Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:microtubule-severing ATPase activity
go back to main search page
Accession:GO:0008568 term browser browse the term
Definition:Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP.
Comment:See also the cellular component term 'katanin complex ; GO:0008352'.
Synonyms:exact_synonym: ATP phosphohydrolase (tubulin-dimerizing)
 narrow_synonym: katanin activity
 xref: EC:5.6.1.1;   MetaCyc:3.6.4.3-RXN;   Reactome:R-HSA-9668419 "SPAST (spastin) mediates the severing of microtubules at chromosome attachment sites"


show annotations for term's descendants           Sort by:
 
microtubule-severing ATPase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fign fidgetin, microtubule severing factor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:49,992,250...50,120,601
Ensembl chr 3:49,992,397...50,120,392
JBrowse link
G Fignl1 fidgetin-like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:91,895,902...91,904,474
Ensembl chr14:91,895,909...91,904,433
JBrowse link
G Katna1 katanin catalytic subunit A1 IBA
IEA
ISO
PMID:21873635
GO_REF:0000003
(PMID:10751153)
UniProt
RGD
PMID:10751153, PMID:21873635 GO_REF:0000003, RGD:13792537 NCBI chr 1:1,826,170...1,867,786
Ensembl chr 1:1,825,872...1,867,787
JBrowse link
G Katnal1 katanin catalytic subunit A1 like 1 ISO
IEA
IBA
ISS
(MGI:MGI:5427753|PMID:22654668)
GO_REF:0000003
PMID:21873635
(PMID:26929214)
GO_REF:0000024
RGD
UniProt
PMID:22654668, PMID:26929214, PMID:21873635 GO_REF:0000003, GO_REF:0000024, MGI:MGI:5427753, RGD:13792537 NCBI chr12:7,495,436...7,550,205
Ensembl chr12:7,208,850...7,271,872
Ensembl chr12:7,208,850...7,271,872
JBrowse link
G Katnal2 katanin catalytic subunit A1 like 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:73,283,756...73,360,367
Ensembl chr18:73,283,748...73,360,373
JBrowse link
G LOC100910196 katanin p60 ATPase-containing subunit A-like 1-like ISS
IEA
IBA
GO_REF:0000024
GO_REF:0000003
PMID:21873635
UniProt PMID:21873635 GO_REF:0000003, GO_REF:0000024, RGD:13792537 NCBI chr12:7,446,804...7,479,232
Ensembl chr12:7,208,850...7,271,872
Ensembl chr12:7,208,850...7,271,872
JBrowse link
G LOC103690050 katanin p60 ATPase-containing subunit A-like 1 ISS
IBA
IEA
GO_REF:0000024
PMID:21873635
GO_REF:0000003
UniProt PMID:21873635 GO_REF:0000003, GO_REF:0000024, RGD:13792537 NCBI chr12:7,208,836...7,273,411
Ensembl chr12:7,208,850...7,271,872
Ensembl chr12:7,208,850...7,271,872
JBrowse link
G Spast spastin ISS
IEA
IBA
ISO
GO_REF:0000024
GO_REF:0000003
PMID:21873635
(PMID:15716377), (PMID:16219033), (PMID:17389232), (PMID:23745751), (PMID:26875866)
UniProt
RGD
PMID:15716377, PMID:16219033, PMID:17389232, PMID:23745751, PMID:26875866, PMID:21873635 GO_REF:0000003, GO_REF:0000024, RGD:13792537 NCBI chr 6:22,230,067...22,282,166
Ensembl chr 6:22,230,928...22,281,886
JBrowse link
G Vps4b vacuolar protein sorting 4 homolog B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:26,825,261...26,850,460
Ensembl chr13:26,825,261...26,850,460
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20467
    catalytic activity 6067
      catalytic activity, acting on a protein 2312
        microtubule-severing ATPase activity 9
Path 2
Term Annotations click to browse term
  molecular_function 20467
    catalytic activity 6067
      hydrolase activity 2637
        hydrolase activity, acting on acid anhydrides 857
          hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 857
            pyrophosphatase activity 855
              nucleoside-triphosphatase activity 789
                ATPase activity 443
                  microtubule-severing ATPase activity 9
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.