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ONTOLOGY REPORT - ANNOTATIONS


Term:attachment of spindle microtubules to kinetochore
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Accession:GO:0008608 term browser browse the term
Definition:The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex.
Comment:This class covers all attachments of spindle microtubules to the kinetochore, including the many incorrect attachments which initially form and are later corrected to stable attachments with the correct orientation for segregation to proceed (sister chromatid biorientation).
Synonyms:exact_synonym: attachment of spindle microtubules to chromosome;   kinetochore-microtubule attachment;   microtubule anchoring at kinetochore;   spindle chromosome attachment;   spindle kinetochore attachment
 narrow_synonym: microtubule capture
 broad_synonym: kinetochore microtubule interaction;   microtubule and chromosome interaction;   spindle-chromosome interaction
 related_synonym: amphotelic attachment;   bipolar attachment;   microtubule and kinetochore interaction
 alt_id: GO:0051313


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attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abraxas1 abraxas 1, BRCA1 A complex subunit IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:10,424,674...10,439,010
Ensembl chr14:10,424,674...10,439,003
JBrowse link
G Abraxas2 abraxas 2, BRISC complex subunit ISO
IBA
(PMID:26195665)
PMID:21873635
RGD PMID:26195665, PMID:21873635 RGD:13792537 NCBI chr 1:204,861,768...204,887,344
Ensembl chr 1:204,861,566...204,887,377
JBrowse link
G Bub3 BUB3 mitotic checkpoint protein ISO (PMID:18199686) RGD PMID:18199686 NCBI chr 1:203,526,853...203,537,459
Ensembl chr 1:203,524,426...203,557,337
JBrowse link
G Cenpe centromere protein E ISO (MGI:MGI:2673075|PMID:12925705) RGD PMID:12925705 MGI:MGI:2673075 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
G Knl1 kinetochore scaffold 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:110,847,304...110,909,807
Ensembl chr 3:110,855,000...110,909,807
JBrowse link
G LOC100911204 protein CASC5-like ISO
IBA
(PMID:17981135)
PMID:21873635
RGD PMID:17981135, PMID:21873635 RGD:13792537 NCBI chr 3:112,531,429...112,560,698
Ensembl chr 3:112,531,703...112,560,634
JBrowse link
G Ndc80 NDC80 kinetochore complex component ISO (PMID:19468067) RGD PMID:19468067 NCBI chr 9:119,837,857...119,871,435
Ensembl chr 9:119,839,016...119,871,382
JBrowse link
G Sgo1 shugoshin 1 ISO (PMID:17621308) RGD PMID:17621308 NCBI chr 9:4,420,158...4,435,939
Ensembl chr 9:4,421,069...4,436,601
JBrowse link
G Tex14 testis expressed 14, intercellular bridge forming factor IEA
IBA
ISS
ISO
GO_REF:0000107
PMID:21873635
GO_REF:0000024
(MGI:MGI:5318128|PMID:22405274)
Ensembl
UniProt
RGD
PMID:22405274, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5318128, RGD:13792537 NCBI chr10:74,724,070...74,849,172
Ensembl chr10:74,724,549...74,849,194
JBrowse link
G Zfp207 zinc finger protein 207 ISO
IBA
(PMID:24462186), (PMID:24462187)
PMID:21873635
RGD PMID:24462186, PMID:24462187, PMID:21873635 RGD:13792537 NCBI chr10:67,762,970...67,784,854
Ensembl chr10:67,762,995...67,774,787
JBrowse link
attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO (PMID:22581055) RGD PMID:22581055 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Cenpc centromere protein C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:23,611,909...23,670,314
Ensembl chr14:23,611,735...23,670,475
JBrowse link
G Cenpe centromere protein E ISO (PMID:15843429) RGD PMID:15843429 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
G Champ1 chromosome alignment maintaining phosphoprotein 1 ISO
IBA
(PMID:21063390)
PMID:21873635
RGD PMID:21063390, PMID:21873635 RGD:13792537 NCBI chr16:80,839,373...80,850,340
Ensembl chr16:80,839,374...80,850,340
JBrowse link
G Kif2c kinesin family member 2C IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:23891108)
Ensembl
UniProt
RGD
PMID:23891108 GO_REF:0000024, GO_REF:0000107 NCBI chr 5:136,027,923...136,053,268
Ensembl chr 5:136,027,934...136,053,210
JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:16,410,083...16,721,232
Ensembl chr12:16,410,083...16,719,824
JBrowse link
G Mis12 MIS12 kinetochore complex component ISO
IEA
ISS
(PMID:23891108)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:23891108 GO_REF:0000024, GO_REF:0000107 NCBI chr10:57,653,685...57,661,833
Ensembl chr10:57,660,067...57,660,687
JBrowse link
G Ndc80 NDC80 kinetochore complex component ISO
IBA
(PMID:23891108), (PMID:25743205)
PMID:21873635
RGD PMID:23891108, PMID:25743205, PMID:21873635 RGD:13792537 NCBI chr 9:119,837,857...119,871,435
Ensembl chr 9:119,839,016...119,871,382
JBrowse link
G Nuf2 NUF2 component of NDC80 kinetochore complex IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:87,818,456...87,847,223
Ensembl chr13:87,818,391...87,847,263
JBrowse link
G Seh1l SEH1-like nucleoporin ISO (PMID:17363900) RGD PMID:17363900 NCBI chr18:63,545,150...63,568,101 JBrowse link
homologous chromosome orientation involved in meiotic metaphase I plate congression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Brca2 BRCA2, DNA repair associated IMP RGD PMID:16964288 RGD:1599505 NCBI chr12:503,660...544,754
Ensembl chr12:504,007...544,748
JBrowse link
lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpe centromere protein E ISO (PMID:23891108) RGD PMID:23891108 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
mitotic sister chromatid biorientation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bod1 biorientation of chromosomes in cell division 1 ISO (PMID:17938248), (PMID:24157919) RGD PMID:17938248, PMID:24157919 NCBI chr10:16,259,728...16,266,069
Ensembl chr10:16,259,728...16,266,061
JBrowse link
monopolar spindle attachment to meiosis I kinetochore term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpc centromere protein C IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:23,611,909...23,670,314
Ensembl chr14:23,611,735...23,670,475
JBrowse link
positive regulation of attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 ISO (PMID:23478334) RGD PMID:23478334 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U IEA
IBA
ISO
ISS
GO_REF:0000107
PMID:21873635
(PMID:21242313)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:21242313, PMID:21873635 GO_REF:0000024, GO_REF:0000107, RGD:13792537 NCBI chr13:96,222,093...96,238,845
Ensembl chr13:96,225,912...96,238,572
JBrowse link
positive regulation of attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 ISO (PMID:18195732) RGD PMID:18195732 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cenpe centromere protein E ISO (MGI:MGI:2447982|PMID:12361599) RGD PMID:12361599 MGI:MGI:2447982 NCBI chr 2:240,395,974...240,454,785
Ensembl chr 2:240,396,152...240,454,747
JBrowse link
G Rcc2 regulator of chromosome condensation 2 ISO (PMID:12919680) RGD PMID:12919680 NCBI chr 5:159,220,531...159,236,313
Ensembl chr 5:159,220,979...159,234,320
JBrowse link
G Sirt2 sirtuin 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5567889|PMID:24334550)
Ensembl
UniProt
RGD
PMID:24334550 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5567889 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952
JBrowse link
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkb aurora kinase B ISO (PMID:28751710) RGD PMID:28751710 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
regulation of attachment of spindle microtubules to kinetochore term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apc APC regulator of WNT signaling pathway ISO
IEA
(PMID:17227893)
GO_REF:0000107
(MGI:MGI:3701148|PMID:17227893)
RGD
Ensembl
PMID:17227893 GO_REF:0000107, MGI:MGI:3701148 NCBI chr18:27,011,710...27,106,323
Ensembl chr18:27,047,382...27,105,531
JBrowse link
G Cdc42 cell division cycle 42 ISO
ISS
(PMID:15642749)
GO_REF:0000024
RGD
UniProt
PMID:15642749 GO_REF:0000024 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Ect2 epithelial cell transforming 2 ISO (PMID:15642749) RGD PMID:15642749 NCBI chr 2:112,769,385...112,831,476
Ensembl chr 2:112,769,385...112,831,476
JBrowse link
G Knstrn kinetochore-localized astrin/SPAG5 binding protein ISO
IBA
ISS
(PMID:21402792)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:21402792, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 3:110,618,256...110,638,024
Ensembl chr 3:110,618,298...110,638,046
JBrowse link
G Nek2 NIMA-related kinase 2 ISO (PMID:18297113) RGD PMID:18297113 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 ISO (PMID:15642749) RGD PMID:15642749 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233
JBrowse link
G Spag5 sperm associated antigen 5 ISO (PMID:21402792) RGD PMID:21402792 NCBI chr10:65,552,780...65,585,773
Ensembl chr10:65,566,171...65,585,760
Ensembl chr10:65,566,171...65,585,760
JBrowse link
sister chromatid biorientation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Champ1 chromosome alignment maintaining phosphoprotein 1 ISO
IBA
(PMID:21063390)
PMID:21873635
RGD PMID:21063390, PMID:21873635 RGD:13792537 NCBI chr16:80,839,373...80,850,340
Ensembl chr16:80,839,374...80,850,340
JBrowse link
G Rb1 RB transcriptional corepressor 1 ISO
IEA
(PMID:20551165)
GO_REF:0000107
RGD
Ensembl
PMID:20551165 GO_REF:0000107 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cell cycle process 1210
        attachment of spindle microtubules to kinetochore 34
          attachment of mitotic spindle microtubules to kinetochore + 14
          attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation + 2
          negative regulation of attachment of spindle microtubules to kinetochore + 0
          positive regulation of attachment of spindle microtubules to kinetochore + 7
          regulation of attachment of spindle microtubules to kinetochore + 14
          sister chromatid biorientation + 3
Path 2
Term Annotations click to browse term
  biological_process 20028
    cellular process 18800
      cell cycle 1534
        cell cycle process 1210
          nuclear chromosome segregation 274
            attachment of spindle microtubules to kinetochore 34
              attachment of mitotic spindle microtubules to kinetochore + 14
              attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation + 2
              negative regulation of attachment of spindle microtubules to kinetochore + 0
              positive regulation of attachment of spindle microtubules to kinetochore + 7
              regulation of attachment of spindle microtubules to kinetochore + 14
              sister chromatid biorientation + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.