloride symporter activity 10
                  sodium:potassium:chloride symporter activity 3
Path 2
Term Annotations click to browse term
  molecular_function 15806
    transporter activity 1159
      transmembrane transporter activity 1021
        ion transmembrane transporter activity 849
          cation transmembrane transporter activity 625
            inorganic cation transmembrane transporter activity 583
              metal ion transmembrane transporter activity 427
                sodium ion transmembrane transporter activity 156
                  solute:sodium symporter activity 77
                    anion:sodium symporter activity 13
                      sodium:chloride symporter activity 10
                        sodium:potassium:chloride symporter activity 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.